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Validation of the ISTH/SSC bleeding assessment tool for inherited platelet disorders: a communication from the Platelet Physiology SSC.

Gresele P, Orsini S, Noris P, Falcinelli E, Christine Alessi M, Bury L, Borhany M, Santoro C, Glembotsky AC, Cid AR, Tosetto A, De Candia E, Fontana P, Guglielmini G, Pecci A; BAT-VAL study investigators.

J Thromb Haemost. 2019 Nov 21. doi: 10.1111/jth.14683. [Epub ahead of print]


Platelet glycoprotein VI genetic quantitative and qualitative defects.

Jandrot-Perrus M, Hermans C, Mezzano D.

Platelets. 2019;30(6):708-713. doi: 10.1080/09537104.2019.1610166. Epub 2019 May 8.


Diagnostic challenges of inherited mild bleeding disorders: a bait for poorly explored clinical and basic research.

Mezzano D, Quiroga T.

J Thromb Haemost. 2019 Feb;17(2):257-270. doi: 10.1111/jth.14363. Epub 2019 Jan 21. Review.


Laboratory monitoring of P2Y12 inhibitors: communication from the SSC of the ISTH.

Frelinger AL 3rd, Gachet C, Mumford AD, Noris P, Mezzano D, Harrison P, Gresele P; Subcommittee on Platelet Physiology.

J Thromb Haemost. 2018 Nov;16(11):2341-2346. doi: 10.1111/jth.14282. Epub 2018 Oct 3. No abstract available.


Immobilized fibrinogen activates human platelets through glycoprotein VI.

Mangin PH, Onselaer MB, Receveur N, Le Lay N, Hardy AT, Wilson C, Sanchez X, Loyau S, Dupuis A, Babar AK, Miller JL, Philippou H, Hughes CE, Herr AB, Ariëns RA, Mezzano D, Jandrot-Perrus M, Gachet C, Watson SP.

Haematologica. 2018 May;103(5):898-907. doi: 10.3324/haematol.2017.182972. Epub 2018 Feb 22.


Fibrin and D-dimer bind to monomeric GPVI.

Onselaer MB, Hardy AT, Wilson C, Sanchez X, Babar AK, Miller JLC, Watson CN, Watson SK, Bonna A, Philippou H, Herr AB, Mezzano D, Ariëns RAS, Watson SP.

Blood Adv. 2017 Aug 15;1(19):1495-1504. doi: 10.1182/bloodadvances.2017007732. eCollection 2017 Aug 22.


Human platelet interaction with E. coli O111 promotes tissue-factor-dependent procoagulant activity, involving Toll like receptor 4.

Matus V, Valenzuela JG, Hidalgo P, Pozo LM, Panes O, Wozniak A, Mezzano D, Pereira J, Sáez CG.

PLoS One. 2017 Sep 28;12(9):e0185431. doi: 10.1371/journal.pone.0185431. eCollection 2017.


Platelet tissue factor activity and membrane cholesterol are increased in hypercholesterolemia and normalized by rosuvastatin, but not by atorvastatin.

Panes O, González C, Hidalgo P, Valderas JP, Acevedo M, Contreras S, Sánchez X, Pereira J, Rigotti A, Mezzano D.

Atherosclerosis. 2017 Feb;257:164-171. doi: 10.1016/j.atherosclerosis.2016.12.019. Epub 2016 Dec 16.


Serotonin- and Dopamine-Related Gene Expression in db/db Mice Islets and in MIN6 β-Cells Treated with Palmitate and Oleate.

Cataldo LR, Mizgier ML, Busso D, Olmos P, Galgani JE, Valenzuela R, Mezzano D, Aranda E, Cortés VA, Santos JL.

J Diabetes Res. 2016;2016:3793781. doi: 10.1155/2016/3793781. Epub 2016 Jun 5.


Inhibition of angiogenesis by platelets in systemic sclerosis patients.

Hirigoyen D, Burgos PI, Mezzano V, Duran J, Barrientos M, Saez CG, Panes O, Mezzano D, Iruretagoyena M.

Arthritis Res Ther. 2015 Nov 19;17:332. doi: 10.1186/s13075-015-0848-2.


Increased RhoA/Rho-Kinase Activity and Markers of Endothelial Dysfunction in Young Adult Subjects with Metabolic Syndrome.

Leguina-Ruzzi A, Pereira J, Pereira-Flores K, Valderas JP, Mezzano D, Velarde V, Sáez CG.

Metab Syndr Relat Disord. 2015 Nov;13(9):373-80. doi: 10.1089/met.2015.0061.


Serum Ferritin Is Associated with Metabolic Syndrome and Red Meat Consumption.

Avila F, Echeverría G, Pérez D, Martinez C, Strobel P, Castillo O, Villaroel L, Mezzano D, Rozowski J, Urquiaga I, Leighton F.

Oxid Med Cell Longev. 2015;2015:769739. doi: 10.1155/2015/769739. Epub 2015 Sep 14.


Fluoxetine impairs insulin secretion without modifying extracellular serotonin levels in MIN6 β-cells.

Cataldo LR, Cortés VA, Mizgier ML, Aranda E, Mezzano D, Olmos P, Galgani JE, Suazo J, Santos JL.

Exp Clin Endocrinol Diabetes. 2015 Sep;123(8):473-8. doi: 10.1055/s-0035-1549964. Epub 2015 May 26.


Platelets enhance tissue factor protein and metastasis initiating cell markers, and act as chemoattractants increasing the migration of ovarian cancer cells.

Orellana R, Kato S, Erices R, Bravo ML, Gonzalez P, Oliva B, Cubillos S, Valdivia A, Ibañez C, Brañes J, Barriga MI, Bravo E, Alonso C, Bustamente E, Castellon E, Hidalgo P, Trigo C, Panes O, Pereira J, Mezzano D, Cuello MA, Owen GI.

BMC Cancer. 2015 Apr 15;15:290. doi: 10.1186/s12885-015-1304-z.


A review of platelet secretion assays for the diagnosis of inherited platelet secretion disorders.

Mumford AD, Frelinger AL 3rd, Gachet C, Gresele P, Noris P, Harrison P, Mezzano D.

Thromb Haemost. 2015 Jul;114(1):14-25. doi: 10.1160/TH14-11-0999. Epub 2015 Apr 16. Review.


Changes in regional cerebral blood flow are associated with endothelial dysfunction markers in cocaine-dependent patients under recent abstinence.

Massardo T, Quintana JC, Jaimovich R, Sáez CG, Cabreras MJ, Pereira-Flores K, Ibáñez C, Pallavicini J, Véliz J, Mezzano D, Pereira J.

J Addict Med. 2015 Mar-Apr;9(2):139-46. doi: 10.1097/ADM.0000000000000109.


Diagnosis of inherited platelet function disorders: guidance from the SSC of the ISTH.

Gresele P; Subcommittee on Platelet Physiology of the International Society on Thrombosis and Hemostasis.

J Thromb Haemost. 2015 Feb;13(2):314-22. doi: 10.1111/jth.12792. Epub 2015 Jan 22. Review. No abstract available.


Inhibition of platelet activation and thrombus formation by adenosine and inosine: studies on their relative contribution and molecular modeling.

Fuentes E, Pereira J, Mezzano D, Alarcón M, Caballero J, Palomo I.

PLoS One. 2014 Nov 13;9(11):e112741. doi: 10.1371/journal.pone.0112741. eCollection 2014.


Atorvastatin reduces the proadhesive and prothrombotic endothelial cell phenotype induced by cocaine and plasma from cocaine consumers in vitro.

Sáez CG, Pereira-Flores K, Ebensperger R, Panes O, Massardo T, Hidalgo P, Mezzano D, Pereira J.

Arterioscler Thromb Vasc Biol. 2014 Nov;34(11):2439-48. doi: 10.1161/ATVBAHA.114.304535. Epub 2014 Sep 18.


Diagnosing type 1 von Willebrand disease: good for patient's health or for doctor's prestige? comment.

Mezzano D, Zúñiga P, Pereira J, Quiroga T.

J Thromb Haemost. 2014 Dec;12(12):2131-4. doi: 10.1111/jth.12727. Epub 2014 Oct 29. No abstract available.

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