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Items: 23


A biparatopic agonistic antibody that mimics fibroblast growth factor 21 ligand activity.

Shi SY, Lu YW, Liu Z, Stevens J, Murawsky CM, Wilson V, Hu Z, Richards WG, Michaels ML, Zhang J, Yan W, Li Y.

J Biol Chem. 2018 Apr 20;293(16):5909-5919. doi: 10.1074/jbc.RA118.001752. Epub 2018 Feb 26.


Anti-PCSK9 antibody pharmacokinetics and low-density lipoprotein-cholesterol pharmacodynamics in nonhuman primates are antigen affinity-dependent and exhibit limited sensitivity to neonatal Fc receptor-binding enhancement.

Henne KR, Ason B, Howard M, Wang W, Sun J, Higbee J, Tang J, Matsuda KC, Xu R, Zhou L, Chan JC, King C, Piper DE, Ketchem RR, Michaels ML, Jackson SM, Retter MW.

J Pharmacol Exp Ther. 2015 Apr;353(1):119-31. doi: 10.1124/jpet.114.221242. Epub 2015 Feb 4.


Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes.

Hecht R, Li YS, Sun J, Belouski E, Hall M, Hager T, Yie J, Wang W, Winters D, Smith S, Spahr C, Tam LT, Shen Z, Stanislaus S, Chinookoswong N, Lau Y, Sickmier A, Michaels ML, Boone T, Véniant MM, Xu J.

PLoS One. 2012;7(11):e49345. doi: 10.1371/journal.pone.0049345. Epub 2012 Nov 27.


Targeted codon optimization improves translational fidelity for an Fc fusion protein.

Hutterer KM, Zhang Z, Michaels ML, Belouski E, Hong RW, Shah B, Berge M, Barkhordarian H, Le E, Smith S, Winters D, Abroson F, Hecht R, Liu J.

Biotechnol Bioeng. 2012 Nov;109(11):2770-7. doi: 10.1002/bit.24555. Epub 2012 May 28.


Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody.

Coxon A, Bready J, Min H, Kaufman S, Leal J, Yu D, Lee TA, Sun JR, Estrada J, Bolon B, McCabe J, Wang L, Rex K, Caenepeel S, Hughes P, Cordover D, Kim H, Han SJ, Michaels ML, Hsu E, Shimamoto G, Cattley R, Hurh E, Nguyen L, Wang SX, Ndifor A, Hayward IJ, Falcón BL, McDonald DM, Li L, Boone T, Kendall R, Radinsky R, Oliner JD.

Mol Cancer Ther. 2010 Oct;9(10):2641-51. doi: 10.1158/1535-7163.MCT-10-0213.


FGF21 N- and C-termini play different roles in receptor interaction and activation.

Yie J, Hecht R, Patel J, Stevens J, Wang W, Hawkins N, Steavenson S, Smith S, Winters D, Fisher S, Cai L, Belouski E, Chen C, Michaels ML, Li YS, Lindberg R, Wang M, Véniant M, Xu J.

FEBS Lett. 2009 Jan 5;583(1):19-24. doi: 10.1016/j.febslet.2008.11.023. Epub 2008 Dec 4.


Unified catalytic mechanism for DNA glycosylases.

Dodson ML, Michaels ML, Lloyd RS.

J Biol Chem. 1994 Dec 30;269(52):32709-12. Review. No abstract available.


Function of the zinc finger in Escherichia coli Fpg protein.

Tchou J, Michaels ML, Miller JH, Grollman AP.

J Biol Chem. 1993 Dec 15;268(35):26738-44.


A repair system for 8-oxo-7,8-dihydrodeoxyguanine.

Michaels ML, Tchou J, Grollman AP, Miller JH.

Biochemistry. 1992 Nov 17;31(45):10964-8.


Family characteristics of children who self-select into a prevention program for children of alcoholics.

Michaels ML, Roosa MW, Gensheimer LK.

Am J Community Psychol. 1992 Oct;20(5):663-72.


Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA.

Michaels ML, Cruz C, Grollman AP, Miller JH.

Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7022-5.


Cloning and sequencing of Escherichia coli mutR shows its identity to topB, encoding topoisomerase III.

Schofield MA, Agbunag R, Michaels ML, Miller JH.

J Bacteriol. 1992 Aug;174(15):5168-70.


Using PCR to extend the limit of oligonucleotide synthesis.

Michaels ML, Hsiao HM, Miller JH.

Biotechniques. 1992 Jan;12(1):44, 46, 48.


MutM, a protein that prevents G.C----T.A transversions, is formamidopyrimidine-DNA glycosylase.

Michaels ML, Pham L, Cruz C, Miller JH.

Nucleic Acids Res. 1991 Jul 11;19(13):3629-32.


mutA and mutC: two mutator loci in Escherichia coli that stimulate transversions.

Michaels ML, Cruz C, Miller JH.

Proc Natl Acad Sci U S A. 1990 Dec;87(23):9211-5.


MutY, an adenine glycosylase active on G-A mispairs, has homology to endonuclease III.

Michaels ML, Pham L, Nghiem Y, Cruz C, Miller JH.

Nucleic Acids Res. 1990 Jul 11;18(13):3841-5.


Escherichia coli thymidylate synthase: amino acid substitutions by suppression of amber nonsense mutations.

Michaels ML, Kim CW, Matthews DA, Miller JH.

Proc Natl Acad Sci U S A. 1990 May;87(10):3957-61.


Evidence for in vitro translesion DNA synthesis past a site-specific aminofluorene adduct.

Michaels ML, Johnson DL, Reid TM, King CM, Romano LJ.

J Biol Chem. 1987 Oct 25;262(30):14648-54.

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