Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 71

1.

The role of Helicobacter pylori DnaA domain I in orisome assembly on a bipartite origin of chromosome replication.

Nowaczyk-Cieszewska M, Zyla-Uklejewicz D, Noszka M, Jaworski P, Mielke T, Zawilak-Pawlik AM.

Mol Microbiol. 2019 Nov 12. doi: 10.1111/mmi.14423. [Epub ahead of print]

PMID:
31715026
2.

Structural transitions during the scaffolding-driven assembly of a viral capsid.

Ignatiou A, Brasilès S, El Sadek Fadel M, Bürger J, Mielke T, Topf M, Tavares P, Orlova EV.

Nat Commun. 2019 Oct 24;10(1):4840. doi: 10.1038/s41467-019-12790-6.

3.

Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium.

Brandt R, Sell T, Lüthen M, Uhlitz F, Klinger B, Riemer P, Giesecke-Thiel C, Schulze S, El-Shimy IA, Kunkel D, Fauler B, Mielke T, Mages N, Herrmann BG, Sers C, Blüthgen N, Morkel M.

Nat Commun. 2019 Jul 2;10(1):2919. doi: 10.1038/s41467-019-10954-y.

4.

Consolidative mediastinal irradiation of malignant lymphoma using active scanning proton beams: clinical outcome and dosimetric comparison.

König L, Bougatf N, Hörner-Rieber J, Chaudhri N, Mielke T, Klüter S, Haefner MF, Rieken S, Haberer T, Debus J, Herfarth K.

Strahlenther Onkol. 2019 Jul;195(7):677-687. doi: 10.1007/s00066-019-01460-7. Epub 2019 Apr 10.

PMID:
30972453
5.

Structural Basis for the Action of an All-Purpose Transcription Anti-termination Factor.

Krupp F, Said N, Huang YH, Loll B, Bürger J, Mielke T, Spahn CMT, Wahl MC.

Mol Cell. 2019 Apr 4;74(1):143-157.e5. doi: 10.1016/j.molcel.2019.01.016. Epub 2019 Feb 19.

PMID:
30795892
6.

tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis.

Flis J, Holm M, Rundlet EJ, Loerke J, Hilal T, Dabrowski M, Bürger J, Mielke T, Blanchard SC, Spahn CMT, Budkevich TV.

Cell Rep. 2018 Dec 4;25(10):2676-2688.e7. doi: 10.1016/j.celrep.2018.11.040.

7.

Dosimetric comparison of advanced radiotherapy approaches using photon techniques and particle therapy in the postoperative management of thymoma.

Haefner MF, Verma V, Bougatf N, Mielke T, Tonndorf-Martini E, König L, Rwigema JM, Simone CB 2nd, Uhlmann L, Eichhorn F, Winter H, Grosch H, Haberer T, Herfarth K, Debus J, Rieken S.

Acta Oncol. 2018 Dec;57(12):1713-1720. doi: 10.1080/0284186X.2018.1502467. Epub 2018 Sep 28.

PMID:
30264630
8.

It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods.

Qureshi BM, Behrmann E, Schöneberg J, Loerke J, Bürger J, Mielke T, Giesebrecht J, Noé F, Lamb TD, Hofmann KP, Spahn CMT, Heck M.

Open Biol. 2018 Aug;8(8). pii: 180075. doi: 10.1098/rsob.180075.

9.

Structure and Function of the Campylobacter jejuni Chromosome Replication Origin.

Jaworski P, Donczew R, Mielke T, Weigel C, Stingl K, Zawilak-Pawlik A.

Front Microbiol. 2018 Jul 12;9:1533. doi: 10.3389/fmicb.2018.01533. eCollection 2018.

10.

Structural Visualization of the Formation and Activation of the 50S Ribosomal Subunit during In Vitro Reconstitution.

Nikolay R, Hilal T, Qin B, Mielke T, Bürger J, Loerke J, Textoris-Taube K, Nierhaus KH, Spahn CMT.

Mol Cell. 2018 Jun 7;70(5):881-893.e3. doi: 10.1016/j.molcel.2018.05.003. Epub 2018 Jun 7.

11.

Simple paired heavy- and light-chain antibody repertoire sequencing using endoplasmic reticulum microsomes.

Devulapally PR, Bürger J, Mielke T, Konthur Z, Lehrach H, Yaspo ML, Glökler J, Warnatz HJ.

Genome Med. 2018 Apr 27;10(1):34. doi: 10.1186/s13073-018-0542-5.

12.

Mechanistic insights into the role of prenyl-binding protein PrBP/δ in membrane dissociation of phosphodiesterase 6.

Qureshi BM, Schmidt A, Behrmann E, Bürger J, Mielke T, Spahn CMT, Heck M, Scheerer P.

Nat Commun. 2018 Jan 8;9(1):90. doi: 10.1038/s41467-017-02569-y.

13.

De Novo Mutations in SLC25A24 Cause a Craniosynostosis Syndrome with Hypertrichosis, Progeroid Appearance, and Mitochondrial Dysfunction.

Ehmke N, Graul-Neumann L, Smorag L, Koenig R, Segebrecht L, Magoulas P, Scaglia F, Kilic E, Hennig AF, Adolphs N, Saha N, Fauler B, Kalscheuer VM, Hennig F, Altmüller J, Netzer C, Thiele H, Nürnberg P, Yigit G, Jäger M, Hecht J, Krüger U, Mielke T, Krawitz PM, Horn D, Schuelke M, Mundlos S, Bacino CA, Bonnen PE, Wollnik B, Fischer-Zirnsak B, Kornak U.

Am J Hum Genet. 2017 Nov 2;101(5):833-843. doi: 10.1016/j.ajhg.2017.09.016.

14.

Stable Positioning of Unc13 Restricts Synaptic Vesicle Fusion to Defined Release Sites to Promote Synchronous Neurotransmission.

Reddy-Alla S, Böhme MA, Reynolds E, Beis C, Grasskamp AT, Mampell MM, Maglione M, Jusyte M, Rey U, Babikir H, McCarthy AW, Quentin C, Matkovic T, Bergeron DD, Mushtaq Z, Göttfert F, Owald D, Mielke T, Hell SW, Sigrist SJ, Walter AM.

Neuron. 2017 Sep 13;95(6):1350-1364.e12. doi: 10.1016/j.neuron.2017.08.016. Epub 2017 Aug 31.

15.

Footprint-free human fetal foreskin derived iPSCs: A tool for modeling hepatogenesis associated gene regulatory networks.

Matz P, Wruck W, Fauler B, Herebian D, Mielke T, Adjaye J.

Sci Rep. 2017 Jul 24;7(1):6294. doi: 10.1038/s41598-017-06546-9.

16.

Structural basis for λN-dependent processive transcription antitermination.

Said N, Krupp F, Anedchenko E, Santos KF, Dybkov O, Huang YH, Lee CT, Loll B, Behrmann E, Bürger J, Mielke T, Loerke J, Urlaub H, Spahn CMT, Weber G, Wahl MC.

Nat Microbiol. 2017 Apr 28;2:17062. doi: 10.1038/nmicrobiol.2017.62.

PMID:
28452979
17.

Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders.

Lorenz C, Lesimple P, Bukowiecki R, Zink A, Inak G, Mlody B, Singh M, Semtner M, Mah N, Auré K, Leong M, Zabiegalov O, Lyras EM, Pfiffer V, Fauler B, Eichhorst J, Wiesner B, Huebner N, Priller J, Mielke T, Meierhofer D, Izsvák Z, Meier JC, Bouillaud F, Adjaye J, Schuelke M, Wanker EE, Lombès A, Prigione A.

Cell Stem Cell. 2017 May 4;20(5):659-674.e9. doi: 10.1016/j.stem.2016.12.013. Epub 2017 Jan 26.

18.

Structural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution.

Hilal T, Yamamoto H, Loerke J, Bürger J, Mielke T, Spahn CM.

Nat Commun. 2016 Dec 20;7:13521. doi: 10.1038/ncomms13521.

19.

Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.

Arumughan A, Roske Y, Barth C, Forero LL, Bravo-Rodriguez K, Redel A, Kostova S, McShane E, Opitz R, Faelber K, Rau K, Mielke T, Daumke O, Selbach M, Sanchez-Garcia E, Rocks O, Panáková D, Heinemann U, Wanker EE.

Nat Commun. 2016 Oct 20;7:13047. doi: 10.1038/ncomms13047.

20.

Unique and Universal Features of Epsilonproteobacterial Origins of Chromosome Replication and DnaA-DnaA Box Interactions.

Jaworski P, Donczew R, Mielke T, Thiel M, Oldziej S, Weigel C, Zawilak-Pawlik A.

Front Microbiol. 2016 Sep 30;7:1555. eCollection 2016.

21.

Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release.

Gupta VK, Pech U, Bhukel A, Fulterer A, Ender A, Mauermann SF, Andlauer TF, Antwi-Adjei E, Beuschel C, Thriene K, Maglione M, Quentin C, Bushow R, Schwärzel M, Mielke T, Madeo F, Dengjel J, Fiala A, Sigrist SJ.

PLoS Biol. 2016 Sep 29;14(9):e1002563. doi: 10.1371/journal.pbio.1002563. eCollection 2016 Sep.

22.

Structures of ribosome-bound initiation factor 2 reveal the mechanism of subunit association.

Sprink T, Ramrath DJ, Yamamoto H, Yamamoto K, Loerke J, Ismer J, Hildebrand PW, Scheerer P, Bürger J, Mielke T, Spahn CM.

Sci Adv. 2016 Mar 4;2(3):e1501502. doi: 10.1126/sciadv.1501502. eCollection 2016 Mar.

23.

Molecular architecture of the ribosome-bound Hepatitis C Virus internal ribosomal entry site RNA.

Yamamoto H, Collier M, Loerke J, Ismer J, Schmidt A, Hilal T, Sprink T, Yamamoto K, Mielke T, Bürger J, Shaikh TR, Dabrowski M, Hildebrand PW, Scheerer P, Spahn CM.

EMBO J. 2015 Dec 14;34(24):3042-58. doi: 10.15252/embj.201592469. Epub 2015 Nov 24.

24.

Structural snapshots of actively translating human ribosomes.

Behrmann E, Loerke J, Budkevich TV, Yamamoto K, Schmidt A, Penczek PA, Vos MR, Bürger J, Mielke T, Scheerer P, Spahn CM.

Cell. 2015 May 7;161(4):845-57. doi: 10.1016/j.cell.2015.03.052.

25.

Parallel Structural Evolution of Mitochondrial Ribosomes and OXPHOS Complexes.

van der Sluis EO, Bauerschmitt H, Becker T, Mielke T, Frauenfeld J, Berninghausen O, Neupert W, Herrmann JM, Beckmann R.

Genome Biol Evol. 2015 Apr 9;7(5):1235-51. doi: 10.1093/gbe/evv061.

26.

Structures of the Apo and FAD-bound forms of 2-hydroxybiphenyl 3-monooxygenase (HbpA) locate activity hotspots identified by using directed evolution.

Jensen CN, Mielke T, Farrugia JE, Frank A, Man H, Hart S, Turkenburg JP, Grogan G.

Chembiochem. 2015 Apr 13;16(6):968-76. doi: 10.1002/cbic.201402701. Epub 2015 Mar 3.

27.

Cryo-EM of ribosomal 80S complexes with termination factors reveals the translocated cricket paralysis virus IRES.

Muhs M, Hilal T, Mielke T, Skabkin MA, Sanbonmatsu KY, Pestova TV, Spahn CM.

Mol Cell. 2015 Feb 5;57(3):422-32. doi: 10.1016/j.molcel.2014.12.016. Epub 2015 Jan 15.

28.

Architecture of polyglutamine-containing fibrils from time-resolved fluorescence decay.

Röthlein C, Miettinen MS, Borwankar T, Bürger J, Mielke T, Kumke MU, Ignatova Z.

J Biol Chem. 2014 Sep 26;289(39):26817-28. doi: 10.1074/jbc.M114.581991. Epub 2014 Aug 4.

29.

Structure of the mammalian 80S initiation complex with initiation factor 5B on HCV-IRES RNA.

Yamamoto H, Unbehaun A, Loerke J, Behrmann E, Collier M, Bürger J, Mielke T, Spahn CM.

Nat Struct Mol Biol. 2014 Aug;21(8):721-7. doi: 10.1038/nsmb.2859. Epub 2014 Jul 27.

PMID:
25064512
30.

Regulation of the mammalian elongation cycle by subunit rolling: a eukaryotic-specific ribosome rearrangement.

Budkevich TV, Giesebrecht J, Behrmann E, Loerke J, Ramrath DJ, Mielke T, Ismer J, Hildebrand PW, Tung CS, Nierhaus KH, Sanbonmatsu KY, Spahn CM.

Cell. 2014 Jul 3;158(1):121-31. doi: 10.1016/j.cell.2014.04.044.

31.

Assembly of Helicobacter pylori initiation complex is determined by sequence-specific and topology-sensitive DnaA-oriC interactions.

Donczew R, Mielke T, Jaworski P, Zakrzewska-Czerwińska J, Zawilak-Pawlik A.

J Mol Biol. 2014 Jul 29;426(15):2769-82. doi: 10.1016/j.jmb.2014.05.018. Epub 2014 May 24.

PMID:
24862285
32.

Structural insights into membrane interaction and caveolar targeting of dynamin-like EHD2.

Shah C, Hegde BG, Morén B, Behrmann E, Mielke T, Moenke G, Spahn CMT, Lundmark R, Daumke O, Langen R.

Structure. 2014 Mar 4;22(3):409-420. doi: 10.1016/j.str.2013.12.015. Epub 2014 Feb 6.

33.

Cryo-electron microscopic structure of SecA protein bound to the 70S ribosome.

Singh R, Kraft C, Jaiswal R, Sejwal K, Kasaragod VB, Kuper J, Bürger J, Mielke T, Luirink J, Bhushan S.

J Biol Chem. 2014 Mar 7;289(10):7190-9. doi: 10.1074/jbc.M113.506634. Epub 2014 Jan 17.

34.

Visualization of two transfer RNAs trapped in transit during elongation factor G-mediated translocation.

Ramrath DJ, Lancaster L, Sprink T, Mielke T, Loerke J, Noller HF, Spahn CM.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):20964-9. doi: 10.1073/pnas.1320387110. Epub 2013 Dec 9.

35.

The Bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesicles.

Matkovic T, Siebert M, Knoche E, Depner H, Mertel S, Owald D, Schmidt M, Thomas U, Sickmann A, Kamin D, Hell SW, Bürger J, Hollmann C, Mielke T, Wichmann C, Sigrist SJ.

J Cell Biol. 2013 Aug 19;202(4):667-83. doi: 10.1083/jcb.201301072.

36.

Photoisomerizable and thermoresponsive N-isopropylacrylamide-surfmer copolymer hydrogels prepared upon electrostatic self-assembly of an azobenzene bolaamphiphile.

Friedrich T, Mielke T, Domogalla M, Hentschel M, Kraus K, Tieke B.

Macromol Rapid Commun. 2013 Mar 12;34(5):393-8. doi: 10.1002/marc.201200630. Epub 2013 Jan 28.

PMID:
23355321
37.

The CoxD protein, a novel AAA+ ATPase involved in metal cluster assembly: hydrolysis of nucleotide-triphosphates and oligomerization.

Maisel T, Joseph S, Mielke T, Bürger J, Schwarzinger S, Meyer O.

PLoS One. 2012;7(10):e47424. doi: 10.1371/journal.pone.0047424. Epub 2012 Oct 15.

38.

The complex of tmRNA-SmpB and EF-G on translocating ribosomes.

Ramrath DJ, Yamamoto H, Rother K, Wittek D, Pech M, Mielke T, Loerke J, Scheerer P, Ivanov P, Teraoka Y, Shpanchenko O, Nierhaus KH, Spahn CM.

Nature. 2012 May 6;485(7399):526-9. doi: 10.1038/nature11006.

PMID:
22622583
39.

Structure and dynamics of the mammalian ribosomal pretranslocation complex.

Budkevich T, Giesebrecht J, Altman RB, Munro JB, Mielke T, Nierhaus KH, Blanchard SC, Spahn CM.

Mol Cell. 2011 Oct 21;44(2):214-24. doi: 10.1016/j.molcel.2011.07.040.

40.

Structure of the no-go mRNA decay complex Dom34-Hbs1 bound to a stalled 80S ribosome.

Becker T, Armache JP, Jarasch A, Anger AM, Villa E, Sieber H, Motaal BA, Mielke T, Berninghausen O, Beckmann R.

Nat Struct Mol Biol. 2011 Jun;18(6):715-20. doi: 10.1038/nsmb.2057. Epub 2011 May 29.

PMID:
21623367
41.

Iwr1 directs RNA polymerase II nuclear import.

Czeko E, Seizl M, Augsberger C, Mielke T, Cramer P.

Mol Cell. 2011 Apr 22;42(2):261-6. doi: 10.1016/j.molcel.2011.02.033.

42.

Cryo-EM structure of the ribosome-SecYE complex in the membrane environment.

Frauenfeld J, Gumbart J, Sluis EO, Funes S, Gartmann M, Beatrix B, Mielke T, Berninghausen O, Becker T, Schulten K, Beckmann R.

Nat Struct Mol Biol. 2011 May;18(5):614-21. doi: 10.1038/nsmb.2026. Epub 2011 Apr 17.

43.

Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunit.

Muhs M, Yamamoto H, Ismer J, Takaku H, Nashimoto M, Uchiumi T, Nakashima N, Mielke T, Hildebrand PW, Nierhaus KH, Spahn CM.

Nucleic Acids Res. 2011 Jul;39(12):5264-75. doi: 10.1093/nar/gkr114. Epub 2011 Mar 4.

44.

SecM-stalled ribosomes adopt an altered geometry at the peptidyl transferase center.

Bhushan S, Hoffmann T, Seidelt B, Frauenfeld J, Mielke T, Berninghausen O, Wilson DN, Beckmann R.

PLoS Biol. 2011 Jan 18;9(1):e1000581. doi: 10.1371/journal.pbio.1000581.

45.

Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites.

Ratje AH, Loerke J, Mikolajka A, Brünner M, Hildebrand PW, Starosta AL, Dönhöfer A, Connell SR, Fucini P, Mielke T, Whitford PC, Onuchic JN, Yu Y, Sanbonmatsu KY, Hartmann RK, Penczek PA, Wilson DN, Spahn CM.

Nature. 2010 Dec 2;468(7324):713-6. doi: 10.1038/nature09547.

46.

Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.

Armache JP, Jarasch A, Anger AM, Villa E, Becker T, Bhushan S, Jossinet F, Habeck M, Dindar G, Franckenberg S, Marquez V, Mielke T, Thomm M, Berninghausen O, Beatrix B, Söding J, Westhof E, Wilson DN, Beckmann R.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19748-53. doi: 10.1073/pnas.1009999107. Epub 2010 Oct 27.

47.

Localization of eukaryote-specific ribosomal proteins in a 5.5-Å cryo-EM map of the 80S eukaryotic ribosome.

Armache JP, Jarasch A, Anger AM, Villa E, Becker T, Bhushan S, Jossinet F, Habeck M, Dindar G, Franckenberg S, Marquez V, Mielke T, Thomm M, Berninghausen O, Beatrix B, Söding J, Westhof E, Wilson DN, Beckmann R.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19754-9. doi: 10.1073/pnas.1010005107. Epub 2010 Oct 25.

48.

Structural basis for translational stalling by human cytomegalovirus and fungal arginine attenuator peptide.

Bhushan S, Meyer H, Starosta AL, Becker T, Mielke T, Berninghausen O, Sattler M, Wilson DN, Beckmann R.

Mol Cell. 2010 Oct 8;40(1):138-46. doi: 10.1016/j.molcel.2010.09.009.

49.

Mechanism of eIF6-mediated inhibition of ribosomal subunit joining.

Gartmann M, Blau M, Armache JP, Mielke T, Topf M, Beckmann R.

J Biol Chem. 2010 May 14;285(20):14848-51. doi: 10.1074/jbc.C109.096057. Epub 2010 Mar 31.

50.

alpha-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnel.

Bhushan S, Gartmann M, Halic M, Armache JP, Jarasch A, Mielke T, Berninghausen O, Wilson DN, Beckmann R.

Nat Struct Mol Biol. 2010 Mar;17(3):313-7. doi: 10.1038/nsmb.1756. Epub 2010 Feb 7.

PMID:
20139981

Supplemental Content

Loading ...
Support Center