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The melanocortin 4 receptor p.Ile269Asn mutation is associated with childhood and adult obesity in Mexicans.

Vázquez-Moreno M, Zeng H, Locia-Morales D, Peralta-Romero J, Asif H, Maharaj A, Tam V, Romero-Figueroa MDS, Sosa-Bustamante GP, Méndez-Martínez S, Mejía-Benítez A, Valladares-Salgado A, Wacher-Rodarte N; National Obesity Network Mexico, Cruz M, Meyre D.

J Clin Endocrinol Metab. 2019 Dec 16. pii: dgz276. doi: 10.1210/clinem/dgz276. [Epub ahead of print]


Deficits in executive function and suppression of default mode network in obesity.

Syan SK, Owens MM, Goodman B, Epstein LH, Meyre D, Sweet LH, MacKillop J.

Neuroimage Clin. 2019;24:102015. doi: 10.1016/j.nicl.2019.102015. Epub 2019 Oct 26.


Association between impulsivity traits and body mass index at the observational and genetic epidemiology level.

Meyre D, Mohamed S, Gray JC, Weafer J, MacKillop J, de Wit H.

Sci Rep. 2019 Nov 26;9(1):17583. doi: 10.1038/s41598-019-53922-8.


Contribution of rare coding mutations in CD36 to type 2 diabetes and cardio-metabolic complications.

Meyre D, Andress EJ, Sharma T, Snippe M, Asif H, Maharaj A, Vatin V, Gaget S, Besnard P, Choquet H, Froguel P, Linton KJ.

Sci Rep. 2019 Nov 20;9(1):17123. doi: 10.1038/s41598-019-53388-8.


Summer Season and Recommended Vitamin D Intake Support Adequate Vitamin D Status throughout Pregnancy in Healthy Canadian Women and Their Newborns.

Perreault M, Atkinson SA, Meyre D, Fusch G, Mottola MF; BHIP Study Team.

J Nutr. 2019 Nov 16. pii: nxz276. doi: 10.1093/jn/nxz276. [Epub ahead of print]


Allelic frequency differences of DAOA variants between Caucasians and Asians and their association with major mood disorders.

Yang Z, Zhang S, Zhang F, Yao Y, Kim K, Meyre D, Zhang H, Liao H, Rao S, Huang X.

Signal Transduct Target Ther. 2019 Oct 4;4:39. doi: 10.1038/s41392-019-0066-5. eCollection 2019. No abstract available.


A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity.

Bradfield JP, Vogelezang S, Felix JF, Chesi A, Helgeland Ø, Horikoshi M, Karhunen V, Lowry E, Cousminer DL, Ahluwalia TS, Thiering E, Boh ET, Zafarmand MH, Vilor-Tejedor N, Wang CA, Joro R, Chen Z, Gauderman WJ, Pitkänen N, Parra EJ, Fernandez-Rhodes L, Alyass A, Monnereau C, Curtin JA, Have CT, McCormack SE, Hollensted M, Frithioff-Bøjsøe C, Valladares-Salgado A, Peralta-Romero J, Teo YY, Standl M, Leinonen JT, Holm JC, Peters T, Vioque J, Vrijheid M, Simpson A, Custovic A, Vaudel M, Canouil M, Lindi V, Atalay M, Kähönen M, Raitakari OT, van Schaik BDC, Berkowitz RI, Cole SA, Voruganti VS, Wang Y, Highland HM, Comuzzie AG, Butte NF, Justice AE, Gahagan S, Blanco E, Lehtimäki T, Lakka TA, Hebebrand J, Bonnefond A, Grarup N, Froguel P, Lyytikäinen LP, Cruz M, Kobes S, Hanson RL, Zemel BS, Hinney A, Teo KK, Meyre D, North KE, Gilliland FD, Bisgaard H, Bustamante M, Bonnelykke K, Pennell CE, Rivadeneira F, Uitterlinden AG, Baier LJ, Vrijkotte TGM, Heinrich J, Sørensen TIA, Saw SM, Pedersen O, Hansen T, Eriksson J, Widén E, McCarthy MI, Njølstad PR, Power C, Hyppönen E, Sebert S, Brown CD, Järvelin MR, Timpson NJ, Johansson S, Hakonarson H, Jaddoe VWV; Early Growth Genetics Consortium, Grant SFA.

Hum Mol Genet. 2019 Oct 1;28(19):3327-3338. doi: 10.1093/hmg/ddz161.


Zinc Supplementation and Body Weight: A Systematic Review and Dose-Response Meta-analysis of Randomized Controlled Trials.

Abdollahi S, Toupchian O, Jayedi A, Meyre D, Tam V, Soltani S.

Adv Nutr. 2019 Aug 22. pii: nmz084. doi: 10.1093/advances/nmz084. [Epub ahead of print]


Loss-of-function mutations in the melanocortin-3 receptor gene confer risk for human obesity: A systematic review and meta-analysis.

Ehtesham S, Qasim A, Meyre D.

Obes Rev. 2019 Aug;20(8):1085-1092. doi: 10.1111/obr.12864. Epub 2019 May 14. Review.


Benefits and limitations of genome-wide association studies.

Tam V, Patel N, Turcotte M, Bossé Y, Paré G, Meyre D.

Nat Rev Genet. 2019 Aug;20(8):467-484. doi: 10.1038/s41576-019-0127-1. Review.


Adiponectin is associated with cardio-metabolic traits in Mexican children.

He J, Stryjecki C, Reddon H, Peralta-Romero J, Karam-Araujo R, Suarez F, Gomez-Zamudio J, Burguete-Garcia A, Alyass A, Cruz M, Meyre D.

Sci Rep. 2019 Feb 28;9(1):3084. doi: 10.1038/s41598-019-39801-2.


Structured diet and exercise guidance in pregnancy to improve health in women and their offspring: study protocol for the Be Healthy in Pregnancy (BHIP) randomized controlled trial.

Perreault M, Atkinson SA, Mottola MF, Phillips SM, Bracken K, Hutton EK, Xie F, Meyre D, Morassut RE, Prapavessis H, Thabane L; BHIP Study team.

Trials. 2018 Dec 19;19(1):691. doi: 10.1186/s13063-018-3065-x.


Comprehensive identification of pleiotropic loci for body fat distribution using the NHGRI-EBI Catalog of published genome-wide association studies.

Kaur Y, Wang DX, Liu HY, Meyre D.

Obes Rev. 2019 Mar;20(3):385-406. doi: 10.1111/obr.12806. Epub 2018 Nov 22. Review.


Established and emerging strategies to crack the genetic code of obesity.

Tam V, Turcotte M, Meyre D.

Obes Rev. 2019 Feb;20(2):212-240. doi: 10.1111/obr.12770. Epub 2018 Oct 23. Review.


Gain-of-function variants in the melanocortin 4 receptor gene confer susceptibility to binge eating disorder in subjects with obesity: a systematic review and meta-analysis.

Qasim A, Mayhew AJ, Ehtesham S, Alyass A, Volckmar AL, Herpertz S, Hinney A, Hebebrand J, Meyre D.

Obes Rev. 2019 Jan;20(1):13-21. doi: 10.1111/obr.12761. Epub 2018 Oct 10.


Revisiting the evolutionary origins of obesity: lazy versus peppy-thrifty genotype hypothesis.

Reddon H, Patel Y, Turcotte M, Pigeyre M, Meyre D.

Obes Rev. 2018 Nov;19(11):1525-1543. doi: 10.1111/obr.12742. Epub 2018 Sep 27. Review.


Blood CSF1 and CXCL12 as Causal Mediators of Coronary Artery Disease.

Sjaarda J, Gerstein H, Chong M, Yusuf S, Meyre D, Anand SS, Hess S, Paré G.

J Am Coll Cardiol. 2018 Jul 17;72(3):300-310. doi: 10.1016/j.jacc.2018.04.067. Epub 2018 Jul 9.


Genetic contribution to waist-to-hip ratio in Mexican children and adolescents based on 12 loci validated in European adults.

Turcotte M, Abadi A, Peralta-Romero J, Suarez F, Reddon H, Gomez-Zamudio J, Burguete-Garcia AI, Cruz M, Meyre D.

Int J Obes (Lond). 2019 Jan;43(1):13-22. doi: 10.1038/s41366-018-0055-8. Epub 2018 Mar 13.


Fine-mapping of 98 obesity loci in Mexican children.

Liu HY, Alyass A, Abadi A, Peralta-Romero J, Suarez F, Gomez-Zamudio J, Audirac A, Parra EJ, Cruz M, Meyre D.

Int J Obes (Lond). 2019 Jan;43(1):23-32. doi: 10.1038/s41366-018-0056-7. Epub 2018 Mar 12.


Exploring metabolic factors and health behaviors in relation to suicide attempts: A case-control study.

Perera S, Eisen RB, Bhatt M, Dennis BB, Bawor M, El-Sheikh W, DeJesus J, Rangarajan S, Sholer H, Iordan E, Mackie P, Islam S, Dehghan M, Brasch J, Meyre D, de Souza R, Thabane L, Samaan Z.

J Affect Disord. 2018 Mar 15;229:386-395. doi: 10.1016/j.jad.2017.12.060. Epub 2018 Jan 2.


The Extending Spectrum of NPC1-Related Human Disorders: From Niemann-Pick C1 Disease to Obesity.

Lamri A, Pigeyre M, Garver WS, Meyre D.

Endocr Rev. 2018 Apr 1;39(2):192-220. doi: 10.1210/er.2017-00176. Review.


Obesity genetics: insights from the Pakistani population.

Pigeyre M, Saqlain M, Turcotte M, Raja GK, Meyre D.

Obes Rev. 2018 Mar;19(3):364-380. doi: 10.1111/obr.12644. Epub 2017 Dec 18.


Rationale and design of GENEiUS: a prospective observational study on the genetic and environmental determinants of body mass index evolution in Canadian undergraduate students.

Morassut RE, Langlois C, Alyass A, Ishola AF, Yazdi FT, Mayhew AJ, Reddon H, MacKillop J, Pigeyre M, Meyre D.

BMJ Open. 2017 Dec 10;7(12):e019365. doi: 10.1136/bmjopen-2017-019365.


Penetrance of Polygenic Obesity Susceptibility Loci across the Body Mass Index Distribution.

Abadi A, Alyass A, Robiou du Pont S, Bolker B, Singh P, Mohan V, Diaz R, Engert JC, Yusuf S, Gerstein HC, Anand SS, Meyre D.

Am J Hum Genet. 2017 Dec 7;101(6):925-938. doi: 10.1016/j.ajhg.2017.10.007.


On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations.

Qasim A, Turcotte M, de Souza RJ, Samaan MC, Champredon D, Dushoff J, Speakman JR, Meyre D.

Obes Rev. 2018 Feb;19(2):121-149. doi: 10.1111/obr.12625. Epub 2017 Nov 16. Review.


Helicobacter pylori colonization and obesity - a Mendelian randomization study.

den Hollander WJ, Broer L, Schurmann C, Meyre D, den Hoed CM, Mayerle J, Hofman A, Homuth G, Uitterlinden AG, Lerch MM, Kuipers EJ.

Sci Rep. 2017 Oct 31;7(1):14467. doi: 10.1038/s41598-017-14106-4.


Assessing the Heritability of Complex Traits in Humans: Methodological Challenges and Opportunities.

Mayhew AJ, Meyre D.

Curr Genomics. 2017 Aug;18(4):332-340. doi: 10.2174/1389202918666170307161450. Review.


An Evolutionary Genetic Perspective of Eating Disorders.

Mayhew AJ, Pigeyre M, Couturier J, Meyre D.

Neuroendocrinology. 2018;106(3):292-306. doi: 10.1159/000484525. Epub 2017 Oct 24. Review.


Give GWAS a Chance.

Meyre D.

Diabetes. 2017 Nov;66(11):2741-2742. doi: 10.2337/dbi17-0026. No abstract available.


Parental and offspring contribution of genetic markers of adult blood pressure in early life: The FAMILY study.

Robiou-du-Pont S, Anand SS, Morrison KM, McDonald SD, Atkinson SA, Teo KK, Meyre D.

PLoS One. 2017 Oct 18;12(10):e0186218. doi: 10.1371/journal.pone.0186218. eCollection 2017.


Ethnic and population differences in the genetic predisposition to human obesity.

Stryjecki C, Alyass A, Meyre D.

Obes Rev. 2018 Jan;19(1):62-80. doi: 10.1111/obr.12604. Epub 2017 Oct 10. Review.


Folate and vitamin B12 status is associated with insulin resistance and metabolic syndrome in morbid obesity.

Li Z, Gueant-Rodriguez RM, Quilliot D, Sirveaux MA, Meyre D, Gueant JL, Brunaud L.

Clin Nutr. 2018 Oct;37(5):1700-1706. doi: 10.1016/j.clnu.2017.07.008. Epub 2017 Jul 24.


A systematic survey of the methods literature on the reporting quality and optimal methods of handling participants with missing outcome data for continuous outcomes in randomized controlled trials.

Zhang Y, Alyass A, Vanniyasingam T, Sadeghirad B, Flórez ID, Pichika SC, Kennedy SA, Abdulkarimova U, Zhang Y, Iljon T, Morgano GP, Colunga Lozano LE, Aloweni FAB, Lopes LC, Yepes-Nuñez JJ, Fei Y, Wang L, Kahale LA, Meyre D, Akl EA, Thabane L, Guyatt GH.

J Clin Epidemiol. 2017 Aug;88:67-80. doi: 10.1016/j.jclinepi.2017.05.016. Epub 2017 Jun 1. Review.


Influence of depression on genetic predisposition to type 2 diabetes in a multiethnic longitudinal study.

Garasia S, Samaan Z, Gerstein HC, Engert JC, Mohan V, Diaz R, Anand SS, Meyre D.

Sci Rep. 2017 May 9;7(1):1629. doi: 10.1038/s41598-017-01406-y.


The Niemann-Pick C1 gene interacts with a high-fat diet to promote weight gain through differential regulation of central energy metabolism pathways.

Castillo JJ, Jelinek D, Wei H, Gannon NP, Vaughan RA, Horwood LJ, Meaney FJ, Garcia-Smith R, Trujillo KA, Heidenreich RA, Meyre D, Orlando RA, LeBoeuf RC, Garver WS.

Am J Physiol Endocrinol Metab. 2017 Aug 1;313(2):E183-E194. doi: 10.1152/ajpendo.00369.2016. Epub 2017 May 9.


A systematic review of genetic syndromes with obesity.

Kaur Y, de Souza RJ, Gibson WT, Meyre D.

Obes Rev. 2017 Jun;18(6):603-634. doi: 10.1111/obr.12531. Epub 2017 Mar 27. Review.


Physical Activity and Global Self-worth in a Longitudinal Study of Children.

Reddon H, Meyre D, Cairney J.

Med Sci Sports Exerc. 2017 Aug;49(8):1606-1613. doi: 10.1249/MSS.0000000000001275.


Genetic contribution to lipid levels in early life based on 158 loci validated in adults: the FAMILY study.

Christie S, Robiou-du-Pont S, Anand SS, Morrison KM, McDonald SD, Paré G, Atkinson SA, Teo KK, Meyre D.

Sci Rep. 2017 Mar 6;7(1):68. doi: 10.1038/s41598-017-00102-1.


Genetic association of rs1344706 in ZNF804A with bipolar disorder and schizophrenia susceptibility in Chinese populations.

Rao S, Yao Y, Ryan J, Jin C, Xu Y, Huang X, Guo J, Wen Y, Mao C, Meyre D, Zhang F.

Sci Rep. 2017 Jan 25;7:41140. doi: 10.1038/srep41140.


Parental and child genetic contributions to obesity traits in early life based on 83 loci validated in adults: the FAMILY study.

Li A, Robiou-du-Pont S, Anand SS, Morrison KM, McDonald SD, Atkinson SA, Teo KK, Meyre D.

Pediatr Obes. 2018 Mar;13(3):133-140. doi: 10.1111/ijpo.12205. Epub 2016 Dec 23.


A genetic link between prepregnancy body mass index, postpartum weight retention, and offspring weight in early childhood.

Li A, Teo KK, Morrison KM, McDonald SD, Atkinson SA, Anand SS, Meyre D.

Obesity (Silver Spring). 2017 Jan;25(1):236-243. doi: 10.1002/oby.21707. Epub 2016 Nov 24.


Evaluating the transferability of 15 European-derived fasting plasma glucose SNPs in Mexican children and adolescents.

Langlois C, Abadi A, Peralta-Romero J, Alyass A, Suarez F, Gomez-Zamudio J, Burguete-Garcia AI, Yazdi FT, Cruz M, Meyre D.

Sci Rep. 2016 Oct 26;6:36202. doi: 10.1038/srep36202.


The importance of gene-environment interactions in human obesity.

Reddon H, Guéant JL, Meyre D.

Clin Sci (Lond). 2016 Sep 1;130(18):1571-97. doi: 10.1042/CS20160221. Review.


Assessing the effects of 35 European-derived BMI-associated SNPs in Mexican children.

Abadi A, Peralta-Romero J, Suarez F, Gomez-Zamudio J, Burguete-Garcia AI, Cruz M, Meyre D.

Obesity (Silver Spring). 2016 Sep;24(9):1989-95. doi: 10.1002/oby.21590. Epub 2016 Aug 3.


Longitudinal relationships between glycemic status and body mass index in a multiethnic study: evidence from observational and genetic epidemiology.

Ishola AF, Gerstein HC, Engert JC, Mohan V, Diaz R, Anand SS, Meyre D.

Sci Rep. 2016 Aug 2;6:30744. doi: 10.1038/srep30744.


Genetic markers of inflammation may not contribute to metabolic traits in Mexican children.

Vashi N, Stryjecki C, Peralta-Romero J, Suarez F, Gomez-Zamudio J, Burguete-Garcia AI, Cruz M, Meyre D.

PeerJ. 2016 Jun 23;4:e2090. doi: 10.7717/peerj.2090. eCollection 2016.


Empirical evaluation of the Q-Genie tool: a protocol for assessment of effectiveness.

Sohani ZN, Sarma S, Alyass A, de Souza RJ, Robiou-du-Pont S, Li A, Mayhew A, Yazdi F, Reddon H, Lamri A, Stryjecki C, Ishola A, Lee YK, Vashi N, Anand SS, Meyre D.

BMJ Open. 2016 Jun 9;6(6):e010403. doi: 10.1136/bmjopen-2015-010403.


Common variants in CACNA1C and MDD susceptibility: A comprehensive meta-analysis.

Rao S, Yao Y, Zheng C, Ryan J, Mao C, Zhang F, Meyre D, Xu Q.

Am J Med Genet B Neuropsychiatr Genet. 2016 Sep;171(6):896-903. doi: 10.1002/ajmg.b.32466. Epub 2016 Jun 3.


Eating Behavior, Low-Frequency Functional Mutations in the Melanocortin-4 Receptor (MC4R) Gene, and Outcomes of Bariatric Operations: A 6-Year Prospective Study.

Bonnefond A, Keller R, Meyre D, Stutzmann F, Thuillier D, Stefanov DG, Froguel P, Horber FF, Kral JG.

Diabetes Care. 2016 Aug;39(8):1384-92. doi: 10.2337/dc16-0115. Epub 2016 May 23.


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