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Items: 1 to 50 of 227

1.

Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase of Trypanosoma brucei brucei.

Balogun EO, Inaoka DK, Shiba T, Tsuge C, May B, Sato T, Kido Y, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Michels PAM, Watanabe YI, Moore AL, Harada S, Kita K.

FASEB J. 2019 Sep 16:fj201901342R. doi: 10.1096/fj.201901342R. [Epub ahead of print]

PMID:
31525300
2.

Pyruvate Kinase Regulates the Pentose-Phosphate Pathway in Response to Hypoxia in Mycobacterium tuberculosis.

Zhong W, Guo J, Cui L, Chionh YH, Li K, El Sahili A, Cai Q, Yuan M, Michels PAM, Fothergill-Gilmore LA, Walkinshaw MD, Mu Y, Lescar J, Dedon PC.

J Mol Biol. 2019 Sep 6;431(19):3690-3705. doi: 10.1016/j.jmb.2019.07.033. Epub 2019 Aug 2.

PMID:
31381898
3.

Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity.

González-Chávez Z, Vázquez C, Mejia-Tlachi M, Márquez-Dueñas C, Manning-Cela R, Encalada R, Rodríguez-Enríquez S, Michels PAM, Moreno-Sánchez R, Saavedra E.

Redox Biol. 2019 Sep;26:101231. doi: 10.1016/j.redox.2019.101231. Epub 2019 May 28.

4.

Proteomic analysis of glycosomes from Trypanosoma cruzi epimastigotes.

Acosta H, Burchmore R, Naula C, Gualdrón-López M, Quintero-Troconis E, Cáceres AJ, Michels PAM, Concepción JL, Quiñones W.

Mol Biochem Parasitol. 2019 Apr;229:62-74. doi: 10.1016/j.molbiopara.2019.02.008. Epub 2019 Mar 1.

5.

Control and regulation of the pyrophosphate-dependent glucose metabolism in Entamoeba histolytica.

Saavedra E, Encalada R, Vázquez C, Olivos-García A, Michels PAM, Moreno-Sánchez R.

Mol Biochem Parasitol. 2019 Apr;229:75-87. doi: 10.1016/j.molbiopara.2019.02.002. Epub 2019 Feb 14. Review.

PMID:
30772421
6.

The kinetic characteristics of human and trypanosomatid phosphofructokinases for the reverse reaction.

Fernandes PM, Kinkead J, McNae IW, Bringaud F, Michels PAM, Walkinshaw MD.

Biochem J. 2019 Jan 18;476(2):179-191. doi: 10.1042/BCJ20180635.

7.

Redox regulation of pyruvate kinase M2 by cysteine oxidation and S-nitrosation.

Mitchell AR, Yuan M, Morgan HP, McNae IW, Blackburn EA, Le Bihan T, Homem RA, Yu M, Loake GJ, Michels PA, Wear MA, Walkinshaw MD.

Biochem J. 2018 Oct 31;475(20):3275-3291. doi: 10.1042/BCJ20180556.

8.

Drug Target Selection for Trypanosoma cruzi Metabolism by Metabolic Control Analysis and Kinetic Modeling.

Saavedra E, Gonzalez-Chavez Z, Moreno-Sanchez R, Michels PAM.

Curr Med Chem. 2018 Sep 16. doi: 10.2174/0929867325666180917104242. [Epub ahead of print]

PMID:
30221599
9.

An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor.

Yuan M, McNae IW, Chen Y, Blackburn EA, Wear MA, Michels PAM, Fothergill-Gilmore LA, Hupp T, Walkinshaw MD.

Biochem J. 2018 May 31;475(10):1821-1837. doi: 10.1042/BCJ20180171.

10.

The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids.

Marchese L, Nascimento JF, Damasceno FS, Bringaud F, Michels PAM, Silber AM.

Pathogens. 2018 Apr 1;7(2). pii: E36. doi: 10.3390/pathogens7020036. Review.

11.

Enolase from Trypanosoma cruzi is inhibited by its interaction with metallocarboxypeptidase-1 and a putative acireductone dioxygenase.

Quintero-Troconis E, Buelvas N, Carrasco-López C, Domingo-Sananes MR, González-González L, Ramírez-Molina R, Osorio L, Lobo-Rojas A, Cáceres AJ, Michels PA, Acosta H, Quiñones W, Concepción JL.

Biochim Biophys Acta Proteins Proteom. 2018 May - Jun;1866(5-6):651-660. doi: 10.1016/j.bbapap.2018.03.003. Epub 2018 Mar 10.

PMID:
29530564
12.

Nanotechnological Strategies for Treatment of Leishmaniasis--A Review.

de Almeida L, Terumi Fujimura A, Del Cistia ML, Fonseca-Santos B, Braga Imamura K, Michels PAM, Chorilli M, Graminha MAS.

J Biomed Nanotechnol. 2017 Feb;13(2):117-33. Review.

PMID:
29376626
13.

A paradigm shift: The mitoproteomes of procyclic and bloodstream Trypanosoma brucei are comparably complex.

Zíková A, Verner Z, Nenarokova A, Michels PAM, Lukeš J.

PLoS Pathog. 2017 Dec 21;13(12):e1006679. doi: 10.1371/journal.ppat.1006679. eCollection 2017 Dec. Review. No abstract available.

14.

Structure and function of Per-ARNT-Sim domains and their possible role in the life-cycle biology of Trypanosoma cruzi.

Rojas-Pirela M, Rigden DJ, Michels PA, Cáceres AJ, Concepción JL, Quiñones W.

Mol Biochem Parasitol. 2018 Jan;219:52-66. doi: 10.1016/j.molbiopara.2017.11.002. Epub 2017 Nov 11. Review.

PMID:
29133150
15.

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.

Linciano P, Dawson A, Pöhner I, Costa DM, Sá MS, Cordeiro-da-Silva A, Luciani R, Gul S, Witt G, Ellinger B, Kuzikov M, Gribbon P, Reinshagen J, Wolf M, Behrens B, Hannaert V, Michels PAM, Nerini E, Pozzi C, di Pisa F, Landi G, Santarem N, Ferrari S, Saxena P, Lazzari S, Cannazza G, Freitas-Junior LH, Moraes CB, Pascoalino BS, Alcântara LM, Bertolacini CP, Fontana V, Wittig U, Müller W, Wade RC, Hunter WN, Mangani S, Costantino L, Costi MP.

ACS Omega. 2017 Sep 30;2(9):5666-5683. doi: 10.1021/acsomega.7b00473. Epub 2017 Sep 11.

16.

Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition.

Yuan M, Vásquez-Valdivieso MG, McNae IW, Michels PAM, Fothergill-Gilmore LA, Walkinshaw MD.

J Mol Biol. 2017 Oct 13;429(20):3075-3089. doi: 10.1016/j.jmb.2017.08.010. Epub 2017 Sep 4.

17.

Glycerol kinase of African trypanosomes possesses an intrinsic phosphatase activity.

Balogun EO, Inaoka DK, Shiba T, Tokuoka SM, Tokumasu F, Sakamoto K, Kido Y, Michels PAM, Watanabe YI, Harada S, Kita K.

Biochim Biophys Acta Gen Subj. 2017 Nov;1861(11 Pt A):2830-2842. doi: 10.1016/j.bbagen.2017.07.028. Epub 2017 Aug 2.

PMID:
28778484
18.

Crystallographic substrate binding studies of Leishmania mexicana SCP2-thiolase (type-2): unique features of oxyanion hole-1.

Harijan RK, Kiema TR, Syed SM, Qadir I, Mazet M, Bringaud F, Michels PAM, Wierenga RK.

Protein Eng Des Sel. 2017 Mar 1;30(3):225-233. doi: 10.1093/protein/gzw080.

PMID:
28062645
19.

Evaluation of Antigens for Development of a Serological Test for Human African Trypanosomiasis.

Biéler S, Waltenberger H, Barrett MP, McCulloch R, Mottram JC, Carrington M, Schwaeble W, McKerrow J, Phillips MA, Michels PA, Büscher P, Sanchez JC, Bishop R, Robinson DR, Bangs J, Ferguson M, Nerima B, Albertini A, Michel G, Radwandska M, Ndung'u JM.

PLoS One. 2016 Dec 9;11(12):e0168074. doi: 10.1371/journal.pone.0168074. eCollection 2016.

20.

The SCP2-thiolase-like protein (SLP) of Trypanosoma brucei is an enzyme involved in lipid metabolism.

Harijan RK, Mazet M, Kiema TR, Bouyssou G, Alexson SE, Bergmann U, Moreau P, Michels PA, Bringaud F, Wierenga RK.

Proteins. 2016 Aug;84(8):1075-96. doi: 10.1002/prot.25054. Epub 2016 May 9.

PMID:
27093562
21.

Trypanosoma evansi contains two auxiliary enzymes of glycolytic metabolism: Phosphoenolpyruvate carboxykinase and pyruvate phosphate dikinase.

Rivero LA, Concepción JL, Quintero-Troconis E, Quiñones W, Michels PA, Acosta H.

Exp Parasitol. 2016 Jun;165:7-15. doi: 10.1016/j.exppara.2016.03.003. Epub 2016 Mar 9.

PMID:
26968775
22.

Peroxisomes in parasitic protists.

Gabaldón T, Ginger ML, Michels PA.

Mol Biochem Parasitol. 2016 Sep - Oct;209(1-2):35-45. doi: 10.1016/j.molbiopara.2016.02.005. Epub 2016 Feb 16. Review.

PMID:
26896770
23.

Biogenesis, maintenance and dynamics of glycosomes in trypanosomatid parasites.

Haanstra JR, González-Marcano EB, Gualdrón-López M, Michels PA.

Biochim Biophys Acta. 2016 May;1863(5):1038-48. doi: 10.1016/j.bbamcr.2015.09.015. Epub 2015 Sep 16. Review.

24.

ATG24 Represses Autophagy and Differentiation and Is Essential for Homeostasy of the Flagellar Pocket in Trypanosoma brucei.

Brennand A, Rico E, Rigden DJ, Van Der Smissen P, Courtoy PJ, Michels PA.

PLoS One. 2015 Jun 19;10(6):e0130365. doi: 10.1371/journal.pone.0130365. eCollection 2015.

25.

Structures of pyruvate kinases display evolutionarily divergent allosteric strategies.

Morgan HP, Zhong W, McNae IW, Michels PA, Fothergill-Gilmore LA, Walkinshaw MD.

R Soc Open Sci. 2014 Sep 24;1(1):140120. doi: 10.1098/rsos.140120. eCollection 2014 Sep.

26.

Synthesis and evaluation of novel prenylated chalcone derivatives as anti-leishmanial and anti-trypanosomal compounds.

Passalacqua TG, Dutra LA, de Almeida L, Velásquez AM, Torres FA, Yamasaki PR, dos Santos MB, Regasini LO, Michels PA, Bolzani Vda S, Graminha MA.

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3342-5. doi: 10.1016/j.bmcl.2015.05.072. Epub 2015 May 30.

PMID:
26055530
27.

The glycosomal-membrane associated phosphoglycerate kinase isoenzyme A plays a role in sustaining the glucose flux in Trypanosoma cruzi epimastigotes.

Barros-Álvarez X, Cáceres AJ, Ruiz MT, Michels PA, Concepción JL, Quiñones W.

Mol Biochem Parasitol. 2015 Mar-Apr;200(1-2):5-8. doi: 10.1016/j.molbiopara.2015.04.003. Epub 2015 Apr 25.

PMID:
25917939
28.

In or out? On the tightness of glycosomal compartmentalization of metabolites and enzymes in Trypanosoma brucei.

Haanstra JR, Bakker BM, Michels PA.

Mol Biochem Parasitol. 2014 Nov;198(1):18-28. doi: 10.1016/j.molbiopara.2014.11.004. Epub 2014 Dec 2. Review.

PMID:
25476771
29.

Evolution, dynamics and specialized functions of glycosomes in metabolism and development of trypanosomatids.

Szöör B, Haanstra JR, Gualdrón-López M, Michels PA.

Curr Opin Microbiol. 2014 Dec;22:79-87. doi: 10.1016/j.mib.2014.09.006. Review.

PMID:
25460800
30.

Molecular basis for the reverse reaction of African human trypanosomes glycerol kinase.

Balogun EO, Inaoka DK, Shiba T, Kido Y, Tsuge C, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Michels PA, Kita K, Harada S.

Mol Microbiol. 2014 Dec;94(6):1315-29. doi: 10.1111/mmi.12831. Epub 2014 Nov 4.

31.

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei.

Shameer S, Logan-Klumpler FJ, Vinson F, Cottret L, Merlet B, Achcar F, Boshart M, Berriman M, Breitling R, Bringaud F, Bütikofer P, Cattanach AM, Bannerman-Chukualim B, Creek DJ, Crouch K, de Koning HP, Denise H, Ebikeme C, Fairlamb AH, Ferguson MA, Ginger ML, Hertz-Fowler C, Kerkhoven EJ, Mäser P, Michels PA, Nayak A, Nes DW, Nolan DP, Olsen C, Silva-Franco F, Smith TK, Taylor MC, Tielens AG, Urbaniak MD, van Hellemond JJ, Vincent IM, Wilkinson SR, Wyllie S, Opperdoes FR, Barrett MP, Jourdan F.

Nucleic Acids Res. 2015 Jan;43(Database issue):D637-44. doi: 10.1093/nar/gku944. Epub 2014 Oct 9.

32.

The Power of Hybrid/Fusion Imaging Metrics in Future PACS Systems: A Case Study into the White Matter Hyperintensity Prenumbra using FLAIR and Diffusion MR.

Tsao S, Ma SJ, Michels PA, Gajawelli N, Law M, Chui H, Lepore N.

Proc SPIE Int Soc Opt Eng. 2014 Apr 9;9039:90390I.

33.

Trypanosomatid phosphoglycerate mutases have multiple conformational and oligomeric states.

Blackburn EA, Fuad FA, Morgan HP, Nowicki MW, Wear MA, Michels PA, Fothergill-Gilmore LA, Walkinshaw MD.

Biochem Biophys Res Commun. 2014 Jul 25;450(2):936-41. doi: 10.1016/j.bbrc.2014.06.113. Epub 2014 Jun 28.

PMID:
24984149
34.

Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase.

Brimacombe KR, Walsh MJ, Liu L, Vásquez-Valdivieso MG, Morgan HP, McNae I, Fothergill-Gilmore LA, Michels PA, Auld DS, Simeonov A, Walkinshaw MD, Shen M, Boxer MB.

ACS Med Chem Lett. 2013 Oct 30;5(1):12-7. doi: 10.1021/ml400259d. eCollection 2014 Jan 9.

35.

The phosphoglycerate kinase isoenzymes have distinct roles in the regulation of carbohydrate metabolism in Trypanosoma cruzi.

Barros-Álvarez X, Cáceres AJ, Michels PA, Concepción JL, Quiñones W.

Exp Parasitol. 2014 Aug;143:39-47. doi: 10.1016/j.exppara.2014.05.010. Epub 2014 May 20.

PMID:
24858924
36.

Phylogenetic relationships and classification of thiolases and thiolase-like proteins of Mycobacterium tuberculosis and Mycobacterium smegmatis.

Anbazhagan P, Harijan RK, Kiema TR, Janardan N, Murthy MR, Michels PA, Juffer AH, Wierenga RK.

Tuberculosis (Edinb). 2014 Jul;94(4):405-12. doi: 10.1016/j.tube.2014.03.003. Epub 2014 Apr 4.

PMID:
24825023
37.

Extracellular functions of glycolytic enzymes of parasites: unpredicted use of ancient proteins.

Gómez-Arreaza A, Acosta H, Quiñones W, Concepción JL, Michels PA, Avilán L.

Mol Biochem Parasitol. 2014 Feb;193(2):75-81. doi: 10.1016/j.molbiopara.2014.02.005. Epub 2014 Mar 3. Review.

PMID:
24602601
38.

Toward the development of dual-targeted glyceraldehyde-3-phosphate dehydrogenase/trypanothione reductase inhibitors against Trypanosoma brucei and Trypanosoma cruzi.

Belluti F, Uliassi E, Veronesi G, Bergamini C, Kaiser M, Brun R, Viola A, Fato R, Michels PA, Krauth-Siegel RL, Cavalli A, Bolognesi ML.

ChemMedChem. 2014 Feb;9(2):371-82. doi: 10.1002/cmdc.201300399. Epub 2014 Jan 8.

PMID:
24403089
39.

Pyruvate kinases have an intrinsic and conserved decarboxylase activity.

Zhong W, Morgan HP, Nowicki MW, McNae IW, Yuan M, Bella J, Michels PA, Fothergill-Gilmore LA, Walkinshaw MD.

Biochem J. 2014 Mar 1;458(2):301-11. doi: 10.1042/BJ20130790.

40.

Identification of Selective Inhibitors of Phosphofructokinase as Lead Compounds Against Trypanosomiasis.

Walsh MJ, Brimacombe KR, Vásquez-Valdivieso MG, Auld DS, Simeonov A, Morgan HP, Fothergill-Gilmore LA, Michels PAM, Walkinshaw MD, Shen M, Boxer MB.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Oct 18 [updated 2013 Feb 25].

41.

`In crystallo' substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinase.

Zhong W, Morgan HP, McNae IW, Michels PA, Fothergill-Gilmore LA, Walkinshaw MD.

Acta Crystallogr D Biol Crystallogr. 2013 Sep;69(Pt 9):1768-79. doi: 10.1107/S0907444913013875. Epub 2013 Aug 17.

PMID:
23999300
42.

Ubiquitination of the glycosomal matrix protein receptor PEX5 in Trypanosoma brucei by PEX4 displays novel features.

Gualdrón-López M, Chevalier N, Van Der Smissen P, Courtoy PJ, Rigden DJ, Michels PAM.

Biochim Biophys Acta. 2013 Dec;1833(12):3076-3092. doi: 10.1016/j.bbamcr.2013.08.008. Epub 2013 Aug 27.

43.

Crystal structures of SCP2-thiolases of Trypanosomatidae, human pathogens causing widespread tropical diseases: the importance for catalysis of the cysteine of the unique HDCF loop.

Harijan RK, Kiema TR, Karjalainen MP, Janardan N, Murthy MR, Weiss MS, Michels PA, Wierenga RK.

Biochem J. 2013 Oct 1;455(1):119-30. doi: 10.1042/BJ20130669.

PMID:
23909465
44.

Glycosomal targets for anti-trypanosomatid drug discovery.

Barros-Alvarez X, Gualdrón-López M, Acosta H, Cáceres AJ, Graminha MA, Michels PA, Concepción JL, Quiñones W.

Curr Med Chem. 2014;21(15):1679-706. Review.

PMID:
23834165
45.

Cytosolic NADPH homeostasis in glucose-starved procyclic Trypanosoma brucei relies on malic enzyme and the pentose phosphate pathway fed by gluconeogenic flux.

Allmann S, Morand P, Ebikeme C, Gales L, Biran M, Hubert J, Brennand A, Mazet M, Franconi JM, Michels PA, Portais JC, Boshart M, Bringaud F.

J Biol Chem. 2013 Jun 21;288(25):18494-505. doi: 10.1074/jbc.M113.462978. Epub 2013 May 10.

46.

Biochemical characterization of highly active Trypanosoma brucei gambiense glycerol kinase, a promising drug target.

Balogun EO, Inaoka DK, Shiba T, Kido Y, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Michels PA, Harada S, Kita K.

J Biochem. 2013 Jul;154(1):77-84. doi: 10.1093/jb/mvt037. Epub 2013 Apr 25.

PMID:
23620597
47.

Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism.

Pieretti S, Haanstra JR, Mazet M, Perozzo R, Bergamini C, Prati F, Fato R, Lenaz G, Capranico G, Brun R, Bakker BM, Michels PA, Scapozza L, Bolognesi ML, Cavalli A.

PLoS Negl Trop Dis. 2013;7(1):e2012. doi: 10.1371/journal.pntd.0002012. Epub 2013 Jan 17.

48.

Antitrypanosomal compounds from the essential oil and extracts of Keetia leucantha leaves with inhibitor activity on Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase.

Bero J, Beaufay C, Hannaert V, Hérent MF, Michels PA, Quetin-Leclercq J.

Phytomedicine. 2013 Feb 15;20(3-4):270-4. doi: 10.1016/j.phymed.2012.10.010. Epub 2013 Jan 11.

PMID:
23312849
49.

Processing of the glycosomal matrix-protein import receptor PEX5 of Trypanosoma brucei.

Gualdrón-López M, Michels PA.

Biochem Biophys Res Commun. 2013 Feb 1;431(1):98-103. doi: 10.1016/j.bbrc.2012.12.075. Epub 2012 Dec 22.

PMID:
23266609
50.

Biochemical effects of riluzole on Leishmania parasites.

Guerrieri D, Ferrari S, Costi MP, Michels PA.

Exp Parasitol. 2013 Mar;133(3):250-4. doi: 10.1016/j.exppara.2012.11.013. Epub 2012 Dec 1.

PMID:
23206955

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