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Items: 1 to 50 of 222

1.

PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection.

Buckley CM, Heath VL, Guého A, Bosmani C, Knobloch P, Sikakana P, Personnic N, Dove SK, Michell RH, Meier R, Hilbi H, Soldati T, Insall RH, King JS.

PLoS Pathog. 2019 Feb 7;15(2):e1007551. doi: 10.1371/journal.ppat.1007551. eCollection 2019 Feb.

2.

Do inositol supplements enhance phosphatidylinositol supply and thus support endoplasmic reticulum function?

Michell RH.

Br J Nutr. 2018 Jun 3:1-16. doi: 10.1017/S0007114518000946. [Epub ahead of print]

PMID:
29859544
3.

Drug Redeployment to Kill Leukemia and Lymphoma Cells by Disrupting SCD1-Mediated Synthesis of Monounsaturated Fatty Acids.

Southam AD, Khanim FL, Hayden RE, Constantinou JK, Koczula KM, Michell RH, Viant MR, Drayson MT, Bunce CM.

Cancer Res. 2015 Jun 15;75(12):2530-40. doi: 10.1158/0008-5472.CAN-15-0202. Epub 2015 May 5.

4.

Inositol lipids: from an archaeal origin to phosphatidylinositol 3,5-bisphosphate faults in human disease.

Michell RH.

FEBS J. 2013 Dec;280(24):6281-94. doi: 10.1111/febs.12452. Epub 2013 Sep 3. Review.

5.

Versatility and nuances of the architecture of haematopoiesis - Implications for the nature of leukaemia.

Brown G, Hughes PJ, Ceredig R, Michell RH.

Leuk Res. 2012 Jan;36(1):14-22. doi: 10.1016/j.leukres.2011.10.010. Epub 2011 Nov 8. Review.

PMID:
22071138
6.

The versatility of haematopoietic stem cells: implications for leukaemia.

Brown G, Hughes PJ, Michell RH, Ceredig R.

Crit Rev Clin Lab Sci. 2010 Aug;47(4):171-80. doi: 10.3109/10408363.2010.530150. Review.

PMID:
21182396
7.

Inositol and its derivatives: their evolution and functions.

Michell RH.

Adv Enzyme Regul. 2011;51(1):84-90. doi: 10.1016/j.advenzreg.2010.10.002. Epub 2010 Nov 9. Review.

PMID:
21070803
8.

First came the link between phosphoinositides and Ca2+ signalling, and then a deluge of other phosphoinositide functions.

Michell RH.

Cell Calcium. 2009 Jun;45(6):521-6. doi: 10.1016/j.ceca.2009.03.007. Epub 2009 Apr 15. Review.

PMID:
19371949
9.

Phosphatidylinositol 3,5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome function.

Dove SK, Dong K, Kobayashi T, Williams FK, Michell RH.

Biochem J. 2009 Apr 1;419(1):1-13. doi: 10.1042/BJ20081950. Review.

PMID:
19272020
10.

Inositol lipid-dependent functions in Saccharomyces cerevisiae: analysis of phosphatidylinositol phosphates.

Dove SK, Michell RH.

Methods Mol Biol. 2009;462:59-74. doi: 10.1007/978-1-60327-115-8_4.

PMID:
19160661
11.

A protein complex that regulates PtdIns(3,5)P2 levels.

Michell RH, Dove SK.

EMBO J. 2009 Jan 21;28(2):86-7. doi: 10.1038/emboj.2008.270.

12.

Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance.

Yang X, Ongusaha PP, Miles PD, Havstad JC, Zhang F, So WV, Kudlow JE, Michell RH, Olefsky JM, Field SJ, Evans RM.

Nature. 2008 Feb 21;451(7181):964-9. doi: 10.1038/nature06668.

PMID:
18288188
13.

Inositol derivatives: evolution and functions.

Michell RH.

Nat Rev Mol Cell Biol. 2008 Feb;9(2):151-61. doi: 10.1038/nrm2334. Review.

PMID:
18216771
14.

The sequential determination model of hematopoiesis.

Brown G, Hughes PJ, Michell RH, Rolink AG, Ceredig R.

Trends Immunol. 2007 Oct;28(10):442-8. Epub 2007 Sep 7.

PMID:
17825625
15.

Evolution of the diverse biological roles of inositols.

Michell RH.

Biochem Soc Symp. 2007;(74):223-46. Review.

PMID:
17233593
16.

Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions.

Michell RH, Heath VL, Lemmon MA, Dove SK.

Trends Biochem Sci. 2006 Jan;31(1):52-63. Epub 2005 Dec 20. Review.

PMID:
16364647
17.

Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors.

Dove SK, Piper RC, McEwen RK, Yu JW, King MC, Hughes DC, Thuring J, Holmes AB, Cooke FT, Michell RH, Parker PJ, Lemmon MA.

EMBO J. 2004 May 5;23(9):1922-33. Epub 2004 Apr 22.

18.

PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49.

Jeffries TR, Dove SK, Michell RH, Parker PJ.

Mol Biol Cell. 2004 Jun;15(6):2652-63. Epub 2004 Mar 12.

19.

Complex changes in cellular inositol phosphate complement accompany transit through the cell cycle.

Barker CJ, Wright J, Hughes PJ, Kirk CJ, Michell RH.

Biochem J. 2004 Jun 1;380(Pt 2):465-73.

20.

Cell differentiation and proliferation--simultaneous but independent?

Brown G, Hughes PJ, Michell RH.

Exp Cell Res. 2003 Dec 10;291(2):282-8. Review.

PMID:
14644151
21.
22.

Morton Medal Lecture. New insights into the roles of phosphoinositides and inositol polyphosphates in yeast.

Michell RH, Perera NM, Dove SK.

Biochem Soc Trans. 2003 Feb;31(Pt 1):11-5.

PMID:
12546644
23.

HL60 cells halted in G1 or S phase differentiate normally.

Brown G, Drayson MT, Durham J, Toellner KM, Hughes PJ, Choudhry MA, Taylor DR, Bird R, Michell RH.

Exp Cell Res. 2002 Nov 15;281(1):28-38.

PMID:
12441127
24.

Vac14 controls PtdIns(3,5)P(2) synthesis and Fab1-dependent protein trafficking to the multivesicular body.

Dove SK, McEwen RK, Mayes A, Hughes DC, Beggs JD, Michell RH.

Curr Biol. 2002 Jun 4;12(11):885-93.

25.

Inositol phosphates: a remarkably versatile enzyme.

Michell RH.

Curr Biol. 2002 Apr 30;12(9):R313-5.

26.

Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices.

Krugmann S, Anderson KE, Ridley SH, Risso N, McGregor A, Coadwell J, Davidson K, Eguinoa A, Ellson CD, Lipp P, Manifava M, Ktistakis N, Painter G, Thuring JW, Cooper MA, Lim ZY, Holmes AB, Dove SK, Michell RH, Grewal A, Nazarian A, Erdjument-Bromage H, Tempst P, Stephens LR, Hawkins PT.

Mol Cell. 2002 Jan;9(1):95-108.

28.

Up-regulation of steroid sulphatase activity in HL60 promyelocytic cells by retinoids and 1alpha,25-dihydroxyvitamin D3.

Hughes PJ, Twist LE, Durham J, Choudhry MA, Drayson M, Chandraratna R, Michell RH, Kirk CJ, Brown G.

Biochem J. 2001 Apr 15;355(Pt 2):361-71.

29.

Estrogenic alkylphenols induce cell death by inhibiting testis endoplasmic reticulum Ca(2+) pumps.

Hughes PJ, McLellan H, Lowes DA, Kahn SZ, Bilmen JG, Tovey SC, Godfrey RE, Michell RH, Kirk CJ, Michelangeli F.

Biochem Biophys Res Commun. 2000 Nov 2;277(3):568-74.

PMID:
11061995
30.

Phosphatidylinositol 3,5-bisphosphate: a novel lipid that links stress responses to membrane trafficking events.

Dove SK, McEwen RK, Cooke FT, Parker PJ, Michell RH.

Biochem Soc Trans. 1999 Aug;27(4):674-7. Review. No abstract available.

PMID:
10917665
31.

Monocytically differentiating HL60 cells proliferate rapidly before they mature.

Brown G, Choudhry MA, Durham J, Drayson MT, Michell RH.

Exp Cell Res. 1999 Dec 15;253(2):511-8.

PMID:
10585274
32.

Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases.

McEwen RK, Dove SK, Cooke FT, Painter GF, Holmes AB, Shisheva A, Ohya Y, Parker PJ, Michell RH.

J Biol Chem. 1999 Nov 26;274(48):33905-12.

33.

The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae.

Cooke FT, Dove SK, McEwen RK, Painter G, Holmes AB, Hall MN, Michell RH, Parker PJ.

Curr Biol. 1998 Nov 5;8(22):1219-22.

34.

Inositol hexakisphosphate in Schizosaccharomyces pombe: synthesis from Ins(1,4,5)P3 and osmotic regulation.

Ongusaha PP, Hughes PJ, Davey J, Michell RH.

Biochem J. 1998 Nov 1;335 ( Pt 3):671-9.

35.

Diacylglycerols and phosphatidates: which molecular species are intracellular messengers?

Hodgkin MN, Pettitt TR, Martin A, Michell RH, Pemberton AJ, Wakelam MJ.

Trends Biochem Sci. 1998 Jun;23(6):200-4. Review.

PMID:
9644971
36.

Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis.

Dove SK, Cooke FT, Douglas MR, Sayers LG, Parker PJ, Michell RH.

Nature. 1997 Nov 13;390(6656):187-92.

PMID:
9367158
37.

Inhibition of phosphatases and increased Ca2+ channel activity by inositol hexakisphosphate.

Larsson O, Barker CJ, Sjöholm A, Carlqvist H, Michell RH, Bertorello A, Nilsson T, Honkanen RE, Mayr GW, Zwiller J, Berggren PO.

Science. 1997 Oct 17;278(5337):471-4.

38.

Altered protein tyrosine phosphorylation in rheumatoid T cells which is mimicked by hydrogen peroxide.

Ritter JL, Young SP, Michell RH, Bacon PA.

Biochem Soc Trans. 1997 May;25(2):303S. No abstract available.

PMID:
9191347
39.

The inositol 1,4,5-trisphosphate 6-kinase of Schizosaccharomyces pombe.

Ongusaha PP, Hughes PJ, Hirata M, Davey J, Michell RH.

Biochem Soc Trans. 1997 Feb;25(1):105S. No abstract available.

PMID:
9057003
40.

The multiplying roles of inositol lipids and phosphates in cell control processes.

Michell RH.

Essays Biochem. 1997;32:31-47. Review. No abstract available.

PMID:
9493009
41.

Intracellular signaling pathways involved in the induction of apoptosis in immature thymic T lymphocytes.

Anderson KL, Anderson G, Michell RH, Jenkinson EJ, Owen JJ.

J Immunol. 1996 Jun 1;156(11):4083-91.

PMID:
8666773
42.
43.

Thyroid-stimulating hormone rapidly stimulates inositol polyphosphate formation in FRTL-5 thyrocytes without activating phosphoinositidase C.

Singh J, Hunt P, Eggo MC, Sheppard MC, Kirk CJ, Michell RH.

Biochem J. 1996 May 15;316 ( Pt 1):175-82.

44.

Synthesis and iron binding studies of myo-inositol 1,2,3-trisphosphate and (+/-)-myo-inositol 1,2-bisphosphate, and iron binding studies of all myo-inositol tetrakisphosphates.

Spiers ID, Barker CJ, Chung SK, Chang YT, Freeman S, Gardiner JM, Hirst PH, Lambert PA, Michell RH, Poyner DR, Schwalbe CH, Smith AW, Solomons KR.

Carbohydr Res. 1996 Feb 28;282(1):81-99.

PMID:
8721738
45.

Inositol lipid-mediated signalling in response to endothelin and ATP in the mammalian testis.

Rudge SA, Hughes PJ, Brown GR, Michell RH, Kirk CJ.

Mol Cell Biochem. 1995 Aug-Sep;149-150:161-74.

PMID:
8569725
46.
47.

Regulation of neurite outgrowth from differentiated human neuroepithelial cells: a comparison of the activities of prothrombin and thrombin.

Turnell AS, Brant DP, Brown GR, Finney M, Gallimore PH, Kirk CJ, Pagliuca TR, Campbell CJ, Michell RH, Grand RJ.

Biochem J. 1995 Jun 15;308 ( Pt 3):965-73.

48.

Altered T lymphocyte signaling in rheumatoid arthritis.

Allen ME, Young SP, Michell RH, Bacon PA.

Eur J Immunol. 1995 Jun;25(6):1547-54.

PMID:
7614981
49.

The involvement of inositol lipids and phosphates in signalling in the fission yeast Schizosaccharomyces pombe.

Stuart JA, Hughes PJ, Kirk CJ, Davey J, Michell RH.

Biochem Soc Trans. 1995 May;23(2):223S. No abstract available.

PMID:
7672243
50.

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