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Items: 1 to 50 of 120


The oral microbiome of early stage Parkinson's disease and its relationship with functional measures of motor and non-motor function.

Mihaila D, Donegan J, Barns S, LaRocca D, Du Q, Zheng D, Vidal M, Neville C, Uhlig R, Middleton FA.

PLoS One. 2019 Jun 27;14(6):e0218252. doi: 10.1371/journal.pone.0218252. eCollection 2019.


An Adaptive Multivariate Two-Sample Test With Application to Microbiome Differential Abundance Analysis.

Banerjee K, Zhao N, Srinivasan A, Xue L, Hicks SD, Middleton FA, Wu R, Zhan X.

Front Genet. 2019 Apr 24;10:350. doi: 10.3389/fgene.2019.00350. eCollection 2019.


Saliva MicroRNA Differentiates Children With Autism From Peers With Typical and Atypical Development.

Hicks SD, Carpenter RL, Wagner KE, Pauley R, Barros M, Tierney-Aves C, Barns S, Greene CD, Middleton FA.

J Am Acad Child Adolesc Psychiatry. 2019 Mar 27. pii: S0890-8567(19)30210-2. doi: 10.1016/j.jaac.2019.03.017. [Epub ahead of print]


Parent Perspectives Towards Genetic and Epigenetic Testing for Autism Spectrum Disorder.

Wagner KE, McCormick JB, Barns S, Carney M, Middleton FA, Hicks SD.

J Autism Dev Disord. 2019 Mar 22. doi: 10.1007/s10803-019-03990-6. [Epub ahead of print]


Mitochondrial carrier protein overloading and misfolding induce aggresomes and proteostatic adaptations in the cytosol.

Liu Y, Wang X, Coyne LP, Yang Y, Qi Y, Middleton FA, Chen XJ.

Mol Biol Cell. 2019 May 15;30(11):1272-1284. doi: 10.1091/mbc.E19-01-0046. Epub 2019 Mar 20.


Effect of lesion proximity on the regenerative response of long descending propriospinal neurons after spinal transection injury.

Swieck K, Conta-Steencken A, Middleton FA, Siebert JR, Osterhout DJ, Stelzner DJ.

BMC Neurosci. 2019 Mar 18;20(1):10. doi: 10.1186/s12868-019-0491-y.


Comparison of serum and saliva miRNAs for identification and characterization of mTBI in adult mixed martial arts fighters.

LaRocca D, Barns S, Hicks SD, Brindle A, Williams J, Uhlig R, Johnson P, Neville C, Middleton FA.

PLoS One. 2019 Jan 2;14(1):e0207785. doi: 10.1371/journal.pone.0207785. eCollection 2019.


The Transcriptional Signature of a Runner's High.

Hicks SD, Jacob P, Perez O, Baffuto M, Gagnon Z, Middleton FA.

Med Sci Sports Exerc. 2019 May;51(5):970-978. doi: 10.1249/MSS.0000000000001865.


Oxytocin receptor gene (OXTR) links to marital quality via social support behavior and perceived partner responsiveness.

Mattson RE, Cameron N, Middleton FA, Starr LR, Davila J, Johnson MD.

J Fam Psychol. 2019 Feb;33(1):44-53. doi: 10.1037/fam0000474. Epub 2018 Nov 29.


Validation of a Salivary RNA Test for Childhood Autism Spectrum Disorder.

Hicks SD, Rajan AT, Wagner KE, Barns S, Carpenter RL, Middleton FA.

Front Genet. 2018 Nov 9;9:534. doi: 10.3389/fgene.2018.00534. eCollection 2018.


A role for genes in the 'caregiver stress process'?

Wolf DA, Middleton FA.

Transl Psychiatry. 2018 Oct 22;8(1):228. doi: 10.1038/s41398-018-0275-7.


Oral microbiome activity in children with autism spectrum disorder.

Hicks SD, Uhlig R, Afshari P, Williams J, Chroneos M, Tierney-Aves C, Wagner K, Middleton FA.

Autism Res. 2018 Sep;11(9):1286-1299. doi: 10.1002/aur.1972. Epub 2018 Aug 14.


Diurnal oscillations in human salivary microRNA and microbial transcription: Implications for human health and disease.

Hicks SD, Khurana N, Williams J, Dowd Greene C, Uhlig R, Middleton FA.

PLoS One. 2018 Jul 18;13(7):e0198288. doi: 10.1371/journal.pone.0198288. eCollection 2018.


Distance running alters peripheral microRNAs implicated in metabolism, fluid balance, and myosin regulation in a sex-specific manner.

Hicks SD, Jacob P, Middleton FA, Perez O, Gagnon Z.

Physiol Genomics. 2018 Aug 1;50(8):658-667. doi: 10.1152/physiolgenomics.00035.2018. Epub 2018 Jun 8.


SHIP1 Deficiency in Inflammatory Bowel Disease Is Associated With Severe Crohn's Disease and Peripheral T Cell Reduction.

Fernandes S, Srivastava N, Sudan R, Middleton FA, Shergill AK, Ryan JC, Kerr WG.

Front Immunol. 2018 May 22;9:1100. doi: 10.3389/fimmu.2018.01100. eCollection 2018.


Reviewer selection biases editorial decisions on manuscripts.

Hausmann L, Schweitzer B, Middleton FA, Schulz JB.

J Neurochem. 2018 Jan 27. doi: 10.1111/jnc.14314. [Epub ahead of print]


Reduced Slc1a1 expression is associated with neuroinflammation and impaired sensorimotor gating and cognitive performance in mice: Implications for schizophrenia.

Afshari P, Yao WD, Middleton FA.

PLoS One. 2017 Sep 8;12(9):e0183854. doi: 10.1371/journal.pone.0183854. eCollection 2017.


Contrast sensitivity to spatial gratings in moderate and dim light conditions in patients with diabetes in the absence of diabetic retinopathy.

Safi S, Rahimi A, Raeesi A, Safi H, Aghazadeh Amiri M, Malek M, Yaseri M, Haeri M, Middleton FA, Solessio E, Ahmadieh H.

BMJ Open Diabetes Res Care. 2017 Aug 8;5(1):e000408. doi: 10.1136/bmjdrc-2017-000408. eCollection 2017.


Analysis of SHIP1 expression and activity in Crohn's disease patients.

Somasundaram R, Fernandes S, Deuring JJ, de Haar C, Kuipers EJ, Vogelaar L, Middleton FA, van der Woude CJ, Peppelenbosch MP, Kerr WG, Fuhler GM.

PLoS One. 2017 Aug 2;12(8):e0182308. doi: 10.1371/journal.pone.0182308. eCollection 2017.


Heterogeneity of p53 dependent genomic responses following ethanol exposure in a developmental mouse model of fetal alcohol spectrum disorder.

Camargo Moreno M, Mooney SM, Middleton FA.

PLoS One. 2017 Jul 19;12(7):e0180873. doi: 10.1371/journal.pone.0180873. eCollection 2017.


The de novo autism spectrum disorder RELN R2290C mutation reduces Reelin secretion and increases protein disulfide isomerase expression.

Lammert DB, Middleton FA, Pan J, Olson EC, Howell BW.

J Neurochem. 2017 Jul;142(1):89-102. doi: 10.1111/jnc.14045. Epub 2017 May 18.


Analysis of Shared Haplotypes amongst Palauans Maps Loci for Psychotic Disorders to 4q28 and 5q23-q31.

Bodea CA, Middleton FA, Melhem NM, Klei L, Song Y, Tiobech J, Marumoto P, Yano V, Faraone SV, Roeder K, Myles-Worsley M, Devlin B, Byerley W.

Mol Neuropsychiatry. 2017 Feb;2(4):173-184. doi: 10.1159/000450726. Epub 2016 Oct 12.


Associations between neurodevelopmental genes, neuroanatomy, and ultra high risk symptoms of psychosis in 22q11.2 deletion syndrome.

Thompson CA, Karelis J, Middleton FA, Gentile K, Coman IL, Radoeva PD, Mehta R, Fremont WP, Antshel KM, Faraone SV, Kates WR.

Am J Med Genet B Neuropsychiatr Genet. 2017 Apr;174(3):295-314. doi: 10.1002/ajmg.b.32515. Epub 2017 Jan 31.


Cortical-amygdala volumetric ratios predict onset of symptoms of psychosis in 22q11.2 deletion syndrome.

Berhanu D, Mattiaccio LM, Antshel KM, Fremont W, Middleton FA, Kates WR.

Psychiatry Res Neuroimaging. 2017 Jan 30;259:10-15. doi: 10.1016/j.pscychresns.2016.11.006. Epub 2016 Nov 25.


A Comparative Review of microRNA Expression Patterns in Autism Spectrum Disorder.

Hicks SD, Middleton FA.

Front Psychiatry. 2016 Nov 4;7:176. eCollection 2016.


Thrombospondin-1 differentially regulates microRNAs in vascular smooth muscle cells.

Maier KG, Ruhle B, Stein JJ, Gentile KL, Middleton FA, Gahtan V.

Mol Cell Biochem. 2016 Jan;412(1-2):111-7. doi: 10.1007/s11010-015-2614-9. Epub 2016 Jan 4.


Characterization of a Novel Mutation in SLC1A1 Associated with Schizophrenia.

Afshari P, Myles-Worsley M, Cohen OS, Tiobech J, Faraone SV, Byerley W, Middleton FA.

Mol Neuropsychiatry. 2015 Oct;1(3):125-44. doi: 10.1159/000433599. Epub 2015 Jul 8.


A splicing-regulatory polymorphism in DRD2 disrupts ZRANB2 binding, impairs cognitive functioning and increases risk for schizophrenia in six Han Chinese samples.

Cohen OS, Weickert TW, Hess JL, Paish LM, McCoy SY, Rothmond DA, Galletly C, Liu D, Weinberg DD, Huang XF, Xu Q, Shen Y, Zhang D, Yue W, Yan J, Wang L, Lu T, He L, Shi Y, Xu M, Che R, Tang W, Chen CH, Chang WH, Hwu HG, Liu CM, Liu YL, Wen CC, Fann CS, Chang CC, Kanazawa T, Middleton FA, Duncan TM, Faraone SV, Weickert CS, Tsuang MT, Glatt SJ.

Mol Psychiatry. 2016 Jul;21(7):975-82. doi: 10.1038/mp.2015.137. Epub 2015 Sep 8.


Alterations in serum microRNA in humans with alcohol use disorders impact cell proliferation and cell death pathways and predict structural and functional changes in brain.

Ignacio C, Hicks SD, Burke P, Lewis L, Szombathyne-Meszaros Z, Middleton FA.

BMC Neurosci. 2015 Sep 5;16:55. doi: 10.1186/s12868-015-0195-x.


Association between autism spectrum disorder in individuals with velocardiofacial (22q11.2 deletion) syndrome and PRODH and COMT genotypes.

Radoeva PD, Coman IL, Salazar CA, Gentile KL, Higgins AM, Middleton FA, Antshel KM, Fremont W, Shprintzen RJ, Morrow BE, Kates WR.

Psychiatr Genet. 2014 Dec;24(6):269-72. doi: 10.1097/YPG.0000000000000062.


Effects of Acute Prenatal Exposure to Ethanol on microRNA Expression are Ameliorated by Social Enrichment.

Ignacio C, Mooney SM, Middleton FA.

Front Pediatr. 2014 Sep 24;2:103. doi: 10.3389/fped.2014.00103. eCollection 2014.


White matter microstructural abnormalities of the cingulum bundle in youths with 22q11.2 deletion syndrome: associations with medication, neuropsychological function, and prodromal symptoms of psychosis.

Kates WR, Olszewski AK, Gnirke MH, Kikinis Z, Nelson J, Antshel KM, Fremont W, Radoeva PD, Middleton FA, Shenton ME, Coman IL.

Schizophr Res. 2015 Jan;161(1):76-84. doi: 10.1016/j.schres.2014.07.010. Epub 2014 Jul 25.


Characterizing runs of homozygosity and their impact on risk for psychosis in a population isolate.

Melhem NM, Lu C, Dresbold C, Middleton FA, Klei L, Wood S, Faraone SV, Vinogradov S, Tiobech J, Yano V, Roeder K, Byerley W, Myles-Worsley M, Devlin B.

Am J Med Genet B Neuropsychiatr Genet. 2014 Sep;165B(6):521-30. doi: 10.1002/ajmg.b.32255. Epub 2014 Jul 1.


Autism-related behavioral phenotypes in an inbred rat substrain.

Zhang-James Y, Yang L, Middleton FA, Yang L, Patak J, Faraone SV.

Behav Brain Res. 2014 Aug 1;269:103-14. doi: 10.1016/j.bbr.2014.04.035. Epub 2014 Apr 26.


White matter abnormalities in 22q11.2 deletion syndrome: preliminary associations with the Nogo-66 receptor gene and symptoms of psychosis.

Perlstein MD, Chohan MR, Coman IL, Antshel KM, Fremont WP, Gnirke MH, Kikinis Z, Middleton FA, Radoeva PD, Shenton ME, Kates WR.

Schizophr Res. 2014 Jan;152(1):117-23. doi: 10.1016/j.schres.2013.11.015. Epub 2013 Dec 8.


Genetic architecture of Wistar-Kyoto rat and spontaneously hypertensive rat substrains from different sources.

Zhang-James Y, Middleton FA, Faraone SV.

Physiol Genomics. 2013 Jul 2;45(13):528-38. doi: 10.1152/physiolgenomics.00002.2013. Epub 2013 May 14.


Deletion at the SLC1A1 glutamate transporter gene co-segregates with schizophrenia and bipolar schizoaffective disorder in a 5-generation family.

Myles-Worsley M, Tiobech J, Browning SR, Korn J, Goodman S, Gentile K, Melhem N, Byerley W, Faraone SV, Middleton FA.

Am J Med Genet B Neuropsychiatr Genet. 2013 Mar;162B(2):87-95. doi: 10.1002/ajmg.b.32125. Epub 2013 Jan 22.


Functional and biochemical characterization of soleus muscle in Down syndrome mice: insight into the muscle dysfunction seen in the human condition.

Cowley PM, Keslacy S, Middleton FA, DeRuisseau LR, Fernhall B, Kanaley JA, DeRuisseau KC.

Am J Physiol Regul Integr Comp Physiol. 2012 Dec 15;303(12):R1251-60. doi: 10.1152/ajpregu.00312.2012. Epub 2012 Oct 31.


Evaluation of cell proliferation, apoptosis, and DNA-repair genes as potential biomarkers for ethanol-induced CNS alterations.

Hicks SD, Lewis L, Ritchie J, Burke P, Abdul-Malak Y, Adackapara N, Canfield K, Shwarts E, Gentile K, Meszaros ZS, Middleton FA.

BMC Neurosci. 2012 Oct 25;13:128. doi: 10.1186/1471-2202-13-128.


Transcriptomic analysis of postmortem brain identifies dysregulated splicing events in novel candidate genes for schizophrenia.

Cohen OS, Mccoy SY, Middleton FA, Bialosuknia S, Zhang-James Y, Liu L, Tsuang MT, Faraone SV, Glatt SJ.

Schizophr Res. 2012 Dec;142(1-3):188-99. doi: 10.1016/j.schres.2012.09.015. Epub 2012 Oct 9.


Hierarchical clustering of gene expression patterns in the Eomes + lineage of excitatory neurons during early neocortical development.

Cameron DA, Middleton FA, Chenn A, Olson EC.

BMC Neurosci. 2012 Aug 1;13:90. doi: 10.1186/1471-2202-13-90.


Differential expression of SLC9A9 and interacting molecules in the hippocampus of rat models for attention deficit/hyperactivity disorder.

Zhang-James Y, Middleton FA, Sagvolden T, Faraone SV.

Dev Neurosci. 2012;34(2-3):218-27. Epub 2012 Jul 6.


Molecular substrates of social avoidance seen following prenatal ethanol exposure and its reversal by social enrichment.

Middleton FA, Varlinskaya EI, Mooney SM.

Dev Neurosci. 2012;34(2-3):115-28. Epub 2012 May 8.


Genetic overlap of schizophrenia and bipolar disorder in a high-density linkage survey in the Portuguese Island population.

Fanous AH, Middleton FA, Gentile K, Amdur RL, Maher BS, Zhao Z, Sun J, Medeiros H, Carvalho C, Ferreira SR, Macedo A, Knowles JA, Azevedo MH, Pato MT, Pato CN.

Am J Med Genet B Neuropsychiatr Genet. 2012 Jun;159B(4):383-91. doi: 10.1002/ajmg.b.32041. Epub 2012 Mar 27.


Increased promoter methylation of the immune regulatory gene SHP-1 in leukocytes of multiple sclerosis subjects.

Kumagai C, Kalman B, Middleton FA, Vyshkina T, Massa PT.

J Neuroimmunol. 2012 May 15;246(1-2):51-7. doi: 10.1016/j.jneuroim.2012.03.003. Epub 2012 Mar 27.


Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder.

Elia J, Glessner JT, Wang K, Takahashi N, Shtir CJ, Hadley D, Sleiman PM, Zhang H, Kim CE, Robison R, Lyon GJ, Flory JH, Bradfield JP, Imielinski M, Hou C, Frackelton EC, Chiavacci RM, Sakurai T, Rabin C, Middleton FA, Thomas KA, Garris M, Mentch F, Freitag CM, Steinhausen HC, Todorov AA, Reif A, Rothenberger A, Franke B, Mick EO, Roeyers H, Buitelaar J, Lesch KP, Banaschewski T, Ebstein RP, Mulas F, Oades RD, Sergeant J, Sonuga-Barke E, Renner TJ, Romanos M, Romanos J, Warnke A, Walitza S, Meyer J, Pálmason H, Seitz C, Loo SK, Smalley SL, Biederman J, Kent L, Asherson P, Anney RJ, Gaynor JW, Shaw P, Devoto M, White PS, Grant SF, Buxbaum JD, Rapoport JL, Williams NM, Nelson SF, Faraone SV, Hakonarson H.

Nat Genet. 2011 Dec 4;44(1):78-84. doi: 10.1038/ng.1013.


Transcriptome-wide gene expression in a rat model of attention deficit hyperactivity disorder symptoms: rats developmentally exposed to polychlorinated biphenyls.

Sazonova NA, DasBanerjee T, Middleton FA, Gowtham S, Schuckers S, Faraone SV.

Am J Med Genet B Neuropsychiatr Genet. 2011 Dec;156B(8):898-912. doi: 10.1002/ajmg.b.31230. Epub 2011 Sep 14.


SLC9A9 mutations, gene expression, and protein-protein interactions in rat models of attention-deficit/hyperactivity disorder.

Zhang-James Y, DasBanerjee T, Sagvolden T, Middleton FA, Faraone SV.

Am J Med Genet B Neuropsychiatr Genet. 2011 Dec;156B(7):835-43. doi: 10.1002/ajmg.b.31229. Epub 2011 Aug 19.


Accuracy of self-reported medical problems in patients with alcohol dependence and co-occurring schizophrenia or schizoaffective disorder.

Meszaros ZS, Dimmock JA, Ploutz-Snyder R, Chauhan SV, Abdul-Malak Y, Middleton FA, Batki SL.

Schizophr Res. 2011 Nov;132(2-3):190-3. doi: 10.1016/j.schres.2011.07.033. Epub 2011 Aug 17.

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