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Items: 1 to 50 of 58

1.

Metabolomics reveals plausible interactive effects between dairy product consumption and metabolic syndrome in humans.

Capel F, Bongard V, Malpuech-Brugère C, Karoly E, Michelotti GA, Rigaudière JP, Jouve C, Ferrières J, Marmonier C, Sébédio JL.

Clin Nutr. 2019 Jun 26. pii: S0261-5614(19)30268-7. doi: 10.1016/j.clnu.2019.06.013. [Epub ahead of print]

PMID:
31279616
2.

Metabolomics Identifies Novel Blood Biomarkers of Pulmonary Function and COPD in the General Population.

Yu B, Flexeder C, McGarrah RW 3rd, Wyss A, Morrison AC, North KE, Boerwinkle E, Kastenmüller G, Gieger C, Suhre K, Karrasch S, Peters A, Wagner GR, Michelotti GA, Mohney RP, Schulz H, London SJ.

Metabolites. 2019 Apr 1;9(4). pii: E61. doi: 10.3390/metabo9040061.

3.

Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02.

Tziotzios C, Petridis C, Dand N, Ainali C, Saklatvala JR, Pullabhatla V, Onoufriadis A, Pramanik R, Baudry D, Lee SH, Wood K, Liu L, Seegobin S, Michelotti GA, Lwin SM, Christou EAA, Curtis CJ, de Rinaldis E, Saxena A, Holmes S, Harries M, Palamaras I, Cunningham F, Parkins G, Kaur M, Farrant P, McDonagh A, Messenger A, Jones J, Jolliffe V, Ali I, Ardern-Jones M, Mitchell C, Burrows N, Atkar R, Banfield C, Alexandroff A, Champagne C, Cooper HL, Vañó-Galván S, Molina-Ruiz AM, Perez NO, Patel GK, Macbeth A, Page M, Bryden A, Mowbray M, Wahie S, Armstrong K, Cooke N, Goodfield M, Man I, de Berker D, Dunnill G, Takwale A, Rao A, Siah TW, Sinclair R, Wade MS, Dlova NC, Setterfield J, Lewis F, Bhargava K, Kirkpatrick N, Estivill X, Stefanato CM, Flohr C, Spector T, Watt FM, Smith CH, Barker JN, Fenton DA, Simpson MA, McGrath JA.

Nat Commun. 2019 Mar 8;10(1):1150. doi: 10.1038/s41467-019-09117-w.

4.

Metabolomic response to coffee consumption: application to a three-stage clinical trial.

Cornelis MC, Erlund I, Michelotti GA, Herder C, Westerhuis JA, Tuomilehto J.

J Intern Med. 2018 Jun;283(6):544-557. doi: 10.1111/joim.12737. Epub 2018 Mar 15.

PMID:
29381822
5.

Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells.

Du K, Hyun J, Premont RT, Choi SS, Michelotti GA, Swiderska-Syn M, Dalton GD, Thelen E, Rizi BS, Jung Y, Diehl AM.

Gastroenterology. 2018 Apr;154(5):1465-1479.e13. doi: 10.1053/j.gastro.2017.12.022. Epub 2018 Jan 3.

6.

Metabolomics Study of the Effects of Inflammation, Hypoxia, and High Glucose on Isolated Human Pancreatic Islets.

Garcia-Contreras M, Tamayo-Garcia A, Pappan KL, Michelotti GA, Stabler CL, Ricordi C, Buchwald P.

J Proteome Res. 2017 Jun 2;16(6):2294-2306. doi: 10.1021/acs.jproteome.7b00160. Epub 2017 May 9.

7.

Loss of pericyte smoothened activity in mice with genetic deficiency of leptin.

Xie G, Swiderska-Syn M, Jewell ML, Machado MV, Michelotti GA, Premont RT, Diehl AM.

BMC Cell Biol. 2017 Apr 20;18(1):20. doi: 10.1186/s12860-017-0135-y.

8.

Hedgehog regulates yes-associated protein 1 in regenerating mouse liver.

Swiderska-Syn M, Xie G, Michelotti GA, Jewell ML, Premont RT, Syn WK, Diehl AM.

Hepatology. 2016 Jul;64(1):232-44. doi: 10.1002/hep.28542. Epub 2016 Apr 21.

9.

Inflammation-Dependent IL18 Signaling Restricts Hepatocellular Carcinoma Growth by Enhancing the Accumulation and Activity of Tumor-Infiltrating Lymphocytes.

Markowitz GJ, Yang P, Fu J, Michelotti GA, Chen R, Sui J, Yang B, Qin WH, Zhang Z, Wang FS, Diehl AM, Li QJ, Wang H, Wang XF.

Cancer Res. 2016 Apr 15;76(8):2394-405. doi: 10.1158/0008-5472.CAN-15-1548. Epub 2016 Feb 18.

10.

Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.

Machado MV, Michelotti GA, Jewell ML, Pereira TA, Xie G, Premont RT, Diehl AM.

Cell Death Dis. 2016 Feb 18;7:e2096. doi: 10.1038/cddis.2016.19.

11.

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin ARMR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, Bishayee A, Blain SW, Block PB, Boosani CS, Carey TE, Carnero A, Carotenuto M, Casey SC, Chakrabarti M, Chaturvedi R, Chen GZ, Chen H, Chen S, Chen YC, Choi BK, Ciriolo MR, Coley HM, Collins AR, Connell M, Crawford S, Curran CS, Dabrosin C, Damia G, Dasgupta S, DeBerardinis RJ, Decker WK, Dhawan P, Diehl AME, Dong JT, Dou QP, Drew JE, Elkord E, El-Rayes B, Feitelson MA, Felsher DW, Ferguson LR, Fimognari C, Firestone GL, Frezza C, Fujii H, Fuster MM, Generali D, Georgakilas AG, Gieseler F, Gilbertson M, Green MF, Grue B, Guha G, Halicka D, Helferich WG, Heneberg P, Hentosh P, Hirschey MD, Hofseth LJ, Holcombe RF, Honoki K, Hsu HY, Huang GS, Jensen LD, Jiang WG, Jones LW, Karpowicz PA, Keith WN, Kerkar SP, Khan GN, Khatami M, Ko YH, Kucuk O, Kulathinal RJ, Kumar NB, Kwon BS, Le A, Lea MA, Lee HY, Lichtor T, Lin LT, Locasale JW, Lokeshwar BL, Longo VD, Lyssiotis CA, MacKenzie KL, Malhotra M, Marino M, Martinez-Chantar ML, Matheu A, Maxwell C, McDonnell E, Meeker AK, Mehrmohamadi M, Mehta K, Michelotti GA, Mohammad RM, Mohammed SI, Morre DJ, Muralidhar V, Muqbil I, Murphy MP, Nagaraju GP, Nahta R, Niccolai E, Nowsheen S, Panis C, Pantano F, Parslow VR, Pawelec G, Pedersen PL, Poore B, Poudyal D, Prakash S, Prince M, Raffaghello L, Rathmell JC, Rathmell WK, Ray SK, Reichrath J, Rezazadeh S, Ribatti D, Ricciardiello L, Robey RB, Rodier F, Rupasinghe HPV, Russo GL, Ryan EP, Samadi AK, Sanchez-Garcia I, Sanders AJ, Santini D, Sarkar M, Sasada T, Saxena NK, Shackelford RE, Shantha Kumara HMC, Sharma D, Shin DM, Sidransky D, Siegelin MD, Signori E, Singh N, Sivanand S, Sliva D, Smythe C, Spagnuolo C, Stafforini DM, Stagg J, Subbarayan PR, Sundin T, Talib WH, Thompson SK, Tran PT, Ungefroren H, Vander Heiden MG, Venkateswaran V, Vinay DS, Vlachostergios PJ, Wang Z, Wellen KE, Whelan RL, Yang ES, Yang H, Yang X, Yaswen P, Yedjou C, Yin X, Zhu J, Zollo M.

Semin Cancer Biol. 2015 Dec;35 Suppl:S276-S304. doi: 10.1016/j.semcancer.2015.09.007. Review.

12.

Vitamin B5 and N-Acetylcysteine in Nonalcoholic Steatohepatitis: A Preclinical Study in a Dietary Mouse Model.

Machado MV, Kruger L, Jewell ML, Michelotti GA, Pereira Tde A, Xie G, Moylan CA, Diehl AM.

Dig Dis Sci. 2016 Jan;61(1):137-48. doi: 10.1007/s10620-015-3871-x. Epub 2015 Sep 24.

13.

Temporal Dissection of Rate Limiting Transcriptional Events Using Pol II ChIP and RNA Analysis of Adrenergic Stress Gene Activation.

Morris DP, Lei B, Longo LD, Bomsztyk K, Schwinn DA, Michelotti GA.

PLoS One. 2015 Aug 5;10(8):e0134442. doi: 10.1371/journal.pone.0134442. eCollection 2015. Erratum in: PLoS One. 2015;10(10):e0140710.

14.

Correction: Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease.

Machado MV, Michelotti GA, Xie G, de Almeida TP, Boursier J, Bohnic B, Guy CD, Diehl AM.

PLoS One. 2015 Jun 29;10(6):e0132315. doi: 10.1371/journal.pone.0132315. eCollection 2015. No abstract available.

15.

Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease.

Machado MV, Michelotti GA, Pereira TA, Xie G, Premont R, Cortez-Pinto H, Diehl AM.

J Hepatol. 2015 Oct;63(4):962-70. doi: 10.1016/j.jhep.2015.05.031. Epub 2015 Jun 10.

16.

Inflammatory models drastically alter tumor growth and the immune microenvironment in hepatocellular carcinoma.

Markowitz GJ, Michelotti GA, Diehl AM, Wang XF.

Sci Bull (Beijing). 2015 Apr 1;60(8):762-772.

17.

Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease.

Machado MV, Michelotti GA, Xie G, Almeida Pereira T, Boursier J, Bohnic B, Guy CD, Diehl AM.

PLoS One. 2015 May 27;10(5):e0127991. doi: 10.1371/journal.pone.0127991. eCollection 2015. Erratum in: PLoS One. 2015;10(6):e0132315. de Almeida, Thiago Pereira [corrected to Almeida Pereira, Thiago].

18.

NADPH Oxidase-Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment.

Das S, Alhasson F, Dattaroy D, Pourhoseini S, Seth RK, Nagarkatti M, Nagarkatti PS, Michelotti GA, Diehl AM, Kalyanaraman B, Chatterjee S.

Am J Pathol. 2015 Jul;185(7):1944-57. doi: 10.1016/j.ajpath.2015.03.024. Epub 2015 May 16.

19.

Upregulation of miR21 and repression of Grhl3 by leptin mediates sinusoidal endothelial injury in experimental nonalcoholic steatohepatitis.

Pourhoseini S, Seth RK, Das S, Dattaroy D, Kadiiska MB, Xie G, Michelotti GA, Nagarkatti M, Diehl AM, Chatterjee S.

PLoS One. 2015 Feb 6;10(2):e0116780. doi: 10.1371/journal.pone.0116780. eCollection 2015.

20.

Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches.

Michelotti GA, Tucker A, Swiderska-Syn M, Machado MV, Choi SS, Kruger L, Soderblom E, Thompson JW, Mayer-Salman M, Himburg HA, Moylan CA, Guy CD, Garman KS, Premont RT, Chute JP, Diehl AM.

Gut. 2016 Apr;65(4):683-92. doi: 10.1136/gutjnl-2014-308176. Epub 2015 Jan 16.

21.

Role of Fn14 in acute alcoholic steatohepatitis in mice.

Karaca G, Xie G, Moylan C, Swiderska-Syn M, Guy CD, Krüger L, Machado MV, Choi SS, Michelotti GA, Burkly LC, Diehl AM.

Am J Physiol Gastrointest Liver Physiol. 2015 Feb 15;308(4):G325-34. doi: 10.1152/ajpgi.00429.2013. Epub 2014 Dec 18.

22.

Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis.

Dattaroy D, Pourhoseini S, Das S, Alhasson F, Seth RK, Nagarkatti M, Michelotti GA, Diehl AM, Chatterjee S.

Am J Physiol Gastrointest Liver Physiol. 2015 Feb 15;308(4):G298-312. doi: 10.1152/ajpgi.00346.2014. Epub 2014 Dec 11.

23.

M1 polarization bias and subsequent nonalcoholic steatohepatitis progression is attenuated by nitric oxide donor DETA NONOate via inhibition of CYP2E1-induced oxidative stress in obese mice.

Seth RK, Das S, Pourhoseini S, Dattaroy D, Igwe S, Ray JB, Fan D, Michelotti GA, Diehl AM, Chatterjee S.

J Pharmacol Exp Ther. 2015 Jan;352(1):77-89. doi: 10.1124/jpet.114.218131. Epub 2014 Oct 27.

24.

Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis.

Machado MV, Michelotti GA, Pereira Tde A, Boursier J, Kruger L, Swiderska-Syn M, Karaca G, Xie G, Guy CD, Bohinc B, Lindblom KR, Johnson E, Kornbluth S, Diehl AM.

Gut. 2015 Jul;64(7):1148-57. doi: 10.1136/gutjnl-2014-307362. Epub 2014 Jul 22.

25.

TWEAK/Fn14 signaling is required for liver regeneration after partial hepatectomy in mice.

Karaca G, Swiderska-Syn M, Xie G, Syn WK, Krüger L, Machado MV, Garman K, Choi SS, Michelotti GA, Burkly LC, Ochoa B, Diehl AM.

PLoS One. 2014 Jan 9;9(1):e83987. doi: 10.1371/journal.pone.0083987. eCollection 2014.

26.

Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy.

Swiderska-Syn M, Syn WK, Xie G, Krüger L, Machado MV, Karaca G, Michelotti GA, Choi SS, Premont RT, Diehl AM.

Gut. 2014 Aug;63(8):1333-44. doi: 10.1136/gutjnl-2013-305962. Epub 2013 Oct 30.

27.

NAFLD, NASH and liver cancer.

Michelotti GA, Machado MV, Diehl AM.

Nat Rev Gastroenterol Hepatol. 2013 Nov;10(11):656-65. doi: 10.1038/nrgastro.2013.183. Epub 2013 Oct 1. Review.

PMID:
24080776
28.

Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease.

Moylan CA, Pang H, Dellinger A, Suzuki A, Garrett ME, Guy CD, Murphy SK, Ashley-Koch AE, Choi SS, Michelotti GA, Hampton DD, Chen Y, Tillmann HL, Hauser MA, Abdelmalek MF, Diehl AM.

Hepatology. 2014 Feb;59(2):471-82. doi: 10.1002/hep.26661. Epub 2013 Dec 13.

29.

Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice.

Xie G, Karaca G, Swiderska-Syn M, Michelotti GA, Krüger L, Chen Y, Premont RT, Choi SS, Diehl AM.

Hepatology. 2013 Nov;58(5):1801-13. doi: 10.1002/hep.26511. Epub 2013 Sep 30.

30.

Smoothened is a master regulator of adult liver repair.

Michelotti GA, Xie G, Swiderska M, Choi SS, Karaca G, Krüger L, Premont R, Yang L, Syn WK, Metzger D, Diehl AM.

J Clin Invest. 2013 Jun;123(6):2380-94.

31.

Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma.

Chan IS, Guy CD, Chen Y, Lu J, Swiderska-Syn M, Michelotti GA, Karaca G, Xie G, Krüger L, Syn WK, Anderson BR, Pereira TA, Choi SS, Baldwin AS, Diehl AM.

Cancer Res. 2012 Dec 15;72(24):6344-50. doi: 10.1158/0008-5472.CAN-12-1068. Epub 2012 Oct 12.

32.

Hedgehog controls hepatic stellate cell fate by regulating metabolism.

Chen Y, Choi SS, Michelotti GA, Chan IS, Swiderska-Syn M, Karaca GF, Xie G, Moylan CA, Garibaldi F, Premont R, Suliman HB, Piantadosi CA, Diehl AM.

Gastroenterology. 2012 Nov;143(5):1319-1329.e11. doi: 10.1053/j.gastro.2012.07.115. Epub 2012 Aug 8.

33.

NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease.

Syn WK, Agboola KM, Swiderska M, Michelotti GA, Liaskou E, Pang H, Xie G, Philips G, Chan IS, Karaca GF, Pereira Tde A, Chen Y, Mi Z, Kuo PC, Choi SS, Guy CD, Abdelmalek MF, Diehl AM.

Gut. 2012 Sep;61(9):1323-9. doi: 10.1136/gutjnl-2011-301857. Epub 2012 Mar 17.

34.

Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation.

Xie G, Choi SS, Syn WK, Michelotti GA, Swiderska M, Karaca G, Chan IS, Chen Y, Diehl AM.

Gut. 2013 Feb;62(2):299-309. doi: 10.1136/gutjnl-2011-301494. Epub 2012 Feb 23.

35.

Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer.

Philips GM, Chan IS, Swiderska M, Schroder VT, Guy C, Karaca GF, Moylan C, Venkatraman T, Feuerlein S, Syn WK, Jung Y, Witek RP, Choi S, Michelotti GA, Rangwala F, Merkle E, Lascola C, Diehl AM.

PLoS One. 2011;6(9):e23943. doi: 10.1371/journal.pone.0023943. Epub 2011 Sep 2.

36.

Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis.

Syn WK, Choi SS, Liaskou E, Karaca GF, Agboola KM, Oo YH, Mi Z, Pereira TA, Zdanowicz M, Malladi P, Chen Y, Moylan C, Jung Y, Bhattacharya SD, Teaberry V, Omenetti A, Abdelmalek MF, Guy CD, Adams DH, Kuo PC, Michelotti GA, Whitington PF, Diehl AM.

Hepatology. 2011 Jan;53(1):106-15. doi: 10.1002/hep.23998. Epub 2010 Oct 21.

37.

Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway.

Choi SS, Syn WK, Karaca GF, Omenetti A, Moylan CA, Witek RP, Agboola KM, Jung Y, Michelotti GA, Diehl AM.

J Biol Chem. 2010 Nov 19;285(47):36551-60. doi: 10.1074/jbc.M110.168542. Epub 2010 Sep 14.

38.

Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis.

Choi SS, Omenetti A, Witek RP, Moylan CA, Syn WK, Jung Y, Yang L, Sudan DL, Sicklick JK, Michelotti GA, Rojkind M, Diehl AM.

Am J Physiol Gastrointest Liver Physiol. 2009 Dec;297(6):G1093-106. doi: 10.1152/ajpgi.00292.2009. Epub 2009 Oct 8.

39.

Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-zeta inhibitors and potential therapeutics for psychostimulant abuse.

Yuan L, Seo JS, Kang NS, Keinan S, Steele SE, Michelotti GA, Wetsel WC, Beratan DN, Gong YD, Lee TH, Hong J.

Mol Biosyst. 2009 Sep;5(9):927-30. doi: 10.1039/b903036k. Epub 2009 May 8.

40.

Targeting inhibition of GluR1 Ser845 phosphorylation with an RNA aptamer that blocks AMPA receptor trafficking.

Liu Y, Sun QA, Chen Q, Lee TH, Huang Y, Wetsel WC, Michelotti GA, Sullenger BA, Zhang X.

J Neurochem. 2009 Jan;108(1):147-57. doi: 10.1111/j.1471-4159.2008.05748.x. Epub 2008 Nov 12.

41.

The alpha1a-adrenergic receptor occupies membrane rafts with its G protein effectors but internalizes via clathrin-coated pits.

Morris DP, Lei B, Wu YX, Michelotti GA, Schwinn DA.

J Biol Chem. 2008 Feb 1;283(5):2973-85. Epub 2007 Nov 29.

42.

Epigenetic regulation of human alpha1d-adrenergic receptor gene expression: a role for DNA methylation in Sp1-dependent regulation.

Michelotti GA, Brinkley DM, Morris DP, Smith MP, Louie RJ, Schwinn DA.

FASEB J. 2007 Jul;21(9):1979-93. Epub 2007 Mar 23.

43.

Differential cardiac gene expression during cardiopulmonary bypass: ischemia-independent upregulation of proinflammatory genes.

Podgoreanu MV, Michelotti GA, Sato Y, Smith MP, Lin S, Morris RW, Grocott HP, Mathew JP, Schwinn DA.

J Thorac Cardiovasc Surg. 2005 Aug;130(2):330-9.

44.

Evidence that phosphorylation of the RNA polymerase II carboxyl-terminal repeats is similar in yeast and humans.

Morris DP, Michelotti GA, Schwinn DA.

J Biol Chem. 2005 Sep 9;280(36):31368-77. Epub 2005 Jul 12.

45.

Update on human alpha1-adrenoceptor subtype signaling and genomic organization.

Hawrylyshyn KA, Michelotti GA, Cogé F, Guénin SP, Schwinn DA.

Trends Pharmacol Sci. 2004 Sep;25(9):449-55. Review.

PMID:
15559245
46.

Mechanistic insights into the role of alpha1adrenergic receptors in lower urinary tract symptoms.

Michelotti GA, Schwinn DA.

Curr Urol Rep. 2004 Aug;5(4):258-66. Review.

PMID:
15260925
47.

Cloning and characterization of the rat alpha 1a-adrenergic receptor gene promoter. Demonstration of cell specificity and regulation by hypoxia.

Michelotti GA, Bauman MJ, Smith MP, Schwinn DA.

J Biol Chem. 2003 Mar 7;278(10):8693-705. Epub 2002 Dec 5.

48.

Alpha 1-adrenergic receptor regulation: basic science and clinical implications.

Michelotti GA, Price DT, Schwinn DA.

Pharmacol Ther. 2000 Dec;88(3):281-309. Review.

PMID:
11337028
49.

Immortalization of a human prostate stromal cell line using a recombinant retroviral approach.

Price DT, Rudner X, Michelotti GA, Schwinn DA.

J Urol. 2000 Dec;164(6):2145-50.

PMID:
11061945

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