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Items: 37

1.

Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel.

LaFavers KA, Macedo E, Garimella PS, Lima C, Khan S, Myslinski J, McClintick J, Witzmann FA, Winfree S, Phillips CL, Hato T, Dagher PC, Wu XR, El-Achkar TM, Micanovic R.

Sci Transl Med. 2019 Oct 2;11(512). pii: eaaw3639. doi: 10.1126/scitranslmed.aaw3639.

PMID:
31578243
2.

Uromodulin (Tamm-Horsfall protein): guardian of urinary and systemic homeostasis.

Micanovic R, LaFavers K, Garimella PS, Wu XR, El-Achkar TM.

Nephrol Dial Transplant. 2019 Jan 14. doi: 10.1093/ndt/gfy394. [Epub ahead of print]

PMID:
30649494
3.

Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney.

Micanovic R, Khan S, Janosevic D, Lee ME, Hato T, Srour EF, Winfree S, Ghosh J, Tong Y, Rice SE, Dagher PC, Wu XR, El-Achkar TM.

J Am Soc Nephrol. 2018 Mar;29(3):841-856. doi: 10.1681/ASN.2017040409. Epub 2017 Nov 27.

4.

Quantitative Three-Dimensional Tissue Cytometry to Study Kidney Tissue and Resident Immune Cells.

Winfree S, Khan S, Micanovic R, Eadon MT, Kelly KJ, Sutton TA, Phillips CL, Dunn KW, El-Achkar TM.

J Am Soc Nephrol. 2017 Jul;28(7):2108-2118. doi: 10.1681/ASN.2016091027. Epub 2017 Feb 2.

5.

Immunofluorescence laser micro-dissection of specific nephron segments in the mouse kidney allows targeted downstream proteomic analysis.

Micanovic R, Khan S, El-Achkar TM.

Physiol Rep. 2015 Feb 12;3(2). pii: e12306. doi: 10.14814/phy2.12306. Print 2015 Feb 1.

6.

Tamm-Horsfall Protein Regulates Granulopoiesis and Systemic Neutrophil Homeostasis.

Micanovic R, Chitteti BR, Dagher PC, Srour EF, Khan S, Hato T, Lyle A, Tong Y, Wu XR, El-Achkar TM.

J Am Soc Nephrol. 2015 Sep;26(9):2172-82. doi: 10.1681/ASN.2014070664. Epub 2015 Jan 2.

7.

The role of tumor necrosis factor alpha in regulating the expression of Tamm-Horsfall Protein (uromodulin) in thick ascending limbs during kidney injury.

Heitmeier M, McCracken R, Micanovic R, Khan S, El-Achkar TM.

Am J Nephrol. 2014;40(5):458-67. doi: 10.1159/000369836. Epub 2014 Dec 6.

8.

An intricate network of conserved DNA upstream motifs and associated transcription factors regulate the expression of uromodulin gene.

Srivastava R, Micanovic R, El-Achkar TM, Janga SC.

J Urol. 2014 Sep;192(3):981-9. doi: 10.1016/j.juro.2014.02.095. Epub 2014 Mar 1.

PMID:
24594405
9.

Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319.

Kharitonenkov A, Beals JM, Micanovic R, Strifler BA, Rathnachalam R, Wroblewski VJ, Li S, Koester A, Ford AM, Coskun T, Dunbar JD, Cheng CC, Frye CC, Bumol TF, Moller DE.

PLoS One. 2013;8(3):e58575. doi: 10.1371/journal.pone.0058575. Epub 2013 Mar 11.

10.

Fundamentals of FGF19 & FGF21 action in vitro and in vivo.

Adams AC, Coskun T, Rovira AR, Schneider MA, Raches DW, Micanovic R, Bina HA, Dunbar JD, Kharitonenkov A.

PLoS One. 2012;7(5):e38438. doi: 10.1371/journal.pone.0038438. Epub 2012 May 31.

11.

Different roles of N- and C- termini in the functional activity of FGF21.

Micanovic R, Raches DW, Dunbar JD, Driver DA, Bina HA, Dickinson CD, Kharitonenkov A.

J Cell Physiol. 2009 May;219(2):227-34. doi: 10.1002/jcp.21675.

PMID:
19117008
12.

FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho.

Kharitonenkov A, Dunbar JD, Bina HA, Bright S, Moyers JS, Zhang C, Ding L, Micanovic R, Mehrbod SF, Knierman MD, Hale JE, Coskun T, Shanafelt AB.

J Cell Physiol. 2008 Apr;215(1):1-7.

PMID:
18064602
13.

pI-shifted insulin analogs with extended in vivo time action and favorable receptor selectivity.

Kohn WD, Micanovic R, Myers SL, Vick AM, Kahl SD, Zhang L, Strifler BA, Li S, Shang J, Beals JM, Mayer JP, DiMarchi RD.

Peptides. 2007 Apr;28(4):935-48. Epub 2007 Jan 25.

PMID:
17328992
14.

FGF-21 as a novel metabolic regulator.

Kharitonenkov A, Shiyanova TL, Koester A, Ford AM, Micanovic R, Galbreath EJ, Sandusky GE, Hammond LJ, Moyers JS, Owens RA, Gromada J, Brozinick JT, Hawkins ED, Wroblewski VJ, Li DS, Mehrbod F, Jaskunas SR, Shanafelt AB.

J Clin Invest. 2005 Jun;115(6):1627-35. Epub 2005 May 2.

15.

Pharmacokinetics, metabolic stability, and subcutaneous bioavailability of a genetically engineered analog of DcR3, FLINT [DcR3(R218Q)], in cynomolgus monkeys and mice.

Wroblewski VJ, McCloud C, Davis K, Manetta J, Micanovic R, Witcher DR.

Drug Metab Dispos. 2003 Apr;31(4):502-7.

PMID:
12642478
16.

Decoy receptor 3 (DcR3) is proteolytically processed to a metabolic fragment having differential activities against Fas ligand and LIGHT.

Wroblewski VJ, Witcher DR, Becker GW, Davis KA, Dou S, Micanovic R, Newton CM, Noblitt TW, Richardson JM, Song HY, Hale JE.

Biochem Pharmacol. 2003 Feb 15;65(4):657-67.

PMID:
12566095
17.

Glycosylation of erythropoietin affects receptor binding kinetics: role of electrostatic interactions.

Darling RJ, Kuchibhotla U, Glaesner W, Micanovic R, Witcher DR, Beals JM.

Biochemistry. 2002 Dec 10;41(49):14524-31.

PMID:
12463751
18.

Competitive, reversible inhibition of cytosolic phospholipase A2 at the lipid-water interface by choline derivatives that partially partition into the phospholipid bilayer.

Burke JR, Witmer MR, Zusi FC, Gregor KR, Davern LB, Padmanabha R, Swann RT, Smith D, Tredup JA, Micanovic R, Manly SP, Villafranca JJ, Tramposch KM.

J Biol Chem. 1999 Jul 2;274(27):18864-71.

19.

Presence of glycerol masks the effects of phosphorylation on the catalytic efficiency of cytosolic phospholipase A2.

Burke JR, Guenther MG, Witmer MR, Tredup JA, Hail ME, Micanovic R, Villafranca JJ.

Arch Biochem Biophys. 1997 May 1;341(1):177-85.

PMID:
9143367
20.

Cooperativity and binding in the mechanism of cytosolic phospholipase A2.

Burke JR, Witmer MR, Tredup J, Micanovic R, Gregor KR, Lahiri J, Tramposch KM, Villafranca JJ.

Biochemistry. 1995 Nov 21;34(46):15165-74. Erratum in: Biochemistry 1997 Jun 3;36(22):6854.

PMID:
7578131
21.

Active recombinant human cytosolic phospholipase A2 is expressed in Escherichia coli.

Witmer MR, Micanovic R, Tredup J, Lin W, Hail M, Villafranca JJ.

Arch Biochem Biophys. 1995 Apr 20;318(2):430-8.

PMID:
7733674
22.

Role of histidine 373 in the catalytic activity of coagulation factor XIII.

Micanovic R, Procyk R, Lin W, Matsueda GR.

J Biol Chem. 1994 Mar 25;269(12):9190-4.

23.

Structural requirements of a nascent protein for processing to a PI-G anchored form: studies in intact cells and cell-free systems.

Udenfriend S, Micanovic R, Kodukula K.

Cell Biol Int Rep. 1991 Sep;15(9):739-59. Review. No abstract available.

PMID:
1802409
24.
25.

Selectivity at the cleavage/attachment site of phosphatidylinositol-glycan anchored membrane proteins is enzymatically determined.

Micanovic R, Kodukula K, Gerber LD, Udenfriend S.

Proc Natl Acad Sci U S A. 1990 Oct;87(20):7939-43.

26.

Secreted alkaline phosphatase: an internal standard for expression of injected mRNAs in the Xenopus oocyte.

Tate SS, Urade R, Micanovic R, Gerber L, Udenfriend S.

FASEB J. 1990 Feb 1;4(2):227-31.

PMID:
2298343
28.

Conversion of placental alkaline phosphatase from a phosphatidylinositol-glycan-anchored protein to an integral transmembrane protein.

Berger J, Micanovic R, Greenspan RJ, Udenfriend S.

Proc Natl Acad Sci U S A. 1989 Mar;86(5):1457-60.

29.

Site-directed antibodies for probing the structure and biogenesis of phosphatidylinositol glycan-linked membrane proteins: application to placental alkaline phosphatase.

Bailey CA, Howard A, Mićanović R, Berger J, Heimer E, Felix A, Gerber L, Brink L, Udenfriend S.

Anal Biochem. 1988 May 1;170(2):532-41.

PMID:
3394951
30.

Aspartic acid-484 of nascent placental alkaline phosphatase condenses with a phosphatidylinositol glycan to become the carboxyl terminus of the mature enzyme.

Micanovic R, Bailey CA, Brink L, Gerber L, Pan YC, Hulmes JD, Udenfriend S.

Proc Natl Acad Sci U S A. 1988 Mar;85(5):1398-402.

31.

Purification and sequence of a novel ovine adrenal medullary peptide and its precursor.

Micanovic R, Ray P, Kruggel W, Lewis RV.

Neuroendocrinology. 1985 Sep;41(3):197-200.

PMID:
4047337
32.

Entropic DNA.

Middaugh CR, Brandau DT, Micanovic R, Katzenstein GE.

Med Hypotheses. 1985 Aug;17(4):387-98.

PMID:
2995776
33.

Protein conformation and reversed-phase high-performance liquid chromatography.

Sadler AJ, Micanovic R, Katzenstein GE, Lewis RV, Middaugh CR.

J Chromatogr. 1984 Dec 28;317:93-101.

PMID:
6530457
34.
35.

Adrenal medullary chromaffin granule peptides: two major ovine peptides and their precursor.

Lewis RV, Micanovic R, Ray P, Blacher R, Stern A.

Arch Biochem Biophys. 1984 Apr;230(1):154-7.

PMID:
6712229
36.

A simple experimental model for hydrophobic interactions in proteins.

Lawson EQ, Sadler AJ, Harmatz D, Brandau DT, Micanovic R, MacElroy RD, Middaugh CR.

J Biol Chem. 1984 Mar 10;259(5):2910-2.

37.

Purification and sequence of an opioid peptide derived from ovine proenkephalin.

Micanovic R, Ray P, Kruggel W, Lewis RV.

Biochem Biophys Res Commun. 1984 Jan 13;118(1):299-303.

PMID:
6546517

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