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Items: 1 to 50 of 103

1.

Mechanics, Structure and Function of Biopolymer Condensates.

Bergeron-Sandoval LP, Michnick SW.

J Mol Biol. 2018 Jun 15. pii: S0022-2836(18)30629-6. doi: 10.1016/j.jmb.2018.06.023. [Epub ahead of print] Review.

PMID:
29913159
2.

Why does biopolymer condensation matter?

Michnick SW, Bergeron-Sandoval LP.

Nat Rev Mol Cell Biol. 2018 May 16. doi: 10.1038/s41580-018-0023-0. [Epub ahead of print] No abstract available.

PMID:
29769647
3.

More than One Way to Skin a Catalyst.

Michnick SW.

Cell Chem Biol. 2017 Oct 19;24(10):1196-1197. doi: 10.1016/j.chembiol.2017.10.004.

PMID:
29053950
4.

Exhaustive search of linear information encoding protein-peptide recognition.

Kelil A, Dubreuil B, Levy ED, Michnick SW.

PLoS Comput Biol. 2017 Apr 20;13(4):e1005499. doi: 10.1371/journal.pcbi.1005499. eCollection 2017 Apr.

5.

Delineating functional principles of the bow tie structure of a kinase-phosphatase network in the budding yeast.

Abd-Rabbo D, Michnick SW.

BMC Syst Biol. 2017 Mar 16;11(1):38. doi: 10.1186/s12918-017-0418-0.

6.

Protein-Fragment Complementation Assays for Large-Scale Analysis, Functional Dissection, and Spatiotemporal Dynamic Studies of Protein-Protein Interactions in Living Cells.

Michnick SW, Landry CR, Levy ED, Diss G, Ear PH, Kowarzyk J, Malleshaiah MK, Messier V, Tchekanda E.

Cold Spring Harb Protoc. 2016 Nov 1;2016(11). doi: 10.1101/pdb.top083543.

PMID:
27803260
7.

Real-Time Protein-Fragment Complementation Assays for Studying Temporal, Spatial, and Spatiotemporal Dynamics of Protein-Protein Interactions in Living Cells.

Malleshaiah M, Tchekanda E, Michnick SW.

Cold Spring Harb Protoc. 2016 Nov 1;2016(11). doi: 10.1101/pdb.prot090068.

PMID:
27803255
8.

Dissecting the Contingent Interactions of Protein Complexes with the Optimized Yeast Cytosine Deaminase Protein-Fragment Complementation Assay.

Ear PH, Kowarzyk J, Michnick SW.

Cold Spring Harb Protoc. 2016 Nov 1;2016(11). doi: 10.1101/pdb.prot090043.

PMID:
27803254
9.

The Dihydrofolate Reductase Protein-Fragment Complementation Assay: A Survival-Selection Assay for Large-Scale Analysis of Protein-Protein Interactions.

Michnick SW, Levy ED, Landry CR, Kowarzyk J, Messier V.

Cold Spring Harb Protoc. 2016 Nov 1;2016(11). doi: 10.1101/pdb.prot090027.

PMID:
27803252
10.

Unravelling the Mechanism of TrkA-Induced Cell Death by Macropinocytosis in Medulloblastoma Daoy Cells.

Li C, MacDonald JI, Talebian A, Leuenberger J, Seah C, Pasternak SH, Michnick SW, Meakin SO.

Mol Cell Biol. 2016 Sep 26;36(20):2596-611. doi: 10.1128/MCB.00255-16. Print 2016 Oct 15.

11.

Evolution of domain-peptide interactions to coadapt specificity and affinity to functional diversity.

Kelil A, Levy ED, Michnick SW.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3862-71. doi: 10.1073/pnas.1518469113. Epub 2016 Jun 17.

12.

Erratum to: Combining the Optimized Yeast Cytosine Deaminase Protein Fragment Complementation Assay and an In Vitro Cdk1 Targeting Assay to Study the Regulation of the γ-Tubulin Complex.

Ear PH, Kowarzyk J, Booth MJ, Abd-Rabbo D, Shulist K, Hall C, Vogel J, Michnick SW.

Methods Mol Biol. 2016;1342:E1. No abstract available.

PMID:
27240595
13.

Mechanisms and Consequences of Macromolecular Phase Separation.

Bergeron-Sandoval LP, Safaee N, Michnick SW.

Cell. 2016 May 19;165(5):1067-1079. doi: 10.1016/j.cell.2016.05.026. Review.

14.

IL23R (Interleukin 23 Receptor) Variants Protective against Inflammatory Bowel Diseases (IBD) Display Loss of Function due to Impaired Protein Stability and Intracellular Trafficking.

Sivanesan D, Beauchamp C, Quinou C, Lee J, Lesage S, Chemtob S, Rioux JD, Michnick SW.

J Biol Chem. 2016 Apr 15;291(16):8673-85. doi: 10.1074/jbc.M116.715870. Epub 2016 Feb 17.

15.

Protein Kinase C ζ Interacts with a Novel Binding Region of Gαq to Act as a Functional Effector.

Sánchez-Fernández G, Cabezudo S, Caballero Á, García-Hoz C, Tall GG, Klett J, Michnick SW, Mayor F Jr, Ribas C.

J Biol Chem. 2016 Apr 29;291(18):9513-25. doi: 10.1074/jbc.M115.684308. Epub 2016 Feb 17.

16.

Combining the Optimized Yeast Cytosine Deaminase Protein Fragment Complementation Assay and an In Vitro Cdk1 Targeting Assay to Study the Regulation of the γ-Tubulin Complex.

Ear PH, Kowarzyk J, Booth MJ, Abd-Rabbo D, Shulist K, Hall C, Vogel J, Michnick SW.

Methods Mol Biol. 2016;1342:237-57. doi: 10.1007/978-1-4939-2957-3_14.

PMID:
26254928
17.

In-vivo detection of binary PKA network interactions upon activation of endogenous GPCRs.

Röck R, Bachmann V, Bhang HE, Malleshaiah M, Raffeiner P, Mayrhofer JE, Tschaikner PM, Bister K, Aanstad P, Pomper MG, Michnick SW, Stefan E.

Sci Rep. 2015 Jun 23;5:11133. doi: 10.1038/srep11133.

18.

Mapping biochemical networks with protein fragment complementation assays.

Remy I, Michnick SW.

Methods Mol Biol. 2015;1278:467-81. doi: 10.1007/978-1-4939-2425-7_31.

PMID:
25859970
19.

A cell-signaling network temporally resolves specific versus promiscuous phosphorylation.

Kanshin E, Bergeron-Sandoval LP, Isik SS, Thibault P, Michnick SW.

Cell Rep. 2015 Feb 24;10(7):1202-14. doi: 10.1016/j.celrep.2015.01.052. Epub 2015 Feb 19.

20.

Fast and accurate discovery of degenerate linear motifs in protein sequences.

Kelil A, Dubreuil B, Levy ED, Michnick SW.

PLoS One. 2014 Sep 10;9(9):e106081. doi: 10.1371/journal.pone.0106081. eCollection 2014.

21.

High-resolution mapping of protein concentration reveals principles of proteome architecture and adaptation.

Levy ED, Kowarzyk J, Michnick SW.

Cell Rep. 2014 May 22;7(4):1333-40. doi: 10.1016/j.celrep.2014.04.009. Epub 2014 May 10.

22.

An infrared reporter to detect spatiotemporal dynamics of protein-protein interactions.

Tchekanda E, Sivanesan D, Michnick SW.

Nat Methods. 2014 Jun;11(6):641-4. doi: 10.1038/nmeth.2934. Epub 2014 Apr 20.

PMID:
24747815
23.

The dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation.

Chognard G, Bellemare L, Pelletier AN, Dominguez-Punaro MC, Beauchamp C, Guyon MJ, Charron G, Morin N, Sivanesan D, Kuchroo V, Xavier R, Michnick SW, Chemtob S, Rioux JD, Lesage S.

PLoS One. 2014 Feb 21;9(2):e89092. doi: 10.1371/journal.pone.0089092. eCollection 2014.

24.

Extracting insight from noisy cellular networks.

Landry CR, Levy ED, Abd Rabbo D, Tarassov K, Michnick SW.

Cell. 2013 Nov 21;155(5):983-9. doi: 10.1016/j.cell.2013.11.003.

25.

Dissection of Cdk1-cyclin complexes in vivo.

Ear PH, Booth MJ, Abd-Rabbo D, Kowarzyk Moreno J, Hall C, Chen D, Vogel J, Michnick SW.

Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15716-21. doi: 10.1073/pnas.1305420110. Epub 2013 Sep 9.

26.

A nutrient-responsive pathway that determines M phase timing through control of B-cyclin mRNA stability.

Messier V, Zenklusen D, Michnick SW.

Cell. 2013 May 23;153(5):1080-93. doi: 10.1016/j.cell.2013.04.035.

27.

Displacement of N/Q-rich peptides on TiO2 beads enhances the depth and coverage of yeast phosphoproteome analyses.

Kanshin E, Michnick SW, Thibault P.

J Proteome Res. 2013 Jun 7;12(6):2905-13. doi: 10.1021/pr400198e. Epub 2013 May 8.

PMID:
23607784
28.

Proteomic characterization of phagosomal membrane microdomains during phagolysosome biogenesis and evolution.

Goyette G, Boulais J, Carruthers NJ, Landry CR, Jutras I, Duclos S, Dermine JF, Michnick SW, LaBoissière S, Lajoie G, Barreiro L, Thibault P, Desjardins M.

Mol Cell Proteomics. 2012 Nov;11(11):1365-77. doi: 10.1074/mcp.M112.021048. Epub 2012 Aug 20.

29.

Protein abundance is key to distinguish promiscuous from functional phosphorylation based on evolutionary information.

Levy ED, Michnick SW, Landry CR.

Philos Trans R Soc Lond B Biol Sci. 2012 Sep 19;367(1602):2594-606. doi: 10.1098/rstb.2012.0078.

30.

Visualizing transient protein-folding intermediates by tryptophan-scanning mutagenesis.

Vallée-Bélisle A, Michnick SW.

Nat Struct Mol Biol. 2012 Jun 10;19(7):731-6. doi: 10.1038/nsmb.2322.

PMID:
22683996
31.

PKA regulatory subunits mediate synergy among conserved G-protein-coupled receptor cascades.

Stefan E, Malleshaiah MK, Breton B, Ear PH, Bachmann V, Beyermann M, Bouvier M, Michnick SW.

Nat Commun. 2011 Dec 20;2:598. doi: 10.1038/ncomms1605.

32.

Protein-fragment complementation assays for large-scale analysis, functional dissection and dynamic studies of protein-protein interactions in living cells.

Michnick SW, Ear PH, Landry C, Malleshaiah MK, Messier V.

Methods Mol Biol. 2011;756:395-425. doi: 10.1007/978-1-61779-160-4_25.

PMID:
21870242
33.

Phosphorylation network rewiring by gene duplication.

Freschi L, Courcelles M, Thibault P, Michnick SW, Landry CR.

Mol Syst Biol. 2011 Jul 5;7:504. doi: 10.1038/msb.2011.43.

34.

Molecular characterization of the evolution of phagosomes.

Boulais J, Trost M, Landry CR, Dieckmann R, Levy ED, Soldati T, Michnick SW, Thibault P, Desjardins M.

Mol Syst Biol. 2010 Oct 19;6:423. doi: 10.1038/msb.2010.80.

35.

A toolkit of protein-fragment complementation assays for studying and dissecting large-scale and dynamic protein-protein interactions in living cells.

Michnick SW, Ear PH, Landry C, Malleshaiah MK, Messier V.

Methods Enzymol. 2010;470:335-68. doi: 10.1016/S0076-6879(10)70014-8. Epub 2010 Mar 1.

PMID:
20946817
36.

Cell signaling. Signaling through cooperation.

Levy ED, Landry CR, Michnick SW.

Science. 2010 May 21;328(5981):983-4. doi: 10.1126/science.1190993. No abstract available.

PMID:
20489011
37.

De novo helical peptides as target sequences for a specific, fluorogenic protein labelling strategy.

Guy J, Castonguay R, Campos-Reales Pineda NB, Jacquier V, Caron K, Michnick SW, Keillor JW.

Mol Biosyst. 2010 Jun;6(6):976-87. doi: 10.1039/b918205e. Epub 2010 Feb 23.

PMID:
20485742
38.

The scaffold protein Ste5 directly controls a switch-like mating decision in yeast.

Malleshaiah MK, Shahrezaei V, Swain PS, Michnick SW.

Nature. 2010 May 6;465(7294):101-5. doi: 10.1038/nature08946. Epub 2010 Apr 18.

PMID:
20400943
39.

A general life-death selection strategy for dissecting protein functions.

Ear PH, Michnick SW.

Nat Methods. 2009 Nov;6(11):813-6. doi: 10.1038/nmeth.1389. Epub 2009 Oct 11.

PMID:
19820714
40.

Hereditary inclusion body myopathy-linked p97/VCP mutations in the NH2 domain and the D1 ring modulate p97/VCP ATPase activity and D2 ring conformation.

Halawani D, LeBlanc AC, Rouiller I, Michnick SW, Servant MJ, Latterich M.

Mol Cell Biol. 2009 Aug;29(16):4484-94. doi: 10.1128/MCB.00252-09. Epub 2009 Jun 8.

41.

Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors.

Skoumbourdis AP, Leclair CA, Stefan E, Turjanski AG, Maguire W, Titus SA, Huang R, Auld DS, Inglese J, Austin CP, Michnick SW, Xia M, Thomas CJ.

Bioorg Med Chem Lett. 2009 Jul 1;19(13):3686-92. doi: 10.1016/j.bmcl.2009.01.057. Epub 2009 Jan 23.

42.

Weak functional constraints on phosphoproteomes.

Landry CR, Levy ED, Michnick SW.

Trends Genet. 2009 May;25(5):193-7. doi: 10.1016/j.tig.2009.03.003. Epub 2009 Apr 6.

PMID:
19349092
43.

How perfect can protein interactomes be?

Levy ED, Landry CR, Michnick SW.

Sci Signal. 2009 Mar 3;2(60):pe11. doi: 10.1126/scisignal.260pe11.

PMID:
19261595
44.

Chromatin- and transcription-related factors repress transcription from within coding regions throughout the Saccharomyces cerevisiae genome.

Cheung V, Chua G, Batada NN, Landry CR, Michnick SW, Hughes TR, Winston F.

PLoS Biol. 2008 Nov 11;6(11):e277. doi: 10.1371/journal.pbio.0060277.

45.

Submitting antibodies to binding arbitration.

Michnick SW, Sidhu SS.

Nat Chem Biol. 2008 Jun;4(6):326-9. doi: 10.1038/nchembio0608-326.

PMID:
18488004
46.

An in vivo map of the yeast protein interactome.

Tarassov K, Messier V, Landry CR, Radinovic S, Serna Molina MM, Shames I, Malitskaya Y, Vogel J, Bussey H, Michnick SW.

Science. 2008 Jun 13;320(5882):1465-70. doi: 10.1126/science.1153878. Epub 2008 May 8.

47.

Identification of ERGIC-53 as an intracellular transport receptor of alpha1-antitrypsin.

Nyfeler B, Reiterer V, Wendeler MW, Stefan E, Zhang B, Michnick SW, Hauri HP.

J Cell Biol. 2008 Feb 25;180(4):705-12. doi: 10.1083/jcb.200709100. Epub 2008 Feb 18.

48.

A novel genetic screen implicates Elm1 in the inactivation of the yeast transcription factor SBF.

Manderson EN, Malleshaiah M, Michnick SW.

PLoS One. 2008 Jan 30;3(1):e1500. doi: 10.1371/journal.pone.0001500.

49.

Multiple tryptophan probes reveal that ubiquitin folds via a late misfolded intermediate.

Vallée-Bélisle A, Michnick SW.

J Mol Biol. 2007 Nov 30;374(3):791-805. Epub 2007 Sep 12.

PMID:
17949746
50.

Quantification of dynamic protein complexes using Renilla luciferase fragment complementation applied to protein kinase A activities in vivo.

Stefan E, Aquin S, Berger N, Landry CR, Nyfeler B, Bouvier M, Michnick SW.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16916-21. Epub 2007 Oct 17.

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