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Items: 17

1.

Pharmacokinetics and metabolism of the prodrug DB289 (2,5-bis[4-(N-methoxyamidino)phenyl]furan monomaleate) in rat and monkey and its conversion to the antiprotozoal/antifungal drug DB75 (2,5-bis(4-guanylphenyl)furan dihydrochloride).

Midgley I, Fitzpatrick K, Taylor LM, Houchen TL, Henderson SJ, Wright SJ, Cybulski ZR, John BA, McBurney A, Boykin DW, Trendler KL.

Drug Metab Dispos. 2007 Jun;35(6):955-67. Epub 2007 Mar 14.

PMID:
17360833
2.

Species differences in the pharmacokinetics and metabolism of reparixin in rat and dog.

Midgley I, Fitzpatrick K, Wright SJ, John BA, Peard AJ, Major RM, Holding JD, McBurney A, Anacardio R, Novellini R, Ferrari MP.

Xenobiotica. 2006 May;36(5):419-40.

PMID:
16854780
3.

[Pharmacokinetics and disposition of silodosin (KMD-3213)].

Matsubara Y, Kanazawa T, Kojima Y, Abe Y, Kobayashi K, Kanbe H, Harada H, Momose Y, Terakado S, Adachi Y, Midgley I.

Yakugaku Zasshi. 2006 Mar;126 Spec no.:237-45. Japanese.

4.

Absorption, distribution and excretion of 14C-pilocarpine following oral administration to rats.

Omori Y, Endo T, Hara Y, Nishiyama M, Midgley I, Smart CI, John AJ, Chasseaud LF, McBurney A, John BA.

Arzneimittelforschung. 2004;54(3):171-8.

PMID:
15112864
5.

Metabolic fate of 14C-camostat mesylate in man, rat and dog after intravenous administration.

Midgley I, Hood AJ, Proctor P, Chasseaud LF, Irons SR, Cheng KN, Brindley CJ, Bonn R.

Xenobiotica. 1994 Jan;24(1):79-92.

PMID:
8165824
6.

Percutaneous absorption of co-administered N-methyl-2-[14C]pyrrolidinone and 2-[14C]pyrrolidinone in the rat.

Midgley I, Hood AJ, Chasseaud LF, Brindley CJ, Baughman S, Allan G.

Food Chem Toxicol. 1992 Jan;30(1):57-64.

PMID:
1544607
7.

Metabolism and pharmacokinetics of the dihydropyridine calcium antagonist, ryosidine, in man.

Midgley I, Chasseaud LF, Taylor IW, Walmsley LM, Fowkes AG, Darragh A, Lambe RF, Bonn R.

Xenobiotica. 1985 Nov;15(11):965-77.

PMID:
4082636
8.

The metabolic fate of the anti-androgenic agent, oxendolone, in man.

Midgley I, Fowkes AG, Darragh A, Lambe R, Chasseaud LF, Taylor T.

Steroids. 1983 Apr;41(4):521-36.

PMID:
6419414
9.

Biotransformation of lofexidine in humans.

Midgley I, Fowkes AG, Chasseaud LF, Hawkins DR, Girkin R, Kesselring K.

Xenobiotica. 1983 Feb;13(2):87-95.

PMID:
6880242
10.

A novel conjugate as a major metabolite of bromperidol in man.

Hawkins DR, Biggs SR, Brodie RR, Chasseaud LF, Midgley I.

J Pharm Pharmacol. 1982 May;34(5):299-303.

PMID:
6123567
11.

The absorption and excretion of 14C-lofexidine hydrochloride in man.

Midgley I, Chasseaud LF, Taylor T, Darragh A.

Arzneimittelforschung. 1982;32(8a):972-5. No abstract available.

PMID:
6890372
12.

The metabolic fate of 3[H]econazole in man.

Midgley I, van Bladeren PJ, Hawkins DR, Chasseaud LF, Darragh A, Brodie RR, Walmsley LM.

Xenobiotica. 1981 Sep;11(9):595-608.

PMID:
7314642
13.

Determination of amitriptyline and its major basic metabolites in human urine by high-performance liquid chromatography.

Biggs SR, Chasseaud LF, Hawkins DR, Midgley I.

Drug Metab Dispos. 1979 Jul-Aug;7(4):233-6.

PMID:
39726
14.
15.

The metabolic fate of the antidepressive agent amitriptylinoxide in man.

Midgley I, Hawkins DR, Chasseaud LF.

Arzneimittelforschung. 1978;28(10b):1911-6. No abstract available.

PMID:
582518
16.

The pharmacokinetics and metabolism of 14C-amitriptylinoxide in rat and dog.

Brodie RR, Chasseaud LF, Hawkins DR, Midgley I.

Arzneimittelforschung. 1978;28(10b):1907-10. No abstract available.

PMID:
582517
17.

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