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Items: 1 to 50 of 137

1.

ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes.

Rawat V, Wang S, Sima J, Bar R, Liraz O, Gundimeda U, Parekh T, Chan J, Johansson JO, Tang C, Chui HC, Harrington MG, Michaelson DM, Yassine HN.

J Neurosci. 2019 Nov 27;39(48):9611-9622. doi: 10.1523/JNEUROSCI.1400-19.2019. Epub 2019 Oct 22.

PMID:
31641056
2.

Extra-Hippocampal Learning Deficits in Young Apolipoprotein E4 Mice and Their Synaptic Underpinning.

Har-Paz I, Roisman N, Michaelson DM, Moran A.

J Alzheimers Dis. 2019;72(1):71-82. doi: 10.3233/JAD-190564.

PMID:
31561365
3.

The Effects of APOE4 on Mitochondrial Dynamics and Proteins in vivo.

Simonovitch S, Schmukler E, Masliah E, Pinkas-Kramarski R, Michaelson DM.

J Alzheimers Dis. 2019;70(3):861-875. doi: 10.3233/JAD-190074.

PMID:
31306119
4.

ApoE4: an emerging therapeutic target for Alzheimer's disease.

Safieh M, Korczyn AD, Michaelson DM.

BMC Med. 2019 Mar 20;17(1):64. doi: 10.1186/s12916-019-1299-4. Review.

5.

The Role of MAPK's Signaling in Mediating ApoE4-Driven Pathology In Vivo.

Salomon-Zimri S, Koren A, Angel A, Ben-Zur T, Offen D, Michaelson DM.

Curr Alzheimer Res. 2019;16(4):281-292. doi: 10.2174/1567205016666190228120254.

PMID:
30819082
6.

The Interplay Between Apolipoprotein E4 and the Autophagic-Endocytic-Lysosomal Axis.

Schmukler E, Michaelson DM, Pinkas-Kramarski R.

Mol Neurobiol. 2018 Aug;55(8):6863-6880. doi: 10.1007/s12035-018-0892-4. Epub 2018 Jan 20. Review.

PMID:
29353455
7.

The effects of apolipoprotein E genotype, α-synuclein deficiency, and sex on brain synaptic and Alzheimer's disease-related pathology.

Bar R, Boehm-Cagan A, Luz I, Kleper-Wall Y, Michaelson DM.

Alzheimers Dement (Amst). 2017 Sep 6;10:1-11. doi: 10.1016/j.dadm.2017.08.003. eCollection 2018.

8.

Omega-3 fatty acids, lipids, and apoE lipidation in Alzheimer's disease: a rationale for multi-nutrient dementia prevention.

Grimm MOW, Michaelson DM, Hartmann T.

J Lipid Res. 2017 Nov;58(11):2083-2101. doi: 10.1194/jlr.R076331. Epub 2017 May 20. Review.

9.

Differential Effects of apoE4 and Activation of ABCA1 on Brain and Plasma Lipoproteins.

Boehm-Cagan A, Bar R, Harats D, Shaish A, Levkovitz H, Bielicki JK, Johansson JO, Michaelson DM.

PLoS One. 2016 Nov 8;11(11):e0166195. doi: 10.1371/journal.pone.0166195. eCollection 2016.

10.

ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies.

Boehm-Cagan A, Bar R, Liraz O, Bielicki JK, Johansson JO, Michaelson DM.

J Alzheimers Dis. 2016 Oct 4;54(3):1219-1233.

PMID:
27567858
11.

Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment.

Salomon-Zimri S, Glat MJ, Barhum Y, Luz I, Boehm-Cagan A, Liraz O, Ben-Zur T, Offen D, Michaelson DM.

J Alzheimers Dis. 2016 Jun 30;53(4):1443-58. doi: 10.3233/JAD-160182.

PMID:
27372644
12.

Behavioral testing affects the phenotypic expression of APOE ε3 and APOE ε4 in targeted replacement mice and reduces the differences between them.

Salomon-Zimri S, Liraz O, Michaelson DM.

Alzheimers Dement (Amst). 2015 Apr 15;1(2):127-35. doi: 10.1016/j.dadm.2014.11.014. eCollection 2015 Jun.

13.

An Anti-apoE4 Specific Monoclonal Antibody Counteracts the Pathological Effects of apoE4 In Vivo.

Luz I, Liraz O, Michaelson DM.

Curr Alzheimer Res. 2016 Jun 2;13(8):918-29.

PMID:
27040139
14.

Impaired Autophagy in APOE4 Astrocytes.

Simonovitch S, Schmukler E, Bespalko A, Iram T, Frenkel D, Holtzman DM, Masliah E, Michaelson DM, Pinkas-Kramarski R.

J Alzheimers Dis. 2016;51(3):915-27. doi: 10.3233/JAD-151101.

PMID:
26923027
15.

The effects of the apoE4 genotype on the developing mouse retina.

Maharshak I, Salomon-Zimri S, Antes R, Liraz O, Nisgav Y, Livnat T, Weinberger D, Colton CA, Solomon AS, Michaelson DM.

Exp Eye Res. 2016 Apr;145:17-25. doi: 10.1016/j.exer.2015.11.001. Epub 2015 Nov 7.

PMID:
26554939
16.

Apolipoprotein E4 reduces evoked hippocampal acetylcholine release in adult mice.

Dolejší E, Liraz O, Rudajev V, Zimčík P, Doležal V, Michaelson DM.

J Neurochem. 2016 Feb;136(3):503-9. doi: 10.1111/jnc.13417. Epub 2015 Nov 19.

17.

VEGF Mediates ApoE4-Induced Neovascularization and Synaptic Pathology in the Choroid and Retina.

Antes R, Salomon-Zimri S, Beck SC, Garcia Garrido M, Livnat T, Maharshak I, Kadar T, Seeliger M, Weinberger D, Michaelson DM.

Curr Alzheimer Res. 2015;12(4):323-34.

PMID:
25817253
18.

APOE ε4: the most prevalent yet understudied risk factor for Alzheimer's disease.

Michaelson DM.

Alzheimers Dement. 2014 Nov;10(6):861-8. doi: 10.1016/j.jalz.2014.06.015. Epub 2014 Sep 10. Review.

PMID:
25217293
19.

Reversal of apoE4-driven brain pathology and behavioral deficits by bexarotene.

Boehm-Cagan A, Michaelson DM.

J Neurosci. 2014 May 21;34(21):7293-301. doi: 10.1523/JNEUROSCI.5198-13.2014.

20.

Involvement of the Apoer2 and Lrp1 receptors in mediating the pathological effects of ApoE4 in vivo.

Gilat-Frenkel M, Boehm-Cagan A, Liraz O, Xian X, Herz J, Michaelson DM.

Curr Alzheimer Res. 2014;11(6):549-57.

21.

Hippocampus-related cognitive impairments in young apoE4 targeted replacement mice.

Salomon-Zimri S, Boehm-Cagan A, Liraz O, Michaelson DM.

Neurodegener Dis. 2014;13(2-3):86-92. doi: 10.1159/000354777. Epub 2013 Sep 24.

PMID:
24080852
22.

Opposing actions of environmental enrichment and Alzheimer's disease on the expression of hippocampal microRNAs in mouse models.

Barak B, Shvarts-Serebro I, Modai S, Gilam A, Okun E, Michaelson DM, Mattson MP, Shomron N, Ashery U.

Transl Psychiatry. 2013 Sep 10;3:e304. doi: 10.1038/tp.2013.77.

23.

ApoE4 induces synaptic and ERG impairments in the retina of young targeted replacement apoE4 mice.

Antes R, Ezra-Elia R, Weinberger D, Solomon A, Ofri R, Michaelson DM.

PLoS One. 2013 May 31;8(5):e64949. doi: 10.1371/journal.pone.0064949. Print 2013.

24.

ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice.

Liraz O, Boehm-Cagan A, Michaelson DM.

Mol Neurodegener. 2013 May 17;8:16. doi: 10.1186/1750-1326-8-16.

25.

ApoE ε4 is associated with eIF2α phosphorylation and impaired learning in young mice.

Segev Y, Michaelson DM, Rosenblum K.

Neurobiol Aging. 2013 Mar;34(3):863-72. doi: 10.1016/j.neurobiolaging.2012.06.020. Epub 2012 Aug 9.

PMID:
22883908
26.

The effects of apolipoproteins E3 and E4 on the transforming growth factor-β system in targeted replacement mice.

Haas A, Liraz O, Michaelson DM.

Neurodegener Dis. 2012;10(1-4):41-5. doi: 10.1159/000334902. Epub 2012 Feb 1.

PMID:
22301441
27.

The isoform-specific pathological effects of apoE4 in vivo are prevented by a fish oil (DHA) diet and are modified by cholesterol.

Kariv-Inbal Z, Yacobson S, Berkecz R, Peter M, Janaky T, Lütjohann D, Broersen LM, Hartmann T, Michaelson DM.

J Alzheimers Dis. 2012;28(3):667-83. doi: 10.3233/JAD-2011-111265.

PMID:
22057027
28.

Anatomical localization of protease-activated receptor-1 and protease-mediated neuroglial crosstalk on peri-synaptic astrocytic endfeet.

Shavit E, Michaelson DM, Chapman J.

J Neurochem. 2011 Nov;119(3):460-73. doi: 10.1111/j.1471-4159.2011.07436.x. Epub 2011 Sep 23.

29.

ApoE4-Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function.

Zepa L, Frenkel M, Belinson H, Kariv-Inbal Z, Kayed R, Masliah E, Michaelson DM.

Int J Alzheimers Dis. 2011 Feb 15;2011:792070. doi: 10.4061/2011/792070.

30.

Following activation of the amyloid cascade, apolipoprotein E4 drives the in vivo oligomerization of amyloid-β resulting in neurodegeneration.

Belinson H, Kariv-Inbal Z, Kayed R, Masliah E, Michaelson DM.

J Alzheimers Dis. 2010;22(3):959-70. doi: 10.3233/JAD-2010-101008.

31.

Possible role of tau in mediating pathological effects of apoE4 in vivo prior to and following activation of the amyloid cascade.

Inbar D, Belinson H, Rosenman H, Michaelson DM.

Neurodegener Dis. 2010;7(1-3):16-23. doi: 10.1159/000283477. Epub 2010 Feb 13.

PMID:
20160452
32.

ApoE4-dependent Abeta-mediated neurodegeneration is associated with inflammatory activation in the hippocampus but not the septum.

Belinson H, Michaelson DM.

J Neural Transm (Vienna). 2009 Nov;116(11):1427-34. doi: 10.1007/s00702-009-0218-9. Epub 2009 Apr 16.

PMID:
19370389
33.

Pathological synergism between amyloid-beta and apolipoprotein E4--the most prevalent yet understudied genetic risk factor for Alzheimer's disease.

Belinson H, Michaelson DM.

J Alzheimers Dis. 2009;17(3):469-81. doi: 10.3233/JAD-2009-1065. Review.

PMID:
19363257
34.

Antiphospholipid syndrome induction exacerbates a transgenic Alzheimer disease model on a female background.

Katzav A, Faust-Socher A, Kvapil F, Michaelson DM, Blank M, Pick CG, Shoenfeld Y, Korczyn AD, Chapman J.

Neurobiol Aging. 2011 Feb;32(2):272-9. doi: 10.1016/j.neurobiolaging.2009.02.007. Epub 2009 Mar 12.

PMID:
19282067
35.

Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficits.

Belinson H, Lev D, Masliah E, Michaelson DM.

J Neurosci. 2008 Apr 30;28(18):4690-701. doi: 10.1523/JNEUROSCI.5633-07.2008.

36.

Activation of the amyloid cascade by intracerebroventricular injection of the protease inhibitor phosphoramidon.

Nisemblat Y, Belinson H, Dolev I, Michaelson DM.

Neurodegener Dis. 2008;5(3-4):166-9. doi: 10.1159/000113692. Epub 2008 Mar 6.

PMID:
18322380
37.

Intraneuronal amyloid-beta plays a role in mediating the synergistic pathological effects of apoE4 and environmental stimulation.

Levi O, Dolev I, Belinson H, Michaelson DM.

J Neurochem. 2007 Nov;103(3):1031-40. Epub 2007 Jul 31.

38.

The nucleation growth and reversibility of Amyloid-beta deposition in vivo.

Dolev I, Michaelson DM.

J Alzheimers Dis. 2006 Nov;10(2-3):291-301. Review.

PMID:
17119294
39.
40.

Neuron-specific susceptibility to apolipoprotein E4.

Belinson H, Dolev I, Michaelson DM.

Neurobiol Aging. 2007 May;28(5):689-92; discussion 704-6. Epub 2006 Oct 4. Review. No abstract available.

PMID:
17023093
41.

Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation.

Levi O, Lütjohann D, Devir A, von Bergmann K, Hartmann T, Michaelson DM.

J Neurochem. 2005 Nov;95(4):987-97. Epub 2005 Sep 29.

42.

Apolipoprotein E4 enhances brain inflammation by modulation of the NF-kappaB signaling cascade.

Ophir G, Amariglio N, Jacob-Hirsch J, Elkon R, Rechavi G, Michaelson DM.

Neurobiol Dis. 2005 Dec;20(3):709-18. Epub 2005 Jun 23.

PMID:
15979312
43.

Brain area- and isoform-specific inhibition of synaptic plasticity by apoE4.

Levi O, Jongen-Relo AL, Feldon J, Michaelson DM.

J Neurol Sci. 2005 Mar 15;229-230:241-8. Epub 2005 Jan 11.

PMID:
15760646
44.
45.

Lack of apolipoprotein-E exacerbates experimental allergic encephalomyelitis.

Karussis D, Michaelson DM, Grigoriadis N, Korezyn AD, Mizrachi-Koll R, Chapman S, Abramsky O, Chapman J.

Mult Scler. 2003 Oct;9(5):476-80.

PMID:
14582773
46.

Apolipoprotein E4 decreases whereas apolipoprotein E3 increases the level of secreted amyloid precursor protein after closed head injury.

Ezra Y, Oron L, Moskovich L, Roses AD, Beni SM, Shohami E, Michaelson DM.

Neuroscience. 2003;121(2):315-25.

PMID:
14521991
47.

ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory.

Levi O, Jongen-Relo AL, Feldon J, Roses AD, Michaelson DM.

Neurobiol Dis. 2003 Aug;13(3):273-82.

PMID:
12901842
48.

Human apoE3 but not apoE4 rescues impaired astrocyte activation in apoE null mice.

Ophir G, Meilin S, Efrati M, Chapman J, Karussis D, Roses A, Michaelson DM.

Neurobiol Dis. 2003 Feb;12(1):56-64.

PMID:
12609489
49.

Increased expression of presenilin 2 inhibits protein synthesis.

Gamliel A, Teicher C, Michaelson DM, Pradier L, Hartmann T, Beyreuther K, Stein R.

Mol Cell Neurosci. 2002 Jan;19(1):111-24.

PMID:
11817902
50.

The effects of APOE genotype on age at onset and progression of neurodegenerative diseases.

Chapman J, Korczyn AD, Karussis DM, Michaelson DM.

Neurology. 2001 Oct 23;57(8):1482-5. Review.

PMID:
11673593

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