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Medical Doctors and Dementia: A Longitudinal Study.

Vassilaki M, Syrjanen JA, Kremers WK, Hagen PT, Knopman DS, Mielke MM, Geda YE, Alhurani RE, Machulda MM, Roberts RO, Petersen RC.

J Am Geriatr Soc. 2020 Feb 22. doi: 10.1111/jgs.16375. [Epub ahead of print]


Association of Dual Decline in Memory and Gait Speed With Risk for Dementia Among Adults Older Than 60 Years: A Multicohort Individual-Level Meta-analysis.

Tian Q, Resnick SM, Mielke MM, Yaffe K, Launer LJ, Jonsson PV, Grande G, Welmer AK, Laukka EJ, Bandinelli S, Cherubini A, Rosano C, Kritchevsky SB, Simonsick EM, Studenski SA, Ferrucci L.

JAMA Netw Open. 2020 Feb 5;3(2):e1921636. doi: 10.1001/jamanetworkopen.2019.21636.


Longitudinal Comparison of in Clinic and at Home Administration of the Cogstate Brief Battery and Demonstrated Practice Effects in the Mayo Clinic Study of Aging.

Stricker NH, Lundt ES, Alden EC, Albertson SM, Machulda MM, Kremers WK, Knopman DS, Petersen RC, Mielke MM.

J Prev Alzheimers Dis. 2020;7(1):21-28. doi: 10.14283/jpad.2019.35.


Relationship Between Risk Factors and Brain Reserve in Late Middle Age: Implications for Cognitive Aging.

Neth BJ, Graff-Radford J, Mielke MM, Przybelski SA, Lesnick TG, Schwarz CG, Reid RI, Senjem ML, Lowe VJ, Machulda MM, Petersen RC, Jr CRJ, Knopman DS, Vemuri P.

Front Aging Neurosci. 2020 Jan 9;11:355. doi: 10.3389/fnagi.2019.00355. eCollection 2019.


Traumatic brain injury preceding clinically diagnosed α-synucleinopathies: A case-control study.

Hasan S, Mielke MM, Turcano P, Ahlskog JE, Bower JH, Savica R.

Neurology. 2020 Feb 25;94(8):e764-e773. doi: 10.1212/WNL.0000000000008995. Epub 2020 Jan 28.


Imaging Biomarkers of Alzheimer Disease in Multiple Sclerosis.

Zeydan B, Lowe VJ, Reichard RR, Przybelski SA, Lesnick TG, Schwarz CG, Senjem ML, Gunter JL, Parisi JE, Machulda MM, Vemuri P, Mielke MM, Knopman DS, Petersen RC, Jack CR Jr, Kantarci OH, Kantarci K.

Ann Neurol. 2020 Jan 22. doi: 10.1002/ana.25684. [Epub ahead of print]


Better stress coping associated with lower tau in amyloid-positive cognitively unimpaired older adults.

Arenaza-Urquijo EM, Przybelski SA, Machulda MM, Knopman DS, Lowe VJ, Mielke MM, Reddy AL, Geda YE, Jack CR Jr, Petersen RC, Vemuri P.

Neurology. 2020 Jan 21. pii: 10.1212/WNL.0000000000008979. doi: 10.1212/WNL.0000000000008979. [Epub ahead of print]


An Update on Blood-Based Markers of Alzheimer's Disease Using the SiMoA Platform.

Li D, Mielke MM.

Neurol Ther. 2019 Dec;8(Suppl 2):73-82. doi: 10.1007/s40120-019-00164-5. Epub 2019 Dec 12. Review.


REM sleep atonia loss distinguishes synucleinopathy in older adults with cognitive impairment.

McCarter SJ, Tabatabai GM, Jong HY, Sandness DJ, Timm PC, Johnson KL, McCarter AR, Savica R, Vemuri P, Machulda MM, Kantarci K, Mielke MM, Boeve BF, Silber MH, St Louis EK.

Neurology. 2020 Jan 7;94(1):e15-e29. doi: 10.1212/WNL.0000000000008694. Epub 2019 Dec 12.


Prostate Cancer, Use of Androgen Deprivation Therapy, and Cognitive Impairment: A Population-based Study.

Alonso Quiñones HJ, Stish BJ, Hagen C, Petersen RC, Mielke MM.

Alzheimer Dis Assoc Disord. 2019 Dec 9. doi: 10.1097/WAD.0000000000000366. [Epub ahead of print]


Consideration of Sex Differences in the Measurement and Interpretation of Alzheimer Disease-Related Biofluid-Based Biomarkers.

Mielke MM.

J Appl Lab Med. 2019 Dec 6. pii: jalm.2019.030023. doi: 10.1373/jalm.2019.030023. [Epub ahead of print] Review.


Cerebral microbleed incidence, relationship to amyloid burden: The Mayo Clinic Study of Aging.

Graff-Radford J, Lesnick T, Rabinstein AA, Gunter J, Aakre J, Przybelski SA, Spychalla AJ, Huston J 3rd, Brown RD Jr, Mielke MM, Lowe VJ, Knopman DS, Petersen RC, Jack CR Jr, Vemuri P, Kremers W, Kantarci K.

Neurology. 2020 Jan 14;94(2):e190-e199. doi: 10.1212/WNL.0000000000008735. Epub 2019 Dec 4.


Association of non-exercise physical activity in mid- and late-life with cognitive trajectories and the impact of APOE ε4 genotype status: the Mayo Clinic Study of Aging.

Krell-Roesch J, Syrjanen JA, Vassilaki M, Barisch-Fritz B, Trautwein S, Boes K, Woll A, Kremers WK, Machulda MM, Mielke MM, Knopman DS, Petersen RC, Geda YE.

Eur J Ageing. 2019 Apr 12;16(4):491-502. doi: 10.1007/s10433-019-00513-1. eCollection 2019 Dec.


Incidence of frontotemporal disorders in Olmsted County: A population-based study.

Turcano P, Stang CD, Mielke MM, Martin PR, Upadhyaya SG, Josephs KA, Boeve BF, Knopman DS, Petersen RC, Savica R.

Alzheimers Dement. 2019 Nov 26. pii: S1552-5260(19)35371-3. doi: 10.1016/j.jalz.2019.08.199. [Epub ahead of print]


Cerebrospinal fluid dynamics disorders: Relationship to Alzheimer biomarkers and cognition.

Graff-Radford J, Gunter JL, Jones DT, Przybelski SA, Schwarz CG, Huston J 3rd, Lowe V, Elder BD, Machulda MM, Gunter NB, Petersen RC, Kantarci K, Vemuri P, Mielke MM, Knopman DS, Graff-Radford NR, Jack CR Jr.

Neurology. 2019 Dec 10;93(24):e2237-e2246. doi: 10.1212/WNL.0000000000008616. Epub 2019 Nov 12.


Practical algorithms for amyloid β probability in subjective or mild cognitive impairment.

Maserejian N, Bian S, Wang W, Jaeger J, Syrjanen JA, Aakre J, Jack CR Jr, Mielke MM, Gao F.

Alzheimers Dement (Amst). 2019 Oct 22;11:180. doi: 10.1016/j.dadm.2019.09.001. eCollection 2019 Dec.


Comparison of variables associated with cerebrospinal fluid neurofilament, total-tau, and neurogranin.

Mielke MM, Syrjanen JA, Blennow K, Zetterberg H, Skoog I, Vemuri P, Machulda MM, Graff-Radford J, Knopman DS, Jack CR Jr, Petersen RC, Kern S.

Alzheimers Dement. 2019 Nov;15(11):1437-1447. doi: 10.1016/j.jalz.2019.07.009. Epub 2019 Oct 23.


Incidence of Convexal Subarachnoid Hemorrhage in the Elderly: The Mayo Clinic Study of Aging.

Yost M, Fiebelkorn CA, Rabinstein AA, Klaas J, Aakre JA, Brown RD Jr, Mielke MM, Knopman DS, Lowe V, Petersen RC, Jack CR Jr, Vemuri P, Graff-Radford J.

J Stroke Cerebrovasc Dis. 2019 Dec;28(12):104451. doi: 10.1016/j.jstrokecerebrovasdis.2019.104451. Epub 2019 Oct 24.


Anesthesia With and Without Nitrous Oxide and Long-term Cognitive Trajectories in Older Adults.

Sprung J, Abcejo ASA, Knopman DS, Petersen RC, Mielke MM, Hanson AC, Schroeder DR, Schulte PJ, Martin DP, Weingarten TN, Pasternak JJ, Warner DO.

Anesth Analg. 2019 Oct 18. doi: 10.1213/ANE.0000000000004490. [Epub ahead of print]


Association of Apolipoprotein E ɛ4, Educational Level, and Sex With Tau Deposition and Tau-Mediated Metabolic Dysfunction in Older Adults.

Ramanan VK, Castillo AM, Knopman DS, Graff-Radford J, Lowe VJ, Petersen RC, Jack CR Jr, Mielke MM, Vemuri P.

JAMA Netw Open. 2019 Oct 2;2(10):e1913909. doi: 10.1001/jamanetworkopen.2019.13909.


Sex-specific norms for verbal memory tests may improve diagnostic accuracy of amnestic MCI.

Sundermann EE, Maki P, Biegon A, Lipton RB, Mielke MM, Machulda M, Bondi MW; Alzheimer's Disease Neuroimaging Initiative.

Neurology. 2019 Nov 12;93(20):e1881-e1889. doi: 10.1212/WNL.0000000000008467. Epub 2019 Oct 9.


Incidence and Trends of Progressive Supranuclear Palsy and Corticobasal Syndrome: A Population-Based Study.

Stang CD, Turcano P, Mielke MM, Josephs KA, Bower JH, Ahlskog JE, Boeve BF, Martin PR, Upadhyaya SG, Savica R.

J Parkinsons Dis. 2020;10(1):179-184. doi: 10.3233/JPD-191744.


Exposure to surgery under general anaesthesia and brain magnetic resonance imaging changes in older adults.

Sprung J, Kruthiventi SC, Warner DO, Knopman DS, Petersen RC, Mielke MM, Jack CR Jr, Graff-Radford J, Martin DP, Hanson AC, Schroeder DR, Przybelski SA, Schulte PJ, Weingarten TN, Vemuri P.

Br J Anaesth. 2019 Dec;123(6):808-817. doi: 10.1016/j.bja.2019.08.024. Epub 2019 Oct 3.


Cardiometabolic Health and Longitudinal Progression of White Matter Hyperintensity: The Mayo Clinic Study of Aging.

Scharf EL, Graff-Radford J, Przybelski SA, Lesnick TG, Mielke MM, Knopman DS, Preboske GM, Schwarz CG, Senjem ML, Gunter JL, Machulda M, Kantarci K, Petersen RC, Jack CR Jr, Vemuri P.

Stroke. 2019 Nov;50(11):3037-3044. doi: 10.1161/STROKEAHA.119.025822. Epub 2019 Sep 12.


Elevated Plasma Ceramides Are Associated With Higher White Matter Hyperintensity Volume-Brief Report.

Mielke MM, Syrjanen JA, Bui HH, Petersen RC, Knopman DS, Jack CR Jr, Graff-Radford J, Vemuri P.

Arterioscler Thromb Vasc Biol. 2019 Nov;39(11):2431-2436. doi: 10.1161/ATVBAHA.119.313099. Epub 2019 Sep 12.


Amyloid, Vascular, and Resilience Pathways Associated with Cognitive Aging.

Vemuri P, Lesnick TG, Knopman DS, Przybelski SA, Reid RI, Mielke MM, Graff-Radford J, Lowe VJ, Machulda MM, Petersen RC, Jack CR Jr, MD.

Ann Neurol. 2019 Dec;86(6):866-877. doi: 10.1002/ana.25600. Epub 2019 Oct 17.


The bivariate distribution of amyloid-β and tau: relationship with established neurocognitive clinical syndromes.

Jack CR, Wiste HJ, Botha H, Weigand SD, Therneau TM, Knopman DS, Graff-Radford J, Jones DT, Ferman TJ, Boeve BF, Kantarci K, Lowe VJ, Vemuri P, Mielke MM, Fields JA, Machulda MM, Schwarz CG, Senjem ML, Gunter JL, Petersen RC.

Brain. 2019 Oct 1;142(10):3230-3242. doi: 10.1093/brain/awz268.


Cognitive function after surgery with regional or general anesthesia: A population-based study.

Sprung J, Schulte PJ, Knopman DS, Mielke MM, Petersen RC, Weingarten TN, Martin DP, Hanson AC, Schroeder DR, Warner DO.

Alzheimers Dement. 2019 Oct;15(10):1243-1252. doi: 10.1016/j.jalz.2019.06.4949. Epub 2019 Sep 5.


Population-Based Evaluation of Lumbar Puncture Opening Pressures.

Wang F, Lesser ER, Cutsforth-Gregory JK, Bhatti MT, Kilgore KP, Hodge DO, Graff-Radford J, Petersen RC, Knopman DS, Mielke MM, Lanzino G, Leavitt JA, Chen JJ.

Front Neurol. 2019 Aug 16;10:899. doi: 10.3389/fneur.2019.00899. eCollection 2019.


Informant-based hearing difficulties and the risk for mild cognitive impairment and dementia.

Vassilaki M, Aakre JA, Knopman DS, Kremers WK, Mielke MM, Geda YE, Machulda MM, Al Fakir R, Undavalli C, Roberts RO, Petersen RC.

Age Ageing. 2019 Nov 1;48(6):888-894. doi: 10.1093/ageing/afz099.


Survival and Progression in Synucleinopathy Phenotypes With Parkinsonism: A Population-Based Study.

Savica R, Turcano P, Bower JH, Ahlskog JE, Mielke MM.

Mayo Clin Proc. 2019 Sep;94(9):1825-1831. doi: 10.1016/j.mayocp.2019.04.010. Epub 2019 Aug 9.


Risk factors of neurovascular ageing in women.

Miller VM, Jayachandran M, Barnes JN, Mielke MM, Kantarci K, Rocca WA.

J Neuroendocrinol. 2020 Jan;32(1):e12777. doi: 10.1111/jne.12777. Epub 2019 Sep 3. Review.


Early temporal characteristics of elderly patient cognitive impairment in electronic health records.

Goudarzvand S, St Sauver J, Mielke MM, Takahashi PY, Lee Y, Sohn S.

BMC Med Inform Decis Mak. 2019 Aug 8;19(Suppl 4):149. doi: 10.1186/s12911-019-0858-0.


Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging-Alzheimer's Association Research Framework.

Jack CR Jr, Therneau TM, Weigand SD, Wiste HJ, Knopman DS, Vemuri P, Lowe VJ, Mielke MM, Roberts RO, Machulda MM, Graff-Radford J, Jones DT, Schwarz CG, Gunter JL, Senjem ML, Rocca WA, Petersen RC.

JAMA Neurol. 2019 Jul 15. doi: 10.1001/jamaneurol.2019.1971. [Epub ahead of print]


Quantity and quality of mental activities and the risk of incident mild cognitive impairment.

Krell-Roesch J, Syrjanen JA, Vassilaki M, Machulda MM, Mielke MM, Knopman DS, Kremers WK, Petersen RC, Geda YE.

Neurology. 2019 Aug 6;93(6):e548-e558. doi: 10.1212/WNL.0000000000007897. Epub 2019 Jul 10.


Associations of Amyloid, Tau, and Neurodegeneration Biomarker Profiles With Rates of Memory Decline Among Individuals Without Dementia.

Jack CR Jr, Wiste HJ, Therneau TM, Weigand SD, Knopman DS, Mielke MM, Lowe VJ, Vemuri P, Machulda MM, Schwarz CG, Gunter JL, Senjem ML, Graff-Radford J, Jones DT, Roberts RO, Rocca WA, Petersen RC.

JAMA. 2019 Jun 18;321(23):2316-2325. doi: 10.1001/jama.2019.7437.


White matter hyperintensities: relationship to amyloid and tau burden.

Graff-Radford J, Arenaza-Urquijo EM, Knopman DS, Schwarz CG, Brown RD, Rabinstein AA, Gunter JL, Senjem ML, Przybelski SA, Lesnick T, Ward C, Mielke MM, Lowe VJ, Petersen RC, Kremers WK, Kantarci K, Jack CR, Vemuri P.

Brain. 2019 Aug 1;142(8):2483-2491. doi: 10.1093/brain/awz162.


Plasma and CSF neurofilament light: Relation to longitudinal neuroimaging and cognitive measures.

Mielke MM, Syrjanen JA, Blennow K, Zetterberg H, Vemuri P, Skoog I, Machulda MM, Kremers WK, Knopman DS, Jack C Jr, Petersen RC, Kern S.

Neurology. 2019 Jul 16;93(3):e252-e260. doi: 10.1212/WNL.0000000000007767. Epub 2019 Jun 10.


Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults.

Lowe VJ, Bruinsma TJ, Wiste HJ, Min HK, Weigand SD, Fang P, Senjem ML, Therneau TM, Boeve BF, Josephs KA, Pandey MK, Murray ME, Kantarci K, Jones DT, Vemuri P, Graff-Radford J, Schwarz CG, Machulda MM, Mielke MM, Roberts RO, Knopman DS, Petersen RC, Jack CR Jr.

Neurology. 2019 Jul 2;93(1):e29-e39. doi: 10.1212/WNL.0000000000007728. Epub 2019 May 30.


Neuropsychological subtypes of incident mild cognitive impairment in the Mayo Clinic Study of Aging.

Machulda MM, Lundt ES, Albertson SM, Kremers WK, Mielke MM, Knopman DS, Bondi MW, Petersen RC.

Alzheimers Dement. 2019 Jul;15(7):878-887. doi: 10.1016/j.jalz.2019.03.014. Epub 2019 May 23.


Association Between Critical Care Admissions and Cognitive Trajectories in Older Adults.

Schulte PJ, Warner DO, Martin DP, Deljou A, Mielke MM, Knopman DS, Petersen RC, Weingarten TN, Warner MA, Rabinstein AA, Hanson AC, Schroeder DR, Sprung J.

Crit Care Med. 2019 Aug;47(8):1116-1124. doi: 10.1097/CCM.0000000000003829.


Erectile Dysfunction Preceding Clinically Diagnosed α-Synucleinopathies: A Case-Control Study in Olmsted County.

Hasan S, Mielke MM, Ahlskog JE, Bower J, Turcano P, Savica R.

Parkinsons Dis. 2019 Apr 9;2019:6303945. doi: 10.1155/2019/6303945. eCollection 2019.


Longitudinal association between phosphatidylcholines, neuroimaging measures of Alzheimer's disease pathophysiology, and cognition in the Mayo Clinic Study of Aging.

Li D, Hagen C, Fett AR, Bui HH, Knopman D, Vemuri P, Machulda MM, Jack CR Jr, Petersen RC, Mielke MM.

Neurobiol Aging. 2019 Jul;79:43-49. doi: 10.1016/j.neurobiolaging.2019.03.005. Epub 2019 Mar 18.


Plasma Sphingolipids Mediate a Relationship Between Type 2 Diabetes and Memory Outcomes in Patients with Coronary Artery Disease Undertaking Exercise.

Eakin KA, Saleem M, Herrmann N, Cogo-Moreira H, Mielke MM, Oh PI, Haughey NJ, Venkata SLV, Lanctôt KL, Swardfager W.

J Alzheimers Dis. 2019;69(3):717-727. doi: 10.3233/JAD-181203.


Plasma Metabolites Associated with Brain MRI Measures of Neurodegeneration in Older Adults in the Atherosclerosis Risk in Communities⁻Neurocognitive Study (ARIC-NCS).

Li D, Misialek JR, Jack CR, Mielke MM, Knopman D, Gottesman R, Mosley T, Alonso A.

Int J Mol Sci. 2019 Apr 9;20(7). pii: E1744. doi: 10.3390/ijms20071744.


Cortical β-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging.

Krell-Roesch J, Vassilaki M, Mielke MM, Kremers WK, Lowe VJ, Vemuri P, Machulda MM, Christianson TJ, Syrjanen JA, Stokin GB, Butler LM, Traber M, Jack CR Jr, Knopman DS, Roberts RO, Petersen RC, Geda YE.

Transl Psychiatry. 2019 Mar 28;9(1):123. doi: 10.1038/s41398-019-0456-z.


The metabolic brain signature of cognitive resilience in the 80+: beyond Alzheimer pathologies.

Arenaza-Urquijo EM, Przybelski SA, Lesnick TL, Graff-Radford J, Machulda MM, Knopman DS, Schwarz CG, Lowe VJ, Mielke MM, Petersen RC, Jack CR, Vemuri P.

Brain. 2019 Apr 1;142(4):1134-1147. doi: 10.1093/brain/awz037.


Sex and Gender Differences in Alzheimer's Disease Dementia.

Mielke MM.

Psychiatr Times. 2018 Nov;35(11):14-17. Epub 2018 Dec 30. No abstract available.


The influence of tau, amyloid, alpha-synuclein, TDP-43, and vascular pathology in clinically normal elderly individuals.

Wennberg AM, Whitwell JL, Tosakulwong N, Weigand SD, Murray ME, Machulda MM, Petrucelli L, Mielke MM, Jack CR Jr, Knopman DS, Parisi JE, Petersen RC, Dickson DW, Josephs KA.

Neurobiol Aging. 2019 May;77:26-36. doi: 10.1016/j.neurobiolaging.2019.01.008. Epub 2019 Jan 21.


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