Sort by
Items per page

Send to

Choose Destination

Search results

Items: 27


The mammary stem cell field wakes up to hibernating cells.

Michalak EM.

Stem Cell Investig. 2017 May 26;4:45. doi: 10.21037/sci.2017.04.08. eCollection 2017. No abstract available.


Dysregulation of histone methyltransferases in breast cancer - Opportunities for new targeted therapies?

Michalak EM, Visvader JE.

Mol Oncol. 2016 Dec;10(10):1497-1515. doi: 10.1016/j.molonc.2016.09.003. Epub 2016 Sep 23. Review.


Using the GEMM-ESC strategy to study gene function in mouse models.

Huijbers IJ, Del Bravo J, Bin Ali R, Pritchard C, Braumuller TM, van Miltenburg MH, Henneman L, Michalak EM, Berns A, Jonkers J.

Nat Protoc. 2015 Nov;10(11):1755-85. doi: 10.1038/nprot.2015.114. Epub 2015 Oct 15.


Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer.

Henneman L, van Miltenburg MH, Michalak EM, Braumuller TM, Jaspers JE, Drenth AP, de Korte-Grimmerink R, Gogola E, Szuhai K, Schlicker A, Bin Ali R, Pritchard C, Huijbers IJ, Berns A, Rottenberg S, Jonkers J.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8409-14. doi: 10.1073/pnas.1500223112. Epub 2015 Jun 22.


Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells.

Huijbers IJ, Bin Ali R, Pritchard C, Cozijnsen M, Kwon MC, Proost N, Song JY, de Vries H, Badhai J, Sutherland K, Krimpenfort P, Michalak EM, Jonkers J, Berns A.

EMBO Mol Med. 2014 Feb;6(2):212-25. doi: 10.1002/emmm.201303297. Epub 2014 Jan 8.


Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice.

Meynet O, Zunino B, Happo L, Pradelli LA, Chiche J, Jacquin MA, Mondragón L, Tanti JF, Taillan B, Garnier G, Reverso-Meinietti J, Mounier N, Michiels JF, Michalak EM, Carles M, Scott CL, Ricci JE.

Blood. 2013 Oct 3;122(14):2402-11. doi: 10.1182/blood-2013-01-478651. Epub 2013 Aug 21.


Polycomb group gene Ezh2 regulates mammary gland morphogenesis and maintains the luminal progenitor pool.

Michalak EM, Nacerddine K, Pietersen A, Beuger V, Pawlitzky I, Cornelissen-Steijger P, Wientjens E, Tanger E, Seibler J, van Lohuizen M, Jonkers J.

Stem Cells. 2013 Sep;31(9):1910-20. doi: 10.1002/stem.1437.


p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa.

Valente LJ, Gray DH, Michalak EM, Pinon-Hofbauer J, Egle A, Scott CL, Janic A, Strasser A.

Cell Rep. 2013 May 30;3(5):1339-45. doi: 10.1016/j.celrep.2013.04.012. Epub 2013 May 9.


Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas.

Spender LC, Carter MJ, O'Brien DI, Clark LJ, Yu J, Michalak EM, Happo L, Cragg MS, Inman GJ.

J Biol Chem. 2013 Feb 15;288(7):5198-209. doi: 10.1074/jbc.M112.410274. Epub 2012 Dec 14.


DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa.

Kerr JB, Hutt KJ, Michalak EM, Cook M, Vandenberg CJ, Liew SH, Bouillet P, Mills A, Scott CL, Findlay JK, Strasser A.

Mol Cell. 2012 Nov 9;48(3):343-52. doi: 10.1016/j.molcel.2012.08.017. Epub 2012 Sep 20.


Developmental stage-specific contribution of LGR5(+) cells to basal and luminal epithelial lineages in the postnatal mammary gland.

de Visser KE, Ciampricotti M, Michalak EM, Tan DW, Speksnijder EN, Hau CS, Clevers H, Barker N, Jonkers J.

J Pathol. 2012 Nov;228(3):300-9. doi: 10.1002/path.4096.


Studying therapy response and resistance in mouse models for BRCA1-deficient breast cancer.

Michalak EM, Jonkers J.

J Mammary Gland Biol Neoplasia. 2011 Apr;16(1):41-50. doi: 10.1007/s10911-011-9199-z. Epub 2011 Feb 18. Review.


Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim.

Happo L, Cragg MS, Phipson B, Haga JM, Jansen ES, Herold MJ, Dewson G, Michalak EM, Vandenberg CJ, Smyth GK, Strasser A, Cory S, Scott CL.

Blood. 2010 Dec 9;116(24):5256-67. doi: 10.1182/blood-2010-04-280818. Epub 2010 Sep 9.


Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death.

Michalak EM, Vandenberg CJ, Delbridge AR, Wu L, Scott CL, Adams JM, Strasser A.

Genes Dev. 2010 Aug 1;24(15):1608-13. doi: 10.1101/gad.1940110.


Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis.

Michalak EM, Jansen ES, Happo L, Cragg MS, Tai L, Smyth GK, Strasser A, Adams JM, Scott CL.

Cell Death Differ. 2009 May;16(5):684-96. doi: 10.1038/cdd.2008.195. Epub 2009 Jan 16.


In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute.

Michalak EM, Villunger A, Adams JM, Strasser A.

Cell Death Differ. 2008 Jun;15(6):1019-29. doi: 10.1038/cdd.2008.16. Epub 2008 Feb 8.


A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.

Lee EF, Czabotar PE, van Delft MF, Michalak EM, Boyle MJ, Willis SN, Puthalakath H, Bouillet P, Colman PM, Huang DC, Fairlie WD.

J Cell Biol. 2008 Jan 28;180(2):341-55. doi: 10.1083/jcb.200708096. Epub 2008 Jan 21.


Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.

Huntington ND, Puthalakath H, Gunn P, Naik E, Michalak EM, Smyth MJ, Tabarias H, Degli-Esposti MA, Dewson G, Willis SN, Motoyama N, Huang DC, Nutt SL, Tarlinton DM, Strasser A.

Nat Immunol. 2007 Aug;8(8):856-63. Epub 2007 Jul 8.


ER stress triggers apoptosis by activating BH3-only protein Bim.

Puthalakath H, O'Reilly LA, Gunn P, Lee L, Kelly PN, Huntington ND, Hughes PD, Michalak EM, McKimm-Breschkin J, Motoyama N, Gotoh T, Akira S, Bouillet P, Strasser A.

Cell. 2007 Jun 29;129(7):1337-49.


Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa.

Naik E, Michalak EM, Villunger A, Adams JM, Strasser A.

J Cell Biol. 2007 Feb 12;176(4):415-24. Epub 2007 Feb 5.


Subversion of the Bcl-2 life/death switch in cancer development and therapy.

Adams JM, Huang DC, Strasser A, Willis S, Chen L, Wei A, van Delft M, Fletcher JI, Puthalakath H, Kuroda J, Michalak EM, Kelly PN, Bouillet P, Villunger A, O'Reilly L, Bath ML, Smith DP, Egle A, Harris AW, Hinds M, Colman P, Cory S.

Cold Spring Harb Symp Quant Biol. 2005;70:469-77.


BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death.

Akhtar RS, Geng Y, Klocke BJ, Latham CB, Villunger A, Michalak EM, Strasser A, Carroll SL, Roth KA.

J Neurosci. 2006 Jul 5;26(27):7257-64.


Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma.

Ekert PG, Jabbour AM, Manoharan A, Heraud JE, Yu J, Pakusch M, Michalak EM, Kelly PN, Callus B, Kiefer T, Verhagen A, Silke J, Strasser A, Borner C, Vaux DL.

Blood. 2006 Sep 1;108(5):1461-8. Epub 2006 May 16. Erratum in: Blood. 2017 Oct 5;130(14 ):1684.


BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.

Erlacher M, Michalak EM, Kelly PN, Labi V, Niederegger H, Coultas L, Adams JM, Strasser A, Villunger A.

Blood. 2005 Dec 15;106(13):4131-8. Epub 2005 Aug 23.


Susceptibility of oral bacteria to Melaleuca alternifolia (tea tree) oil in vitro.

Hammer KA, Dry L, Johnson M, Michalak EM, Carson CF, Riley TV.

Oral Microbiol Immunol. 2003 Dec;18(6):389-92.


p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa.

Villunger A, Michalak EM, Coultas L, Müllauer F, Böck G, Ausserlechner MJ, Adams JM, Strasser A.

Science. 2003 Nov 7;302(5647):1036-8. Epub 2003 Sep 18.

Supplemental Content

Loading ...
Support Center