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Items: 1 to 50 of 233


White matter hyperintensities: relationship to amyloid and tau burden.

Graff-Radford J, Arenaza-Urquijo EM, Knopman DS, Schwarz CG, Brown RD, Rabinstein AA, Gunter JL, Senjem ML, Przybelski SA, Lesnick T, Ward C, Mielke MM, Lowe VJ, Petersen RC, Kremers WK, Kantarci K, Jack CR, Vemuri P.

Brain. 2019 Jun 14. pii: awz162. doi: 10.1093/brain/awz162. [Epub ahead of print]


Plasma and CSF neurofilament light: Relation to longitudinal neuroimaging and cognitive measures.

Mielke MM, Syrjanen JA, Blennow K, Zetterberg H, Vemuri P, Skoog I, Machulda MM, Kremers WK, Knopman DS, Jack C Jr, Petersen RC, Kern S.

Neurology. 2019 Jun 10. pii: 10.1212/WNL.0000000000007767. doi: 10.1212/WNL.0000000000007767. [Epub ahead of print]


Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults.

Lowe VJ, Bruinsma TJ, Wiste HJ, Min HK, Weigand SD, Fang P, Senjem ML, Therneau TM, Boeve BF, Josephs KA, Pandey MK, Murray ME, Kantarci K, Jones DT, Vemuri P, Graff-Radford J, Schwarz CG, Machulda MM, Mielke MM, Roberts RO, Knopman DS, Petersen RC, Jack CR Jr.

Neurology. 2019 May 30. pii: 10.1212/WNL.0000000000007728. doi: 10.1212/WNL.0000000000007728. [Epub ahead of print]


Neuropsychological subtypes of incident mild cognitive impairment in the Mayo Clinic Study of Aging.

Machulda MM, Lundt ES, Albertson SM, Kremers WK, Mielke MM, Knopman DS, Bondi MW, Petersen RC.

Alzheimers Dement. 2019 May 22. pii: S1552-5260(19)30089-5. doi: 10.1016/j.jalz.2019.03.014. [Epub ahead of print]


Association Between Critical Care Admissions and Cognitive Trajectories in Older Adults.

Schulte PJ, Warner DO, Martin DP, Deljou A, Mielke MM, Knopman DS, Petersen RC, Weingarten TN, Warner MA, Rabinstein AA, Hanson AC, Schroeder DR, Sprung J.

Crit Care Med. 2019 May 17. doi: 10.1097/CCM.0000000000003829. [Epub ahead of print]


Erectile Dysfunction Preceding Clinically Diagnosed α-Synucleinopathies: A Case-Control Study in Olmsted County.

Hasan S, Mielke MM, Ahlskog JE, Bower J, Turcano P, Savica R.

Parkinsons Dis. 2019 Apr 9;2019:6303945. doi: 10.1155/2019/6303945. eCollection 2019.


Longitudinal association between phosphatidylcholines, neuroimaging measures of Alzheimer's disease pathophysiology, and cognition in the Mayo Clinic Study of Aging.

Li D, Hagen C, Fett AR, Bui HH, Knopman D, Vemuri P, Machulda MM, Jack CR Jr, Petersen RC, Mielke MM.

Neurobiol Aging. 2019 Mar 18;79:43-49. doi: 10.1016/j.neurobiolaging.2019.03.005. [Epub ahead of print]


Plasma Sphingolipids Mediate a Relationship Between Type 2 Diabetes and Memory Outcomes in Patients with Coronary Artery Disease Undertaking Exercise.

Eakin KA, Saleem M, Herrmann N, Cogo-Moreira H, Mielke MM, Oh PI, Haughey NJ, Venkata SLV, Lanctôt KL, Swardfager W.

J Alzheimers Dis. 2019;69(3):717-727. doi: 10.3233/JAD-181203.


Plasma Metabolites Associated with Brain MRI Measures of Neurodegeneration in Older Adults in the Atherosclerosis Risk in Communities⁻Neurocognitive Study (ARIC-NCS).

Li D, Misialek JR, Jack CR, Mielke MM, Knopman D, Gottesman R, Mosley T, Alonso A.

Int J Mol Sci. 2019 Apr 9;20(7). pii: E1744. doi: 10.3390/ijms20071744.


Cortical β-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging.

Krell-Roesch J, Vassilaki M, Mielke MM, Kremers WK, Lowe VJ, Vemuri P, Machulda MM, Christianson TJ, Syrjanen JA, Stokin GB, Butler LM, Traber M, Jack CR Jr, Knopman DS, Roberts RO, Petersen RC, Geda YE.

Transl Psychiatry. 2019 Mar 28;9(1):123. doi: 10.1038/s41398-019-0456-z.


The metabolic brain signature of cognitive resilience in the 80+: beyond Alzheimer pathologies.

Arenaza-Urquijo EM, Przybelski SA, Lesnick TL, Graff-Radford J, Machulda MM, Knopman DS, Schwarz CG, Lowe VJ, Mielke MM, Petersen RC, Jack CR, Vemuri P.

Brain. 2019 Apr 1;142(4):1134-1147. doi: 10.1093/brain/awz037.


Sex and Gender Differences in Alzheimer's Disease Dementia.

Mielke MM.

Psychiatr Times. 2018 Nov;35(11):14-17. Epub 2018 Dec 30. No abstract available.


The influence of tau, amyloid, alpha-synuclein, TDP-43, and vascular pathology in clinically normal elderly individuals.

Wennberg AM, Whitwell JL, Tosakulwong N, Weigand SD, Murray ME, Machulda MM, Petrucelli L, Mielke MM, Jack CR Jr, Knopman DS, Parisi JE, Petersen RC, Dickson DW, Josephs KA.

Neurobiol Aging. 2019 May;77:26-36. doi: 10.1016/j.neurobiolaging.2019.01.008. Epub 2019 Jan 21.


Entorhinal cortex tau, amyloid-β, cortical thickness and memory performance in non-demented subjects.

Knopman DS, Lundt ES, Therneau TM, Vemuri P, Lowe VJ, Kantarci K, Gunter JL, Senjem ML, Mielke MM, Machulda MM, Boeve BF, Jones DT, Graff-Radford J, Albertson SM, Schwarz CG, Petersen RC, Jack CR.

Brain. 2019 Apr 1;142(4):1148-1160. doi: 10.1093/brain/awz025.


Cerebral microbleeds: Prevalence and relationship to amyloid burden.

Graff-Radford J, Botha H, Rabinstein AA, Gunter JL, Przybelski SA, Lesnick T, Huston J 3rd, Flemming KD, Preboske GM, Senjem ML, Brown RD Jr, Mielke MM, Roberts RO, Lowe VJ, Knopman DS, Petersen RC, Kremers W, Vemuri P, Jack CR Jr, Kantarci K.

Neurology. 2019 Jan 15;92(3):e253-e262. doi: 10.1212/WNL.0000000000006780. Epub 2018 Dec 19.


Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need.

Babulal GM, Quiroz YT, Albensi BC, Arenaza-Urquijo E, Astell AJ, Babiloni C, Bahar-Fuchs A, Bell J, Bowman GL, Brickman AM, Chételat G, Ciro C, Cohen AD, Dilworth-Anderson P, Dodge HH, Dreux S, Edland S, Esbensen A, Evered L, Ewers M, Fargo KN, Fortea J, Gonzalez H, Gustafson DR, Head E, Hendrix JA, Hofer SM, Johnson LA, Jutten R, Kilborn K, Lanctôt KL, Manly JJ, Martins RN, Mielke MM, Morris MC, Murray ME, Oh ES, Parra MA, Rissman RA, Roe CM, Santos OA, Scarmeas N, Schneider LS, Schupf N, Sikkes S, Snyder HM, Sohrabi HR, Stern Y, Strydom A, Tang Y, Terrera GM, Teunissen C, Melo van Lent D, Weinborn M, Wesselman L, Wilcock DM, Zetterberg H, O'Bryant SE; International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association.

Alzheimers Dement. 2019 Feb;15(2):292-312. doi: 10.1016/j.jalz.2018.09.009. Epub 2018 Dec 13.


Electronic Algorithm Is Superior to Hospital Discharge Codes for Diagnoses of Hypertensive Disorders of Pregnancy in Historical Cohorts.

Milic NM, Codsi E, Butler Tobah YS, White WM, Kattah AG, Weissgerber TL, Saiki M, Parashuram S, Vaughan LE, Weaver AL, Savic M, Mielke MM, Garovic VD.

Mayo Clin Proc. 2018 Dec;93(12):1707-1719. doi: 10.1016/j.mayocp.2018.08.031.


Association between sphingolipids and cardiopulmonary fitness in coronary artery disease patients undertaking cardiac rehabilitation.

Saleem M, Herrmann N, Dinoff A, Marzolini S, Mielke MM, Andreazza A, Oh PI, Vattem Venkata SL, Haughey NJ, Lanctôt KL.

J Gerontol A Biol Sci Med Sci. 2018 Dec 8. doi: 10.1093/gerona/gly273. [Epub ahead of print]


Predicting Progression to Mild Cognitive Impairment.

Petersen RC, Lundt ES, Therneau TM, Weigand SD, Knopman DS, Mielke MM, Roberts RO, Lowe VJ, Machulda MM, Kremers WK, Geda YE, Jack CR Jr.

Ann Neurol. 2019 Jan;85(1):155-160. doi: 10.1002/ana.25388. Epub 2019 Jan 7.


Current state of Alzheimer's fluid biomarkers.

Molinuevo JL, Ayton S, Batrla R, Bednar MM, Bittner T, Cummings J, Fagan AM, Hampel H, Mielke MM, Mikulskis A, O'Bryant S, Scheltens P, Sevigny J, Shaw LM, Soares HD, Tong G, Trojanowski JQ, Zetterberg H, Blennow K.

Acta Neuropathol. 2018 Dec;136(6):821-853. doi: 10.1007/s00401-018-1932-x. Epub 2018 Nov 28. Review.


Association Between Functional Performance and Alzheimer's Disease Biomarkers in Individuals Without Dementia.

Vassilaki M, Aakre JA, Kremers WK, Mielke MM, Geda YE, Machulda MM, Knopman DS, Coloma PM, Schauble B, Vemuri P, Lowe VJ, Jack CR Jr, Petersen RC, Roberts RO.

J Am Geriatr Soc. 2018 Dec;66(12):2274-2281. doi: 10.1111/jgs.15577. Epub 2018 Nov 21.


Association of Cerebrospinal Fluid Neurofilament Light Protein With Risk of Mild Cognitive Impairment Among Individuals Without Cognitive Impairment.

Kern S, Syrjanen JA, Blennow K, Zetterberg H, Skoog I, Waern M, Hagen CE, van Harten AC, Knopman DS, Jack CR Jr, Petersen RC, Mielke MM.

JAMA Neurol. 2018 Nov 12. doi: 10.1001/jamaneurol.2018.3459. [Epub ahead of print]


Comparison of PC and iPad administrations of the Cogstate Brief Battery in the Mayo Clinic Study of Aging: assessing cross-modality equivalence of computerized neuropsychological tests.

Stricker NH, Lundt ES, Edwards KK, Machulda MM, Kremers WK, Roberts RO, Knopman DS, Petersen RC, Mielke MM.

Clin Neuropsychol. 2018 Nov 10:1-25. doi: 10.1080/13854046.2018.1519085. [Epub ahead of print]


Levodopa-induced dyskinesia in Parkinson disease: A population-based cohort study.

Turcano P, Mielke MM, Bower JH, Parisi JE, Cutsforth-Gregory JK, Ahlskog JE, Savica R.

Neurology. 2018 Dec 11;91(24):e2238-e2243. doi: 10.1212/WNL.0000000000006643. Epub 2018 Nov 7.


Association of Bilateral Salpingo-Oophorectomy Before Menopause Onset With Medial Temporal Lobe Neurodegeneration.

Zeydan B, Tosakulwong N, Schwarz CG, Senjem ML, Gunter JL, Reid RI, Gazzuola Rocca L, Lesnick TG, Smith CY, Bailey KR, Lowe VJ, Roberts RO, Jack CR Jr, Petersen RC, Miller VM, Mielke MM, Rocca WA, Kantarci K.

JAMA Neurol. 2019 Jan 1;76(1):95-100. doi: 10.1001/jamaneurol.2018.3057.


Personal, reproductive, and familial characteristics associated with bilateral oophorectomy in premenopausal women: A population-based case-control study.

Rocca WA, Gazzuola Rocca L, Smith CY, Grossardt BR, Faubion SS, Shuster LT, Stewart EA, Mielke MM, Kantarci K, Miller VM.

Maturitas. 2018 Nov;117:64-77. doi: 10.1016/j.maturitas.2018.09.002. Epub 2018 Sep 14.


Loss of Ovarian Hormones and Accelerated Somatic and Mental Aging.

Rocca WA, Gazzuola Rocca L, Smith CY, Grossardt BR, Faubion SS, Shuster LT, Kirkland JL, LeBrasseur NK, Schafer MJ, Mielke MM, Kantarci K, Stewart EA, Miller VM.

Physiology (Bethesda). 2018 Nov 1;33(6):374-383. doi: 10.1152/physiol.00024.2018. Review.


Development of a cerebrovascular magnetic resonance imaging biomarker for cognitive aging.

Vemuri P, Lesnick TG, Przybelski SA, Graff-Radford J, Reid RI, Lowe VJ, Zuk SM, Senjem ML, Schwarz CG, Gunter JL, Kantarci K, Machulda MM, Mielke MM, Petersen RC, Knopman DS, Jack CR Jr.

Ann Neurol. 2018 Nov;84(5):705-716. doi: 10.1002/ana.25346. Epub 2018 Oct 25.


The Cross-Sectional and Longitudinal Associations Between IL-6, IL-10, and TNFα and Cognitive Outcomes in the Mayo Clinic Study of Aging.

Wennberg AMV, Hagen CE, Machulda MM, Knopman DS, Petersen RC, Mielke MM.

J Gerontol A Biol Sci Med Sci. 2018 Sep 25. doi: 10.1093/gerona/gly217. [Epub ahead of print]


Sex-related differences in the prevalence of cognitive impairment among overweight and obese adults with type 2 diabetes.

Espeland MA, Carmichael O, Yasar S, Hugenschmidt C, Hazzard W, Hayden KM, Rapp SR, Neiberg R, Johnson KC, Hoscheidt S, Mielke MM; Action for Health in Diabetes (Look AHEAD) Research Group.

Alzheimers Dement. 2018 Sep;14(9):1184-1192. doi: 10.1016/j.jalz.2018.05.015. Epub 2018 Jul 5.


Sex and gender in Alzheimer's disease - Does it matter?

Mielke MM, Ferretti MT, Iulita MF, Hayden K, Khachaturian AS.

Alzheimers Dement. 2018 Sep;14(9):1101-1103. doi: 10.1016/j.jalz.2018.08.003. No abstract available.


Statins and Brain Health: Alzheimer's Disease and Cerebrovascular Disease Biomarkers in Older Adults.

Ramanan VK, Przybelski SA, Graff-Radford J, Castillo AM, Lowe VJ, Mielke MM, Roberts RO, Reid RI, Knopman DS, Jack CR, Petersen RC, Vemuri P.

J Alzheimers Dis. 2018;65(4):1345-1352. doi: 10.3233/JAD-180446.


The Association of Multimorbidity With Preclinical AD Stages and SNAP in Cognitively Unimpaired Persons.

Vassilaki M, Aakre JA, Kremers WK, Mielke MM, Geda YE, Alhurani RE, Dutt T, Machulda MM, Knopman DS, Vemuri P, Coloma PM, Schauble B, Lowe VJ, Jack CR, Petersen RC, Roberts RO.

J Gerontol A Biol Sci Med Sci. 2019 May 16;74(6):877-883. doi: 10.1093/gerona/gly149.


Functional Activity and Neuropsychiatric Symptoms in Normal Aging and Mild Cognitive Impairment: The Mayo Clinic Study of Aging.

Krell-Roesch J, Cerhan LP, Machulda MM, Roberts RO, Mielke MM, Knopman DS, Syrjanen JA, Christianson TJ, Petersen RC, Geda YE.

Alzheimer Dis Assoc Disord. 2019 Jan-Mar;33(1):68-71. doi: 10.1097/WAD.0000000000000266. No abstract available.


Orthostatic Hypotension as a Prodromal Marker of α-Synucleinopathies-Reply.

Savica R, Boeve BF, Mielke MM.

JAMA Neurol. 2018 Sep 1;75(9):1155. doi: 10.1001/jamaneurol.2018.2251. No abstract available.


Ceramide Accumulation Is Associated with Declining Verbal Memory in Coronary Artery Disease Patients: An Observational Study.

Chan P, Saleem M, Herrmann N, Mielke MM, Haughey NJ, Oh PI, Kiss A, Lanctôt KL.

J Alzheimers Dis. 2018;64(4):1235-1246. doi: 10.3233/JAD-180030.


Subjective cognitive decline and risk of MCI: The Mayo Clinic Study of Aging.

van Harten AC, Mielke MM, Swenson-Dravis DM, Hagen CE, Edwards KK, Roberts RO, Geda YE, Knopman DS, Petersen RC.

Neurology. 2018 Jul 24;91(4):e300-e312. doi: 10.1212/WNL.0000000000005863. Epub 2018 Jun 29.


Understanding the impact of sex and gender in Alzheimer's disease: A call to action.

Nebel RA, Aggarwal NT, Barnes LL, Gallagher A, Goldstein JM, Kantarci K, Mallampalli MP, Mormino EC, Scott L, Yu WH, Maki PM, Mielke MM.

Alzheimers Dement. 2018 Sep;14(9):1171-1183. doi: 10.1016/j.jalz.2018.04.008. Epub 2018 Jun 12.


Mediterranean Diet, Its Components, and Amyloid Imaging Biomarkers.

Vassilaki M, Aakre JA, Syrjanen JA, Mielke MM, Geda YE, Kremers WK, Machulda MM, Alhurani RE, Staubo SC, Knopman DS, Petersen RC, Lowe VJ, Jack CR, Roberts RO.

J Alzheimers Dis. 2018;64(1):281-290. doi: 10.3233/JAD-171121.


Association of antidiabetic medication use, cognitive decline, and risk of cognitive impairment in older people with type 2 diabetes: Results from the population-based Mayo Clinic Study of Aging.

Wennberg AMV, Hagen CE, Edwards K, Roberts RO, Machulda MM, Knopman DS, Petersen RC, Mielke MM.

Int J Geriatr Psychiatry. 2018 Aug;33(8):1114-1120. doi: 10.1002/gps.4900. Epub 2018 Jun 5.


New thinking about thinking, part two. Theoretical articles for Alzheimer's & Dementia.

Khachaturian AS, Hayden KM, Mielke MM, Tang Y, Lutz MW, Gold M, Kukull WA, Mohs R, Gauthier S, Molinuevo JL, Zetterberg H, Khachaturian ZS.

Alzheimers Dement. 2018 Jun;14(6):703-706. doi: 10.1016/j.jalz.2018.05.002. Epub 2018 May 26. No abstract available.


Impact of a History of Hypertension in Pregnancy on Later Diagnosis of Atrial Fibrillation.

Scantlebury DC, Kattah AG, Weissgerber TL, Agarwal S, Mielke MM, Weaver AL, Vaughan LE, Henkin S, Zimmerman K, Miller VM, White WM, Hayes SN, Garovic VD.

J Am Heart Assoc. 2018 May 13;7(10). pii: e007584. doi: 10.1161/JAHA.117.007584.


Prevalence and Outcomes of Amyloid Positivity Among Persons Without Dementia in a Longitudinal, Population-Based Setting.

Roberts RO, Aakre JA, Kremers WK, Vassilaki M, Knopman DS, Mielke MM, Alhurani R, Geda YE, Machulda MM, Coloma P, Schauble B, Lowe VJ, Jack CR Jr, Petersen RC.

JAMA Neurol. 2018 Aug 1;75(8):970-979. doi: 10.1001/jamaneurol.2018.0629.


Future prospects and challenges for Alzheimer's disease drug development in the era of the NIA-AA Research Framework.

Khachaturian AS, Hayden KM, Mielke MM, Tang Y, Lutz MW, Gustafson DR, Kukull WA, Mohs R, Khachaturian ZS.

Alzheimers Dement. 2018 Apr;14(4):532-534. doi: 10.1016/j.jalz.2018.03.003. No abstract available.


Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau- and amyloid-positron emission tomography.

Mielke MM, Hagen CE, Xu J, Chai X, Vemuri P, Lowe VJ, Airey DC, Knopman DS, Roberts RO, Machulda MM, Jack CR Jr, Petersen RC, Dage JL.

Alzheimers Dement. 2018 Aug;14(8):989-997. doi: 10.1016/j.jalz.2018.02.013. Epub 2018 Apr 5.


Leisure-Time Physical Activity and the Risk of Incident Dementia: The Mayo Clinic Study of Aging.

Krell-Roesch J, Feder NT, Roberts RO, Mielke MM, Christianson TJ, Knopman DS, Petersen RC, Geda YE.

J Alzheimers Dis. 2018;63(1):149-155. doi: 10.3233/JAD-171141.


The association between peripheral total IGF-1, IGFBP-3, and IGF-1/IGFBP-3 and functional and cognitive outcomes in the Mayo Clinic Study of Aging.

Wennberg AMV, Hagen CE, Machulda MM, Hollman JH, Roberts RO, Knopman DS, Petersen RC, Mielke MM.

Neurobiol Aging. 2018 Jun;66:68-74. doi: 10.1016/j.neurobiolaging.2017.11.017. Epub 2018 Feb 19.


Longitudinal tau PET in ageing and Alzheimer's disease.

Jack CR Jr, Wiste HJ, Schwarz CG, Lowe VJ, Senjem ML, Vemuri P, Weigand SD, Therneau TM, Knopman DS, Gunter JL, Jones DT, Graff-Radford J, Kantarci K, Roberts RO, Mielke MM, Machulda MM, Petersen RC.

Brain. 2018 May 1;141(5):1517-1528. doi: 10.1093/brain/awy059.


Association of Excessive Daytime Sleepiness With Longitudinal β-Amyloid Accumulation in Elderly Persons Without Dementia.

Carvalho DZ, St Louis EK, Knopman DS, Boeve BF, Lowe VJ, Roberts RO, Mielke MM, Przybelski SA, Machulda MM, Petersen RC, Jack CR Jr, Vemuri P.

JAMA Neurol. 2018 Jun 1;75(6):672-680. doi: 10.1001/jamaneurol.2018.0049.


Trajectories of plasma IGF-1, IGFBP-3, and their ratio in the Mayo Clinic Study of Aging.

Wennberg AMV, Hagen CE, Petersen RC, Mielke MM.

Exp Gerontol. 2018 Jun;106:67-73. doi: 10.1016/j.exger.2018.02.015. Epub 2018 Feb 21.

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