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Items: 40

1.

Insights into the structure and dynamics of lysyl oxidase propeptide, a flexible protein with numerous partners.

Vallet SD, Miele AE, Uciechowska-Kaczmarzyk U, Liwo A, Duclos B, Samsonov SA, Ricard-Blum S.

Sci Rep. 2018 Aug 6;8(1):11768. doi: 10.1038/s41598-018-30190-6.

2.

The oligomeric assembly of the phosphodiesterase-5 is a mixture of dimers and tetramers: A putative role in the regulation of function.

Cardarelli S, Miele AE, Zamparelli C, Biagioni S, Naro F, Malatesta F, Giorgi M, Saliola M.

Biochim Biophys Acta Gen Subj. 2018 Oct;1862(10):2183-2190. doi: 10.1016/j.bbagen.2018.07.010. Epub 2018 Jul 17.

PMID:
30025857
3.

Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry.

Silvestri I, Lyu H, Fata F, Boumis G, Miele AE, Ardini M, Ippoliti R, Bellelli A, Jadhav A, Lea WA, Simeonov A, Cheng Q, Arnér ESJ, Thatcher GRJ, Petukhov PA, Williams DL, Angelucci F.

ACS Chem Biol. 2018 Aug 17;13(8):2190-2202. doi: 10.1021/acschembio.8b00349. Epub 2018 Jun 11.

PMID:
29800515
4.

Pichia pastoris Fep1 is a [2Fe-2S] protein with a Zn finger that displays an unusual oxygen-dependent role in cluster binding.

Cutone A, Howes BD, Miele AE, Miele R, Giorgi A, Battistoni A, Smulevich G, Musci G, di Patti MC.

Sci Rep. 2016 Aug 22;6:31872. doi: 10.1038/srep31872.

5.

Typical 2-Cys peroxiredoxins in human parasites: Several physiological roles for a potential chemotherapy target.

Angelucci F, Miele AE, Ardini M, Boumis G, Saccoccia F, Bellelli A.

Mol Biochem Parasitol. 2016 Mar-Apr;206(1-2):2-12. doi: 10.1016/j.molbiopara.2016.03.005. Epub 2016 Mar 18. Review.

PMID:
27002228
6.

Uncovering new structural insights for antimalarial activity from cost-effective aculeatin-like derivatives.

Winkler M, Maynadier M, Wein S, Lespinasse MA, Boumis G, Miele AE, Vial H, Wong YS.

Org Biomol Chem. 2015 Feb 21;13(7):2064-77. doi: 10.1039/c4ob02459a.

PMID:
25519040
7.

Selenocysteine robustness versus cysteine versatility: a hypothesis on the evolution of the moonlighting behaviour of peroxiredoxins.

Saccoccia F, Angelucci F, Boumis G, Desiato G, Miele AE, Bellelli A.

Biochem Soc Trans. 2014 Dec;42(6):1768-72. doi: 10.1042/BST20140212. Review.

PMID:
25399604
8.

Thioredoxin reductase and its inhibitors.

Saccoccia F, Angelucci F, Boumis G, Carotti D, Desiato G, Miele AE, Bellelli A.

Curr Protein Pept Sci. 2014;15(6):621-46. Review.

9.

Switching between the alternative structures and functions of a 2-Cys peroxiredoxin, by site-directed mutagenesis.

Angelucci F, Saccoccia F, Ardini M, Boumis G, Brunori M, Di Leandro L, Ippoliti R, Miele AE, Natoli G, Scotti S, Bellelli A.

J Mol Biol. 2013 Nov 15;425(22):4556-68. doi: 10.1016/j.jmb.2013.09.002. Epub 2013 Sep 8.

PMID:
24021815
10.

Hemoglobin allostery: new views on old players.

Miele AE, Bellelli A, Brunori M.

J Mol Biol. 2013 May 13;425(9):1515-26. doi: 10.1016/j.jmb.2012.12.018. Epub 2012 Dec 28.

PMID:
23274140
11.

Crystal structure of Plasmodium falciparum thioredoxin reductase, a validated drug target.

Boumis G, Giardina G, Angelucci F, Bellelli A, Brunori M, Dimastrogiovanni D, Saccoccia F, Miele AE.

Biochem Biophys Res Commun. 2012 Sep 7;425(4):806-11. doi: 10.1016/j.bbrc.2012.07.156. Epub 2012 Aug 6.

PMID:
22889878
12.

Moonlighting by different stressors: crystal structure of the chaperone species of a 2-Cys peroxiredoxin.

Saccoccia F, Di Micco P, Boumis G, Brunori M, Koutris I, Miele AE, Morea V, Sriratana P, Williams DL, Bellelli A, Angelucci F.

Structure. 2012 Mar 7;20(3):429-39. doi: 10.1016/j.str.2012.01.004.

13.

On the mechanism and rate of gold incorporation into thiol-dependent flavoreductases.

Saccoccia F, Angelucci F, Boumis G, Brunori M, Miele AE, Williams DL, Bellelli A.

J Inorg Biochem. 2012 Mar;108:105-11. doi: 10.1016/j.jinorgbio.2011.11.005. Epub 2011 Nov 27.

14.

Macromolecular bases of antischistosomal therapy.

Angelucci F, Miele AE, Boumis G, Brunori M, Dimastrogiovanni D, Bellelli A.

Curr Top Med Chem. 2011;11(16):2012-28. Review.

PMID:
21619508
15.

Structural and functional characterization of Schistosoma mansoni Thioredoxin.

Boumis G, Angelucci F, Bellelli A, Brunori M, Dimastrogiovanni D, Miele AE.

Protein Sci. 2011 Jun;20(6):1069-76. doi: 10.1002/pro.634. Epub 2011 May 5.

16.

Mapping the catalytic cycle of Schistosoma mansoni thioredoxin glutathione reductase by X-ray crystallography.

Angelucci F, Dimastrogiovanni D, Boumis G, Brunori M, Miele AE, Saccoccia F, Bellelli A.

J Biol Chem. 2010 Oct 15;285(42):32557-67. doi: 10.1074/jbc.M110.141960. Epub 2010 Jul 21.

17.

Combining crystallography and molecular dynamics: the case of Schistosoma mansoni phospholipid glutathione peroxidase.

Dimastrogiovanni D, Anselmi M, Miele AE, Boumis G, Petersson L, Angelucci F, Nola AD, Brunori M, Bellelli A.

Proteins. 2010 Feb 1;78(2):259-70. doi: 10.1002/prot.22536.

PMID:
19714775
18.

Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects.

Angelucci F, Sayed AA, Williams DL, Boumis G, Brunori M, Dimastrogiovanni D, Miele AE, Pauly F, Bellelli A.

J Biol Chem. 2009 Oct 16;284(42):28977-85. doi: 10.1074/jbc.M109.020701. Epub 2009 Aug 26.

19.

Investigating the structural plasticity of a cytochrome P450: three-dimensional structures of P450 EryK and binding to its physiological substrate.

Savino C, Montemiglio LC, Sciara G, Miele AE, Kendrew SG, Jemth P, Gianni S, Vallone B.

J Biol Chem. 2009 Oct 16;284(42):29170-9. doi: 10.1074/jbc.M109.003590. Epub 2009 Jul 22.

20.

Pattern of cavities in globins: the case of human hemoglobin.

Savino C, Miele AE, Draghi F, Johnson KA, Sciara G, Brunori M, Vallone B.

Biopolymers. 2009 Dec;91(12):1097-107. doi: 10.1002/bip.21201.

PMID:
19365817
21.
22.

Will new antischistosomal drugs finally emerge?

Cioli D, Valle C, Angelucci F, Miele AE.

Trends Parasitol. 2008 Sep;24(9):379-82. doi: 10.1016/j.pt.2008.05.006. Epub 2008 Jul 31.

PMID:
18675590
23.

Glutathione reductase and thioredoxin reductase at the crossroad: the structure of Schistosoma mansoni thioredoxin glutathione reductase.

Angelucci F, Miele AE, Boumis G, Dimastrogiovanni D, Brunori M, Bellelli A.

Proteins. 2008 Aug 15;72(3):936-45. doi: 10.1002/prot.21986.

PMID:
18300227
24.

Hb(alphaalpha,betabeta): a novel fusion construct for a dimeric, four-domain hemoglobin.

Panetta G, Arcovito A, Morea V, Bellelli A, Miele AE.

Biochim Biophys Acta. 2008 Oct;1784(10):1462-70. doi: 10.1016/j.bbapap.2008.01.003. Epub 2008 Jan 18.

PMID:
18267132
25.

The three-dimensional structure of two redox states of cyclophilin A from Schistosoma mansoni. Evidence for redox regulation of peptidyl-prolyl cis-trans isomerase activity.

Gourlay LJ, Angelucci F, Baiocco P, Boumis G, Brunori M, Bellelli A, Miele AE.

J Biol Chem. 2007 Aug 24;282(34):24851-7. Epub 2007 Jun 25.

26.

Probing the mechanism of GSH activation in Schistosoma haematobium glutathione-S-transferase by site-directed mutagenesis and X-ray crystallography.

Baiocco P, Gourlay LJ, Angelucci F, Fontaine J, Hervé M, Miele AE, Trottein F, Brunori M, Bellelli A.

J Mol Biol. 2006 Jul 14;360(3):678-89. Epub 2006 Jun 2.

PMID:
16777141
27.

The allosteric properties of hemoglobin: insights from natural and site directed mutants.

Bellelli A, Brunori M, Miele AE, Panetta G, Vallone B.

Curr Protein Pept Sci. 2006 Feb;7(1):17-45. Review.

PMID:
16472167
28.

Evaluating the usefulness of protein structure models for molecular replacement.

Giorgetti A, Raimondo D, Miele AE, Tramontano A.

Bioinformatics. 2005 Sep 1;21 Suppl 2:ii72-6.

PMID:
16204129
29.

Schistosoma mansoni fatty acid binding protein: specificity and functional control as revealed by crystallographic structure.

Angelucci F, Johnson KA, Baiocco P, Miele AE, Brunori M, Valle C, Vigorosi F, Troiani AR, Liberti P, Cioli D, Klinkert MQ, Bellelli A.

Biochemistry. 2004 Oct 19;43(41):13000-11.

PMID:
15476393
30.

Two distinct interaction motifs in amphiphysin bind two independent sites on the clathrin terminal domain beta-propeller.

Miele AE, Watson PJ, Evans PR, Traub LM, Owen DJ.

Nat Struct Mol Biol. 2004 Mar;11(3):242-8. Epub 2004 Feb 15.

PMID:
14981508
31.

Complex landscape of protein structural dynamics unveiled by nanosecond Laue crystallography.

Bourgeois D, Vallone B, Schotte F, Arcovito A, Miele AE, Sciara G, Wulff M, Anfinrud P, Brunori M.

Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8704-9. Epub 2003 Jul 7.

32.

Analysis of the effect of microgravity on protein crystal quality: the case of a myoglobin triple mutant.

Miele AE, Federici L, Sciara G, Draghi F, Brunori M, Vallone B.

Acta Crystallogr D Biol Crystallogr. 2003 Jun;59(Pt 6):982-8. Epub 2003 May 23.

PMID:
12777759
33.

The structure of ActVA-Orf6, a novel type of monooxygenase involved in actinorhodin biosynthesis.

Sciara G, Kendrew SG, Miele AE, Marsh NG, Federici L, Malatesta F, Schimperna G, Savino C, Vallone B.

EMBO J. 2003 Jan 15;22(2):205-15.

34.
35.

Structural dynamics of myoglobin: ligand migration among protein cavities studied by Fourier transform infrared/temperature derivative spectroscopy.

Lamb DC, Nienhaus K, Arcovito A, Draghi F, Miele AE, Brunori M, Nienhaus GU.

J Biol Chem. 2002 Apr 5;277(14):11636-44. Epub 2002 Jan 15.

36.

Controlling ligand binding in myoglobin by mutagenesis.

Draghi F, Miele AE, Travaglini-Allocatelli C, Vallone B, Brunori M, Gibson QH, Olson JS.

J Biol Chem. 2002 Mar 1;277(9):7509-19. Epub 2001 Dec 14.

37.

Control of heme reactivity by diffusion: structural basis and functional characterization in hemoglobin mutants.

Miele AE, Draghi F, Arcovito A, Bellelli A, Brunori M, Travaglini-Allocatelli C, Vallone B.

Biochemistry. 2001 Dec 4;40(48):14449-58.

PMID:
11724557
38.

Modulation of ligand binding in engineered human hemoglobin distal pocket.

Miele AE, Santanché S, Travaglini-Allocatelli C, Vallone B, Brunori M, Bellelli A.

J Mol Biol. 1999 Jul 9;290(2):515-24.

PMID:
10390349
39.

Free energy of burying hydrophobic residues in the interface between protein subunits.

Vallone B, Miele AE, Vecchini P, Chiancone E, Brunori M.

Proc Natl Acad Sci U S A. 1998 May 26;95(11):6103-7.

40.

Probing the alpha 1 beta 2 interface of human hemoglobin by mutagenesis. Role of the FG-C contact regions.

Vallone B, Bellelli A, Miele AE, Brunori M, Fermi G.

J Biol Chem. 1996 May 24;271(21):12472-80.

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