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Pharmacologic Inhibition of Epidermal Growth Factor Receptor Suppresses Nonalcoholic Fatty Liver Disease in a Murine Fast-Food Diet Model.

Bhushan B, Banerjee S, Paranjpe S, Koral K, Mars WM, Stoops JW, Orr A, Bowen WC, Locker J, Michalopoulos GK.

Hepatology. 2019 May 7. doi: 10.1002/hep.30696. [Epub ahead of print]


A Noncanonical Role for Plasminogen Activator Inhibitor Type 1 in Obesity-Induced Diabetes.

Coudriet GM, Stoops J, Orr AV, Bhushan B, Koral K, Lee S, Previte DM, Dong HH, Michalopoulos GK, Mars WM, Piganelli JD.

Am J Pathol. 2019 Jul;189(7):1413-1422. doi: 10.1016/j.ajpath.2019.04.004. Epub 2019 May 2.


Lymphocyte-Specific Protein-1 Controls Sorafenib Sensitivity and Hepatocellular Proliferation through Extracellular Signal-Regulated Kinase 1/2 Activation.

Koral K, Haynes M, Bowen WC, Orr A, Mars W, Michalopoulos GK.

Am J Pathol. 2018 Sep;188(9):2074-2086. doi: 10.1016/j.ajpath.2018.06.005. Epub 2018 Jul 3.


Combined Systemic Disruption of MET and Epidermal Growth Factor Receptor Signaling Causes Liver Failure in Normal Mice.

Tsagianni A, Mars WM, Bhushan B, Bowen WC, Orr A, Stoops J, Paranjpe S, Tseng GC, Liu S, Michalopoulos GK.

Am J Pathol. 2018 Oct;188(10):2223-2235. doi: 10.1016/j.ajpath.2018.06.009. Epub 2018 Jul 20.


The Regenerative Altruism of Hepatocytes and Cholangiocytes.

Michalopoulos GK.

Cell Stem Cell. 2018 Jul 5;23(1):11-12. doi: 10.1016/j.stem.2018.06.006.


TCPOBOP-Induced Hepatomegaly and Hepatocyte Proliferation are Attenuated by Combined Disruption of MET and EGFR Signaling.

Bhushan B, Stoops JW, Mars WM, Orr A, Bowen WC, Paranjpe S, Michalopoulos GK.

Hepatology. 2019 Apr;69(4):1702-1718. doi: 10.1002/hep.30109. Epub 2018 Dec 31.


Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis.

Yokota S, Ono Y, Nakao T, Zhang P, Michalopoulos GK, Khan Z.

J Vis Exp. 2018 Mar 28;(133). doi: 10.3791/56930.


Hepatitis C Virus Mimics Effects of Glypican-3 on CD81 and Promotes Development of Hepatocellular Carcinomas via Activation of Hippo Pathway in Hepatocytes.

Xue Y, Mars WM, Bowen W, Singhi AD, Stoops J, Michalopoulos GK.

Am J Pathol. 2018 Jun;188(6):1469-1477. doi: 10.1016/j.ajpath.2018.02.013. Epub 2018 Mar 22.


Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice.

Chartoumpekis DV, Yagishita Y, Fazzari M, Palliyaguru DL, Rao UN, Zaravinos A, Khoo NK, Schopfer FJ, Weiss KR, Michalopoulos GK, Sipula I, O'Doherty RM, Kensler TW, Wakabayashi N.

JCI Insight. 2018 Mar 8;3(5). pii: 97735. doi: 10.1172/jci.insight.97735.


Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice.

Chartoumpekis DV, Palliyaguru DL, Wakabayashi N, Fazzari M, Khoo NKH, Schopfer FJ, Sipula I, Yagishita Y, Michalopoulos GK, O'Doherty RM, Kensler TW.

Am J Physiol Endocrinol Metab. 2018 Aug 1;315(2):E180-E195. doi: 10.1152/ajpendo.00311.2017. Epub 2018 Feb 27.


Oct4 Is Crucial for Transdifferentiation of Hepatocytes to Biliary Epithelial Cells in an In Vitro Organoid Culture Model.

Doffou M, Adams G, Bowen WC, Paranjpe S, Parihar HS, Nguyen H, Michalopoulos GK, Bhave VS.

Gene Expr. 2018 Mar 21;18(1):51-62. doi: 10.3727/105221617X15124876321401. Epub 2017 Dec 6.


Targeting genomic rearrangements in tumor cells through Cas9-mediated insertion of a suicide gene.

Chen ZH, Yu YP, Zuo ZH, Nelson JB, Michalopoulos GK, Monga S, Liu S, Tseng G, Luo JH.

Nat Biotechnol. 2017 Jun;35(6):543-550. doi: 10.1038/nbt.3843. Epub 2017 May 1.


Immunohistochemical Analysis of the Stem Cell Marker LGR5 in Pediatric Liver Disease.

Khan Z, Orr A, Michalopoulos GK, Ranganathan S.

Pediatr Dev Pathol. 2017 Jan-Feb;20(1):16-27. doi: 10.1177/1093526616686244.


MAN2A1-FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice.

Chen ZH, Yu YP, Tao J, Liu S, Tseng G, Nalesnik M, Hamilton R, Bhargava R, Nelson JB, Pennathur A, Monga SP, Luketich JD, Michalopoulos GK, Luo JH.

Gastroenterology. 2017 Oct;153(4):1120-1132.e15. doi: 10.1053/j.gastro.2016.12.036. Epub 2017 Feb 27.


Hepatostat: Liver regeneration and normal liver tissue maintenance.

Michalopoulos GK.

Hepatology. 2017 Apr;65(4):1384-1392. doi: 10.1002/hep.28988. Epub 2017 Mar 6. Review.


Bile Duct Ligation Induces ATZ Globule Clearance in a Mouse Model of α-1 Antitrypsin Deficiency.

Khan Z, Yokota S, Ono Y, Bell AW, Oertel M, Stolz DB, Michalopoulos GK.

Gene Expr. 2017 Feb 10;17(2):115-127. doi: 10.3727/105221616X692991. Epub 2016 Aug 18.


Combined systemic elimination of MET and epidermal growth factor receptor signaling completely abolishes liver regeneration and leads to liver decompensation.

Paranjpe S, Bowen WC, Mars WM, Orr A, Haynes MM, DeFrances MC, Liu S, Tseng GC, Tsagianni A, Michalopoulos GK.

Hepatology. 2016 Nov;64(5):1711-1724. doi: 10.1002/hep.28721. Epub 2016 Oct 1.


Gene Expression Analysis Indicates Divergent Mechanisms in DEN-Induced Carcinogenesis in Wild Type and Bid-Deficient Livers.

Yu C, Yan S, Khambu B, Chen X, Dong Z, Luo J, Michalopoulos GK, Wu S, Yin XM.

PLoS One. 2016 May 19;11(5):e0155211. doi: 10.1371/journal.pone.0155211. eCollection 2016.


Liver-Specific Deletion of Integrin-Linked Kinase in Mice Attenuates Hepatotoxicity and Improves Liver Regeneration After Acetaminophen Overdose.

Bhushan B, Edwards G, Desai A, Michalopoulos GK, Apte U.

Gene Expr. 2016;17(1):35-45. doi: 10.3727/105221616X691578. Epub 2016 Apr 27.


Liver Stem Cells: Experimental Findings and Implications for Human Liver Disease.

Michalopoulos GK, Khan Z.

Gastroenterology. 2015 Oct;149(4):876-882. doi: 10.1053/j.gastro.2015.08.004. Epub 2015 Aug 14. Review.


Tissue-type plasminogen activator suppresses activated stellate cells through low-density lipoprotein receptor-related protein 1.

Kang LI, Isse K, Koral K, Bowen WC, Muratoglu S, Strickland DK, Michalopoulos GK, Mars WM.

Lab Invest. 2015 Oct;95(10):1117-29. doi: 10.1038/labinvest.2015.94. Epub 2015 Aug 3.


Novel fusion transcripts associate with progressive prostate cancer.

Yu YP, Ding Y, Chen Z, Liu S, Michalopoulos A, Chen R, Gulzar ZG, Yang B, Cieply KM, Luvison A, Ren BG, Brooks JD, Jarrard D, Nelson JB, Michalopoulos GK, Tseng GC, Luo JH.

Am J Pathol. 2014 Oct;184(10):2840-9. doi: 10.1016/j.ajpath.2014.06.025.


Leukocyte-specific protein 1: a novel regulator of hepatocellular proliferation and migration deleted in human hepatocellular carcinoma.

Koral K, Paranjpe S, Bowen WC, Mars W, Luo J, Michalopoulos GK.

Hepatology. 2015 Feb;61(2):537-47. doi: 10.1002/hep.27444. Epub 2014 Dec 24.


Advances in liver regeneration.

Michalopoulos GK.

Expert Rev Gastroenterol Hepatol. 2014 Nov;8(8):897-907. doi: 10.1586/17474124.2014.934358. Epub 2014 Jun 26. Review.


Synthesis of IL-6 by hepatocytes is a normal response to common hepatic stimuli.

Norris CA, He M, Kang LI, Ding MQ, Radder JE, Haynes MM, Yang Y, Paranjpe S, Bowen WC, Orr A, Michalopoulos GK, Stolz DB, Mars WM.

PLoS One. 2014 Apr 24;9(4):e96053. doi: 10.1371/journal.pone.0096053. eCollection 2014.


Development of a chemically defined medium and discovery of new mitogenic growth factors for mouse hepatocytes: mitogenic effects of FGF1/2 and PDGF.

Bowen WC, Michalopoulos AW, Orr A, Ding MQ, Stolz DB, Michalopoulos GK.

PLoS One. 2014 Apr 17;9(4):e95487. doi: 10.1371/journal.pone.0095487. eCollection 2014.


NRF2, not always friendly but perhaps misunderstood.

Michalopoulos GK.

Hepatology. 2014 Aug;60(2):461-3. doi: 10.1002/hep.27090. Epub 2014 Jun 18. No abstract available.


The liver is a peculiar organ when it comes to stem cells.

Michalopoulos GK.

Am J Pathol. 2014 May;184(5):1263-7. doi: 10.1016/j.ajpath.2014.02.020. Epub 2014 Mar 27.


The degree of segmental aneuploidy measured by total copy number abnormalities predicts survival and recurrence in superficial gastroesophageal adenocarcinoma.

Davison JM, Yee M, Krill-Burger JM, Lyons-Weiler MA, Kelly LA, Sciulli CM, Nason KS, Luketich JD, Michalopoulos GK, LaFramboise WA.

PLoS One. 2014 Jan 16;9(1):e79079. doi: 10.1371/journal.pone.0079079. eCollection 2014.


Role of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesis.

Donthamsetty S, Bhave VS, Mars WM, Bowen WC, Orr A, Haynes MM, Wu C, Michalopoulos GK.

PLoS One. 2013 Sep 18;8(9):e74625. doi: 10.1371/journal.pone.0074625. eCollection 2013.


Assessing the potential of induced liver regeneration.

Michalopoulos GK, Grompe M, Theise ND.

Nat Med. 2013 Sep;19(9):1096-7. doi: 10.1038/nm.3325. No abstract available.


Principles of liver regeneration and growth homeostasis.

Michalopoulos GK.

Compr Physiol. 2013 Jan;3(1):485-513. doi: 10.1002/cphy.c120014. Review.


Regulation of liver growth by glypican 3, CD81, hedgehog, and Hhex.

Bhave VS, Mars W, Donthamsetty S, Zhang X, Tan L, Luo J, Bowen WC, Michalopoulos GK.

Am J Pathol. 2013 Jul;183(1):153-9. doi: 10.1016/j.ajpath.2013.03.013. Epub 2013 May 8.


Gliotoxin-induced changes in rat liver regeneration after partial hepatectomy.

Nejak-Bowen KN, Orr AV, Bowen WC Jr, Michalopoulos GK.

Liver Int. 2013 Aug;33(7):1044-55. doi: 10.1111/liv.12164. Epub 2013 Apr 1.


Conditional genetic elimination of hepatocyte growth factor in mice compromises liver regeneration after partial hepatectomy.

Nejak-Bowen K, Orr A, Bowen WC Jr, Michalopoulos GK.

PLoS One. 2013;8(3):e59836. doi: 10.1371/journal.pone.0059836. Epub 2013 Mar 20.


Growth factor pathways in development and progression of hepatocellular carcinoma.

Nalesnik MA, Michalopoulos GK.

Front Biosci (Schol Ed). 2012 Jun 1;4:1487-515. Review.


Phenotypic fidelity (or not?) of epithelial cells in the liver.

Michalopoulos GK.

Hepatology. 2012 Jun;55(6):2024-7. doi: 10.1002/hep.25703. No abstract available.


Gene deletions and amplifications in human hepatocellular carcinomas: correlation with hepatocyte growth regulation.

Nalesnik MA, Tseng G, Ding Y, Xiang GS, Zheng ZL, Yu Y, Marsh JW, Michalopoulos GK, Luo JH.

Am J Pathol. 2012 Apr;180(4):1495-508. doi: 10.1016/j.ajpath.2011.12.021. Epub 2012 Feb 8.


Signals and cells involved in regulating liver regeneration.

Kang LI, Mars WM, Michalopoulos GK.

Cells. 2012 Dec 13;1(4):1261-92. doi: 10.3390/cells1041261.


Protection against Fas-induced fulminant hepatic failure in liver specific integrin linked kinase knockout mice.

Donthamsetty S, Mars WM, Orr A, Wu C, Michalopoulos GK.

Comp Hepatol. 2011 Nov 21;10:11. doi: 10.1186/1476-5926-10-11.


A mouse model of accelerated liver aging caused by a defect in DNA repair.

Gregg SQ, Gutiérrez V, Robinson AR, Woodell T, Nakao A, Ross MA, Michalopoulos GK, Rigatti L, Rothermel CE, Kamileri I, Garinis GA, Stolz DB, Niedernhofer LJ.

Hepatology. 2012 Feb;55(2):609-21. doi: 10.1002/hep.24713.


Genes inducing iPS phenotype play a role in hepatocyte survival and proliferation in vitro and liver regeneration in vivo.

Bhave VS, Paranjpe S, Bowen WC, Donthamsetty S, Bell AW, Khillan JS, Michalopoulos GK.

Hepatology. 2011 Oct;54(4):1360-70. doi: 10.1002/hep.24507. Epub 2011 Aug 24.


Hepatocyte proliferation and hepatomegaly induced by phenobarbital and 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene is suppressed in hepatocyte-targeted glypican 3 transgenic mice.

Lin CW, Mars WM, Paranjpe S, Donthamsetty S, Bhave VS, Kang LI, Orr A, Bowen WC, Bell AW, Michalopoulos GK.

Hepatology. 2011 Aug;54(2):620-30. doi: 10.1002/hep.24417. Erratum in: Hepatology. 2014 Sep;60(3):1116.


Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene.

Donthamsetty S, Bhave VS, Kliment CS, Bowen WC, Mars WM, Bell AW, Stewart RE, Orr A, Wu C, Michalopoulos GK.

Hepatology. 2011 Feb;53(2):587-95. doi: 10.1002/hep.24040. Epub 2011 Jan 6. Erratum in: Hepatology. 2014 Aug;60(2):771.


Suppression of liver regeneration and hepatocyte proliferation in hepatocyte-targeted glypican 3 transgenic mice.

Liu B, Bell AW, Paranjpe S, Bowen WC, Khillan JS, Luo JH, Mars WM, Michalopoulos GK.

Hepatology. 2010 Sep;52(3):1060-7. doi: 10.1002/hep.23794.


Bid agonist regulates murine hepatocyte proliferation by controlling endoplasmic reticulum calcium homeostasis.

Ni HM, Baty CJ, Li N, Ding WX, Gao W, Li M, Chen X, Ma J, Michalopoulos GK, Yin XM.

Hepatology. 2010 Jul;52(1):338-48. doi: 10.1002/hep.23672.


Interaction of integrin-linked kinase and miniature chromosome maintenance 7-mediating integrin {alpha}7 induced cell growth suppression.

Han YC, Yu YP, Nelson J, Wu C, Wang H, Michalopoulos GK, Luo JH.

Cancer Res. 2010 Jun 1;70(11):4375-84. doi: 10.1158/0008-5472.CAN-09-4403. Epub 2010 May 11.

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