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Items: 14

1.

A modified gene trap approach for improved high-throughput cancer drug discovery.

Morris SM, Mhyre AJ, Carmack SS, Myers CH, Burns C, Ye W, Ferrer M, Olson JM, Klinghoffer RA.

Oncogene. 2018 Aug;37(31):4226-4238. doi: 10.1038/s41388-018-0274-4. Epub 2018 May 2.

PMID:
29717260
2.

Publisher Correction: Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets.

Crook ZR, Sevilla GP, Friend D, Brusniak MY, Bandaranayake AD, Clarke M, Gewe M, Mhyre AJ, Baker D, Strong RK, Bradley P, Olson JM.

Nat Commun. 2018 Mar 9;9(1):1072. doi: 10.1038/s41467-018-03350-5.

3.

Pacifastin-derived Peptides Target Tumors for Use in In Vivo Imaging.

Sottero TL, Girard EJ, Myers C, Hopping G, Mhyre AJ, Olson JM.

Anticancer Res. 2018 Jan;38(1):51-60.

PMID:
29277756
4.

Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets.

Crook ZR, Sevilla GP, Friend D, Brusniak MY, Bandaranayake AD, Clarke M, Gewe M, Mhyre AJ, Baker D, Strong RK, Bradley P, Olson JM.

Nat Commun. 2017 Dec 21;8(1):2244. doi: 10.1038/s41467-017-02098-8. Erratum in: Nat Commun. 2018 Mar 9;9(1):1072.

5.

Synthesis and Biological Evaluation of N-((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1.

Cioffi CL, Liu S, Wolf MA, Guzzo PR, Sadalapure K, Parthasarathy V, Loong DT, Maeng JH, Carulli E, Fang X, Karunakaran K, Matta L, Choo SH, Panduga S, Buckle RN, Davis RN, Sakwa SA, Gupta P, Sargent BJ, Moore NA, Luche MM, Carr GJ, Khmelnitsky YL, Ismail J, Chung M, Bai M, Leong WY, Sachdev N, Swaminathan S, Mhyre AJ.

J Med Chem. 2016 Sep 22;59(18):8473-94. doi: 10.1021/acs.jmedchem.6b00914. Epub 2016 Sep 9.

6.

The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties.

Guo C, Hu M, DeOrazio RJ, Usyatinsky A, Fitzpatrick K, Zhang Z, Maeng JH, Kitchen DB, Tom S, Luche M, Khmelnitsky Y, Mhyre AJ, Guzzo PR, Liu S.

Bioorg Med Chem. 2014 Jul 1;22(13):3414-22. doi: 10.1016/j.bmc.2014.04.036. Epub 2014 Apr 28.

PMID:
24842618
7.

Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1.

Cioffi CL, Wolf MA, Guzzo PR, Sadalapure K, Parthasarathy V, Dethe D, Maeng JH, Carulli E, Loong DT, Fang X, Hu M, Gupta P, Chung M, Bai M, Moore N, Luche M, Khmelnitsky Y, Love PL, Watson MA, Mhyre AJ, Liu S.

Bioorg Med Chem Lett. 2013 Mar 1;23(5):1257-61. doi: 10.1016/j.bmcl.2013.01.006. Epub 2013 Jan 11.

PMID:
23380375
8.

Stroma-dependent apoptosis in clonal hematopoietic precursors correlates with expression of PYCARD.

Mhyre AJ, Marcondes AM, Spaulding EY, Deeg HJ.

Blood. 2009 Jan 15;113(3):649-58. doi: 10.1182/blood-2008-04-152686. Epub 2008 Oct 22.

9.

Disease-causing mutation in GPR54 reveals the importance of the second intracellular loop for class A G-protein-coupled receptor function.

Wacker JL, Feller DB, Tang XB, Defino MC, Namkung Y, Lyssand JS, Mhyre AJ, Tan X, Jensen JB, Hague C.

J Biol Chem. 2008 Nov 7;283(45):31068-78. doi: 10.1074/jbc.M805251200. Epub 2008 Sep 4.

10.

Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function.

Marcondes AM, Mhyre AJ, Stirewalt DL, Kim SH, Dinarello CA, Deeg HJ.

Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2865-70. doi: 10.1073/pnas.0712391105. Epub 2008 Feb 19.

11.

Tumour necrosis factor-induced gene expression in human marrow stroma: clues to the pathophysiology of MDS?

Stirewalt DL, Mhyre AJ, Marcondes M, Pogosova-Agadjanyan E, Abbasi N, Radich JP, Deeg HJ.

Br J Haematol. 2008 Feb;140(4):444-53. Epub 2007 Dec 19.

PMID:
18162123
12.

Control of hematopoiesis and apoptosis in MDS: more than FLIPing the coin.

Mhyre AJ, Deeg HJ.

Leuk Res. 2007 Jun;31(6):747-9. Epub 2007 Feb 22. Review. No abstract available.

PMID:
17320170
13.
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