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Airway Epithelial Cells Generate Pro-inflammatory Tenascin-C and Small Extracellular Vesicles in Response to TLR3 Stimuli and Rhinovirus Infection.

Mills JT, Schwenzer A, Marsh EK, Edwards MR, Sabroe I, Midwood KS, Parker LC.

Front Immunol. 2019 Aug 21;10:1987. doi: 10.3389/fimmu.2019.01987. eCollection 2019.


Treatment of severe periodontitis may improve clinical disease activity in otherwise treatment-refractory rheumatoid arthritis patients.

Möller B, Bender P, Eick S, Kuchen S, Maldonado A, Potempa J, Reichenbach S, Sculean A, Schwenzer A, Villiger PM, Wong A, Midwood KS.

Rheumatology (Oxford). 2019 Jul 10. pii: kez287. doi: 10.1093/rheumatology/kez287. [Epub ahead of print] No abstract available.


Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion.

Stefanelli VL, Choudhury S, Hu P, Liu Y, Schwenzer A, Yeh CR, Chambers DM, Pesson K, Li W, Segura T, Midwood KS, Torres M, Barker TH.

Matrix Biol. 2019 Sep;82:86-104. doi: 10.1016/j.matbio.2019.04.002. Epub 2019 Apr 17.


Response to: 'Potential roles for tenascin in (very) early diagnosis and treatment of rheumatoid arthritis' by Cutolo et al.

Aungier S, Cartwright AJ, Schwenzer A, Marshall J, Dyson MR, Slavny P, Parthiban K, Karatt-Vellatt A, Sahbudin I, Culbert E, Hextall P, Clanchy FI, Williams R, Marsden BD, Raza K, Filer A, Buckley CD, McCafferty J, Midwood KS.

Ann Rheum Dis. 2019 Feb 12. pii: annrheumdis-2019-215108. doi: 10.1136/annrheumdis-2019-215108. [Epub ahead of print] No abstract available.


Targeting early changes in the synovial microenvironment: a new class of immunomodulatory therapy?

Aungier SR, Cartwright AJ, Schwenzer A, Marshall JL, Dyson MR, Slavny P, Parthiban K, Karatt-Vellatt A, Sahbudin I, Culbert E, Hextall P, Clanchy FI, Williams R, Marsden BD, Raza K, Filer A, Buckley CD, McCafferty J, Midwood KS.

Ann Rheum Dis. 2019 Feb;78(2):186-191. doi: 10.1136/annrheumdis-2018-214294. Epub 2018 Dec 14.


Time to Include Fine Specificity Anti-Citrullinated Protein Antibodies in the Routine Diagnosis and Management of Rheumatoid Arthritis?

Schwenzer A, Quirke AM, Montgomery AB, Venables PJ, Sayles HR, Schlumberger W, Payne JB, Mikuls TR, Midwood KS.

Arthritis Rheumatol. 2019 Mar;71(3):476-478. doi: 10.1002/art.40767. Epub 2019 Feb 9. No abstract available.


Inhibition of Endothelial NOTCH1 Signaling Attenuates Inflammation by Reducing Cytokine-Mediated Histone Acetylation at Inflammatory Enhancers.

Poulsen LC, Edelmann RJ, Krüger S, Diéguez-Hurtado R, Shah A, Stav-Noraas TE, Renzi A, Szymanska M, Wang J, Ehling M, Benedito R, Kasprzycka M, Bækkevold E, Sundnes O, Midwood KS, Scott H, Collas P, Siebel CW, Adams RH, Haraldsen G, Sundlisæter E, Hol J.

Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):854-869. doi: 10.1161/ATVBAHA.117.310388. Epub 2018 Feb 15.


Internal Affairs: Tenascin-C as a Clinically Relevant, Endogenous Driver of Innate Immunity.

Marzeda AM, Midwood KS.

J Histochem Cytochem. 2018 Apr;66(4):289-304. doi: 10.1369/0022155418757443. Epub 2018 Jan 31. Review.


How to detect and purify tenascin-C.

Giblin SP, Murdamoothoo D, Deligne C, Schwenzer A, Orend G, Midwood KS.

Methods Cell Biol. 2018;143:371-400. doi: 10.1016/bs.mcb.2017.08.022. Epub 2017 Nov 26.


Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers.

Zuliani-Alvarez L, Marzeda AM, Deligne C, Schwenzer A, McCann FE, Marsden BD, Piccinini AM, Midwood KS.

Nat Commun. 2017 Nov 17;8(1):1595. doi: 10.1038/s41467-017-01718-7.


Association of Distinct Fine Specificities of Anti-Citrullinated Peptide Antibodies With Elevated Immune Responses to Prevotella intermedia in a Subgroup of Patients With Rheumatoid Arthritis and Periodontitis.

Schwenzer A, Quirke AM, Marzeda AM, Wong A, Montgomery AB, Sayles HR, Eick S, Gawron K, Chomyszyn-Gajewska M, Łazarz-Bartyzel K, Davis S, Potempa J, Kessler BM, Fischer R, Venables PJ, Payne JB, Mikuls TR, Midwood KS.

Arthritis Rheumatol. 2017 Dec;69(12):2303-2313. doi: 10.1002/art.40227. Epub 2017 Oct 30.


Toll-Like Receptor-4 Signaling Drives Persistent Fibroblast Activation and Prevents Fibrosis Resolution in Scleroderma.

Bhattacharyya S, Midwood KS, Yin H, Varga J.

Adv Wound Care (New Rochelle). 2017 Oct 1;6(10):356-369. doi: 10.1089/wound.2017.0732. Review.


Screening for Novel Endogenous Inflammatory Stimuli Using the Secreted Embryonic Alkaline Phosphatase NF-κB Reporter Assay.

Zuliani-Alvarez L, Piccinini AM, Midwood KS.

Bio Protoc. 2017 Apr 5;7(7). pii: e2220. doi: 10.21769/BioProtoc.2220.


Detection of antibodies to citrullinated tenascin-C in patients with early synovitis is associated with the development of rheumatoid arthritis.

Raza K, Schwenzer A, Juarez M, Venables P, Filer A, Buckley CD, Midwood KS.

RMD Open. 2016 Dec 1;2(2):e000318. eCollection 2016. No abstract available.


Tenascin-C at a glance.

Midwood KS, Chiquet M, Tucker RP, Orend G.

J Cell Sci. 2016 Dec 1;129(23):4321-4327. Epub 2016 Nov 10. Review.


Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages.

Piccinini AM, Zuliani-Alvarez L, Lim JM, Midwood KS.

Sci Signal. 2016 Aug 30;9(443):ra86. doi: 10.1126/scisignal.aaf3596.


Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4.

Maqbool A, Spary EJ, Manfield IW, Ruhmann M, Zuliani-Alvarez L, Gamboa-Esteves FO, Porter KE, Drinkhill MJ, Midwood KS, Turner NA.

World J Cardiol. 2016 May 26;8(5):340-50. doi: 10.4330/wjc.v8.i5.340.


Investigating the Role of Toll-Like Receptors in Models of Arthritis.

Piccinini AM, Williams L, McCann FE, Midwood KS.

Methods Mol Biol. 2016;1390:351-81. doi: 10.1007/978-1-4939-3335-8_22.


Identification of an immunodominant peptide from citrullinated tenascin-C as a major target for autoantibodies in rheumatoid arthritis.

Schwenzer A, Jiang X, Mikuls TR, Payne JB, Sayles HR, Quirke AM, Kessler BM, Fischer R, Venables PJ, Lundberg K, Midwood KS.

Ann Rheum Dis. 2016 Oct;75(10):1876-83. doi: 10.1136/annrheumdis-2015-208495. Epub 2015 Dec 9.


Potent anti-inflammatory effects of the narrow spectrum kinase inhibitor RV1088 on rheumatoid arthritis synovial membrane cells.

To WS, Aungier SR, Cartwright AJ, Ito K, Midwood KS.

Br J Pharmacol. 2015 Aug;172(15):3805-16. doi: 10.1111/bph.13170. Epub 2015 Jun 12.


Advances in Toll-like receptor biology: Modes of activation by diverse stimuli.

Bryant CE, Gay NJ, Heymans S, Sacre S, Schaefer L, Midwood KS.

Crit Rev Biochem Mol Biol. 2015;50(5):359-79. doi: 10.3109/10409238.2015.1033511. Epub 2015 Apr 10. Review.


Tenascin-C: Form versus function.

Giblin SP, Midwood KS.

Cell Adh Migr. 2015;9(1-2):48-82. doi: 10.4161/19336918.2014.987587. Review.


Illustrating the interplay between the extracellular matrix and microRNAs.

Piccinini AM, Midwood KS.

Int J Exp Pathol. 2014 Jun;95(3):158-80. doi: 10.1111/iep.12079. Epub 2014 Apr 25. Review.


Tenascins in stem cell niches.

Chiquet-Ehrismann R, Orend G, Chiquet M, Tucker RP, Midwood KS.

Matrix Biol. 2014 Jul;37:112-23. doi: 10.1016/j.matbio.2014.01.007. Epub 2014 Jan 25. Review.


Isometric contraction of Dupuytren's myofibroblasts is inhibited by blocking intercellular junctions.

Verhoekx JSN, Verjee LS, Izadi D, Chan JKK, Nicolaidou V, Davidson D, Midwood KS, Nanchahal J.

J Invest Dermatol. 2013 Dec;133(12):2664-2671. doi: 10.1038/jid.2013.219. Epub 2013 May 7.


Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target.

Verjee LS, Verhoekx JS, Chan JK, Krausgruber T, Nicolaidou V, Izadi D, Davidson D, Feldmann M, Midwood KS, Nanchahal J.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E928-37. doi: 10.1073/pnas.1301100110. Epub 2013 Feb 19.


Raised circulating tenascin-C in rheumatoid arthritis.

Page TH, Charles PJ, Piccinini AM, Nicolaidou V, Taylor PC, Midwood KS.

Arthritis Res Ther. 2012 Nov 29;14(6):R260. doi: 10.1186/ar4105.


Endogenous control of immunity against infection: tenascin-C regulates TLR4-mediated inflammation via microRNA-155.

Piccinini AM, Midwood KS.

Cell Rep. 2012 Oct 25;2(4):914-26. doi: 10.1016/j.celrep.2012.09.005. Epub 2012 Oct 19.


The alarmin IL-33 is a notch target in quiescent endothelial cells.

Sundlisaeter E, Edelmann RJ, Hol J, Sponheim J, Küchler AM, Weiss M, Udalova IA, Midwood KS, Kasprzycka M, Haraldsen G.

Am J Pathol. 2012 Sep;181(3):1099-111. doi: 10.1016/j.ajpath.2012.06.003. Epub 2012 Jul 16.


Endogenous activation of adaptive immunity: tenascin-C drives interleukin-17 synthesis in murine arthritic joint disease.

Ruhmann M, Piccinini AM, Kong PL, Midwood KS.

Arthritis Rheum. 2012 Jul;64(7):2179-90. doi: 10.1002/art.34401.


Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis.

Goh FG, Midwood KS.

Rheumatology (Oxford). 2012 Jan;51(1):7-23. doi: 10.1093/rheumatology/ker257. Epub 2011 Oct 8. Review.


Plasma and cellular fibronectin: distinct and independent functions during tissue repair.

To WS, Midwood KS.

Fibrogenesis Tissue Repair. 2011 Sep 16;4:21. doi: 10.1186/1755-1536-4-21.


Advances in tenascin-C biology.

Midwood KS, Hussenet T, Langlois B, Orend G.

Cell Mol Life Sci. 2011 Oct;68(19):3175-99. doi: 10.1007/s00018-011-0783-6. Epub 2011 Aug 5. Review.


Expression and immune function of tenascin-C.

Udalova IA, Ruhmann M, Thomson SJ, Midwood KS.

Crit Rev Immunol. 2011;31(2):115-45. Review.


Toll-like receptor signaling: common pathways that drive cardiovascular disease and rheumatoid arthritis.

Monaco C, Terrando N, Midwood KS.

Arthritis Care Res (Hoboken). 2011 Apr;63(4):500-11. doi: 10.1002/acr.20382. Review. No abstract available.


Identification of novel and distinct binding sites within tenascin-C for soluble and fibrillar fibronectin.

To WS, Midwood KS.

J Biol Chem. 2011 Apr 29;286(17):14881-91. doi: 10.1074/jbc.M110.189019. Epub 2011 Feb 15.


Cryptic domains of tenascin-C differentially control fibronectin fibrillogenesis.

To WS, Midwood KS.

Matrix Biol. 2010 Sep;29(7):573-85. doi: 10.1016/j.matbio.2010.08.003. Epub 2010 Aug 10.


DAMPening inflammation by modulating TLR signalling.

Piccinini AM, Midwood KS.

Mediators Inflamm. 2010;2010. pii: 672395. doi: 10.1155/2010/672395. Epub 2010 Jul 13. Review.


Transcriptional regulation of the endogenous danger signal tenascin-C: a novel autocrine loop in inflammation.

Goh FG, Piccinini AM, Krausgruber T, Udalova IA, Midwood KS.

J Immunol. 2010 Mar 1;184(5):2655-62. doi: 10.4049/jimmunol.0903359. Epub 2010 Jan 27.


The role of tenascin-C in tissue injury and tumorigenesis.

Midwood KS, Orend G.

J Cell Commun Signal. 2009 Dec;3(3-4):287-310. doi: 10.1007/s12079-009-0075-1. Epub 2009 Oct 17.


Targeting Toll-like receptors in autoimmunity.

Midwood KS, Piccinini AM, Sacre S.

Curr Drug Targets. 2009 Nov;10(11):1139-55. Review.


Regulation of fibroblast migration by tenascin-C.

Trebaul A, Chan EK, Midwood KS.

Biochem Soc Trans. 2007 Aug;35(Pt 4):695-7. Review.


Modulation of cell-fibronectin matrix interactions during tissue repair.

Midwood KS, Mao Y, Hsia HC, Valenick LV, Schwarzbauer JE.

J Investig Dermatol Symp Proc. 2006 Sep;11(1):73-8. Review.


Easy and efficient bonding of biomolecules to an oxide surface of silicon.

Midwood KS, Carolus MD, Danahy MP, Schwarzbauer JE, Schwartz J.

Langmuir. 2004 Jun 22;20(13):5501-5.


Self-assembled monolayers of alpha,omega-diphosphonic acids on Ti enable complete or spatially controlled surface derivatization.

Danahy MP, Avaltroni MJ, Midwood KS, Schwarzbauer JE, Schwartz J.

Langmuir. 2004 Jun 22;20(13):5333-7.


Coregulation of fibronectin signaling and matrix contraction by tenascin-C and syndecan-4.

Midwood KS, Valenick LV, Hsia HC, Schwarzbauer JE.

Mol Biol Cell. 2004 Dec;15(12):5670-7. Epub 2004 Oct 13.


Tissue repair and the dynamics of the extracellular matrix.

Midwood KS, Williams LV, Schwarzbauer JE.

Int J Biochem Cell Biol. 2004 Jun;36(6):1031-7. Review.


Preparation and analysis of synthetic multicomponent extracellular matrix.

Midwood KS, Wierzbicka-Patynowski I, Schwarzbauer JE.

Methods Cell Biol. 2002;69:145-61. No abstract available.


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