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Incidence of frontotemporal disorders in Olmsted County: A population-based study.

Turcano P, Stang CD, Mielke MM, Martin PR, Upadhyaya SG, Josephs KA, Boeve BF, Knopman DS, Petersen RC, Savica R.

Alzheimers Dement. 2019 Nov 26. pii: S1552-5260(19)35371-3. doi: 10.1016/j.jalz.2019.08.199. [Epub ahead of print]


Cerebrospinal fluid dynamics disorders: Relationship to Alzheimer biomarkers and cognition.

Graff-Radford J, Gunter JL, Jones DT, Przybelski SA, Schwarz CG, Huston J 3rd, Lowe V, Elder BD, Machulda MM, Gunter NB, Petersen RC, Kantarci K, Vemuri P, Mielke MM, Knopman DS, Graff-Radford NR, Jack CR Jr.

Neurology. 2019 Nov 12. pii: 10.1212/WNL.0000000000008616. doi: 10.1212/WNL.0000000000008616. [Epub ahead of print]


Practical algorithms for amyloid β probability in subjective or mild cognitive impairment.

Maserejian N, Bian S, Wang W, Jaeger J, Syrjanen JA, Aakre J, Jack CR Jr, Mielke MM, Gao F.

Alzheimers Dement (Amst). 2019 Oct 22;11:180. doi: 10.1016/j.dadm.2019.09.001. eCollection 2019 Dec.


Comparison of variables associated with cerebrospinal fluid neurofilament, total-tau, and neurogranin.

Mielke MM, Syrjanen JA, Blennow K, Zetterberg H, Skoog I, Vemuri P, Machulda MM, Graff-Radford J, Knopman DS, Jack CR Jr, Petersen RC, Kern S.

Alzheimers Dement. 2019 Nov;15(11):1437-1447. doi: 10.1016/j.jalz.2019.07.009. Epub 2019 Oct 23.


Incidence of Convexal Subarachnoid Hemorrhage in the Elderly: The Mayo Clinic Study of Aging.

Yost M, Fiebelkorn CA, Rabinstein AA, Klaas J, Aakre JA, Brown RD Jr, Mielke MM, Knopman DS, Lowe V, Petersen RC, Jack CR Jr, Vemuri P, Graff-Radford J.

J Stroke Cerebrovasc Dis. 2019 Dec;28(12):104451. doi: 10.1016/j.jstrokecerebrovasdis.2019.104451. Epub 2019 Oct 24.


Anesthesia With and Without Nitrous Oxide and Long-term Cognitive Trajectories in Older Adults.

Sprung J, Abcejo ASA, Knopman DS, Petersen RC, Mielke MM, Hanson AC, Schroeder DR, Schulte PJ, Martin DP, Weingarten TN, Pasternak JJ, Warner DO.

Anesth Analg. 2019 Oct 18. doi: 10.1213/ANE.0000000000004490. [Epub ahead of print]


Association of Apolipoprotein E ɛ4, Educational Level, and Sex With Tau Deposition and Tau-Mediated Metabolic Dysfunction in Older Adults.

Ramanan VK, Castillo AM, Knopman DS, Graff-Radford J, Lowe VJ, Petersen RC, Jack CR Jr, Mielke MM, Vemuri P.

JAMA Netw Open. 2019 Oct 2;2(10):e1913909. doi: 10.1001/jamanetworkopen.2019.13909.


Sex-specific norms for verbal memory tests may improve diagnostic accuracy of amnestic MCI.

Sundermann EE, Maki P, Biegon A, Lipton RB, Mielke MM, Machulda M, Bondi MW; Alzheimer's Disease Neuroimaging Initiative.

Neurology. 2019 Nov 12;93(20):e1881-e1889. doi: 10.1212/WNL.0000000000008467. Epub 2019 Oct 9.


Progressive Supranuclear Palsy and Corticobasal Syndrome: A Population-Based Study.

Stang CD, Turcano P, Mielke MM, Josephs KA, Bower JH, Eric Ahlskog J, Boeve BF, Martin PR, Upadhyaya SG, Savica R.

J Parkinsons Dis. 2019 Sep 28. doi: 10.3233/JPD-191744. [Epub ahead of print]


Exposure to surgery under general anaesthesia and brain magnetic resonance imaging changes in older adults.

Sprung J, Kruthiventi SC, Warner DO, Knopman DS, Petersen RC, Mielke MM, Jack CR Jr, Graff-Radford J, Martin DP, Hanson AC, Schroeder DR, Przybelski SA, Schulte PJ, Weingarten TN, Vemuri P.

Br J Anaesth. 2019 Dec;123(6):808-817. doi: 10.1016/j.bja.2019.08.024. Epub 2019 Oct 3.


Cardiometabolic Health and Longitudinal Progression of White Matter Hyperintensity: The Mayo Clinic Study of Aging.

Scharf EL, Graff-Radford J, Przybelski SA, Lesnick TG, Mielke MM, Knopman DS, Preboske GM, Schwarz CG, Senjem ML, Gunter JL, Machulda M, Kantarci K, Petersen RC, Jack CR Jr, Vemuri P.

Stroke. 2019 Nov;50(11):3037-3044. doi: 10.1161/STROKEAHA.119.025822. Epub 2019 Sep 12.


Elevated Plasma Ceramides Are Associated With Higher White Matter Hyperintensity Volume-Brief Report.

Mielke MM, Syrjanen JA, Bui HH, Petersen RC, Knopman DS, Jack CR Jr, Graff-Radford J, Vemuri P.

Arterioscler Thromb Vasc Biol. 2019 Nov;39(11):2431-2436. doi: 10.1161/ATVBAHA.119.313099. Epub 2019 Sep 12.


Amyloid, Vascular, and Resilience Pathways Associated with Cognitive Aging.

Vemuri P, Lesnick TG, Knopman DS, Przybelski SA, Reid RI, Mielke MM, Graff-Radford J, Lowe VJ, Machulda MM, Petersen RC, Jack CR Jr, MD.

Ann Neurol. 2019 Dec;86(6):866-877. doi: 10.1002/ana.25600. Epub 2019 Oct 17.


The bivariate distribution of amyloid-β and tau: relationship with established neurocognitive clinical syndromes.

Jack CR, Wiste HJ, Botha H, Weigand SD, Therneau TM, Knopman DS, Graff-Radford J, Jones DT, Ferman TJ, Boeve BF, Kantarci K, Lowe VJ, Vemuri P, Mielke MM, Fields JA, Machulda MM, Schwarz CG, Senjem ML, Gunter JL, Petersen RC.

Brain. 2019 Oct 1;142(10):3230-3242. doi: 10.1093/brain/awz268.


Cognitive function after surgery with regional or general anesthesia: A population-based study.

Sprung J, Schulte PJ, Knopman DS, Mielke MM, Petersen RC, Weingarten TN, Martin DP, Hanson AC, Schroeder DR, Warner DO.

Alzheimers Dement. 2019 Oct;15(10):1243-1252. doi: 10.1016/j.jalz.2019.06.4949. Epub 2019 Sep 5.


Population-Based Evaluation of Lumbar Puncture Opening Pressures.

Wang F, Lesser ER, Cutsforth-Gregory JK, Bhatti MT, Kilgore KP, Hodge DO, Graff-Radford J, Petersen RC, Knopman DS, Mielke MM, Lanzino G, Leavitt JA, Chen JJ.

Front Neurol. 2019 Aug 16;10:899. doi: 10.3389/fneur.2019.00899. eCollection 2019.


Informant-based hearing difficulties and the risk for mild cognitive impairment and dementia.

Vassilaki M, Aakre JA, Knopman DS, Kremers WK, Mielke MM, Geda YE, Machulda MM, Al Fakir R, Undavalli C, Roberts RO, Petersen RC.

Age Ageing. 2019 Nov 1;48(6):888-894. doi: 10.1093/ageing/afz099.


Survival and Progression in Synucleinopathy Phenotypes With Parkinsonism: A Population-Based Study.

Savica R, Turcano P, Bower JH, Ahlskog JE, Mielke MM.

Mayo Clin Proc. 2019 Sep;94(9):1825-1831. doi: 10.1016/j.mayocp.2019.04.010. Epub 2019 Aug 9.


Risk factors of neurovascular ageing in women.

Miller VM, Jayachandran M, Barnes JN, Mielke MM, Kantarci K, Rocca WA.

J Neuroendocrinol. 2019 Aug 9:e12777. doi: 10.1111/jne.12777. [Epub ahead of print] Review.


Early temporal characteristics of elderly patient cognitive impairment in electronic health records.

Goudarzvand S, St Sauver J, Mielke MM, Takahashi PY, Lee Y, Sohn S.

BMC Med Inform Decis Mak. 2019 Aug 8;19(Suppl 4):149. doi: 10.1186/s12911-019-0858-0.


Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging-Alzheimer's Association Research Framework.

Jack CR Jr, Therneau TM, Weigand SD, Wiste HJ, Knopman DS, Vemuri P, Lowe VJ, Mielke MM, Roberts RO, Machulda MM, Graff-Radford J, Jones DT, Schwarz CG, Gunter JL, Senjem ML, Rocca WA, Petersen RC.

JAMA Neurol. 2019 Jul 15. doi: 10.1001/jamaneurol.2019.1971. [Epub ahead of print]


Quantity and quality of mental activities and the risk of incident mild cognitive impairment.

Krell-Roesch J, Syrjanen JA, Vassilaki M, Machulda MM, Mielke MM, Knopman DS, Kremers WK, Petersen RC, Geda YE.

Neurology. 2019 Aug 6;93(6):e548-e558. doi: 10.1212/WNL.0000000000007897. Epub 2019 Jul 10.


Associations of Amyloid, Tau, and Neurodegeneration Biomarker Profiles With Rates of Memory Decline Among Individuals Without Dementia.

Jack CR Jr, Wiste HJ, Therneau TM, Weigand SD, Knopman DS, Mielke MM, Lowe VJ, Vemuri P, Machulda MM, Schwarz CG, Gunter JL, Senjem ML, Graff-Radford J, Jones DT, Roberts RO, Rocca WA, Petersen RC.

JAMA. 2019 Jun 18;321(23):2316-2325. doi: 10.1001/jama.2019.7437.


White matter hyperintensities: relationship to amyloid and tau burden.

Graff-Radford J, Arenaza-Urquijo EM, Knopman DS, Schwarz CG, Brown RD, Rabinstein AA, Gunter JL, Senjem ML, Przybelski SA, Lesnick T, Ward C, Mielke MM, Lowe VJ, Petersen RC, Kremers WK, Kantarci K, Jack CR, Vemuri P.

Brain. 2019 Aug 1;142(8):2483-2491. doi: 10.1093/brain/awz162.


Plasma and CSF neurofilament light: Relation to longitudinal neuroimaging and cognitive measures.

Mielke MM, Syrjanen JA, Blennow K, Zetterberg H, Vemuri P, Skoog I, Machulda MM, Kremers WK, Knopman DS, Jack C Jr, Petersen RC, Kern S.

Neurology. 2019 Jul 16;93(3):e252-e260. doi: 10.1212/WNL.0000000000007767. Epub 2019 Jun 10.


Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults.

Lowe VJ, Bruinsma TJ, Wiste HJ, Min HK, Weigand SD, Fang P, Senjem ML, Therneau TM, Boeve BF, Josephs KA, Pandey MK, Murray ME, Kantarci K, Jones DT, Vemuri P, Graff-Radford J, Schwarz CG, Machulda MM, Mielke MM, Roberts RO, Knopman DS, Petersen RC, Jack CR Jr.

Neurology. 2019 Jul 2;93(1):e29-e39. doi: 10.1212/WNL.0000000000007728. Epub 2019 May 30.


Neuropsychological subtypes of incident mild cognitive impairment in the Mayo Clinic Study of Aging.

Machulda MM, Lundt ES, Albertson SM, Kremers WK, Mielke MM, Knopman DS, Bondi MW, Petersen RC.

Alzheimers Dement. 2019 Jul;15(7):878-887. doi: 10.1016/j.jalz.2019.03.014. Epub 2019 May 23.


Association Between Critical Care Admissions and Cognitive Trajectories in Older Adults.

Schulte PJ, Warner DO, Martin DP, Deljou A, Mielke MM, Knopman DS, Petersen RC, Weingarten TN, Warner MA, Rabinstein AA, Hanson AC, Schroeder DR, Sprung J.

Crit Care Med. 2019 Aug;47(8):1116-1124. doi: 10.1097/CCM.0000000000003829.


Erectile Dysfunction Preceding Clinically Diagnosed α-Synucleinopathies: A Case-Control Study in Olmsted County.

Hasan S, Mielke MM, Ahlskog JE, Bower J, Turcano P, Savica R.

Parkinsons Dis. 2019 Apr 9;2019:6303945. doi: 10.1155/2019/6303945. eCollection 2019.


Longitudinal association between phosphatidylcholines, neuroimaging measures of Alzheimer's disease pathophysiology, and cognition in the Mayo Clinic Study of Aging.

Li D, Hagen C, Fett AR, Bui HH, Knopman D, Vemuri P, Machulda MM, Jack CR Jr, Petersen RC, Mielke MM.

Neurobiol Aging. 2019 Jul;79:43-49. doi: 10.1016/j.neurobiolaging.2019.03.005. Epub 2019 Mar 18.


Plasma Sphingolipids Mediate a Relationship Between Type 2 Diabetes and Memory Outcomes in Patients with Coronary Artery Disease Undertaking Exercise.

Eakin KA, Saleem M, Herrmann N, Cogo-Moreira H, Mielke MM, Oh PI, Haughey NJ, Venkata SLV, Lanctôt KL, Swardfager W.

J Alzheimers Dis. 2019;69(3):717-727. doi: 10.3233/JAD-181203.


Plasma Metabolites Associated with Brain MRI Measures of Neurodegeneration in Older Adults in the Atherosclerosis Risk in Communities⁻Neurocognitive Study (ARIC-NCS).

Li D, Misialek JR, Jack CR, Mielke MM, Knopman D, Gottesman R, Mosley T, Alonso A.

Int J Mol Sci. 2019 Apr 9;20(7). pii: E1744. doi: 10.3390/ijms20071744.


Cortical β-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging.

Krell-Roesch J, Vassilaki M, Mielke MM, Kremers WK, Lowe VJ, Vemuri P, Machulda MM, Christianson TJ, Syrjanen JA, Stokin GB, Butler LM, Traber M, Jack CR Jr, Knopman DS, Roberts RO, Petersen RC, Geda YE.

Transl Psychiatry. 2019 Mar 28;9(1):123. doi: 10.1038/s41398-019-0456-z.


The metabolic brain signature of cognitive resilience in the 80+: beyond Alzheimer pathologies.

Arenaza-Urquijo EM, Przybelski SA, Lesnick TL, Graff-Radford J, Machulda MM, Knopman DS, Schwarz CG, Lowe VJ, Mielke MM, Petersen RC, Jack CR, Vemuri P.

Brain. 2019 Apr 1;142(4):1134-1147. doi: 10.1093/brain/awz037.


Sex and Gender Differences in Alzheimer's Disease Dementia.

Mielke MM.

Psychiatr Times. 2018 Nov;35(11):14-17. Epub 2018 Dec 30. No abstract available.


The influence of tau, amyloid, alpha-synuclein, TDP-43, and vascular pathology in clinically normal elderly individuals.

Wennberg AM, Whitwell JL, Tosakulwong N, Weigand SD, Murray ME, Machulda MM, Petrucelli L, Mielke MM, Jack CR Jr, Knopman DS, Parisi JE, Petersen RC, Dickson DW, Josephs KA.

Neurobiol Aging. 2019 May;77:26-36. doi: 10.1016/j.neurobiolaging.2019.01.008. Epub 2019 Jan 21.


Entorhinal cortex tau, amyloid-β, cortical thickness and memory performance in non-demented subjects.

Knopman DS, Lundt ES, Therneau TM, Vemuri P, Lowe VJ, Kantarci K, Gunter JL, Senjem ML, Mielke MM, Machulda MM, Boeve BF, Jones DT, Graff-Radford J, Albertson SM, Schwarz CG, Petersen RC, Jack CR.

Brain. 2019 Apr 1;142(4):1148-1160. doi: 10.1093/brain/awz025.


Cerebral microbleeds: Prevalence and relationship to amyloid burden.

Graff-Radford J, Botha H, Rabinstein AA, Gunter JL, Przybelski SA, Lesnick T, Huston J 3rd, Flemming KD, Preboske GM, Senjem ML, Brown RD Jr, Mielke MM, Roberts RO, Lowe VJ, Knopman DS, Petersen RC, Kremers W, Vemuri P, Jack CR Jr, Kantarci K.

Neurology. 2019 Jan 15;92(3):e253-e262. doi: 10.1212/WNL.0000000000006780. Epub 2018 Dec 19.


Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need.

Babulal GM, Quiroz YT, Albensi BC, Arenaza-Urquijo E, Astell AJ, Babiloni C, Bahar-Fuchs A, Bell J, Bowman GL, Brickman AM, Chételat G, Ciro C, Cohen AD, Dilworth-Anderson P, Dodge HH, Dreux S, Edland S, Esbensen A, Evered L, Ewers M, Fargo KN, Fortea J, Gonzalez H, Gustafson DR, Head E, Hendrix JA, Hofer SM, Johnson LA, Jutten R, Kilborn K, Lanctôt KL, Manly JJ, Martins RN, Mielke MM, Morris MC, Murray ME, Oh ES, Parra MA, Rissman RA, Roe CM, Santos OA, Scarmeas N, Schneider LS, Schupf N, Sikkes S, Snyder HM, Sohrabi HR, Stern Y, Strydom A, Tang Y, Terrera GM, Teunissen C, Melo van Lent D, Weinborn M, Wesselman L, Wilcock DM, Zetterberg H, O'Bryant SE; International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association.

Alzheimers Dement. 2019 Feb;15(2):292-312. doi: 10.1016/j.jalz.2018.09.009. Epub 2018 Dec 13.


Electronic Algorithm Is Superior to Hospital Discharge Codes for Diagnoses of Hypertensive Disorders of Pregnancy in Historical Cohorts.

Milic NM, Codsi E, Butler Tobah YS, White WM, Kattah AG, Weissgerber TL, Saiki M, Parashuram S, Vaughan LE, Weaver AL, Savic M, Mielke MM, Garovic VD.

Mayo Clin Proc. 2018 Dec;93(12):1707-1719. doi: 10.1016/j.mayocp.2018.08.031.


Association between sphingolipids and cardiopulmonary fitness in coronary artery disease patients undertaking cardiac rehabilitation.

Saleem M, Herrmann N, Dinoff A, Marzolini S, Mielke MM, Andreazza A, Oh PI, Vattem Venkata SL, Haughey NJ, Lanctôt KL.

J Gerontol A Biol Sci Med Sci. 2018 Dec 8. doi: 10.1093/gerona/gly273. [Epub ahead of print]


Predicting Progression to Mild Cognitive Impairment.

Petersen RC, Lundt ES, Therneau TM, Weigand SD, Knopman DS, Mielke MM, Roberts RO, Lowe VJ, Machulda MM, Kremers WK, Geda YE, Jack CR Jr.

Ann Neurol. 2019 Jan;85(1):155-160. doi: 10.1002/ana.25388. Epub 2019 Jan 7.


Current state of Alzheimer's fluid biomarkers.

Molinuevo JL, Ayton S, Batrla R, Bednar MM, Bittner T, Cummings J, Fagan AM, Hampel H, Mielke MM, Mikulskis A, O'Bryant S, Scheltens P, Sevigny J, Shaw LM, Soares HD, Tong G, Trojanowski JQ, Zetterberg H, Blennow K.

Acta Neuropathol. 2018 Dec;136(6):821-853. doi: 10.1007/s00401-018-1932-x. Epub 2018 Nov 28. Review.


Association Between Functional Performance and Alzheimer's Disease Biomarkers in Individuals Without Dementia.

Vassilaki M, Aakre JA, Kremers WK, Mielke MM, Geda YE, Machulda MM, Knopman DS, Coloma PM, Schauble B, Vemuri P, Lowe VJ, Jack CR Jr, Petersen RC, Roberts RO.

J Am Geriatr Soc. 2018 Dec;66(12):2274-2281. doi: 10.1111/jgs.15577. Epub 2018 Nov 21.


Association of Cerebrospinal Fluid Neurofilament Light Protein With Risk of Mild Cognitive Impairment Among Individuals Without Cognitive Impairment.

Kern S, Syrjanen JA, Blennow K, Zetterberg H, Skoog I, Waern M, Hagen CE, van Harten AC, Knopman DS, Jack CR Jr, Petersen RC, Mielke MM.

JAMA Neurol. 2019 Feb 1;76(2):187-193. doi: 10.1001/jamaneurol.2018.3459.


Comparison of PC and iPad administrations of the Cogstate Brief Battery in the Mayo Clinic Study of Aging: Assessing cross-modality equivalence of computerized neuropsychological tests.

Stricker NH, Lundt ES, Edwards KK, Machulda MM, Kremers WK, Roberts RO, Knopman DS, Petersen RC, Mielke MM.

Clin Neuropsychol. 2019 Aug;33(6):1102-1126. doi: 10.1080/13854046.2018.1519085. Epub 2018 Nov 10.


Levodopa-induced dyskinesia in Parkinson disease: A population-based cohort study.

Turcano P, Mielke MM, Bower JH, Parisi JE, Cutsforth-Gregory JK, Ahlskog JE, Savica R.

Neurology. 2018 Dec 11;91(24):e2238-e2243. doi: 10.1212/WNL.0000000000006643. Epub 2018 Nov 7.


Association of Bilateral Salpingo-Oophorectomy Before Menopause Onset With Medial Temporal Lobe Neurodegeneration.

Zeydan B, Tosakulwong N, Schwarz CG, Senjem ML, Gunter JL, Reid RI, Gazzuola Rocca L, Lesnick TG, Smith CY, Bailey KR, Lowe VJ, Roberts RO, Jack CR Jr, Petersen RC, Miller VM, Mielke MM, Rocca WA, Kantarci K.

JAMA Neurol. 2019 Jan 1;76(1):95-100. doi: 10.1001/jamaneurol.2018.3057.


Personal, reproductive, and familial characteristics associated with bilateral oophorectomy in premenopausal women: A population-based case-control study.

Rocca WA, Gazzuola Rocca L, Smith CY, Grossardt BR, Faubion SS, Shuster LT, Stewart EA, Mielke MM, Kantarci K, Miller VM.

Maturitas. 2018 Nov;117:64-77. doi: 10.1016/j.maturitas.2018.09.002. Epub 2018 Sep 14.


Loss of Ovarian Hormones and Accelerated Somatic and Mental Aging.

Rocca WA, Gazzuola Rocca L, Smith CY, Grossardt BR, Faubion SS, Shuster LT, Kirkland JL, LeBrasseur NK, Schafer MJ, Mielke MM, Kantarci K, Stewart EA, Miller VM.

Physiology (Bethesda). 2018 Nov 1;33(6):374-383. doi: 10.1152/physiol.00024.2018. Review.

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