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Novel Antiplatelet Agents in Cardiovascular Disease.

Tscharre M, Michelson AD, Gremmel T.

J Cardiovasc Pharmacol Ther. 2020 Jan 21:1074248419899314. doi: 10.1177/1074248419899314. [Epub ahead of print]


An exploratory, randomised, placebo-controlled, 14 day trial of the soluble guanylate cyclase stimulator praliciguat in participants with type 2 diabetes and hypertension.

Hanrahan JP, Seferovic JP, Wakefield JD, Wilson PJ, Chickering JG, Jung J, Carlson KE, Zimmer DP, Frelinger AL 3rd, Michelson AD, Morrow L, Hall M, Currie MG, Milne GT, Profy AT.

Diabetologia. 2019 Dec 19. doi: 10.1007/s00125-019-05062-x. [Epub ahead of print]


Changes in neurocognitive function and central nervous system structure in childhood acute lymphoblastic leukaemia survivors after treatment: a meta-analysis.

Zhou C, Zhuang Y, Lin X, Michelson AD, Zhang A.

Br J Haematol. 2019 Dec 10. doi: 10.1111/bjh.16279. [Epub ahead of print]


Redefining the Threshold for Broad-Spectrum Antibiotics.

Michelson AP, Kollef MH.

Ann Am Thorac Soc. 2019 Nov;16(11):1367-1369. doi: 10.1513/AnnalsATS.201908-608ED. No abstract available.


Ultrastructural markers of tissue endometrial receptivity in patients with recurrent implantation failure.

Melkozerova OA, Bashmakova NV, Malgina GB, Bragina EE, Michelson AA, Chistyakova GN.

Gynecol Endocrinol. 2019;35(sup1):45-48. doi: 10.1080/09513590.2019.1653562.


Ticagrelor versus placebo for the reduction of vaso-occlusive crises in pediatric sickle cell disease: Rationale and design of a randomized, double-blind, parallel-group, multicenter phase 3 study (HESTIA3).

Heeney MM, Abboud MR, Amilon C, Andersson M, Githanga J, Inusa B, Kanter J, Leonsson-Zachrisson M, Michelson AD, Berggren AR; HESTIA3 study investigators.

Contemp Clin Trials. 2019 Oct;85:105835. doi: 10.1016/j.cct.2019.105835. Epub 2019 Aug 22.


The Effect of Two Types of Pasta Versus White Rice on Postprandial Blood Glucose Levels in Adults with Type 1 Diabetes: A Randomized Crossover Trial.

Zavitsanou S, Massa J, Deshpande S, Pinsker JE, Church MM, Andre C, Doyle Iii FJ, Michelson A, Creason J, Dassau E, Eisenberg DM.

Diabetes Technol Ther. 2019 Sep;21(9):485-492. doi: 10.1089/dia.2019.0109. Epub 2019 Jun 21.


Rivaroxaban, a direct Factor Xa inhibitor, versus acetylsalicylic acid as thromboprophylaxis in children post-Fontan procedure: Rationale and design of a prospective, randomized trial (the UNIVERSE study).

Pina LM, Dong X, Zhang L, Samtani MN, Michelson AD, Justino H, Bonnet D, Harris KC, Jefferies J, McCrindle BW, Li JS.

Am Heart J. 2019 Jul;213:97-104. doi: 10.1016/j.ahj.2019.04.009. Epub 2019 May 1.


Usefulness of anti-platelet therapy testing in children supported with a ventricular assist device.

May LJ, Liu X, Tesoro T, Yang J, Lo C, Chen S, Murray J, Rosenthal DN, Massicotte P, Michelson AD, Almond CS.

J Heart Lung Transplant. 2019 Jul;38(7):781-783. doi: 10.1016/j.healun.2019.03.012. Epub 2019 Apr 3. No abstract available.


Using extracellular calcium concentration and electric pulse conditions to tune platelet-rich plasma growth factor release and clotting.

Garner AL, Frelinger AL 3rd, Gerrits AJ, Gremmel T, Forde EE, Carmichael SL, Michelson AD, Neculaes VB.

Med Hypotheses. 2019 Apr;125:100-105. doi: 10.1016/j.mehy.2019.02.036. Epub 2019 Feb 16.


PF-04447943, a Phosphodiesterase 9A Inhibitor, in Stable Sickle Cell Disease Patients: A Phase Ib Randomized, Placebo-Controlled Study.

Charnigo RJ, Beidler D, Rybin D, Pittman DD, Tan B, Howard J, Michelson AD, Frelinger AL , III, Clarke N.

Clin Transl Sci. 2019 Mar;12(2):180-188. doi: 10.1111/cts.12604. Epub 2018 Dec 31.


Publisher Correction: GLS-409, an Antagonist of Both P2Y1 and P2Y12, Potently Inhibits Canine Coronary Artery Thrombosis and Reversibly Inhibits Human Platelet Activation.

Smolensky Koganov E, Michelson AD, Yanachkov IB, Yanachkova MI, Wright GE, Przyklenk K, Frelinger AL 3rd.

Sci Rep. 2018 Nov 29;8(1):17580. doi: 10.1038/s41598-018-35956-6.


GLS-409, an Antagonist of Both P2Y1 and P2Y12, Potently Inhibits Canine Coronary Artery Thrombosis and Reversibly Inhibits Human Platelet Activation.

Smolensky Koganov E, Michelson AD, Yanachkov IB, Yanachkova MI, Wright GE, Przyklenk K, Frelinger AL 3rd.

Sci Rep. 2018 Sep 28;8(1):14529. doi: 10.1038/s41598-018-32797-1. Erratum in: Sci Rep. 2018 Nov 29;8(1):17580.


Avatrombopag increases platelet count but not platelet activation in patients with thrombocytopenia resulting from liver disease.

Michelson AD, Smolensky Koganov E, Forde EE, Carmichael SL, Frelinger AL 3rd.

J Thromb Haemost. 2018 Dec;16(12):2515-2519. doi: 10.1111/jth.14295. Epub 2018 Oct 15.


Tunable activation of therapeutic platelet-rich plasma by pulse electric field: Differential effects on clot formation, growth factor release, and platelet morphology.

Frelinger AL 3rd, Gerrits AJ, Neculaes VB, Gremmel T, Torres AS, Caiafa A, Carmichael SL, Michelson AD.

PLoS One. 2018 Sep 26;13(9):e0203557. doi: 10.1371/journal.pone.0203557. eCollection 2018.


Association between the "Timed Up and Go Test" at transplant evaluation and outcomes after kidney transplantation.

Michelson AT, Tsapepas DS, Husain SA, Brennan C, Chiles MC, Runge B, Lione J, Kil BH, Cohen DJ, Ratner LE, Mohan S.

Clin Transplant. 2018 Nov;32(11):e13410. doi: 10.1111/ctr.13410. Epub 2018 Oct 28.


Novel aspects of antiplatelet therapy in cardiovascular disease.

Gremmel T, Michelson AD, Frelinger AL III, Bhatt DL.

Res Pract Thromb Haemost. 2018 May 27;2(3):439-449. doi: 10.1002/rth2.12115. eCollection 2018 Jul. Review.


Mass Cytometry Reveals Distinct Platelet Subtypes in Healthy Subjects and Novel Alterations in Surface Glycoproteins in Glanzmann Thrombasthenia.

Blair TA, Michelson AD, Frelinger AL 3rd.

Sci Rep. 2018 Jul 9;8(1):10300. doi: 10.1038/s41598-018-28211-5.


Patients prioritize waitlist over posttransplant outcomes when evaluating kidney transplant centers.

Husain SA, Brennan C, Michelson A, Tsapepas D, Patzer RE, Schold JD, Mohan S.

Am J Transplant. 2018 Nov;18(11):2781-2790. doi: 10.1111/ajt.14985. Epub 2018 Jul 30.


Incomplete reversibility of platelet inhibition following prolonged exposure to ticagrelor: reply.

Gerrits AJ, Jakubowski JA, Michelson AD, Frelinger AL 3rd.

J Thromb Haemost. 2018 Mar;16(3):607-608. doi: 10.1111/jth.13939. Epub 2018 Jan 29. No abstract available.


Platelet Function in ITP, Independent of Platelet Count, Is Consistent Over Time and Is Associated with Both Current and Subsequent Bleeding Severity.

Frelinger AL 3rd, Grace RF, Gerrits AJ, Carmichael SL, Forde EE, Michelson AD.

Thromb Haemost. 2018 Jan;118(1):143-151. doi: 10.1160/TH17-06-0387. Epub 2018 Jan 5.


Immature platelet fraction in immune thrombocytopenia: Useful in diagnosis but does it predict bleeding?

Michelson AD.

Pediatr Blood Cancer. 2018 Feb;65(2). doi: 10.1002/pbc.26842. Epub 2017 Oct 8. No abstract available.


High serum serotonin in sudden infant death syndrome.

Haynes RL, Frelinger AL 3rd, Giles EK, Goldstein RD, Tran H, Kozakewich HP, Haas EA, Gerrits AJ, Mena OJ, Trachtenberg FL, Paterson DS, Berry GT, Adeli K, Kinney HC, Michelson AD.

Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):7695-7700. doi: 10.1073/pnas.1617374114. Epub 2017 Jul 3.


How I use laboratory monitoring of antiplatelet therapy.

Michelson AD, Bhatt DL.

Blood. 2017 Aug 10;130(6):713-721. doi: 10.1182/blood-2017-03-742338. Epub 2017 Jun 9. Review.


Incomplete reversibility of platelet inhibition following prolonged exposure to ticagrelor.

Gerrits AJ, Jakubowski JA, Sugidachi A, Michelson AD, Frelinger AL 3rd.

J Thromb Haemost. 2017 May;15(5):858-867. doi: 10.1111/jth.13627. Epub 2017 Feb 18.


Whole Blood Analysis of Leukocyte-Platelet Aggregates.

Gerrits AJ, Frelinger AL 3rd, Michelson AD.

Curr Protoc Cytom. 2016 Oct 10;78:6.15.1-6.15.10. doi: 10.1002/cpcy.8.


Modification of Pulsed Electric Field Conditions Results in Distinct Activation Profiles of Platelet-Rich Plasma.

Frelinger AL 3rd, Gerrits AJ, Garner AL, Torres AS, Caiafa A, Morton CA, Berny-Lang MA, Carmichael SL, Neculaes VB, Michelson AD.

PLoS One. 2016 Aug 24;11(8):e0160933. doi: 10.1371/journal.pone.0160933. eCollection 2016.


Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium.

Jain A, van der Meer AD, Papa AL, Barrile R, Lai A, Schlechter BL, Otieno MA, Louden CS, Hamilton GA, Michelson AD, Frelinger AL 3rd, Ingber DE.

Biomed Microdevices. 2016 Aug;18(4):73. doi: 10.1007/s10544-016-0095-6.


Diabetes mellitus, CYP2C19 genotype, and response to escalating doses of clopidogrel. Insights from the ELEVATE-TIMI 56 Trial.

Carreras ET, Hochholzer W, Frelinger AL 3rd, Nordio F, O'Donoghue ML, Wiviott SD, Angiolillo DJ, Michelson AD, Sabatine MS, Mega JL.

Thromb Haemost. 2016 Jul 4;116(1):69-77. doi: 10.1160/TH15-12-0981. Epub 2016 Mar 24.


Platelet Physiology.

Gremmel T, Frelinger AL 3rd, Michelson AD.

Semin Thromb Hemost. 2016 Apr;42(3):191-204. doi: 10.1055/s-0035-1564835. Epub 2016 Feb 29. Review.


Synergistic Inhibition of Both P2Y1 and P2Y12 Adenosine Diphosphate Receptors As Novel Approach to Rapidly Attenuate Platelet-Mediated Thrombosis.

Gremmel T, Yanachkov IB, Yanachkova MI, Wright GE, Wider J, Undyala VV, Michelson AD, Frelinger AL 3rd, Przyklenk K.

Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):501-9. doi: 10.1161/ATVBAHA.115.306885. Epub 2016 Jan 7.


Two Forkhead transcription factors regulate cardiac progenitor specification by controlling the expression of receptors of the fibroblast growth factor and Wnt signaling pathways.

Ahmad SM, Bhattacharyya P, Jeffries N, Gisselbrecht SS, Michelson AM.

Development. 2016 Jan 15;143(2):306-17. doi: 10.1242/dev.122952. Epub 2015 Dec 10.


New highly active antiplatelet agents with dual specificity for platelet P2Y1 and P2Y12 adenosine diphosphate receptors.

Yanachkov IB, Chang H, Yanachkova MI, Dix EJ, Berny-Lang MA, Gremmel T, Michelson AD, Wright GE, Frelinger AL 3rd.

Eur J Med Chem. 2016 Jan 1;107:204-18. doi: 10.1016/j.ejmech.2015.10.055. Epub 2015 Nov 9.


In Vivo and protease-activated receptor-1-mediated platelet activation in patients presenting for cardiac catheterization.

Gremmel T, Michelson AD, Frelinger AL 3rd.

Platelets. 2016 Jun;27(4):308-16. doi: 10.3109/09537104.2015.1095876. Epub 2015 Nov 10.


An Orthologous Epigenetic Gene Expression Signature Derived from Differentiating Embryonic Stem Cells Identifies Regulators of Cardiogenesis.

Busser BW, Lin Y, Yang Y, Zhu J, Chen G, Michelson AM.

PLoS One. 2015 Oct 20;10(10):e0141066. doi: 10.1371/journal.pone.0141066. eCollection 2015.


Obliterative Bronchiolitis.

Aguilar PR, Michelson AP, Isakow W.

Transplantation. 2016 Feb;100(2):272-83. doi: 10.1097/TP.0000000000000892. Review.


Aspirin response: Differences in serum thromboxane B2 levels between clinical studies.

Brun C, Daali Y, Combescure C, Zufferey A, Michelson AD, Fontana P, Reny JL, Frelinger AL 3rd.

Platelets. 2016;27(3):196-202. doi: 10.3109/09537104.2015.1072147. Epub 2015 Aug 13.


Soluble CD40 Ligand in Aspirin-Treated Patients Undergoing Cardiac Catheterization.

Gremmel T, Frelinger AL 3rd, Michelson AD.

PLoS One. 2015 Aug 3;10(8):e0134599. doi: 10.1371/journal.pone.0134599. eCollection 2015.


Effects of eltrombopag on platelet count and platelet activation in Wiskott-Aldrich syndrome/X-linked thrombocytopenia.

Gerrits AJ, Leven EA, Frelinger AL 3rd, Brigstocke SL, Berny-Lang MA, Mitchell WB, Revel-Vilk S, Tamary H, Carmichael SL, Barnard MR, Michelson AD, Bussel JB.

Blood. 2015 Sep 10;126(11):1367-78. doi: 10.1182/blood-2014-09-602573. Epub 2015 Jul 29.


Platelet function tests, independent of platelet count, are associated with bleeding severity in ITP.

Frelinger AL 3rd, Grace RF, Gerrits AJ, Berny-Lang MA, Brown T, Carmichael SL, Neufeld EJ, Michelson AD.

Blood. 2015 Aug 13;126(7):873-9. doi: 10.1182/blood-2015-02-628461. Epub 2015 Jul 2.


Platelet-rich plasma stimulated by pulse electric fields: Platelet activation, procoagulant markers, growth factor release and cell proliferation.

Frelinger AL 3rd, Torres AS, Caiafa A, Morton CA, Berny-Lang MA, Gerrits AJ, Carmichael SL, Neculaes VB, Michelson AD.

Platelets. 2016;27(2):128-35. doi: 10.3109/09537104.2015.1048214. Epub 2015 Jun 1.


Platelet geometry sensing spatially regulates α-granule secretion to enable matrix self-deposition.

Sakurai Y, Fitch-Tewfik JL, Qiu Y, Ahn B, Myers DR, Tran R, Fay ME, Ding L, Spearman PW, Michelson AD, Flaumenhaft R, Lam WA.

Blood. 2015 Jul 23;126(4):531-8. doi: 10.1182/blood-2014-11-607614. Epub 2015 May 11.


Enhancer modeling uncovers transcriptional signatures of individual cardiac cell states in Drosophila.

Busser BW, Haimovich J, Huang D, Ovcharenko I, Michelson AM.

Nucleic Acids Res. 2015 Feb 18;43(3):1726-39. doi: 10.1093/nar/gkv011. Epub 2015 Jan 21.


Challenges and priorities for research: a report from the National Heart, Lung, and Blood Institute (NHLBI)/National Institutes of Health (NIH) Working Group on thrombosis in pediatric cardiology and congenital heart disease.

McCrindle BW, Li JS, Manlhiot C, Tweddell JS, Giglia TM, Massicotte MP, Monagle P, Krishnamurthy R, Mahaffey KW, Michelson AD, Verdun N, Almond CS, Newburger JW, Brandão LR, Esmon CT, Manco-Johnson MJ, Ichord R, Ortel TL, Chan AK, Portman R, Rose M, Strony J, Kaltman JR.

Circulation. 2014 Sep 30;130(14):1192-203. doi: 10.1161/CIRCULATIONAHA.113.008428. No abstract available.


Platelet activation using electric pulse stimulation: growth factor profile and clinical implications.

Torres AS, Caiafa A, Garner AL, Klopman S, LaPlante N, Morton C, Conway K, Michelson AD, Frelinger AL 3rd, Neculaes VB.

J Trauma Acute Care Surg. 2014 Sep;77(3 Suppl 2):S94-S100. doi: 10.1097/TA.0000000000000322.


Variability of individual platelet reactivity over time in patients treated with clopidogrel: insights from the ELEVATE-TIMI 56 trial.

Hochholzer W, Ruff CT, Mesa RA, Mattimore JF, Cyr JF, Lei L, Frelinger AL 3rd, Michelson AD, Berg DD, Angiolillo DJ, O'Donoghue ML, Sabatine MS, Mega JL.

J Am Coll Cardiol. 2014 Jul 29;64(4):361-8. doi: 10.1016/j.jacc.2014.03.051.


Do synchronous airway lesions predict treatment failure after adenotonsillectomy in children less than 3 years of age with obstructive sleep apnea?

Michelson AP, Hawley K, Anne S.

Int J Pediatr Otorhinolaryngol. 2014 Sep;78(9):1439-43. doi: 10.1016/j.ijporl.2014.05.033. Epub 2014 Jun 20.


Do immature platelet levels in chest pain patients presenting to the emergency department aid in the diagnosis of acute coronary syndrome?

Berny-Lang MA, Darling CE, Frelinger AL 3rd, Barnard MR, Smith CS, Michelson AD.

Int J Lab Hematol. 2015 Feb;37(1):112-9. doi: 10.1111/ijlh.12250. Epub 2014 May 8.


Antiplatelet activity, P2Y₁ and P2Y₁₂ inhibition, and metabolism in plasma of stereoisomers of diadenosine 5',5'″-P¹ ,P⁴-dithio-P²,P³-chloromethylenetetraphosphate.

Chang H, Yanachkov IB, Dix EJ, Yanachkova M, Li Y, Barnard MR, Wright GE, Michelson AD, Frelinger AL 3rd.

PLoS One. 2014 Apr 10;9(4):e94780. doi: 10.1371/journal.pone.0094780. eCollection 2014.


Machine learning classification of cell-specific cardiac enhancers uncovers developmental subnetworks regulating progenitor cell division and cell fate specification.

Ahmad SM, Busser BW, Huang D, Cozart EJ, Michaud S, Zhu X, Jeffries N, Aboukhalil A, Bulyk ML, Ovcharenko I, Michelson AM.

Development. 2014 Feb;141(4):878-88. doi: 10.1242/dev.101709.

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