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Items: 1 to 50 of 52

1.

AKT/mTORC2 Inhibition Activates FOXO1 Function in CLL Cells Reducing B-Cell Receptor-Mediated Survival.

Cosimo E, Tarafdar A, Moles MW, Holroyd AK, Malik N, Catherwood MA, Hay J, Dunn KM, Macdonald AM, Guichard SM, O'Rourke D, Leach MT, Sansom OJ, Cosulich SC, McCaig AM, Michie AM.

Clin Cancer Res. 2019 Mar 1;25(5):1574-1587. doi: 10.1158/1078-0432.CCR-18-2036. Epub 2018 Dec 17.

2.

Targeting quiescent leukemic stem cells using second generation autophagy inhibitors.

Baquero P, Dawson A, Mukhopadhyay A, Kuntz EM, Mitchell R, Olivares O, Ianniciello A, Scott MT, Dunn K, Nicastri MC, Winkler JD, Michie AM, Ryan KM, Halsey C, Gottlieb E, Keaney EP, Murphy LO, Amaravadi RK, Holyoake TL, Helgason GV.

Leukemia. 2019 Apr;33(4):981-994. doi: 10.1038/s41375-018-0252-4. Epub 2018 Sep 5.

3.

The role of mTOR-mediated signals during haemopoiesis and lineage commitment.

Malik N, Sansom OJ, Michie AM.

Biochem Soc Trans. 2018 Oct 19;46(5):1313-1324. doi: 10.1042/BST20180141. Epub 2018 Aug 28. Review.

4.

The role of mTOR-mediated signaling in the regulation of cellular migration.

Holroyd AK, Michie AM.

Immunol Lett. 2018 Apr;196:74-79. doi: 10.1016/j.imlet.2018.01.015. Epub 2018 Feb 3. Review.

PMID:
29408410
5.

Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells.

Kuntz EM, Baquero P, Michie AM, Dunn K, Tardito S, Holyoake TL, Helgason GV, Gottlieb E.

Nat Med. 2017 Oct;23(10):1234-1240. doi: 10.1038/nm.4399. Epub 2017 Sep 18.

6.

CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression.

Tarafdar A, Hopcroft LE, Gallipoli P, Pellicano F, Cassels J, Hair A, Korfi K, Jørgensen HG, Vetrie D, Holyoake TL, Michie AM.

Blood. 2017 Jan 12;129(2):199-208. doi: 10.1182/blood-2016-09-742049. Epub 2016 Oct 28.

7.

CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells.

Sinclair A, Park L, Shah M, Drotar M, Calaminus S, Hopcroft LE, Kinstrie R, Guitart AV, Dunn K, Abraham SA, Sansom O, Michie AM, Machesky L, Kranc KR, Graham GJ, Pellicano F, Holyoake TL.

Blood. 2016 Jul 21;128(3):371-83. doi: 10.1182/blood-2015-08-661785. Epub 2016 May 24.

8.

Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice.

Selman C, Sinclair A, Pedroni SM, Irvine EE, Michie AM, Withers DJ.

Oncotarget. 2016 May 24;7(21):29937-43. doi: 10.18632/oncotarget.8729.

9.

Nfix expression critically modulates early B lymphopoiesis and myelopoiesis.

O'Connor C, Campos J, Osinski JM, Gronostajski RM, Michie AM, Keeshan K.

PLoS One. 2015 Mar 17;10(3):e0120102. doi: 10.1371/journal.pone.0120102. eCollection 2015.

10.

Generation of a poor prognostic chronic lymphocytic leukemia-like disease model: PKCα subversion induces up-regulation of PKCβII expression in B lymphocytes.

Nakagawa R, Vukovic M, Tarafdar A, Cosimo E, Dunn K, McCaig AM, Holroyd A, McClanahan F, Ramsay AG, Gribben JG, Michie AM.

Haematologica. 2015 Apr;100(4):499-510. doi: 10.3324/haematol.2014.112276. Epub 2015 Jan 23.

11.

Protein kinase C in cellular transformation: a valid target for therapy?

Tarafdar A, Michie AM.

Biochem Soc Trans. 2014 Dec;42(6):1556-62. doi: 10.1042/BST20140255. Review.

12.

Complement deficiencies limit CD20 monoclonal antibody treatment efficacy in CLL.

Middleton O, Cosimo E, Dobbin E, McCaig AM, Clarke C, Brant AM, Leach MT, Michie AM, Wheadon H.

Leukemia. 2015 Jan;29(1):107-14. doi: 10.1038/leu.2014.146. Epub 2014 May 2.

PMID:
24787488
13.

Chromatin looping defines expression of TAL1, its flanking genes, and regulation in T-ALL.

Zhou Y, Kurukuti S, Saffrey P, Vukovic M, Michie AM, Strogantsev R, West AG, Vetrie D.

Blood. 2013 Dec 19;122(26):4199-209. doi: 10.1182/blood-2013-02-483875. Epub 2013 Nov 7.

PMID:
24200685
14.

Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes prosurvival stimuli to induce apoptosis in chronic lymphocytic leukemia cells.

Cosimo E, McCaig AM, Carter-Brzezinski LJ, Wheadon H, Leach MT, Le Ster K, Berthou C, Durieu E, Oumata N, Galons H, Meijer L, Michie AM.

Clin Cancer Res. 2013 May 1;19(9):2393-405. doi: 10.1158/1078-0432.CCR-12-2170. Epub 2013 Mar 26.

15.

Individuals with developmental delay and problematic sexual behaviors.

Lindsay WR, Michie AM.

Curr Psychiatry Rep. 2013 Apr;15(4):350. doi: 10.1007/s11920-013-0350-y. Review.

PMID:
23471782
16.

Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane.

Schachtner H, Calaminus SD, Sinclair A, Monypenny J, Blundell MP, Leon C, Holyoake TL, Thrasher AJ, Michie AM, Vukovic M, Gachet C, Jones GE, Thomas SG, Watson SP, Machesky LM.

Blood. 2013 Mar 28;121(13):2542-52. doi: 10.1182/blood-2012-07-443457. Epub 2013 Jan 10.

PMID:
23305739
17.

Dasatinib inhibits CXCR4 signaling in chronic lymphocytic leukaemia cells and impairs migration towards CXCL12.

McCaig AM, Cosimo E, Leach MT, Michie AM.

PLoS One. 2012;7(11):e48929. doi: 10.1371/journal.pone.0048929. Epub 2012 Nov 2.

18.

Immune complex-mediated co-ligation of the BCR with FcγRIIB results in homeostatic apoptosis of B cells involving Fas signalling that is defective in the MRL/Lpr model of systemic lupus erythematosus.

Paunovic V, Carter NA, Thalhamer T, Blair D, Gordon B, Lacey E, Michie AM, Harnett MM.

J Autoimmun. 2012 Dec;39(4):332-46. doi: 10.1016/j.jaut.2012.04.006. Epub 2012 May 28.

PMID:
22647731
19.

Modulation of PKC-α promotes lineage reprogramming of committed B lymphocytes.

Nakagawa R, Vukovic M, Cosimo E, Michie AM.

Eur J Immunol. 2012 Apr;42(4):1005-15. doi: 10.1002/eji.201141442.

20.

Dasatinib inhibits B cell receptor signalling in chronic lymphocytic leukaemia but novel combination approaches are required to overcome additional pro-survival microenvironmental signals.

McCaig AM, Cosimo E, Leach MT, Michie AM.

Br J Haematol. 2011 Apr;153(2):199-211. doi: 10.1111/j.1365-2141.2010.08507.x. Epub 2011 Feb 24.

PMID:
21352196
21.

Uptake of synthetic Low Density Lipoprotein by leukemic stem cells--a potential stem cell targeted drug delivery strategy.

Zhou P, Hatziieremia S, Elliott MA, Scobie L, Crossan C, Michie AM, Holyoake TL, Halbert GW, Jørgensen HG.

J Control Release. 2010 Dec 20;148(3):380-7. doi: 10.1016/j.jconrel.2010.09.016. Epub 2010 Sep 22.

PMID:
20869412
22.

Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer.

Michie AM, McCaig AM, Nakagawa R, Vukovic M.

FEBS J. 2010 Jan;277(1):74-80. doi: 10.1111/j.1742-4658.2009.07414.x. Epub 2009 Oct 30. Review.

23.

Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals.

Michie AM, Chan AC, Ciofani M, Carleton M, Lefebvre JM, He Y, Allman DM, Wiest DL, Zúñiga-Pflücker JC, Izon DJ.

Int Immunol. 2007 Dec;19(12):1421-30. Epub 2007 Nov 1.

PMID:
17981791
24.

Murine models for chronic lymphocytic leukaemia.

Michie AM, Nakagawa R, McCaig AM.

Biochem Soc Trans. 2007 Nov;35(Pt 5):1009-12. Review.

PMID:
17956265
25.
26.
27.

Elucidating the role of protein kinase C in chronic lymphocytic leukaemia.

Michie AM, Nakagawa R.

Hematol Oncol. 2006 Sep;24(3):134-8. Review.

PMID:
16841369
28.

Notch is constitutively active in Theileria-transformed B cells and can be further stimulated by the filarial nematode-secreted product, ES-62.

Chaussepied M, Michie AM, Moreau MF, Harnett MM, Harnett W, Langsley G.

Microbes Infect. 2006 Apr;8(4):1189-91. Epub 2006 Jan 20.

PMID:
16524753
30.

The link between PKCalpha regulation and cellular transformation.

Michie AM, Nakagawa R.

Immunol Lett. 2005 Jan 31;96(2):155-62. Review.

PMID:
15585319
32.

Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation.

Ciofani M, Schmitt TM, Ciofani A, Michie AM, Cuburu N, Aublin A, Maryanski JL, Zúñiga-Pflücker JC.

J Immunol. 2004 May 1;172(9):5230-9.

33.

Regulation of thymocyte differentiation: pre-TCR signals and beta-selection.

Michie AM, Zúñiga-Pflücker JC.

Semin Immunol. 2002 Oct;14(5):311-23. Review.

PMID:
12220932
34.

Duration and strength of extracellular signal-regulated kinase signals are altered during positive versus negative thymocyte selection.

Mariathasan S, Zakarian A, Bouchard D, Michie AM, Zúñiga-Pflücker JC, Ohashi PS.

J Immunol. 2001 Nov 1;167(9):4966-73.

35.

In vivo detection of intracellular signaling pathways in developing thymocytes.

Michie AM, Zúñiga-Pflücker JC.

Dev Immunol. 2000;8(1):31-45.

36.

Allelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes.

Michie AM, Soh JW, Hawley RG, Weinstein IB, Zuniga-Pflucker JC.

Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):609-14. Epub 2001 Jan 9.

37.

Branching out to gain control: how the pre-TCR is linked to multiple functions.

Kruisbeek AM, Haks MC, Carleton M, Michie AM, Zúñiga-Pflücker JC, Wiest DL.

Immunol Today. 2000 Dec;21(12):637-44. Review.

PMID:
11114425
38.

Transfection and transcription of genes in developing thymocytes.

Michie AM, Zúñiga-Pflücker JC.

Methods Mol Biol. 2000;134:55-62. No abstract available.

PMID:
10730248
39.

Clonal characterization of a bipotent T cell and NK cell progenitor in the mouse fetal thymus.

Michie AM, Carlyle JR, Schmitt TM, Ljutic B, Cho SK, Fong Q, Zúñiga-Pflücker JC.

J Immunol. 2000 Feb 15;164(4):1730-3.

40.

Extracellular signal-regulated kinase (ERK) activation by the pre-T cell receptor in developing thymocytes in vivo.

Michie AM, Trop S, Wiest DL, Zúñiga-Pflücker JC.

J Exp Med. 1999 Dec 6;190(11):1647-56.

41.

Natural killer cell development and function precede alpha beta T cell differentiation in mouse fetal thymic ontogeny.

Carlyle JR, Michie AM, Cho SK, Zúñiga-Pflücker JC.

J Immunol. 1998 Jan 15;160(2):744-53.

42.

Changes following community living skills training: a controlled study.

Michie AM, Lindsay WR, Smith AH, Todman J.

Br J Clin Psychol. 1998 Feb;37(1):109-11.

PMID:
9547966
44.

Early intrathymic precursor cells acquire a CD4(low) phenotype.

Michie AM, Carlyle JR, Zúñiga-Pflücker JC.

J Immunol. 1998 Feb 15;160(4):1735-41.

45.

Identification of a novel developmental stage marking lineage commitment of progenitor thymocytes.

Carlyle JR, Michie AM, Furlonger C, Nakano T, Lenardo MJ, Paige CJ, Zúñiga-Pflücker JC.

J Exp Med. 1997 Jul 21;186(2):173-82.

48.

Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: 'designer' changes in Vmax, stability and membrane association.

Houslay MD, Scotland G, Pooley L, Spence S, Wilkinson I, McCallum F, Julien P, Rena NG, Michie AM, Erdogan S, et al.

Biochem Soc Trans. 1995 May;23(2):393-8. Review. No abstract available.

PMID:
7672427
49.

The consistency of reports about feelings and emotions from people with intellectual disability.

Lindsay WR, Michie AM, Baty FJ, Smith AH, Miller S.

J Intellect Disabil Res. 1994 Feb;38 ( Pt 1):61-6.

PMID:
8173224
50.

Teaching mentally handicapped adults how to use a cafeteria.

Baty FJ, Michie AM, Lindsay WR.

J Ment Defic Res. 1989 Apr;33 ( Pt 2):137-48.

PMID:
2724331

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