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Items: 44

1.

Universality of filamentous aggregation phenomena.

Michaels TCT, Dear AJ, Knowles TPJ.

Phys Rev E. 2019 Jun;99(6-1):062415. doi: 10.1103/PhysRevE.99.062415.

PMID:
31330719
2.

Optimal control strategies for inhibition of protein aggregation.

Michaels TCT, Weber CA, Mahadevan L.

Proc Natl Acad Sci U S A. 2019 Jul 16;116(29):14593-14598. doi: 10.1073/pnas.1904090116. Epub 2019 Jun 28.

PMID:
31253705
3.

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes.

Limbocker R, Chia S, Ruggeri FS, Perni M, Cascella R, Heller GT, Meisl G, Mannini B, Habchi J, Michaels TCT, Challa PK, Ahn M, Casford ST, Fernando N, Xu CK, Kloss ND, Cohen SIA, Kumita JR, Cecchi C, Zasloff M, Linse S, Knowles TPJ, Chiti F, Vendruscolo M, Dobson CM.

Nat Commun. 2019 Jan 15;10(1):225. doi: 10.1038/s41467-018-07699-5.

4.

Physical Determinants of Amyloid Assembly in Biofilm Formation.

Andreasen M, Meisl G, Taylor JD, Michaels TCT, Levin A, Otzen DE, Chapman MR, Dobson CM, Matthews SJ, Knowles TPJ.

MBio. 2019 Jan 8;10(1). pii: e02279-18. doi: 10.1128/mBio.02279-18.

5.

Quantifying Co-Oligomer Formation by α-Synuclein.

Iljina M, Dear AJ, Garcia GA, De S, Tosatto L, Flagmeier P, Whiten DR, Michaels TCT, Frenkel D, Dobson CM, Knowles TPJ, Klenerman D.

ACS Nano. 2018 Nov 27;12(11):10855-10866. doi: 10.1021/acsnano.8b03575. Epub 2018 Oct 29.

6.

Statistical Mechanics of Globular Oligomer Formation by Protein Molecules.

Dear AJ, Šarić A, Michaels TCT, Dobson CM, Knowles TPJ.

J Phys Chem B. 2018 Dec 13;122(49):11721-11730. doi: 10.1021/acs.jpcb.8b07805. Epub 2018 Oct 31.

PMID:
30336667
7.

SAR by kinetics for drug discovery in protein misfolding diseases.

Chia S, Habchi J, Michaels TCT, Cohen SIA, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10245-10250. doi: 10.1073/pnas.1807884115. Epub 2018 Sep 26.

8.

Self-Assembly-Mediated Release of Peptide Nanoparticles through Jets Across Microdroplet Interfaces.

Levin A, Michaels TCT, Mason TO, Müller T, Adler-Abramovich L, Mahadevan L, Cates ME, Gazit E, Knowles TPJ.

ACS Appl Mater Interfaces. 2018 Aug 22;10(33):27578-27583. doi: 10.1021/acsami.8b09511. Epub 2018 Aug 9.

PMID:
30080033
9.

Secondary nucleation in amyloid formation.

Törnquist M, Michaels TCT, Sanagavarapu K, Yang X, Meisl G, Cohen SIA, Knowles TPJ, Linse S.

Chem Commun (Camb). 2018 Aug 2;54(63):8667-8684. doi: 10.1039/c8cc02204f. Review.

PMID:
29978862
10.

Kinetic Analysis of Amyloid Formation.

Meisl G, Michaels TCT, Linse S, Knowles TPJ.

Methods Mol Biol. 2018;1779:181-196. doi: 10.1007/978-1-4939-7816-8_12.

PMID:
29886534
11.

Budding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils.

Song Y, Michaels TCT, Ma Q, Liu Z, Yuan H, Takayama S, Knowles TPJ, Shum HC.

Nat Commun. 2018 May 29;9(1):2110. doi: 10.1038/s41467-018-04510-3.

12.

Cooperative Assembly of Hsp70 Subdomain Clusters.

Wright MA, Aprile FA, Bellaiche MMJ, Michaels TCT, Müller T, Arosio P, Vendruscolo M, Dobson CM, Knowles TPJ.

Biochemistry. 2018 Jul 3;57(26):3641-3649. doi: 10.1021/acs.biochem.8b00151. Epub 2018 May 29.

13.

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes.

Habchi J, Chia S, Galvagnion C, Michaels TCT, Bellaiche MMJ, Ruggeri FS, Sanguanini M, Idini I, Kumita JR, Sparr E, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M.

Nat Chem. 2018 Jun;10(6):673-683. doi: 10.1038/s41557-018-0031-x. Epub 2018 May 7.

PMID:
29736006
14.

Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading.

Kundel F, Hong L, Falcon B, McEwan WA, Michaels TCT, Meisl G, Esteras N, Abramov AY, Knowles TJP, Goedert M, Klenerman D.

ACS Chem Neurosci. 2018 Jun 20;9(6):1276-1282. doi: 10.1021/acschemneuro.8b00094. Epub 2018 Apr 8.

15.

Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide.

Cohen SIA, Cukalevski R, Michaels TCT, Šarić A, Törnquist M, Vendruscolo M, Dobson CM, Buell AK, Knowles TPJ, Linse S.

Nat Chem. 2018 May;10(5):523-531. doi: 10.1038/s41557-018-0023-x. Epub 2018 Mar 26.

16.

Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.

Michaels TCT, Šarić A, Habchi J, Chia S, Meisl G, Vendruscolo M, Dobson CM, Knowles TPJ.

Annu Rev Phys Chem. 2018 Apr 20;69:273-298. doi: 10.1146/annurev-physchem-050317-021322. Epub 2018 Feb 28. Review.

PMID:
29490200
17.

Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2.

Yang J, Dear AJ, Michaels TCT, Dobson CM, Knowles TPJ, Wu S, Perrett S.

J Am Chem Soc. 2018 Feb 21;140(7):2493-2503. doi: 10.1021/jacs.7b10439. Epub 2018 Feb 7.

18.

Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit.

Mason TO, Michaels TCT, Levin A, Dobson CM, Gazit E, Knowles TPJ, Buell AK.

J Am Chem Soc. 2017 Nov 15;139(45):16134-16142. doi: 10.1021/jacs.7b00229. Epub 2017 Oct 23.

PMID:
28994295
19.

Kinetic constraints on self-assembly into closed supramolecular structures.

Michaels TCT, Bellaiche MMJ, Hagan MF, Knowles TPJ.

Sci Rep. 2017 Sep 25;7(1):12295. doi: 10.1038/s41598-017-12528-8.

20.

Kinetics of spontaneous filament nucleation via oligomers: Insights from theory and simulation.

Šarić A, Michaels TCT, Zaccone A, Knowles TPJ, Frenkel D.

J Chem Phys. 2016 Dec 7;145(21):211926. doi: 10.1063/1.4965040.

PMID:
28799382
21.

Sequential Release of Proteins from Structured Multishell Microcapsules.

Shimanovich U, Michaels TCT, De Genst E, Matak-Vinkovic D, Dobson CM, Knowles TPJ.

Biomacromolecules. 2017 Oct 9;18(10):3052-3059. doi: 10.1021/acs.biomac.7b00351. Epub 2017 Sep 7.

PMID:
28792742
22.

Physical principles of filamentous protein self-assembly kinetics.

Michaels TC, Liu LX, Meisl G, Knowles TP.

J Phys Condens Matter. 2017 Apr 20;29(15):153002. doi: 10.1088/1361-648X/aa5f10. Epub 2017 Feb 7.

PMID:
28170349
23.

Dynamics of heteromolecular filament formation.

Dear AJ, Michaels TC, Knowles TP.

J Chem Phys. 2016 Nov 7;145(17):175101.

PMID:
27825219
24.

β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces.

Brown JW, Buell AK, Michaels TC, Meisl G, Carozza J, Flagmeier P, Vendruscolo M, Knowles TP, Dobson CM, Galvagnion C.

Sci Rep. 2016 Nov 3;6:36010. doi: 10.1038/srep36010.

25.

Dynamic microfluidic control of supramolecular peptide self-assembly.

Arnon ZA, Vitalis A, Levin A, Michaels TCT, Caflisch A, Knowles TPJ, Adler-Abramovich L, Gazit E.

Nat Commun. 2016 Oct 25;7:13190. doi: 10.1038/ncomms13190.

26.

Fabrication of fibrillosomes from droplets stabilized by protein nanofibrils at all-aqueous interfaces.

Song Y, Shimanovich U, Michaels TC, Ma Q, Li J, Knowles TP, Shum HC.

Nat Commun. 2016 Oct 11;7:12934. doi: 10.1038/ncomms12934.

27.

Physical determinants of the self-replication of protein fibrils.

Šarić A, Buell AK, Meisl G, Michaels TCT, Dobson CM, Linse S, Knowles TPJ, Frenkel D.

Nat Phys. 2016 Sep;12(9):874-880. doi: 10.1038/nphys3828. Epub 2016 Jul 18.

28.

Fluctuations in the Kinetics of Linear Protein Self-Assembly.

Michaels TC, Dear AJ, Kirkegaard JB, Saar KL, Weitz DA, Knowles TP.

Phys Rev Lett. 2016 Jun 24;116(25):258103. doi: 10.1103/PhysRevLett.116.258103. Epub 2016 Jun 21.

PMID:
27391756
29.

Synthesis of Nonequilibrium Supramolecular Peptide Polymers on a Microfluidic Platform.

Mason TO, Michaels TC, Levin A, Gazit E, Dobson CM, Buell AK, Knowles TP.

J Am Chem Soc. 2016 Aug 3;138(30):9589-96. doi: 10.1021/jacs.6b04136. Epub 2016 Jul 26.

PMID:
27387359
30.

Controlling the Physical Dimensions of Peptide Nanotubes by Supramolecular Polymer Coassembly.

Adler-Abramovich L, Marco P, Arnon ZA, Creasey RC, Michaels TC, Levin A, Scurr DJ, Roberts CJ, Knowles TP, Tendler SJ, Gazit E.

ACS Nano. 2016 Aug 23;10(8):7436-42. doi: 10.1021/acsnano.6b01587. Epub 2016 Jul 5.

PMID:
27351519
31.

Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms.

Iljina M, Garcia GA, Dear AJ, Flint J, Narayan P, Michaels TC, Dobson CM, Frenkel D, Knowles TP, Klenerman D.

Sci Rep. 2016 Jun 27;6:28658. doi: 10.1038/srep28658.

32.

Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation.

Arosio P, Michaels TC, Linse S, Månsson C, Emanuelsson C, Presto J, Johansson J, Vendruscolo M, Dobson CM, Knowles TP.

Nat Commun. 2016 Mar 24;7:10948. doi: 10.1038/ncomms10948.

33.

Hamiltonian Dynamics of Protein Filament Formation.

Michaels TC, Cohen SI, Vendruscolo M, Dobson CM, Knowles TP.

Phys Rev Lett. 2016 Jan 22;116(3):038101. doi: 10.1103/PhysRevLett.116.038101. Epub 2016 Jan 22.

PMID:
26849615
34.

Molecular mechanisms of protein aggregation from global fitting of kinetic models.

Meisl G, Kirkegaard JB, Arosio P, Michaels TC, Vendruscolo M, Dobson CM, Linse S, Knowles TP.

Nat Protoc. 2016 Feb;11(2):252-72. doi: 10.1038/nprot.2016.010. Epub 2016 Jan 7.

PMID:
26741409
35.

The length distribution of frangible biofilaments.

Michaels TC, Yde P, Willis JC, Jensen MH, Otzen D, Dobson CM, Buell AK, Knowles TP.

J Chem Phys. 2015 Oct 28;143(16):164901. doi: 10.1063/1.4933230.

PMID:
26520548
36.

Dynamics of protein aggregation and oligomer formation governed by secondary nucleation.

Michaels TC, Lazell HW, Arosio P, Knowles TP.

J Chem Phys. 2015 Aug 7;143(5):054901. doi: 10.1063/1.4927655.

PMID:
26254664
37.

Force generation by the growth of amyloid aggregates.

Herling TW, Garcia GA, Michaels TC, Grentz W, Dean J, Shimanovich U, Gang H, Müller T, Kav B, Terentjev EM, Dobson CM, Knowles TP.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9524-9. doi: 10.1073/pnas.1417326112. Epub 2015 Jul 20.

38.

Aggregation-Prone Amyloid-β⋅Cu(II) Species Formed on the Millisecond Timescale under Mildly Acidic Conditions.

Pedersen JT, Borg CB, Michaels TC, Knowles TP, Faller P, Teilum K, Hemmingsen L.

Chembiochem. 2015 Jun 15;16(9):1293-7. doi: 10.1002/cbic.201500080. Epub 2015 May 18.

PMID:
25989377
39.

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation.

Galvagnion C, Buell AK, Meisl G, Michaels TC, Vendruscolo M, Knowles TP, Dobson CM.

Nat Chem Biol. 2015 Mar;11(3):229-34. doi: 10.1038/nchembio.1750. Epub 2015 Feb 2.

40.

Shortness of breath in a woman after hemicolectomy.

Shuaib W, Walkers SL, Alweis R, Michaels TC.

JAAPA. 2014 Dec;27(12):46-9. doi: 10.1097/01.JAA.0000456581.47133.a2. No abstract available.

PMID:
25417666
41.

Scaling theory of electric-field-assisted tunnelling.

Michaels TC, Cabrera H, Zanin DA, De Pietro L, Ramsperger U, Vindigni A, Pescia D.

Proc Math Phys Eng Sci. 2014 Jul 8;470(2167):20140014.

42.

Role of filament annealing in the kinetics and thermodynamics of nucleated polymerization.

Michaels TC, Knowles TP.

J Chem Phys. 2014 Jun 7;140(21):214904. doi: 10.1063/1.4880121.

PMID:
24908038
43.

Asymptotic solutions of the Oosawa model for the length distribution of biofilaments.

Michaels TC, Garcia GA, Knowles TP.

J Chem Phys. 2014 May 21;140(19):194906. doi: 10.1063/1.4875897.

PMID:
24852562
44.

Quantitative Analysis of Diffusive Reactions at the Solid-Liquid Interface in Finite Systems.

Michaels TC, Buell AK, Terentjev EM, Knowles TP.

J Phys Chem Lett. 2014 Feb 20;5(4):695-9. doi: 10.1021/jz4024833. Epub 2014 Feb 4.

PMID:
26270839

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