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Correction: Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli.

Norris CA, He M, Kang LI, Ding MQ, Radder JE, Haynes MM, Yang Y, Paranjpe S, Bowen WC, Orr A, Michalopoulos GK, Stolz DB, Mars WM.

PLoS One. 2019 Oct 23;14(10):e0224498. doi: 10.1371/journal.pone.0224498. eCollection 2019.


Novel potential biomarkers for the diagnosis and monitoring of patients with ulcerative colitis.

Kourkoulis P, Kapizioni C, Michalopoulos G, Andreou NP, Papaconstantinou I, Karamanolis G, Gazouli M.

Eur J Gastroenterol Hepatol. 2019 Oct;31(10):1173-1183. doi: 10.1097/MEG.0000000000001490.


Optimal duration of concomitant nonbismuth quadruple therapy as first-line therapy for Helicobacter pylori: a prospective, open-label, comparative study.

Kapizioni C, Koutoufaris G, Ntouli V, Makris K, Milioni K, Kourkoulis P, Giannelis P, Mellos A, Michalopoulos G, Vrakas S, Xourgias V.

Eur J Gastroenterol Hepatol. 2019 Oct;31(10):1206-1210. doi: 10.1097/MEG.0000000000001517.


Is Ustekinumab the best treatment option in patients with Crohn's disease and coexistent multiple sclerosis?

Kapizioni C, Makris K, Kourkoulis P, Vrakas S, Michalopoulos G.

Acta Gastroenterol Belg. 2019 Apr-Jun;82(2):337. No abstract available.


Detection of fusion transcripts in the serum samples of patients with hepatocellular carcinoma.

Yu YP, Tsung A, Liu S, Nalesnick M, Geller D, Michalopoulos G, Luo JH.

Oncotarget. 2019 May 21;10(36):3352-3360. eCollection 2019 May 21.


Pharmacologic Inhibition of Epidermal Growth Factor Receptor Suppresses Nonalcoholic Fatty Liver Disease in a Murine Fast-Food Diet Model.

Bhushan B, Banerjee S, Paranjpe S, Koral K, Mars WM, Stoops JW, Orr A, Bowen WC, Locker J, Michalopoulos GK.

Hepatology. 2019 Nov;70(5):1546-1563. doi: 10.1002/hep.30696. Epub 2019 Jun 19.


A Noncanonical Role for Plasminogen Activator Inhibitor Type 1 in Obesity-Induced Diabetes.

Coudriet GM, Stoops J, Orr AV, Bhushan B, Koral K, Lee S, Previte DM, Dong HH, Michalopoulos GK, Mars WM, Piganelli JD.

Am J Pathol. 2019 Jul;189(7):1413-1422. doi: 10.1016/j.ajpath.2019.04.004. Epub 2019 May 2.


Increased Reactivity of the Mesolimbic Reward System after Ketamine Injection in Patients with Treatment-resistant Major Depressive Disorder.

Sterpenich V, Vidal S, Hofmeister J, Michalopoulos G, Bancila V, Warrot D, Dayer A, Desseilles M, Aubry JM, Kosel M, Schwartz S, Vutskits L.

Anesthesiology. 2019 Jun;130(6):923-935. doi: 10.1097/ALN.0000000000002667.


Concomitant cholecystectomy during bariatric surgery: The jury is still out.

Doulamis IP, Michalopoulos G, Boikou V, Schizas D, Spartalis E, Menenakos E, Economopoulos KP.

Am J Surg. 2019 Aug;218(2):401-410. doi: 10.1016/j.amjsurg.2019.02.006. Epub 2019 Feb 12. Review.


Identification of recurrent fusion genes across multiple cancer types.

Yu YP, Liu P, Nelson J, Hamilton RL, Bhargava R, Michalopoulos G, Chen Q, Zhang J, Ma D, Pennathur A, Luketich J, Nalesnik M, Tseng G, Luo JH.

Sci Rep. 2019 Jan 31;9(1):1074. doi: 10.1038/s41598-019-38550-6.


Efficacy and Safety of a Rapid Intravenous Injection of Ketamine 0.5 mg/kg in Treatment-Resistant Major Depression: An Open 4-Week Longitudinal Study.

Vidal S, Gex-Fabry M, Bancila V, Michalopoulos G, Warrot D, Jermann F, Dayer A, Sterpenich V, Schwartz S, Vutskits L, Khan N, Aubry JM, Kosel M.

J Clin Psychopharmacol. 2018 Dec;38(6):590-597. doi: 10.1097/JCP.0000000000000960.


Lymphocyte-Specific Protein-1 Controls Sorafenib Sensitivity and Hepatocellular Proliferation through Extracellular Signal-Regulated Kinase 1/2 Activation.

Koral K, Haynes M, Bowen WC, Orr A, Mars W, Michalopoulos GK.

Am J Pathol. 2018 Sep;188(9):2074-2086. doi: 10.1016/j.ajpath.2018.06.005. Epub 2018 Jul 3.


Combined Systemic Disruption of MET and Epidermal Growth Factor Receptor Signaling Causes Liver Failure in Normal Mice.

Tsagianni A, Mars WM, Bhushan B, Bowen WC, Orr A, Stoops J, Paranjpe S, Tseng GC, Liu S, Michalopoulos GK.

Am J Pathol. 2018 Oct;188(10):2223-2235. doi: 10.1016/j.ajpath.2018.06.009. Epub 2018 Jul 20.


The Regenerative Altruism of Hepatocytes and Cholangiocytes.

Michalopoulos GK.

Cell Stem Cell. 2018 Jul 5;23(1):11-12. doi: 10.1016/j.stem.2018.06.006.


TCPOBOP-Induced Hepatomegaly and Hepatocyte Proliferation are Attenuated by Combined Disruption of MET and EGFR Signaling.

Bhushan B, Stoops JW, Mars WM, Orr A, Bowen WC, Paranjpe S, Michalopoulos GK.

Hepatology. 2019 Apr;69(4):1702-1718. doi: 10.1002/hep.30109. Epub 2018 Dec 31.


Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis.

Yokota S, Ono Y, Nakao T, Zhang P, Michalopoulos GK, Khan Z.

J Vis Exp. 2018 Mar 28;(133). doi: 10.3791/56930.


Hepatitis C Virus Mimics Effects of Glypican-3 on CD81 and Promotes Development of Hepatocellular Carcinomas via Activation of Hippo Pathway in Hepatocytes.

Xue Y, Mars WM, Bowen W, Singhi AD, Stoops J, Michalopoulos GK.

Am J Pathol. 2018 Jun;188(6):1469-1477. doi: 10.1016/j.ajpath.2018.02.013. Epub 2018 Mar 22.


Phenotypic Assessment of Drug Metabolic Pathways and P-Glycoprotein in Patients Treated With Antidepressants in an Ambulatory Setting.

Lloret-Linares C, Bosilkovska M, Daali Y, Gex-Fabry M, Heron K, Bancila V, Michalopoulos G, Perroud N, Richard-Lepouriel H, Aubry JM, Desmeules J, Besson M.

J Clin Psychiatry. 2018 Mar/Apr;79(2). pii: 16m11387. doi: 10.4088/JCP.16m11387.


Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice.

Chartoumpekis DV, Yagishita Y, Fazzari M, Palliyaguru DL, Rao UN, Zaravinos A, Khoo NK, Schopfer FJ, Weiss KR, Michalopoulos GK, Sipula I, O'Doherty RM, Kensler TW, Wakabayashi N.

JCI Insight. 2018 Mar 8;3(5). pii: 97735. doi: 10.1172/jci.insight.97735.


Association of sleep quality and mucosal healing in patients with inflammatory bowel disease in clinical remission.

Michalopoulos G, Vrakas S, Makris K, Tzathas C.

Ann Gastroenterol. 2018 Mar-Apr;31(2):211-216. doi: 10.20524/aog.2018.0227. Epub 2018 Jan 22.


Heart transplantation versus left ventricular assist devices as destination therapy or bridge to transplantation for 1-year mortality: a systematic review and meta-analysis.

Theochari CA, Michalopoulos G, Oikonomou EK, Giannopoulos S, Doulamis IP, Villela MA, Kokkinidis DG.

Ann Cardiothorac Surg. 2018 Jan;7(1):3-11. doi: 10.21037/acs.2017.09.18. Review.


Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice.

Chartoumpekis DV, Palliyaguru DL, Wakabayashi N, Fazzari M, Khoo NKH, Schopfer FJ, Sipula I, Yagishita Y, Michalopoulos GK, O'Doherty RM, Kensler TW.

Am J Physiol Endocrinol Metab. 2018 Aug 1;315(2):E180-E195. doi: 10.1152/ajpendo.00311.2017. Epub 2018 Feb 27.


Oct4 Is Crucial for Transdifferentiation of Hepatocytes to Biliary Epithelial Cells in an In Vitro Organoid Culture Model.

Doffou M, Adams G, Bowen WC, Paranjpe S, Parihar HS, Nguyen H, Michalopoulos GK, Bhave VS.

Gene Expr. 2018 Mar 21;18(1):51-62. doi: 10.3727/105221617X15124876321401. Epub 2017 Dec 6.


MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock.

Kader M, Alaoui-El-Azher M, Vorhauer J, Kode BB, Wells JZ, Stolz D, Michalopoulos G, Wells A, Scott M, Ismail N.

PLoS Pathog. 2017 Oct 19;13(10):e1006644. doi: 10.1371/journal.ppat.1006644. eCollection 2017 Oct.


Targeting genomic rearrangements in tumor cells through Cas9-mediated insertion of a suicide gene.

Chen ZH, Yu YP, Zuo ZH, Nelson JB, Michalopoulos GK, Monga S, Liu S, Tseng G, Luo JH.

Nat Biotechnol. 2017 Jun;35(6):543-550. doi: 10.1038/nbt.3843. Epub 2017 May 1.


Immunohistochemical Analysis of the Stem Cell Marker LGR5 in Pediatric Liver Disease.

Khan Z, Orr A, Michalopoulos GK, Ranganathan S.

Pediatr Dev Pathol. 2017 Jan-Feb;20(1):16-27. doi: 10.1177/1093526616686244.


MAN2A1-FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice.

Chen ZH, Yu YP, Tao J, Liu S, Tseng G, Nalesnik M, Hamilton R, Bhargava R, Nelson JB, Pennathur A, Monga SP, Luketich JD, Michalopoulos GK, Luo JH.

Gastroenterology. 2017 Oct;153(4):1120-1132.e15. doi: 10.1053/j.gastro.2016.12.036. Epub 2017 Feb 27.


Intestinal Bacteria Composition and Translocation of Bacteria in Inflammatory Bowel Disease.

Vrakas S, Mountzouris KC, Michalopoulos G, Karamanolis G, Papatheodoridis G, Tzathas C, Gazouli M.

PLoS One. 2017 Jan 18;12(1):e0170034. doi: 10.1371/journal.pone.0170034. eCollection 2017.


Eltrombopag, a thrombopoietin mimetic, crosses the blood-brain barrier and impairs iron-dependent hippocampal neuron dendrite development.

Bastian TW, Duck KA, Michalopoulos GC, Chen MJ, Liu ZJ, Connor JR, Lanier LM, Sola-Visner MC, Georgieff MK.

J Thromb Haemost. 2017 Mar;15(3):565-574. doi: 10.1111/jth.13602. Epub 2017 Feb 16.


Hepatostat: Liver regeneration and normal liver tissue maintenance.

Michalopoulos GK.

Hepatology. 2017 Apr;65(4):1384-1392. doi: 10.1002/hep.28988. Epub 2017 Mar 6. Review.


Bile Duct Ligation Induces ATZ Globule Clearance in a Mouse Model of α-1 Antitrypsin Deficiency.

Khan Z, Yokota S, Ono Y, Bell AW, Oertel M, Stolz DB, Michalopoulos GK.

Gene Expr. 2017 Feb 10;17(2):115-127. doi: 10.3727/105221616X692991. Epub 2016 Aug 18.


Combined systemic elimination of MET and epidermal growth factor receptor signaling completely abolishes liver regeneration and leads to liver decompensation.

Paranjpe S, Bowen WC, Mars WM, Orr A, Haynes MM, DeFrances MC, Liu S, Tseng GC, Tsagianni A, Michalopoulos GK.

Hepatology. 2016 Nov;64(5):1711-1724. doi: 10.1002/hep.28721. Epub 2016 Oct 1.


Gene Expression Analysis Indicates Divergent Mechanisms in DEN-Induced Carcinogenesis in Wild Type and Bid-Deficient Livers.

Yu C, Yan S, Khambu B, Chen X, Dong Z, Luo J, Michalopoulos GK, Wu S, Yin XM.

PLoS One. 2016 May 19;11(5):e0155211. doi: 10.1371/journal.pone.0155211. eCollection 2016.


Liver-Specific Deletion of Integrin-Linked Kinase in Mice Attenuates Hepatotoxicity and Improves Liver Regeneration After Acetaminophen Overdose.

Bhushan B, Edwards G, Desai A, Michalopoulos GK, Apte U.

Gene Expr. 2016;17(1):35-45. doi: 10.3727/105221616X691578. Epub 2016 Apr 27.


Liver Stem Cells: Experimental Findings and Implications for Human Liver Disease.

Michalopoulos GK, Khan Z.

Gastroenterology. 2015 Oct;149(4):876-882. doi: 10.1053/j.gastro.2015.08.004. Epub 2015 Aug 14. Review.


Tissue-type plasminogen activator suppresses activated stellate cells through low-density lipoprotein receptor-related protein 1.

Kang LI, Isse K, Koral K, Bowen WC, Muratoglu S, Strickland DK, Michalopoulos GK, Mars WM.

Lab Invest. 2015 Oct;95(10):1117-29. doi: 10.1038/labinvest.2015.94. Epub 2015 Aug 3.


Systemic lupus erythematosus in Crohn's disease: drug-induced or idiopathic?

Michalopoulos G, Vrakas S, Makris K, Tzathas C.

Ann Gastroenterol. 2015 Jul-Sep;28(3):408-409.


Tregs: A Therapeutic Target for the Treatment of Portal Fibrosis?

Xue Y, Michalopoulos G.

Dig Dis Sci. 2015 Jul;60(7):1878-80. doi: 10.1007/s10620-015-3687-8. Epub 2015 May 14. No abstract available.


Sessile serrated adenomas versus conventional adenomas. Different polyps in different populations?

Michalopoulos G, Vrakas S, Ntouli V, Lamprinakos S, Makris K, Tzathas C.

Indian J Gastroenterol. 2015 May;34(3):245-51. doi: 10.1007/s12664-015-0562-7. Epub 2015 Apr 29.


Liver preservation with machine perfusion and a newly developed cell-free oxygen carrier solution under subnormothermic conditions.

Fontes P, Lopez R, van der Plaats A, Vodovotz Y, Minervini M, Scott V, Soltys K, Shiva S, Paranjpe S, Sadowsky D, Barclay D, Zamora R, Stolz D, Demetris A, Michalopoulos G, Marsh JW.

Am J Transplant. 2015 Feb;15(2):381-94.


The DNA replication licensing factor miniature chromosome maintenance 7 is essential for RNA splicing of epidermal growth factor receptor, c-Met, and platelet-derived growth factor receptor.

Chen ZH, Yu YP, Michalopoulos G, Nelson J, Luo JH.

J Biol Chem. 2015 Jan 16;290(3):1404-11. doi: 10.1074/jbc.M114.622761. Epub 2014 Nov 25.


Novel fusion transcripts associate with progressive prostate cancer.

Yu YP, Ding Y, Chen Z, Liu S, Michalopoulos A, Chen R, Gulzar ZG, Yang B, Cieply KM, Luvison A, Ren BG, Brooks JD, Jarrard D, Nelson JB, Michalopoulos GK, Tseng GC, Luo JH.

Am J Pathol. 2014 Oct;184(10):2840-9. doi: 10.1016/j.ajpath.2014.06.025.


Leukocyte-specific protein 1: a novel regulator of hepatocellular proliferation and migration deleted in human hepatocellular carcinoma.

Koral K, Paranjpe S, Bowen WC, Mars W, Luo J, Michalopoulos GK.

Hepatology. 2015 Feb;61(2):537-47. doi: 10.1002/hep.27444. Epub 2014 Dec 24.


Comorbidity between attention deficit hyperactivity disorder (ADHD) and bipolar disorder in a specialized mood disorders outpatient clinic.

Perroud N, Cordera P, Zimmermann J, Michalopoulos G, Bancila V, Prada P, Dayer A, Aubry JM.

J Affect Disord. 2014 Oct;168:161-6. doi: 10.1016/j.jad.2014.06.053. Epub 2014 Jul 9.


Advances in liver regeneration.

Michalopoulos GK.

Expert Rev Gastroenterol Hepatol. 2014 Nov;8(8):897-907. doi: 10.1586/17474124.2014.934358. Epub 2014 Jun 26. Review.


CYP2E1 immunoglobulin G4 subclass antibodies after desflurane anesthesia.

Batistaki C, Michalopoulos G, Matsota P, Nomikos T, Kalimeris K, Riga M, Nakou M, Kostopanagiotou G.

World J Hepatol. 2014 May 27;6(5):340-6. doi: 10.4254/wjh.v6.i5.340.


Synthesis of IL-6 by hepatocytes is a normal response to common hepatic stimuli.

Norris CA, He M, Kang LI, Ding MQ, Radder JE, Haynes MM, Yang Y, Paranjpe S, Bowen WC, Orr A, Michalopoulos GK, Stolz DB, Mars WM.

PLoS One. 2014 Apr 24;9(4):e96053. doi: 10.1371/journal.pone.0096053. eCollection 2014. Erratum in: PLoS One. 2019 Oct 23;14(10):e0224498.


Development of a chemically defined medium and discovery of new mitogenic growth factors for mouse hepatocytes: mitogenic effects of FGF1/2 and PDGF.

Bowen WC, Michalopoulos AW, Orr A, Ding MQ, Stolz DB, Michalopoulos GK.

PLoS One. 2014 Apr 17;9(4):e95487. doi: 10.1371/journal.pone.0095487. eCollection 2014.


NRF2, not always friendly but perhaps misunderstood.

Michalopoulos GK.

Hepatology. 2014 Aug;60(2):461-3. doi: 10.1002/hep.27090. Epub 2014 Jun 18. No abstract available.


The liver is a peculiar organ when it comes to stem cells.

Michalopoulos GK.

Am J Pathol. 2014 May;184(5):1263-7. doi: 10.1016/j.ajpath.2014.02.020. Epub 2014 Mar 27.

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