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Items: 47

1.

Malassezia Is Associated with Crohn's Disease and Exacerbates Colitis in Mouse Models.

Limon JJ, Tang J, Li D, Wolf AJ, Michelsen KS, Funari V, Gargus M, Nguyen C, Sharma P, Maymi VI, Iliev ID, Skalski JH, Brown J, Landers C, Borneman J, Braun J, Targan SR, McGovern DPB, Underhill DM.

Cell Host Microbe. 2019 Mar 13;25(3):377-388.e6. doi: 10.1016/j.chom.2019.01.007. Epub 2019 Mar 5.

PMID:
30850233
2.

A role for BATF3 in TH9 differentiation and T-cell-driven mucosal pathologies.

Tsuda M, Hamade H, Thomas LS, Salumbides BC, Potdar AA, Wong MH, Nunnelee JS, Stamps JT, Neutzsky-Wulff AV, Barrett RJ, Wang Y, Tang J, Funari VA, Targan SR, Michelsen KS.

Mucosal Immunol. 2019 May;12(3):644-655. doi: 10.1038/s41385-018-0122-4. Epub 2019 Jan 7.

3.

Failure of the Anti-Inflammatory Parasitic Worm Product ES-62 to Provide Protection in Mouse Models of Type I Diabetes, Multiple Sclerosis, and Inflammatory Bowel Disease.

Doonan J, Thomas D, Wong MH, Ramage HJ, Al-Riyami L, Lumb FE, Bell KS, Fairlie-Clarke KJ, Suckling CJ, Michelsen KS, Jiang HR, Cooke A, Harnett MM, Harnett W.

Molecules. 2018 Oct 17;23(10). pii: E2669. doi: 10.3390/molecules23102669.

4.

Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome.

Jacob N, Jacobs JP, Kumagai K, Ha CWY, Kanazawa Y, Lagishetty V, Altmayer K, Hamill AM, Von Arx A, Sartor RB, Devkota S, Braun J, Michelsen KS, Targan SR, Shih DQ.

Mucosal Immunol. 2018 Sep;11(5):1466-1476. doi: 10.1038/s41385-018-0055-y. Epub 2018 Jul 9.

5.

The TNF family member TL1A induces IL-22 secretion in committed human Th17 cells via IL-9 induction.

Thomas LS, Targan SR, Tsuda M, Yu QT, Salumbides BC, Haritunians T, Mengesha E, McGovern DP, Michelsen KS.

J Leukoc Biol. 2017 Mar;101(3):727-737. doi: 10.1189/jlb.3A0316-129R. Epub 2016 Oct 12.

6.

Chronic intestinal inflammation alters hippocampal neurogenesis.

Zonis S, Pechnick RN, Ljubimov VA, Mahgerefteh M, Wawrowsky K, Michelsen KS, Chesnokova V.

J Neuroinflammation. 2015 Apr 3;12:65. doi: 10.1186/s12974-015-0281-0.

7.

HMPL-004 (Andrographis paniculata extract) prevents development of murine colitis by inhibiting T-cell proliferation and TH1/TH17 responses.

Michelsen KS, Wong MH, Ko B, Thomas LS, Dhall D, Targan SR.

Inflamm Bowel Dis. 2013 Jan;19(1):151-64. doi: 10.1002/ibd.22983.

8.

Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis.

Barrett R, Zhang X, Koon HW, Vu M, Chang JY, Yeager N, Nguyen MA, Michelsen KS, Berel D, Pothoulakis C, Targan SR, Shih DQ.

Am J Pathol. 2012 Feb;180(2):636-49. doi: 10.1016/j.ajpath.2011.10.026. Epub 2011 Dec 2.

9.

Myeloid differentiation factor-2 interacts with Lyn kinase and is tyrosine phosphorylated following lipopolysaccharide-induced activation of the TLR4 signaling pathway.

Gray P, Dagvadorj J, Michelsen KS, Brikos C, Rentsendorj A, Town T, Crother TR, Arditi M.

J Immunol. 2011 Oct 15;187(8):4331-7. doi: 10.4049/jimmunol.1100890. Epub 2011 Sep 14.

10.

Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis.

Shih DQ, Barrett R, Zhang X, Yeager N, Koon HW, Phaosawasdi P, Song Y, Ko B, Wong MH, Michelsen KS, Martins G, Pothoulakis C, Targan SR.

PLoS One. 2011 Jan 11;6(1):e16090. doi: 10.1371/journal.pone.0016090.

11.

Insights into TL1A and IBD pathogenesis.

Shih DQ, Michelsen KS, Barrett RJ, Biener-Ramanujan E, Gonsky R, Zhang X, Targan SR.

Adv Exp Med Biol. 2011;691:279-88. doi: 10.1007/978-1-4419-6612-4_29. Review. No abstract available.

PMID:
21153332
12.

Platelet-activating factor induces TLR4 expression in intestinal epithelial cells: implication for the pathogenesis of necrotizing enterocolitis.

Soliman A, Michelsen KS, Karahashi H, Lu J, Meng FJ, Qu X, Crother TR, Rabizadeh S, Chen S, Caplan MS, Arditi M, Jilling T.

PLoS One. 2010 Oct 15;5(10):e15044. doi: 10.1371/journal.pone.0015044.

13.

Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer.

Lowe EL, Crother TR, Rabizadeh S, Hu B, Wang H, Chen S, Shimada K, Wong MH, Michelsen KS, Arditi M.

PLoS One. 2010 Sep 27;5(9):e13027. doi: 10.1371/journal.pone.0013027.

14.

Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling.

Gray P, Michelsen KS, Sirois CM, Lowe E, Shimada K, Crother TR, Chen S, Brikos C, Bulut Y, Latz E, Underhill D, Arditi M.

J Immunol. 2010 Jun 1;184(11):6359-66. doi: 10.4049/jimmunol.0903543. Epub 2010 Apr 30.

15.

TLR8-mediated activation of human monocytes inhibits TL1A expression.

Saruta M, Michelsen KS, Thomas LS, Yu QT, Landers CJ, Targan SR.

Eur J Immunol. 2009 Aug;39(8):2195-202. doi: 10.1002/eji.200939216.

16.

Lipopolysaccharide-induced apoptosis in transformed bovine brain endothelial cells and human dermal microvessel endothelial cells: the role of JNK.

Karahashi H, Michelsen KS, Arditi M.

J Immunol. 2009 Jun 1;182(11):7280-6. doi: 10.4049/jimmunol.0801376.

17.

IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein.

Michelsen KS, Thomas LS, Taylor KD, Yu QT, Mei L, Landers CJ, Derkowski C, McGovern DP, Rotter JI, Targan SR.

PLoS One. 2009;4(3):e4719. doi: 10.1371/journal.pone.0004719. Epub 2009 Mar 5.

18.

HMGB1 mediates endogenous TLR2 activation and brain tumor regression.

Curtin JF, Liu N, Candolfi M, Xiong W, Assi H, Yagiz K, Edwards MR, Michelsen KS, Kroeger KM, Liu C, Muhammad AK, Clark MC, Arditi M, Comin-Anduix B, Ribas A, Lowenstein PR, Castro MG.

PLoS Med. 2009 Jan 13;6(1):e10. doi: 10.1371/journal.pmed.1000010.

19.

TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis.

Naiki Y, Sorrentino R, Wong MH, Michelsen KS, Shimada K, Chen S, Yilmaz A, Slepenkin A, Schröder NW, Crother TR, Bulut Y, Doherty TM, Bradley M, Shaposhnik Z, Peterson EM, Tontonoz P, Shah PK, Arditi M.

J Immunol. 2008 Nov 15;181(10):7176-85.

20.

TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation.

Takedatsu H, Michelsen KS, Wei B, Landers CJ, Thomas LS, Dhall D, Braun J, Targan SR.

Gastroenterology. 2008 Aug;135(2):552-67. doi: 10.1053/j.gastro.2008.04.037. Epub 2008 May 7.

21.

Differential expression of Toll-like receptor 2 (TLR2) and responses to TLR2 ligands between human and murine vascular endothelial cells.

Shuang Chen, Wong MH, Schulte DJ, Arditi M, Michelsen KS.

J Endotoxin Res. 2007;13(5):281-96.

PMID:
17986487
22.

The T cell costimulator TL1A is induced by FcgammaR signaling in human monocytes and dendritic cells.

Prehn JL, Thomas LS, Landers CJ, Yu QT, Michelsen KS, Targan SR.

J Immunol. 2007 Apr 1;178(7):4033-8.

23.

Toll-like receptors and innate immunity in gut homeostasis and pathology.

Michelsen KS, Arditi M.

Curr Opin Hematol. 2007 Jan;14(1):48-54. Review.

PMID:
17133100
24.

Toll-like receptor signaling and atherosclerosis.

Michelsen KS, Arditi M.

Curr Opin Hematol. 2006 May;13(3):163-8. Review.

PMID:
16567960
25.

TLR2 and MyD88 contribute to Lactobacillus casei extract-induced focal coronary arteritis in a mouse model of Kawasaki disease.

Rosenkranz ME, Schulte DJ, Agle LM, Wong MH, Zhang W, Ivashkiv L, Doherty TM, Fishbein MC, Lehman TJ, Michelsen KS, Arditi M.

Circulation. 2005 Nov 8;112(19):2966-73.

PMID:
16275884
26.

CsgA is a pathogen-associated molecular pattern of Salmonella enterica serotype Typhimurium that is recognized by Toll-like receptor 2.

Tükel C, Raffatellu M, Humphries AD, Wilson RP, Andrews-Polymenis HL, Gull T, Figueiredo JF, Wong MH, Michelsen KS, Akçelik M, Adams LG, Bäumler AJ.

Mol Microbiol. 2005 Oct;58(1):289-304.

27.

Blood-brain barrier invasion by group B Streptococcus depends upon proper cell-surface anchoring of lipoteichoic acid.

Doran KS, Engelson EJ, Khosravi A, Maisey HC, Fedtke I, Equils O, Michelsen KS, Arditi M, Peschel A, Nizet V.

J Clin Invest. 2005 Sep;115(9):2499-507.

28.

Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease.

Schröder NW, Diterich I, Zinke A, Eckert J, Draing C, von Baehr V, Hassler D, Priem S, Hahn K, Michelsen KS, Hartung T, Burmester GR, Göbel UB, Hermann C, Schumann RR.

J Immunol. 2005 Aug 15;175(4):2534-40. Erratum in: J Immunol. 2006 May 1;176(9):5682.

29.

MyD88 is pivotal for the early inflammatory response and subsequent bacterial clearance and survival in a mouse model of Chlamydia pneumoniae pneumonia.

Naiki Y, Michelsen KS, Schröder NW, Alsabeh R, Slepenkin A, Zhang W, Chen S, Wei B, Bulut Y, Wong MH, Peterson EM, Arditi M.

J Biol Chem. 2005 Aug 12;280(32):29242-9. Epub 2005 Jun 17.

30.

Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis.

Fukata M, Michelsen KS, Eri R, Thomas LS, Hu B, Lukasek K, Nast CC, Lechago J, Xu R, Naiki Y, Soliman A, Arditi M, Abreu MT.

Am J Physiol Gastrointest Liver Physiol. 2005 May;288(5):G1055-65.

31.

Mycobacterium tuberculosis heat shock proteins use diverse Toll-like receptor pathways to activate pro-inflammatory signals.

Bulut Y, Michelsen KS, Hayrapetian L, Naiki Y, Spallek R, Singh M, Arditi M.

J Biol Chem. 2005 Jun 3;280(22):20961-7. Epub 2005 Apr 4.

32.

Mastoparan, a G protein agonist peptide, differentially modulates TLR4- and TLR2-mediated signaling in human endothelial cells and murine macrophages.

Lentschat A, Karahashi H, Michelsen KS, Thomas LS, Zhang W, Vogel SN, Arditi M.

J Immunol. 2005 Apr 1;174(7):4252-61.

33.

Transforming growth factor-beta differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling.

Naiki Y, Michelsen KS, Zhang W, Chen S, Doherty TM, Arditi M.

J Biol Chem. 2005 Feb 18;280(7):5491-5. Epub 2004 Dec 28.

34.

Role of Toll-like receptors in atherosclerosis.

Michelsen KS, Doherty TM, Shah PK, Arditi M.

Circ Res. 2004 Dec 10;95(12):e96-7. No abstract available.

PMID:
15591233
35.

TLR signaling: an emerging bridge from innate immunity to atherogenesis.

Michelsen KS, Doherty TM, Shah PK, Arditi M.

J Immunol. 2004 Nov 15;173(10):5901-7. Review.

36.

Beta-defensin-2 expression is regulated by TLR signaling in intestinal epithelial cells.

Vora P, Youdim A, Thomas LS, Fukata M, Tesfay SY, Lukasek K, Michelsen KS, Wada A, Hirayama T, Arditi M, Abreu MT.

J Immunol. 2004 Nov 1;173(9):5398-405.

37.

Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E.

Michelsen KS, Wong MH, Shah PK, Zhang W, Yano J, Doherty TM, Akira S, Rajavashisth TB, Arditi M.

Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10679-84. Epub 2004 Jul 12.

38.

Rac1 and Toll-IL-1 receptor domain-containing adapter protein mediate Toll-like receptor 4 induction of HIV-long terminal repeat.

Equils O, Madak Z, Liu C, Michelsen KS, Bulut Y, Lu D.

J Immunol. 2004 Jun 15;172(12):7642-6.

39.

TLR signaling at the intestinal epithelial interface.

Abreu MT, Thomas LS, Arnold ET, Lukasek K, Michelsen KS, Arditi M.

J Endotoxin Res. 2003;9(5):322-30.

PMID:
14577850
41.

Human intestinal epithelial cells are broadly unresponsive to Toll-like receptor 2-dependent bacterial ligands: implications for host-microbial interactions in the gut.

Melmed G, Thomas LS, Lee N, Tesfay SY, Lukasek K, Michelsen KS, Zhou Y, Hu B, Arditi M, Abreu MT.

J Immunol. 2003 Feb 1;170(3):1406-15.

42.

Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway.

Bulut Y, Faure E, Thomas L, Karahashi H, Michelsen KS, Equils O, Morrison SG, Morrison RP, Arditi M.

J Immunol. 2002 Feb 1;168(3):1435-40.

43.

The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCS). Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2.

Michelsen KS, Aicher A, Mohaupt M, Hartung T, Dimmeler S, Kirschning CJ, Schumann RR.

J Biol Chem. 2001 Jul 13;276(28):25680-6. Epub 2001 Apr 20.

44.
45.

Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-kappaB translocation.

Opitz B, Schröder NW, Spreitzer I, Michelsen KS, Kirschning CJ, Hallatschek W, Zähringer U, Hartung T, Göbel UB, Schumann RR.

J Biol Chem. 2001 Jun 22;276(25):22041-7. Epub 2001 Apr 2.

46.

Activation of mitogen-activated protein kinases p42/44, p38, and stress-activated protein kinases in myelo-monocytic cells by Treponema lipoteichoic acid.

Schröder NW, Pfeil D, Opitz B, Michelsen KS, Amberger J, Zähringer U, Göbel UB, Schumann RR.

J Biol Chem. 2001 Mar 30;276(13):9713-9. Epub 2000 Dec 28.

47.

Involvement of lipopolysaccharide binding protein, CD14, and Toll-like receptors in the initiation of innate immune responses by Treponema glycolipids.

Schröder NW, Opitz B, Lamping N, Michelsen KS, Zähringer U, Göbel UB, Schumann RR.

J Immunol. 2000 Sep 1;165(5):2683-93.

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