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Items: 32


The role of oxidative stress in the crosstalk between leptin and mineralocorticoid receptor in the cardiac fibrosis associated with obesity.

Gutiérrez-Tenorio J, Marín-Royo G, Martínez-Martínez E, Martín R, Miana M, López-Andrés N, Jurado-López R, Gallardo I, Luaces M, San Román JA, González-Amor M, Salaices M, Nieto ML, Cachofeiro V.

Sci Rep. 2017 Dec 1;7(1):16802. doi: 10.1038/s41598-017-17103-9.


Continuous synthesis of drug-loaded nanoparticles using microchannel emulsification and numerical modeling: effect of passive mixing.

Ortiz de Solorzano I, Uson L, Larrea A, Miana M, Sebastian V, Arruebo M.

Int J Nanomedicine. 2016 Jul 25;11:3397-416. doi: 10.2147/IJN.S108812. eCollection 2016.


The lysyl oxidase inhibitor (β-aminopropionitrile) reduces leptin profibrotic effects and ameliorates cardiovascular remodeling in diet-induced obesity in rats.

Martínez-Martínez E, Rodríguez C, Galán M, Miana M, Jurado-López R, Bartolomé MV, Luaces M, Islas F, Martínez-González J, López-Andrés N, Cachofeiro V.

J Mol Cell Cardiol. 2016 Mar;92:96-104. doi: 10.1016/j.yjmcc.2016.01.012. Epub 2016 Jan 15.


The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats.

Miana M, Galán M, Martínez-Martínez E, Varona S, Jurado-López R, Bausa-Miranda B, Antequera A, Luaces M, Martínez-González J, Rodríguez C, Cachofeiro V.

Dis Model Mech. 2015 Jun;8(6):543-51. doi: 10.1242/dmm.020107. Epub 2015 Apr 7.


Interleukin-33/ST2 system attenuates aldosterone-induced adipogenesis and inflammation.

Martínez-Martínez E, Cachofeiro V, Rousseau E, Álvarez V, Calvier L, Fernández-Celis A, Leroy C, Miana M, Jurado-López R, Briones AM, Jaisser F, Zannad F, Rossignol P, López-Andrés N.

Mol Cell Endocrinol. 2015 Aug 15;411:20-7. doi: 10.1016/j.mce.2015.04.007. Epub 2015 Apr 17.


The impact of galectin-3 inhibition on aldosterone-induced cardiac and renal injuries.

Calvier L, Martinez-Martinez E, Miana M, Cachofeiro V, Rousseau E, Sádaba JR, Zannad F, Rossignol P, López-Andrés N.

JACC Heart Fail. 2015 Jan;3(1):59-67. doi: 10.1016/j.jchf.2014.08.002. Epub 2014 Nov 11.


Leptin, a mediator of cardiac damage associated with obesity.

Martínez-Martínez E, Jurado-López R, Cervantes-Escalera P, Cachofeiro V, Miana M.

Horm Mol Biol Clin Investig. 2014 Apr;18(1):3-14. doi: 10.1515/hmbci-2013-0060. Review.


Leptin induces cardiac fibrosis through galectin-3, mTOR and oxidative stress: potential role in obesity.

Martínez-Martínez E, Jurado-López R, Valero-Muñoz M, Bartolomé MV, Ballesteros S, Luaces M, Briones AM, López-Andrés N, Miana M, Cachofeiro V.

J Hypertens. 2014 May;32(5):1104-14; discussion 1114. doi: 10.1097/HJH.0000000000000149.


The potential role of leptin in the vascular remodeling associated with obesity.

Martínez-Martínez E, Miana M, Jurado-López R, Bartolomé MV, Souza Neto FV, Salaices M, López-Andrés N, Cachofeiro V.

Int J Obes (Lond). 2014 Dec;38(12):1565-72. doi: 10.1038/ijo.2014.37. Epub 2014 Mar 3.


A role for soluble ST2 in vascular remodeling associated with obesity in rats.

Martínez-Martínez E, Miana M, Jurado-López R, Rousseau E, Rossignol P, Zannad F, Cachofeiro V, López-Andrés N.

PLoS One. 2013 Nov 12;8(11):e79176. doi: 10.1371/journal.pone.0079176. eCollection 2013.


Left and right ventricle late remodeling following myocardial infarction in rats.

Stefanon I, Valero-Muñoz M, Fernandes AA, Ribeiro RF Jr, Rodríguez C, Miana M, Martínez-González J, Spalenza JS, Lahera V, Vassallo PF, Cachofeiro V.

PLoS One. 2013 May 31;8(5):e64986. doi: 10.1371/journal.pone.0064986. Print 2013.


Study of hyperglycemia in non critically-ill patients receiving parenteral nutrition: incidence and risk factors.

Llop JM, Leiva E, Mateu-de Antonio J, Berlana D, Badia M, Casasín T, Miana M, Pons M, Maroto M, Chicharro L, López-Suñé E, Díaz-Munio E, Sevilla D, Martínez I, Vitales M, Casajuana MT, Bobis MA.

Nutr Hosp. 2012 Sep-Oct;27(5):1521-6. doi: 10.3305/nh.2012.27.5.5880.


The impact of bariatric surgery on renal and cardiac functions in morbidly obese patients.

Luaces M, Martínez-Martínez E, Medina M, Miana M, González N, Fernández-Pérez C, Cachofeiro V.

Nephrol Dial Transplant. 2012 Dec;27 Suppl 4:iv53-7. doi: 10.1093/ndt/gfs529.


Galectin-3 mediates aldosterone-induced vascular fibrosis.

Calvier L, Miana M, Reboul P, Cachofeiro V, Martinez-Martinez E, de Boer RA, Poirier F, Lacolley P, Zannad F, Rossignol P, López-Andrés N.

Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):67-75. doi: 10.1161/ATVBAHA.112.300569. Epub 2012 Nov 1.


Ezetimibe inhibits PMA-induced monocyte/macrophage differentiation by altering microRNA expression: a novel anti-atherosclerotic mechanism.

Muñoz-Pacheco P, Ortega-Hernández A, Miana M, Cachofeiro V, Fernández-Cruz A, Gómez-Garre D.

Pharmacol Res. 2012 Dec;66(6):536-43. doi: 10.1016/j.phrs.2012.09.005. Epub 2012 Sep 15.


DIOL triterpenes block profibrotic effects of angiotensin II and protect from cardiac hypertrophy.

Martín R, Miana M, Jurado-López R, Martínez-Martínez E, Gómez-Hurtado N, Delgado C, Bartolomé MV, San Román JA, Cordova C, Lahera V, Nieto ML, Cachofeiro V.

PLoS One. 2012;7(7):e41545. doi: 10.1371/journal.pone.0041545. Epub 2012 Jul 23.


A wound-like inflammatory aortic response in chronic portal hypertensive rats.

de Las Heras N, Aller MA, Martín-Fernández B, Miana M, Ballesteros S, Regadera J, Cachofeiro V, Arias J, Lahera V.

Mol Immunol. 2012 Jun;51(2):177-87. doi: 10.1016/j.molimm.2012.03.016. Epub 2012 Mar 29.


Spironolactone prevents alterations associated with cardiac hypertrophy produced by isoproterenol in rats: involvement of serum- and glucocorticoid-regulated kinase type 1.

Martín-Fernández B, de las Heras N, Miana M, Ballesteros S, Valero-Muñoz M, Vassallo D, Davel AP, Rossoni LV, Cachofeiro V, Lahera V.

Exp Physiol. 2012 Jun;97(6):710-8. doi: 10.1113/expphysiol.2011.063230. Epub 2012 Feb 10.


The effects of adiponectin and leptin on human endothelial cell proliferation: a live-cell study.

Alvarez G, Visitación Bartolomé M, Miana M, Jurado-López R, Martín R, Zuluaga P, Martinez-Martinez E, Nieto ML, Alvarez-Sala LA, Millán J, Lahera V, Cachofeiro V.

J Vasc Res. 2012;49(2):111-22. doi: 10.1159/000332332. Epub 2012 Jan 13.


Cardiac benefits of exercise training in aging spontaneously hypertensive rats.

Rossoni LV, Oliveira RA, Caffaro RR, Miana M, Sanz-Rosa D, Koike MK, Do Amaral SL, Michelini LC, Lahera V, Cachofeiro V.

J Hypertens. 2011 Dec;29(12):2349-58. doi: 10.1097/HJH.0b013e32834d2532.


Effect of eplerenone on hypertension-associated renal damage in rats: potential role of peroxisome proliferator activated receptor gamma (PPAR-γ).

Miana M, de Las Heras N, Rodriguez C, Sanz-Rosa D, Martin-Fernandez B, Mezzano S, Lahera V, Martinez-Gonzalez J, Cachofeiro V.

J Physiol Pharmacol. 2011 Feb;62(1):87-94.


Aldosterone and the cardiovascular system: a dangerous association.

Cachofeiro V, López-Andrés N, Miana M, Martín-Fernández B, de Las Heras N, Martínez E, Lahera V, Fortuño MA.

Horm Mol Biol Clin Investig. 2010 Dec 1;4(2):539-48. doi: 10.1515/HMBCI.2010.057.


Structural, functional, and molecular alterations produced by aldosterone plus salt in rat heart: association with enhanced serum and glucocorticoid-regulated kinase-1 expression.

Martín-Fernández B, de las Heras N, Miana M, Ballesteros S, Delgado C, Song S, Hintze T, Cachofeiro V, Lahera V.

J Cardiovasc Pharmacol. 2011 Jan;57(1):114-21. doi: 10.1097/FJC.0b013e31820088ca.


A proteomic approach to determine changes in proteins involved in the myocardial metabolism in left ventricles of spontaneously hypertensive rats.

Zamorano-León JJ, Modrego J, Mateos-Cáceres PJ, Macaya C, Martín-Fernández B, Miana M, de las Heras N, Cachofeiro V, Lahera V, López-Farré AJ.

Cell Physiol Biochem. 2010;25(2-3):347-58. doi: 10.1159/000276567. Epub 2010 Jan 12.


The protective effect of irbesartan in rats fed a high fat diet is associated with modification of leptin-adiponectin imbalance.

de las Heras N, Martín-Fernández B, Miana M, Ballesteros S, Oubiña MP, López-Farré AJ, Cachofeiro V, Lahera V.

J Hypertens Suppl. 2009 Aug;27(6):S37-41. doi: 10.1097/01.hjh.0000358836.64052.43.


Cardiac L-type calcium current is increased in a model of hyperaldosteronism in the rat.

Martin-Fernandez B, Miana M, De Las Heras N, Ruiz-Hurtado G, Fernandez-Velasco M, Bas M, Ballesteros S, Lahera V, Cachofeiro V, Delgado C.

Exp Physiol. 2009 Jun;94(6):675-83. doi: 10.1113/expphysiol.2009.047688. Epub 2009 Apr 24.


Aldosterone and the vascular system.

Cachofeiro V, Miana M, de Las Heras N, Martín-Fernández B, Ballesteros S, Fernández-Tresguerres J, Lahera V.

J Steroid Biochem Mol Biol. 2008 Apr;109(3-5):331-5. doi: 10.1016/j.jsbmb.2008.03.005. Epub 2008 Mar 6. Review.


Role of connective tissue growth factor in vascular and renal damage associated with hypertension in rats. Interactions with angiotensin II.

de las Heras N, Ruiz-Ortega M, Rupérez M, Sanz-Rosa D, Miana M, Aragoncillo P, Mezzano S, Lahera V, Egido J, Cachofeiro V.

J Renin Angiotensin Aldosterone Syst. 2006 Dec;7(4):192-200.


Interactions between aldosterone and connective tissue growth factor in vascular and renal damage in spontaneously hypertensive rats.

de las Heras N, Ruiz-Ortega M, Miana M, Rupérez M, Sanz-Rosa D, Aragoncillo P, Mezzano S, Cachofeiro V, Egido J, Lahera V.

J Hypertens. 2007 Mar;25(3):629-38.


Endothelial dysfunction, oxidative stress and inflammation in atherosclerosis: beneficial effects of statins.

Lahera V, Goicoechea M, de Vinuesa SG, Miana M, de las Heras N, Cachofeiro V, Luño J.

Curr Med Chem. 2007;14(2):243-8. Review.


[Reflections on betalactam antibiotics administered by continuous infusion].

López E, Soy D, Miana MT, Codina C, Ribas J.

Enferm Infecc Microbiol Clin. 2006 Aug-Sep;24(7):445-52. Review. Spanish.


Participation of aldosterone in the vascular inflammatory response of spontaneously hypertensive rats: role of the NFkappaB/IkappaB system.

Sanz-Rosa D, Cediel E, de las Heras N, Miana M, Balfagón G, Lahera V, Cachofeiro V.

J Hypertens. 2005 Jun;23(6):1167-72.


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