Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 71

1.

Point of Care Exome Sequencing Reveals Allelic and Phenotypic Heterogeneity Underlying Mendelian disease in Qatar.

Fakhro KA, Robay A, Rodrigues-Flores JL, Mezey JG, Al-Shakaki AA, Chidiac O, Stadler D, Malek JA, Imam AB, Sheikh A, Azzam A, Janahi I, Khanjar I, Osman K, Ziki MA, Mahmah MA, Selim M, Numeiri N, Ali R, Lakhani S, Butt F, Omran TB, Crystal RG.

Hum Mol Genet. 2019 Oct 18. pii: ddz134. doi: 10.1093/hmg/ddz134. [Epub ahead of print]

PMID:
31625567
2.

Role of KRAS in regulating normal human airway basal cell differentiation.

Ogawa F, Walters MS, Shafquat A, O'Beirne SL, Kaner RJ, Mezey JG, Zhang H, Leopold PL, Crystal RG.

Respir Res. 2019 Aug 9;20(1):181. doi: 10.1186/s12931-019-1129-4.

3.

Exaggerated BMP4 signalling alters human airway basal progenitor cell differentiation to cigarette smoking-related phenotypes.

Zuo WL, Yang J, Strulovici-Barel Y, Salit J, Rostami M, Mezey JG, O'Beirne SL, Kaner RJ, Crystal RG.

Eur Respir J. 2019 May 18;53(5). pii: 1702553. doi: 10.1183/13993003.02553-2017. Print 2019 May.

PMID:
30705127
4.

Corneal confocal microscopy: Neurologic disease biomarker in Friedreich ataxia.

Pagovich OE, Vo ML, Zhao ZZ, Petropoulos IN, Yuan M, Lertsuwanroj B, Ciralsky J, Lai E, Kiss S, D'Amico DJ, Mezey JG, Malik RA, Crystal RG.

Ann Neurol. 2018 Dec;84(6):893-904. doi: 10.1002/ana.25355.

PMID:
30294800
5.

Exome sequencing-based identification of novel type 2 diabetes risk allele loci in the Qatari population.

O'Beirne SL, Salit J, Rodriguez-Flores JL, Staudt MR, Abi Khalil C, Fakhro KA, Robay A, Ramstetter MD, Malek JA, Zirie M, Jayyousi A, Badii R, Al-Nabet Al-Marri A, Bener A, Mahmoud M, Chiuchiolo MJ, Al-Shakaki A, Chidiac O, Stadler D, Mezey JG, Crystal RG.

PLoS One. 2018 Sep 13;13(9):e0199837. doi: 10.1371/journal.pone.0199837. eCollection 2018.

6.

Inferring Identical-by-Descent Sharing of Sample Ancestors Promotes High-Resolution Relative Detection.

Ramstetter MD, Shenoy SA, Dyer TD, Lehman DM, Curran JE, Duggirala R, Blangero J, Mezey JG, Williams AL.

Am J Hum Genet. 2018 Jul 5;103(1):30-44. doi: 10.1016/j.ajhg.2018.05.008. Epub 2018 Jun 21.

7.

Ambient Pollution-related Reprogramming of the Human Small Airway Epithelial Transcriptome.

O'Beirne SL, Shenoy SA, Salit J, Strulovici-Barel Y, Kaner RJ, Visvanathan S, Fine JS, Mezey JG, Crystal RG.

Am J Respir Crit Care Med. 2018 Dec 1;198(11):1413-1422. doi: 10.1164/rccm.201712-2526OC.

PMID:
29897792
8.

Ontogeny and Biology of Human Small Airway Epithelial Club Cells.

Zuo WL, Shenoy SA, Li S, O'Beirne SL, Strulovici-Barel Y, Leopold PL, Wang G, Staudt MR, Walters MS, Mason C, Kaner RJ, Mezey JG, Crystal RG.

Am J Respir Crit Care Med. 2018 Dec 1;198(11):1375-1388. doi: 10.1164/rccm.201710-2107OC.

PMID:
29874100
9.

Point-of-care whole-exome sequencing of idiopathic male infertility.

Fakhro KA, Elbardisi H, Arafa M, Robay A, Rodriguez-Flores JL, Al-Shakaki A, Syed N, Mezey JG, Abi Khalil C, Malek JA, Al-Ansari A, Al Said S, Crystal RG.

Genet Med. 2018 Nov;20(11):1365-1373. doi: 10.1038/gim.2018.10. Epub 2018 Apr 12.

PMID:
29790874
10.

Mandatory role of HMGA1 in human airway epithelial normal differentiation and post-injury regeneration.

Zhang H, Yang J, Walters MS, Staudt MR, Strulovici-Barel Y, Salit J, Mezey JG, Leopold PL, Crystal RG.

Oncotarget. 2018 Feb 16;9(18):14324-14337. doi: 10.18632/oncotarget.24511. eCollection 2018 Mar 6.

11.

Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population.

Yousri NA, Fakhro KA, Robay A, Rodriguez-Flores JL, Mohney RP, Zeriri H, Odeh T, Kader SA, Aldous EK, Thareja G, Kumar M, Al-Shakaki A, Chidiac OM, Mohamoud YA, Mezey JG, Malek JA, Crystal RG, Suhre K.

Nat Commun. 2018 Jan 23;9(1):333. doi: 10.1038/s41467-017-01972-9.

12.

XX Disorder of Sex Development is associated with an insertion on chromosome 9 and downregulation of RSPO1 in dogs (Canis lupus familiaris).

Meyers-Wallen VN, Boyko AR, Danko CG, Grenier JK, Mezey JG, Hayward JJ, Shannon LM, Gao C, Shafquat A, Rice EJ, Pujar S, Eggers S, Ohnesorg T, Sinclair AH.

PLoS One. 2017 Oct 20;12(10):e0186331. doi: 10.1371/journal.pone.0186331. eCollection 2017.

13.

Benchmarking Relatedness Inference Methods with Genome-Wide Data from Thousands of Relatives.

Ramstetter MD, Dyer TD, Lehman DM, Curran JE, Duggirala R, Blangero J, Mezey JG, Williams AL.

Genetics. 2017 Sep;207(1):75-82. doi: 10.1534/genetics.117.1122. Epub 2017 Jul 24.

14.

An independent component analysis confounding factor correction framework for identifying broad impact expression quantitative trait loci.

Ju JH, Shenoy SA, Crystal RG, Mezey JG.

PLoS Comput Biol. 2017 May 15;13(5):e1005537. doi: 10.1371/journal.pcbi.1005537. eCollection 2017 May.

15.

Waterpipe smoking induces epigenetic changes in the small airway epithelium.

Walters MS, Salit J, Ju JH, Staudt MR, Kaner RJ, Rogalski AM, Sodeinde TB, Rahim R, Strulovici-Barel Y, Mezey JG, Almulla AM, Sattar H, Mahmoud M, Crystal RG.

PLoS One. 2017 Mar 8;12(3):e0171112. doi: 10.1371/journal.pone.0171112. eCollection 2017.

16.

Rare Synaptogenesis-Impairing Mutations in SLITRK5 Are Associated with Obsessive Compulsive Disorder.

Song M, Mathews CA, Stewart SE, Shmelkov SV, Mezey JG, Rodriguez-Flores JL, Rasmussen SA, Britton JC, Oh YS, Walkup JT, Lee FS, Glatt CE.

PLoS One. 2017 Jan 13;12(1):e0169994. doi: 10.1371/journal.pone.0169994. eCollection 2017.

17.

Correction: Type 2 Diabetes Risk Allele Loci in the Qatari Population.

O'Beirne SL, Salit J, Rodriguez-Flores JL, Staudt MR, Abi Khalil C, Fakhro KA, Robay A, Ramstetter MD, Al-Azwani IK, Malek JA, Zirie M, Jayyousi A, Badii R, Al-Nabet Al-Marri A, Chiuchiolo MJ, Al-Shakaki A, Chidiac O, Gharbiah M, Bener A, Stadler D, Hackett NR, Mezey JG, Crystal RG.

PLoS One. 2016 Aug 23;11(8):e0161910. doi: 10.1371/journal.pone.0161910. eCollection 2016.

18.

Persistence of circulating endothelial microparticles in COPD despite smoking cessation.

Strulovici-Barel Y, Staudt MR, Krause A, Gordon C, Tilley AE, Harvey BG, Kaner RJ, Hollmann C, Mezey JG, Bitter H, Pillai SG, Hilton H, Wolff G, Stevenson CS, Visvanathan S, Fine JS, Crystal RG.

Thorax. 2016 Dec;71(12):1137-1144. doi: 10.1136/thoraxjnl-2015-208274. Epub 2016 Jul 26.

19.

The Qatar genome: a population-specific tool for precision medicine in the Middle East.

Fakhro KA, Staudt MR, Ramstetter MD, Robay A, Malek JA, Badii R, Al-Marri AA, Abi Khalil C, Al-Shakaki A, Chidiac O, Stadler D, Zirie M, Jayyousi A, Salit J, Mezey JG, Crystal RG, Rodriguez-Flores JL.

Hum Genome Var. 2016 Jun 30;3:16016. doi: 10.1038/hgv.2016.16. eCollection 2016.

20.

Type 2 Diabetes Risk Allele Loci in the Qatari Population.

O'Beirne SL, Salit J, Rodriguez-Flores JL, Staudt MR, Abi Khalil C, Fakhro KA, Robay A, Ramstetter MD, Al-Azwani IK, Malek JA, Zirie M, Jayyousi A, Badii R, Al-Nabet Al-Marri A, Chiuchiolo MJ, Al-Shakaki A, Chidiac O, Gharbiah M, Bener A, Stadler D, Hackett NR, Mezey JG, Crystal RG.

PLoS One. 2016 Jul 6;11(7):e0156834. doi: 10.1371/journal.pone.0156834. eCollection 2016. Erratum in: PLoS One. 2016;11(8):e0161910.

21.

Anti-hIgE gene therapy of peanut-induced anaphylaxis in a humanized murine model of peanut allergy.

Pagovich OE, Wang B, Chiuchiolo MJ, Kaminsky SM, Sondhi D, Jose CL, Price CC, Brooks SF, Mezey JG, Crystal RG.

J Allergy Clin Immunol. 2016 Dec;138(6):1652-1662.e7. doi: 10.1016/j.jaci.2016.03.053. Epub 2016 Jun 29.

PMID:
27372563
22.

Progression to COPD in smokers with normal spirometry/low DLCO using different methods to determine normal levels.

Harvey BG, Strulovici-Barel Y, Kaner RJ, Sanders A, Vincent TL, Mezey JG, Crystal RG.

Eur Respir J. 2016 Jun;47(6):1888-9. doi: 10.1183/13993003.00435-2016. No abstract available.

23.

Pulmonary Abnormalities in Young, Light-Use Waterpipe (Hookah) Smokers.

Strulovici-Barel Y, Shaykhiev R, Salit J, Deeb RS, Krause A, Kaner RJ, Vincent TL, Agosto-Perez F, Wang G, Hollmann C, Shanmugam V, Almulla AM, Sattar H, Mahmoud M, Mezey JG, Gross SS, Staudt MR, Walters MS, Crystal RG.

Am J Respir Crit Care Med. 2016 Sep 1;194(5):587-95. doi: 10.1164/rccm.201512-2470OC.

24.

POU2AF1 Functions in the Human Airway Epithelium To Regulate Expression of Host Defense Genes.

Zhou H, Brekman A, Zuo WL, Ou X, Shaykhiev R, Agosto-Perez FJ, Wang R, Walters MS, Salit J, Strulovici-Barel Y, Staudt MR, Kaner RJ, Mezey JG, Crystal RG, Wang G.

J Immunol. 2016 Apr 1;196(7):3159-67. doi: 10.4049/jimmunol.1502400. Epub 2016 Feb 29.

25.

Cigarette Smoking Induces Changes in Airway Epithelial Expression of Genes Associated with Monogenic Lung Disorders.

Tilley AE, Staudt MR, Salit J, Van de Graaf B, Strulovici-Barel Y, Kaner RJ, Vincent T, Agosto-Perez F, Mezey JG, Raby BA, Crystal RG.

Am J Respir Crit Care Med. 2016 Jan 15;193(2):215-7. doi: 10.1164/rccm.201412-2290LE. No abstract available.

26.

Indigenous Arabs are descendants of the earliest split from ancient Eurasian populations.

Rodriguez-Flores JL, Fakhro K, Agosto-Perez F, Ramstetter MD, Arbiza L, Vincent TL, Robay A, Malek JA, Suhre K, Chouchane L, Badii R, Al-Nabet Al-Marri A, Abi Khalil C, Zirie M, Jayyousi A, Salit J, Keinan A, Clark AG, Crystal RG, Mezey JG.

Genome Res. 2016 Feb;26(2):151-62. doi: 10.1101/gr.191478.115. Epub 2016 Jan 4.

27.

Risk of COPD with obstruction in active smokers with normal spirometry and reduced diffusion capacity.

Harvey BG, Strulovici-Barel Y, Kaner RJ, Sanders A, Vincent TL, Mezey JG, Crystal RG.

Eur Respir J. 2015 Dec;46(6):1589-1597. doi: 10.1183/13993003.02377-2014. Epub 2015 Nov 5.

28.

Copy number variations in the genome of the Qatari population.

Fakhro KA, Yousri NA, Rodriguez-Flores JL, Robay A, Staudt MR, Agosto-Perez F, Salit J, Malek JA, Suhre K, Jayyousi A, Zirie M, Stadler D, Mezey JG, Crystal RG.

BMC Genomics. 2015 Oct 22;16:834. doi: 10.1186/s12864-015-1991-5.

29.

Persistence of smoking-induced dysregulation of miRNA expression in the small airway epithelium despite smoking cessation.

Wang G, Wang R, Strulovici-Barel Y, Salit J, Staudt MR, Ahmed J, Tilley AE, Yee-Levin J, Hollmann C, Harvey BG, Kaner RJ, Mezey JG, Sridhar S, Pillai SG, Hilton H, Wolff G, Bitter H, Visvanathan S, Fine JS, Stevenson CS, Crystal RG.

PLoS One. 2015 Apr 17;10(4):e0120824. doi: 10.1371/journal.pone.0120824. eCollection 2015.

30.

Airway Basal stem/progenitor cells have diminished capacity to regenerate airway epithelium in chronic obstructive pulmonary disease.

Staudt MR, Buro-Auriemma LJ, Walters MS, Salit J, Vincent T, Shaykhiev R, Mezey JG, Tilley AE, Kaner RJ, Ho MW, Crystal RG.

Am J Respir Crit Care Med. 2014 Oct 15;190(8):955-8. doi: 10.1164/rccm.201406-1167LE. No abstract available.

31.

Smoking accelerates aging of the small airway epithelium.

Walters MS, De BP, Salit J, Buro-Auriemma LJ, Wilson T, Rogalski AM, Lief L, Hackett NR, Staudt MR, Tilley AE, Harvey BG, Kaner RJ, Mezey JG, Ashbridge B, Moore MA, Crystal RG.

Respir Res. 2014 Sep 24;15:94. doi: 10.1186/s12931-014-0094-1.

32.

lrgpr: interactive linear mixed model analysis of genome-wide association studies with composite hypothesis testing and regression diagnostics in R.

Hoffman GE, Mezey JG, Schadt EE.

Bioinformatics. 2014 Nov 1;30(21):3134-5. doi: 10.1093/bioinformatics/btu435. Epub 2014 Jul 16.

33.

Smoking dysregulates the human airway basal cell transcriptome at COPD risk locus 19q13.2.

Ryan DM, Vincent TL, Salit J, Walters MS, Agosto-Perez F, Shaykhiev R, Strulovici-Barel Y, Downey RJ, Buro-Auriemma LJ, Staudt MR, Hackett NR, Mezey JG, Crystal RG.

PLoS One. 2014 Feb 3;9(2):e88051. doi: 10.1371/journal.pone.0088051. eCollection 2014.

34.

HEFT: eQTL analysis of many thousands of expressed genes while simultaneously controlling for hidden factors.

Gao C, Tignor NL, Salit J, Strulovici-Barel Y, Hackett NR, Crystal RG, Mezey JG.

Bioinformatics. 2014 Feb 1;30(3):369-76. doi: 10.1093/bioinformatics/btt690. Epub 2013 Dec 4.

35.

Prevalence of the apolipoprotein E Arg145Cys dyslipidemia at-risk polymorphism in African-derived populations.

Abou Ziki MD, Strulovici-Barel Y, Hackett NR, Rodriguez-Flores JL, Mezey JG, Salit J, Radisch S, Hollmann C, Chouchane L, Malek J, Zirie MA, Jayyuosi A, Gotto AM Jr, Crystal RG.

Am J Cardiol. 2014 Jan 15;113(2):302-8. doi: 10.1016/j.amjcard.2013.09.021. Epub 2013 Oct 3.

36.

Exome sequencing identifies potential risk variants for Mendelian disorders at high prevalence in Qatar.

Rodriguez-Flores JL, Fakhro K, Hackett NR, Salit J, Fuller J, Agosto-Perez F, Gharbiah M, Malek JA, Zirie M, Jayyousi A, Badii R, Al-Nabet Al-Marri A, Chouchane L, Stadler DJ, Mezey JG, Crystal RG.

Hum Mutat. 2014 Jan;35(1):105-16. doi: 10.1002/humu.22460. Epub 2013 Nov 10.

37.

IQCB1 and PDE6B mutations cause similar early onset retinal degenerations in two closely related terrier dog breeds.

Goldstein O, Mezey JG, Schweitzer PA, Boyko AR, Gao C, Bustamante CD, Jordan JA, Aguirre GD, Acland GM.

Invest Ophthalmol Vis Sci. 2013 Oct 25;54(10):7005-19. doi: 10.1167/iovs.13-12915.

38.

High correlation of the response of upper and lower lobe small airway epithelium to smoking.

Harvey BG, Strulovici-Barel Y, Vincent TL, Mezey JG, Raviram R, Gordon C, Salit J, Tilley AE, Chung A, Sanders A, Crystal RG.

PLoS One. 2013 Sep 9;8(9):e72669. doi: 10.1371/journal.pone.0072669. eCollection 2013.

39.

Spectrum of ocular manifestations in CLN2-associated batten (Jansky-Bielschowsky) disease correlate with advancing age and deteriorating neurological function.

Orlin A, Sondhi D, Witmer MT, Wessel MM, Mezey JG, Kaminsky SM, Hackett NR, Yohay K, Kosofsky B, Souweidane MM, Kaplitt MG, D'Amico DJ, Crystal RG, Kiss S.

PLoS One. 2013 Aug 28;8(8):e73128. doi: 10.1371/journal.pone.0073128. eCollection 2013.

40.

Differential expression of vitamin E and selenium-responsive genes by disease severity in chronic obstructive pulmonary disease.

Agler AH, Crystal RG, Mezey JG, Fuller J, Gao C, Hansen JG, Cassano PA.

COPD. 2013 Aug;10(4):450-8. doi: 10.3109/15412555.2012.761958.

41.

PUMA: a unified framework for penalized multiple regression analysis of GWAS data.

Hoffman GE, Logsdon BA, Mezey JG.

PLoS Comput Biol. 2013;9(6):e1003101. doi: 10.1371/journal.pcbi.1003101. Epub 2013 Jun 27.

42.

Safety of direct cardiac administration of AdVEGF-All6A+, a replication-deficient adenovirus vector cDNA/genomic hybrid expressing all three major isoforms of human vascular endothelial growth factor, to the ischemic myocardium of rats.

Kaminsky SM, Quach L, Chen S, Pierre-Destine L, Van de Graaf B, Monette S, Rosenberg JB, De BP, Sondhi D, Hackett NR, Mezey JG, Rosengart TK, Crystal RG.

Hum Gene Ther Clin Dev. 2013 Mar;24(1):38-46. doi: 10.1089/humc.2013.054.

PMID:
23692382
43.

Lung adenocarcinoma subtypes based on expression of human airway basal cell genes.

Fukui T, Shaykhiev R, Agosto-Perez F, Mezey JG, Downey RJ, Travis WD, Crystal RG.

Eur Respir J. 2013 Nov;42(5):1332-44. doi: 10.1183/09031936.00144012. Epub 2013 May 3.

44.

PCAdmix: principal components-based assignment of ancestry along each chromosome in individuals with admixed ancestry from two or more populations.

Brisbin A, Bryc K, Byrnes J, Zakharia F, Omberg L, Degenhardt J, Reynolds A, Ostrer H, Mezey JG, Bustamante CD.

Hum Biol. 2012 Aug;84(4):343-64. doi: 10.3378/027.084.0401.

45.

Exome sequencing of only seven Qataris identifies potentially deleterious variants in the Qatari population.

Rodriguez-Flores JL, Fuller J, Hackett NR, Salit J, Malek JA, Al-Dous E, Chouchane L, Zirie M, Jayoussi A, Mahmoud MA, Crystal RG, Mezey JG.

PLoS One. 2012;7(11):e47614. doi: 10.1371/journal.pone.0047614. Epub 2012 Nov 6.

46.

Airway epithelial expression of TLR5 is downregulated in healthy smokers and smokers with chronic obstructive pulmonary disease.

Wang R, Ahmed J, Wang G, Hassan I, Strulovici-Barel Y, Salit J, Mezey JG, Crystal RG.

J Immunol. 2012 Sep 1;189(5):2217-25. doi: 10.4049/jimmunol.1101895. Epub 2012 Aug 1.

47.

Four loci explain 83% of size variation in the horse.

Makvandi-Nejad S, Hoffman GE, Allen JJ, Chu E, Gu E, Chandler AM, Loredo AI, Bellone RR, Mezey JG, Brooks SA, Sutter NB.

PLoS One. 2012;7(7):e39929. doi: 10.1371/journal.pone.0039929. Epub 2012 Jul 11.

48.

Inferring genome-wide patterns of admixture in Qataris using fifty-five ancestral populations.

Omberg L, Salit J, Hackett N, Fuller J, Matthew R, Chouchane L, Rodriguez-Flores JL, Bustamante C, Crystal RG, Mezey JG.

BMC Genet. 2012 Jun 26;13:49. doi: 10.1186/1471-2156-13-49.

49.

Empirical Bayes conditional independence graphs for regulatory network recovery.

Mahdi R, Madduri AS, Wang G, Strulovici-Barel Y, Salit J, Hackett NR, Crystal RG, Mezey JG.

Bioinformatics. 2012 Aug 1;28(15):2029-36. doi: 10.1093/bioinformatics/bts312. Epub 2012 Jun 8.

50.

Genes associated with MUC5AC expression in small airway epithelium of human smokers and non-smokers.

Wang G, Xu Z, Wang R, Al-Hijji M, Salit J, Strulovici-Barel Y, Tilley AE, Mezey JG, Crystal RG.

BMC Med Genomics. 2012 Jun 7;5:21. doi: 10.1186/1755-8794-5-21.

Supplemental Content

Loading ...
Support Center