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IFN-λ Decreases Murid Herpesvirus-4 Infection of the Olfactory Epithelium but Fails to Prevent Virus Reactivation in the Vaginal Mucosa.

Jacobs S, Zeippen C, Wavreil F, Gillet L, Michiels T.

Viruses. 2019 Aug 16;11(8). pii: E757. doi: 10.3390/v11080757.


The leader protein of Theiler's virus prevents the activation of PKR by dsRNA.

Borghese F, Sorgeloos F, Cesaro T, Michiels T.

J Virol. 2019 Jul 10. pii: JVI.01010-19. doi: 10.1128/JVI.01010-19. [Epub ahead of print]


Creation of RANKL mutants with low affinity for decoy receptor OPG and their potential anti-fibrosis activity.

Wang Y, Michiels T, Setroikromo R, van Merkerk R, Cool RH, Quax WJ.

FEBS J. 2019 May 13. doi: 10.1111/febs.14925. [Epub ahead of print]


Innate Immune Detection of Cardioviruses and Viral Disruption of Interferon Signaling.

Freundt EC, Drappier M, Michiels T.

Front Microbiol. 2018 Oct 12;9:2448. doi: 10.3389/fmicb.2018.02448. eCollection 2018. Review.


Species Specificity of Type III Interferon Activity and Development of a Sensitive Luciferase-Based Bioassay for Quantitation of Mouse Interferon-λ.

Jacobs S, Wavreil F, Schepens B, Gad HH, Hartmann R, Rocha-Pereira J, Neyts J, Saelens X, Michiels T.

J Interferon Cytokine Res. 2018 Nov;38(11):469-479. doi: 10.1089/jir.2018.0066. Epub 2018 Oct 18.


An Affinity-Based Probe for the Human Adenosine A2A Receptor.

Yang X, Michiels TJM, de Jong C, Soethoudt M, Dekker N, Gordon E, van der Stelt M, Heitman LH, van der Es D, IJzerman AP.

J Med Chem. 2018 Sep 13;61(17):7892-7901. doi: 10.1021/acs.jmedchem.8b00860. Epub 2018 Aug 21.


A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L.

Drappier M, Jha BK, Stone S, Elliott R, Zhang R, Vertommen D, Weiss SR, Silverman RH, Michiels T.

PLoS Pathog. 2018 Apr 13;14(4):e1006989. doi: 10.1371/journal.ppat.1006989. eCollection 2018 Apr.


Interferon lambda (IFN-λ) efficiently blocks norovirus transmission in a mouse model.

Rocha-Pereira J, Jacobs S, Noppen S, Verbeken E, Michiels T, Neyts J.

Antiviral Res. 2018 Jan;149:7-15. doi: 10.1016/j.antiviral.2017.10.017. Epub 2017 Nov 10.


Mouse nidovirus LDV infection alleviates graft versus host disease and induces type I IFN-dependent inhibition of dendritic cells and allo-responsive T cells.

Gaignage M, Marillier RG, Uyttenhove C, Dauguet N, Saxena A, Ryffel B, Michiels T, Coutelier JP, Van Snick J.

Immun Inflamm Dis. 2017 Jun;5(2):200-213. doi: 10.1002/iid3.157. Epub 2017 Apr 4.


Nonstructural Protein L* Species Specificity Supports a Mouse Origin for Vilyuisk Human Encephalitis Virus.

Drappier M, Opperdoes FR, Michiels T.

J Virol. 2017 Jun 26;91(14). pii: e00573-17. doi: 10.1128/JVI.00573-17. Print 2017 Jul 15.


PKC epsilon-dependent calcium oscillations associated with metabotropic glutamate receptor 5 prevent agonist-mediated receptor desensitization in astrocytes.

Vergouts M, Doyen PJ, Peeters M, Opsomer R, Michiels T, Hermans E.

J Neurochem. 2017 May;141(3):387-399. doi: 10.1111/jnc.14007. Epub 2017 Mar 30.


Conserved Fever Pathways across Vertebrates: A Herpesvirus Expressed Decoy TNF-α Receptor Delays Behavioral Fever in Fish.

Rakus K, Ronsmans M, Forlenza M, Boutier M, Piazzon MC, Jazowiecka-Rakus J, Gatherer D, Athanasiadis A, Farnir F, Davison AJ, Boudinot P, Michiels T, Wiegertjes GF, Vanderplasschen A.

Cell Host Microbe. 2017 Feb 8;21(2):244-253. doi: 10.1016/j.chom.2017.01.010.


Improvement of abnormal vaginal flora in Ugandan women by self-testing and short use of intravaginal antimicrobials.

Donders G, Bellen G, Donders F, Pinget J, Vandevelde I, Michiels T, Byamughisa J.

Eur J Clin Microbiol Infect Dis. 2017 Apr;36(4):731-738. doi: 10.1007/s10096-016-2856-9. Epub 2016 Dec 8.


A covalent antagonist for the human adenosine A2A receptor.

Yang X, Dong G, Michiels TJM, Lenselink EB, Heitman L, Louvel J, IJzerman AP.

Purinergic Signal. 2017 Jun;13(2):191-201. doi: 10.1007/s11302-016-9549-9. Epub 2016 Dec 3.


Increased vaginal pH in Ugandan women: what does it indicate?

Donders GG, Gonzaga A, Marconi C, Donders F, Michiels T, Eggermont N, Bellen G, Lule J, Byamughisa J.

Eur J Clin Microbiol Infect Dis. 2016 Aug;35(8):1297-303. doi: 10.1007/s10096-016-2664-2. Epub 2016 May 14.


Screening for abnormal vaginal microflora by self-assessed vaginal pH does not enable detection of sexually transmitted infections in Ugandan women.

Donders GG, Donders F, Bellen G, Depuydt C, Eggermont N, Michiels T, Lule J, Byamughisa J.

Diagn Microbiol Infect Dis. 2016 Jun;85(2):227-30. doi: 10.1016/j.diagmicrobio.2015.12.018. Epub 2015 Dec 28.


Study of hepatitis E virus infection of genotype 1 and 3 in mice with humanised liver.

Sayed IM, Verhoye L, Cocquerel L, Abravanel F, Foquet L, Montpellier C, Debing Y, Farhoudi A, Wychowski C, Dubuisson J, Leroux-Roels G, Neyts J, Izopet J, Michiels T, Meuleman P.

Gut. 2017 May;66(5):920-929. doi: 10.1136/gutjnl-2015-311109. Epub 2016 Mar 22.


Cellular microRNAs Repress Vesicular Stomatitis Virus but Not Theiler's Virus Replication.

De Cock A, Michiels T.

Viruses. 2016 Mar 10;8(3):75. doi: 10.3390/v8030075.


Neurotropism of Saffold virus in a mouse model.

Sorgeloos F, Lardinois C, Jacobs S, van Kuppeveld FJM, Kaspers B, Michiels T.

J Gen Virol. 2016 Jun;97(6):1350-1355. doi: 10.1099/jgv.0.000452. Epub 2016 Mar 9.


Prevalence of Mycoplasma gallisepticum and Mycoplasma synoviae in commercial poultry, racing pigeons and wild birds in Belgium.

Michiels T, Welby S, Vanrobaeys M, Quinet C, Rouffaer L, Lens L, Martel A, Butaye P.

Avian Pathol. 2016;45(2):244-52. doi: 10.1080/03079457.2016.1145354.


Abortively Infected Astrocytes Appear To Represent the Main Source of Interferon Beta in the Virus-Infected Brain.

Pfefferkorn C, Kallfass C, Lienenklaus S, Spanier J, Kalinke U, Rieder M, Conzelmann KK, Michiels T, Staeheli P.

J Virol. 2015 Dec 9;90(4):2031-8. doi: 10.1128/JVI.02979-15. Print 2016 Feb 15.


Inhibition of the OAS/RNase L pathway by viruses.

Drappier M, Michiels T.

Curr Opin Virol. 2015 Dec;15:19-26. doi: 10.1016/j.coviro.2015.07.002. Epub 2015 Jul 29. Review.


The Interferon-Inducible Mouse Apolipoprotein L9 and Prohibitins Cooperate to Restrict Theiler's Virus Replication.

Kreit M, Vertommen D, Gillet L, Michiels T.

PLoS One. 2015 Jul 21;10(7):e0133190. doi: 10.1371/journal.pone.0133190. eCollection 2015.


Characterization of Ribosomal Frameshifting in Theiler's Murine Encephalomyelitis Virus.

Finch LK, Ling R, Napthine S, Olspert A, Michiels T, Lardinois C, Bell S, Loughran G, Brierley I, Firth AE.

J Virol. 2015 Aug;89(16):8580-9.


Lack of effect of Theiler's murine encephalomyelitis virus infection on system xc⁻.

Merckx E, Demuyser T, Bentea E, Van Liefferinge J, Albertini G, Deneyer L, Michiels T, Massie A.

Neurosci Lett. 2015 Apr 23;593:124-8. doi: 10.1016/j.neulet.2015.03.026. Epub 2015 Mar 18.


High seroprevalence of respiratory pathogens in hobby poultry.

Haesendonck R, Verlinden M, Devos G, Michiels T, Butaye P, Haesebrouck F, Pasmans F, Martel A.

Avian Dis. 2014 Dec;58(4):623-7.


Effect of short training on vaginal fluid microscopy (wet mount) learning.

Donders GG, Marconi C, Bellen G, Donders F, Michiels T.

J Low Genit Tract Dis. 2015 Apr;19(2):165-9. doi: 10.1097/LGT.0000000000000052.


Interferon-λ in the context of viral infections: production, response and therapeutic implications.

Hermant P, Michiels T.

J Innate Immun. 2014;6(5):563-74. doi: 10.1159/000360084. Epub 2014 Apr 17. Review.


Human but not mouse hepatocytes respond to interferon-lambda in vivo.

Hermant P, Demarez C, Mahlakõiv T, Staeheli P, Meuleman P, Michiels T.

PLoS One. 2014 Jan 31;9(1):e87906. doi: 10.1371/journal.pone.0087906. eCollection 2014.


Inefficient type I interferon-mediated antiviral protection of primary mouse neurons is associated with the lack of apolipoprotein l9 expression.

Kreit M, Paul S, Knoops L, De Cock A, Sorgeloos F, Michiels T.

J Virol. 2014 Apr;88(7):3874-84. doi: 10.1128/JVI.03018-13. Epub 2014 Jan 22.


IFN-ε is constitutively expressed by cells of the reproductive tract and is inefficiently secreted by fibroblasts and cell lines.

Hermant P, Francius C, Clotman F, Michiels T.

PLoS One. 2013 Aug 9;8(8):e71320. doi: 10.1371/journal.pone.0071320. eCollection 2013.


Evasion of antiviral innate immunity by Theiler's virus L* protein through direct inhibition of RNase L.

Sorgeloos F, Jha BK, Silverman RH, Michiels T.

PLoS Pathog. 2013;9(6):e1003474. doi: 10.1371/journal.ppat.1003474. Epub 2013 Jun 27.


Antiviral type I and type III interferon responses in the central nervous system.

Sorgeloos F, Kreit M, Hermant P, Lardinois C, Michiels T.

Viruses. 2013 Mar 15;5(3):834-57. doi: 10.3390/v5030834. Review.


Acceptance of self-testing for increased vaginal pH in different subsets of Ugandan women.

Donders GG, Andabati G, Donders F, Michiels T, Eggermont N, Bellen G, Lulé J.

Int J STD AIDS. 2012 Jan;23(1):30-5. doi: 10.1258/ijsa.2011.011190.


The leader protein of cardioviruses inhibits stress granule assembly.

Borghese F, Michiels T.

J Virol. 2011 Sep;85(18):9614-22. doi: 10.1128/JVI.00480-11. Epub 2011 Jul 13.


IFN-lambda determines the intestinal epithelial antiviral host defense.

Pott J, Mahlakõiv T, Mordstein M, Duerr CU, Michiels T, Stockinger S, Staeheli P, Hornef MW.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7944-9. doi: 10.1073/pnas.1100552108. Epub 2011 Apr 25.


Theiler's virus L* protein is targeted to the mitochondrial outer membrane.

Sorgeloos F, Vertommen D, Rider MH, Michiels T.

J Virol. 2011 Apr;85(7):3690-4. doi: 10.1128/JVI.02023-10. Epub 2011 Jan 12.


What have we learned from the IL28 receptor knockout mouse?

Mordstein M, Michiels T, Staeheli P.

J Interferon Cytokine Res. 2010 Aug;30(8):579-84. doi: 10.1089/jir.2010.0061. Review.


Type I interferon signaling contributes to chronic inflammation in a murine model of silicosis.

Giordano G, van den Brûle S, Lo Re S, Triqueneaux P, Uwambayinema F, Yakoub Y, Couillin I, Ryffel B, Michiels T, Renauld JC, Lison D, Huaux F.

Toxicol Sci. 2010 Aug;116(2):682-92. doi: 10.1093/toxsci/kfq158. Epub 2010 May 31.


Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections.

Mordstein M, Neugebauer E, Ditt V, Jessen B, Rieger T, Falcone V, Sorgeloos F, Ehl S, Mayer D, Kochs G, Schwemmle M, Günther S, Drosten C, Michiels T, Staeheli P.

J Virol. 2010 Jun;84(11):5670-7. doi: 10.1128/JVI.00272-10. Epub 2010 Mar 24.


Differential IFN-alpha/beta production suppressing capacities of the leader proteins of mengovirus and foot-and-mouth disease virus.

Hato SV, Sorgeloos F, Ricour C, Zoll J, Melchers WJ, Michiels T, van Kuppeveld FJ.

Cell Microbiol. 2010 Mar;12(3):310-7. doi: 10.1111/j.1462-5822.2009.01395.x. Epub 2009 Oct 27.


Random mutagenesis defines a domain of Theiler's virus leader protein that is essential for antagonism of nucleocytoplasmic trafficking and cytokine gene expression.

Ricour C, Borghese F, Sorgeloos F, Hato SV, van Kuppeveld FJ, Michiels T.

J Virol. 2009 Nov;83(21):11223-32. doi: 10.1128/JVI.00829-09. Epub 2009 Aug 26.


Inhibition of mRNA export and dimerization of interferon regulatory factor 3 by Theiler's virus leader protein.

Ricour C, Delhaye S, Hato SV, Olenyik TD, Michel B, van Kuppeveld FJ, Gustin KE, Michiels T.

J Gen Virol. 2009 Jan;90(Pt 1):177-86. doi: 10.1099/vir.0.005678-0.


PCR-based simultaneous analysis of the interferon-alpha family reveals distinct kinetics for early interferons.

Lienenklaus S, Walisko R, te Boekhorst A, May T, Samuelsson C, Michiels T, Weiss S.

J Interferon Cytokine Res. 2008 Nov;28(11):653-60. doi: 10.1089/jir.2008.0082.


TLR Ligand-Induced Type I IFNs Affect Thymopoiesis.

Baron ML, Gauchat D, La Motte-Mohs R, Kettaf N, Abdallah A, Michiels T, Zúñiga-Pflücker JC, Sékaly RP.

J Immunol. 2008 Jun 1;180(11):7134-46.


IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo.

Sommereyns C, Paul S, Staeheli P, Michiels T.

PLoS Pathog. 2008 Mar 14;4(3):e1000017. doi: 10.1371/journal.ppat.1000017.


The mengovirus leader protein blocks interferon-alpha/beta gene transcription and inhibits activation of interferon regulatory factor 3.

Hato SV, Ricour C, Schulte BM, Lanke KH, de Bruijni M, Zoll J, Melchers WJ, Michiels T, van Kuppeveld FJ.

Cell Microbiol. 2007 Dec;9(12):2921-30.


Anti-IL-17A autovaccination prevents clinical and histological manifestations of experimental autoimmune encephalomyelitis.

Uyttenhove C, Sommereyns C, Théate I, Michiels T, Van Snick J.

Ann N Y Acad Sci. 2007 Sep;1110:330-6.


Type I interferon response in the central nervous system.

Paul S, Ricour C, Sommereyns C, Sorgeloos F, Michiels T.

Biochimie. 2007 Jun-Jul;89(6-7):770-8. Epub 2007 Feb 24. Review.


La Crosse bunyavirus nonstructural protein NSs serves to suppress the type I interferon system of mammalian hosts.

Blakqori G, Delhaye S, Habjan M, Blair CD, Sánchez-Vargas I, Olson KE, Attarzadeh-Yazdi G, Fragkoudis R, Kohl A, Kalinke U, Weiss S, Michiels T, Staeheli P, Weber F.

J Virol. 2007 May;81(10):4991-9. Epub 2007 Mar 7.

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