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Items: 1 to 50 of 242

1.

The crystal structure of gurmarin, a sweet-taste suppressing protein: Identification of the amino acid residues essential for inhibition.

Sigoillot M, Brockhoff A, Neiers F, Poirier N, Belloir C, Legrand P, Charron C, Roblin P, Meyerhof W, Briand L.

Chem Senses. 2018 Aug 18. doi: 10.1093/chemse/bjy054. [Epub ahead of print]

PMID:
30137256
2.

Intestinal bitter taste receptor activation alters hormone secretion and imparts metabolic benefits.

Kok BP, Galmozzi A, Littlejohn NK, Albert V, Godio C, Kim W, Kim SM, Bland JS, Grayson N, Fang M, Meyerhof W, Siuzdak G, Srinivasan S, Behrens M, Saez E.

Mol Metab. 2018 Aug 4. pii: S2212-8778(18)30656-2. doi: 10.1016/j.molmet.2018.07.013. [Epub ahead of print]

3.

Human Bitter Taste Receptors Are Activated by Different Classes of Polyphenols.

Soares S, Silva MS, García-Estevez I, Groβmann P, Brás N, Brandão E, Mateus N, de Freitas V, Behrens M, Meyerhof W.

J Agric Food Chem. 2018 Aug 22;66(33):8814-8823. doi: 10.1021/acs.jafc.8b03569. Epub 2018 Aug 14.

PMID:
30056706
4.

Reengineering the ligand sensitivity of the broadly tuned human bitter taste receptor TAS2R14.

Nowak S, Di Pizio A, Levit A, Niv MY, Meyerhof W, Behrens M.

Biochim Biophys Acta Gen Subj. 2018 Jul 19;1862(10):2162-2173. doi: 10.1016/j.bbagen.2018.07.009. [Epub ahead of print]

PMID:
30009876
5.

Proton Transport Chains in Glucose Metabolism: Mind the Proton.

Roosterman D, Meyerhof W, Cottrell GS.

Front Neurosci. 2018 Jun 15;12:404. doi: 10.3389/fnins.2018.00404. eCollection 2018. Review.

6.

Tastant-Evoked Arc Expression in the Nucleus of the Solitary Tract and Nodose/Petrosal Ganglion of the Mouse Is Specific for Bitter Compounds.

Töle J, Stolzenburg A, Tyree SM, Stähler F, Meyerhof W.

Chem Senses. 2018 Apr 23;43(4):261-272. doi: 10.1093/chemse/bjy017.

PMID:
29514200
7.

Molecular Features Underlying Selectivity in Chicken Bitter Taste Receptors.

Di Pizio A, Shy N, Behrens M, Meyerhof W, Niv MY.

Front Mol Biosci. 2018 Jan 31;5:6. doi: 10.3389/fmolb.2018.00006. eCollection 2018.

8.

Structure-Function Relationships of Olfactory and Taste Receptors.

Behrens M, Briand L, de March CA, Matsunami H, Yamashita A, Meyerhof W, Weyand S.

Chem Senses. 2018 Feb 2;43(2):81-87. doi: 10.1093/chemse/bjx083.

PMID:
29342245
9.

Amino acid sensing in hypothalamic tanycytes via umami taste receptors.

Lazutkaite G, Soldà A, Lossow K, Meyerhof W, Dale N.

Mol Metab. 2017 Nov;6(11):1480-1492. doi: 10.1016/j.molmet.2017.08.015. Epub 2017 Sep 14.

10.

Genetic Labeling of Car4-expressing Cells Reveals Subpopulations of Type III Taste Cells.

Lossow K, Hermans-Borgmeyer I, Behrens M, Meyerhof W.

Chem Senses. 2017 Oct 31;42(9):747-758. doi: 10.1093/chemse/bjx048.

PMID:
29099943
11.

Blends of Non-caloric Sweeteners Saccharin and Cyclamate Show Reduced Off-Taste due to TAS2R Bitter Receptor Inhibition.

Behrens M, Blank K, Meyerhof W.

Cell Chem Biol. 2017 Oct 19;24(10):1199-1204.e2. doi: 10.1016/j.chembiol.2017.08.004. Epub 2017 Sep 14.

PMID:
28919036
12.

Bitter substances from plants used in traditional Chinese medicine exert biased activation of human bitter taste receptors.

Behrens M, Gu M, Fan S, Huang C, Meyerhof W.

Chem Biol Drug Des. 2018 Feb;91(2):422-433. doi: 10.1111/cbdd.13089. Epub 2017 Sep 14.

PMID:
28834122
13.

Ligand binding modes from low resolution GPCR models and mutagenesis: chicken bitter taste receptor as a test-case.

Di Pizio A, Kruetzfeldt LM, Cheled-Shoval S, Meyerhof W, Behrens M, Niv MY.

Sci Rep. 2017 Aug 15;7(1):8223. doi: 10.1038/s41598-017-08344-9.

14.

Expression profiling of Tas2r genes reveals a complex pattern along the mouse GI tract and the presence of Tas2r131 in a subset of intestinal Paneth cells.

Prandi S, Voigt A, Meyerhof W, Behrens M.

Cell Mol Life Sci. 2018 Jan;75(1):49-65. doi: 10.1007/s00018-017-2621-y. Epub 2017 Aug 11.

PMID:
28801754
15.

Caffeine induces gastric acid secretion via bitter taste signaling in gastric parietal cells.

Liszt KI, Ley JP, Lieder B, Behrens M, Stöger V, Reiner A, Hochkogler CM, Köck E, Marchiori A, Hans J, Widder S, Krammer G, Sanger GJ, Somoza MM, Meyerhof W, Somoza V.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6260-E6269. doi: 10.1073/pnas.1703728114. Epub 2017 Jul 10.

16.

From Cell to Beak: In-Vitro and In-Vivo Characterization of Chicken Bitter Taste Thresholds.

Cheled-Shoval S, Behrens M, Korb A, Di Pizio A, Meyerhof W, Uni Z, Niv MY.

Molecules. 2017 May 17;22(5). pii: E821. doi: 10.3390/molecules22050821.

17.

Probing the Evolutionary History of Human Bitter Taste Receptor Pseudogenes by Restoring Their Function.

Risso D, Behrens M, Sainz E, Meyerhof W, Drayna D.

Mol Biol Evol. 2017 Jul 1;34(7):1587-1595. doi: 10.1093/molbev/msx097.

18.

A sweet taste receptor-dependent mechanism of glucosensing in hypothalamic tanycytes.

Benford H, Bolborea M, Pollatzek E, Lossow K, Hermans-Borgmeyer I, Liu B, Meyerhof W, Kasparov S, Dale N.

Glia. 2017 May;65(5):773-789. doi: 10.1002/glia.23125. Epub 2017 Feb 16.

19.

Vertebrate Bitter Taste Receptors: Keys for Survival in Changing Environments.

Behrens M, Meyerhof W.

J Agric Food Chem. 2018 Mar 14;66(10):2204-2213. doi: 10.1021/acs.jafc.6b04835. Epub 2017 Jan 5. Review.

PMID:
28013542
20.

The Odorant ( R)-Citronellal Attenuates Caffeine Bitterness by Inhibiting the Bitter Receptors TAS2R43 and TAS2R46.

Suess B, Brockhoff A, Meyerhof W, Hofmann T.

J Agric Food Chem. 2018 Mar 14;66(10):2301-2311. doi: 10.1021/acs.jafc.6b03554. Epub 2016 Sep 1.

PMID:
27569025
21.

Copy Number Variation in TAS2R Bitter Taste Receptor Genes: Structure, Origin, and Population Genetics.

Roudnitzky N, Risso D, Drayna D, Behrens M, Meyerhof W, Wooding SP.

Chem Senses. 2016 Oct;41(8):649-59. doi: 10.1093/chemse/bjw067. Epub 2016 Jun 23.

PMID:
27340135
22.

Comprehensive Analysis of Mouse Bitter Taste Receptors Reveals Different Molecular Receptive Ranges for Orthologous Receptors in Mice and Humans.

Lossow K, Hübner S, Roudnitzky N, Slack JP, Pollastro F, Behrens M, Meyerhof W.

J Biol Chem. 2016 Jul 15;291(29):15358-77. doi: 10.1074/jbc.M116.718544. Epub 2016 May 20.

23.

Probing the Binding Pocket of the Broadly Tuned Human Bitter Taste Receptor TAS2R14 by Chemical Modification of Cognate Agonists.

Karaman R, Nowak S, Di Pizio A, Kitaneh H, Abu-Jaish A, Meyerhof W, Niv MY, Behrens M.

Chem Biol Drug Des. 2016 Jul;88(1):66-75. doi: 10.1111/cbdd.12734. Epub 2016 Feb 17.

PMID:
26825540
24.

The Role of 5-HT3 Receptors in Signaling from Taste Buds to Nerves.

Larson ED, Vandenbeuch A, Voigt A, Meyerhof W, Kinnamon SC, Finger TE.

J Neurosci. 2015 Dec 2;35(48):15984-95. doi: 10.1523/JNEUROSCI.1868-15.2015.

25.

Evidence for a Transient Additional Ligand Binding Site in the TAS2R46 Bitter Taste Receptor.

Sandal M, Behrens M, Brockhoff A, Musiani F, Giorgetti A, Carloni P, Meyerhof W.

J Chem Theory Comput. 2015 Sep 8;11(9):4439-49. doi: 10.1021/acs.jctc.5b00472. Epub 2015 Aug 24.

PMID:
26575934
26.

Receptor Polymorphism and Genomic Structure Interact to Shape Bitter Taste Perception.

Roudnitzky N, Behrens M, Engel A, Kohl S, Thalmann S, Hübner S, Lossow K, Wooding SP, Meyerhof W.

PLoS Genet. 2015 Sep 25;11(9):e1005530. doi: 10.1371/journal.pgen.1005530. eCollection 2015.

27.

Cre-Mediated Recombination in Tas2r131 Cells-A Unique Way to Explore Bitter Taste Receptor Function Inside and Outside of the Taste System.

Voigt A, Hübner S, Döring L, Perlach N, Hermans-Borgmeyer I, Boehm U, Meyerhof W.

Chem Senses. 2015 Nov;40(9):627-39. doi: 10.1093/chemse/bjv049. Epub 2015 Sep 16.

PMID:
26377344
28.

Rubemamine and Rubescenamine, Two Naturally Occurring N-Cinnamoyl Phenethylamines with Umami-Taste-Modulating Properties.

Backes M, Obst K, Bojahr J, Thorhauer A, Roudnitzky N, Paetz S, Reichelt KV, Krammer GE, Meyerhof W, Ley JP.

J Agric Food Chem. 2015 Oct 7;63(39):8694-704. doi: 10.1021/acs.jafc.5b04402. Epub 2015 Sep 24.

PMID:
26375852
29.

Transsynaptic Tracing from Taste Receptor Cells Reveals Local Taste Receptor Gene Expression in Gustatory Ganglia and Brain.

Voigt A, Bojahr J, Narukawa M, Hübner S, Boehm U, Meyerhof W.

J Neurosci. 2015 Jul 1;35(26):9717-29. doi: 10.1523/JNEUROSCI.0381-15.2015.

30.

Cholinergic chemosensory cells of the thymic medulla express the bitter receptor Tas2r131.

Soultanova A, Voigt A, Chubanov V, Gudermann T, Meyerhof W, Boehm U, Kummer W.

Int Immunopharmacol. 2015 Nov;29(1):143-7. doi: 10.1016/j.intimp.2015.06.005. Epub 2015 Jun 20.

PMID:
26102274
31.

Identification of cholinergic chemosensory cells in mouse tracheal and laryngeal glandular ducts.

Krasteva-Christ G, Soultanova A, Schütz B, Papadakis T, Weiss C, Deckmann K, Chubanov V, Gudermann T, Voigt A, Meyerhof W, Boehm U, Weihe E, Kummer W.

Int Immunopharmacol. 2015 Nov;29(1):158-65. doi: 10.1016/j.intimp.2015.05.028. Epub 2015 May 29.

PMID:
26033492
32.

Variability in Human Bitter Taste Sensitivity to Chemically Diverse Compounds Can Be Accounted for by Differential TAS2R Activation.

Roura E, Aldayyani A, Thavaraj P, Prakash S, Greenway D, Thomas WG, Meyerhof W, Roudnitzky N, Foster SR.

Chem Senses. 2015 Jul;40(6):427-35. doi: 10.1093/chemse/bjv024. Epub 2015 May 21.

PMID:
25999325
33.

A Binary Genetic Approach to Characterize TRPM5 Cells in Mice.

Kusumakshi S, Voigt A, Hübner S, Hermans-Borgmeyer I, Ortalli A, Pyrski M, Dörr J, Zufall F, Flockerzi V, Meyerhof W, Montmayeur JP, Boehm U.

Chem Senses. 2015 Jul;40(6):413-25. doi: 10.1093/chemse/bjv023. Epub 2015 May 4.

PMID:
25940069
34.

Perinatal administration of a bitter tastant influences gene expression in chicken palate and duodenum.

Cheled-Shoval SL, Behrens M, Meyerhof W, Niv MY, Uni Z.

J Agric Food Chem. 2014 Dec 31;62(52):12512-20. doi: 10.1021/jf502219a. Epub 2014 Dec 17.

PMID:
25427148
35.

Human taste and umami receptor responses to chemosensorica generated by Maillard-type N²-alkyl- and N²-arylthiomethylation of guanosine 5'-monophosphates.

Suess B, Brockhoff A, Degenhardt A, Billmayer S, Meyerhof W, Hofmann T.

J Agric Food Chem. 2014 Nov 26;62(47):11429-40. doi: 10.1021/jf504686s. Epub 2014 Nov 17.

PMID:
25375264
36.

TAS2R bitter taste receptors regulate thyroid function.

Clark AA, Dotson CD, Elson AE, Voigt A, Boehm U, Meyerhof W, Steinle NI, Munger SD.

FASEB J. 2015 Jan;29(1):164-72. doi: 10.1096/fj.14-262246. Epub 2014 Oct 23.

37.

Tuning properties of avian and frog bitter taste receptors dynamically fit gene repertoire sizes.

Behrens M, Korsching SI, Meyerhof W.

Mol Biol Evol. 2014 Dec;31(12):3216-27. doi: 10.1093/molbev/msu254. Epub 2014 Aug 31.

PMID:
25180257
38.

Bitter taste receptor agonists elicit G-protein-dependent negative inotropy in the murine heart.

Foster SR, Blank K, See Hoe LE, Behrens M, Meyerhof W, Peart JN, Thomas WG.

FASEB J. 2014 Oct;28(10):4497-508. doi: 10.1096/fj.14-256305. Epub 2014 Jul 1.

PMID:
25002118
39.

ORA1, a zebrafish olfactory receptor ancestral to all mammalian V1R genes, recognizes 4-hydroxyphenylacetic acid, a putative reproductive pheromone.

Behrens M, Frank O, Rawel H, Ahuja G, Potting C, Hofmann T, Meyerhof W, Korsching S.

J Biol Chem. 2014 Jul 11;289(28):19778-88. doi: 10.1074/jbc.M114.573162. Epub 2014 May 15.

40.

The role of lipolysis in human orosensory fat perception.

Voigt N, Stein J, Galindo MM, Dunkel A, Raguse JD, Meyerhof W, Hofmann T, Behrens M.

J Lipid Res. 2014 May;55(5):870-82. doi: 10.1194/jlr.M046029. Epub 2014 Mar 31.

41.

A subset of mouse colonic goblet cells expresses the bitter taste receptor Tas2r131.

Prandi S, Bromke M, Hübner S, Voigt A, Boehm U, Meyerhof W, Behrens M.

PLoS One. 2013 Dec 18;8(12):e82820. doi: 10.1371/journal.pone.0082820. eCollection 2013.

42.

The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14.

Levit A, Nowak S, Peters M, Wiener A, Meyerhof W, Behrens M, Niv MY.

FASEB J. 2014 Mar;28(3):1181-97. doi: 10.1096/fj.13-242594. Epub 2013 Nov 27.

PMID:
24285091
43.

Oligomerization of sweet and bitter taste receptors.

Kuhn C, Meyerhof W.

Methods Cell Biol. 2013;117:229-42. doi: 10.1016/B978-0-12-408143-7.00013-X.

PMID:
24143981
44.

Neurodegeneration--from multiple sclerosis to Alzheimer's disease.

Meyerhof W, Richter D.

FEBS J. 2013 Sep;280(18):4337. doi: 10.1111/febs.12430. Epub 2013 Jul 29. No abstract available.

45.

Coarse-grained/molecular mechanics of the TAS2R38 bitter taste receptor: experimentally-validated detailed structural prediction of agonist binding.

Marchiori A, Capece L, Giorgetti A, Gasparini P, Behrens M, Carloni P, Meyerhof W.

PLoS One. 2013 May 31;8(5):e64675. doi: 10.1371/journal.pone.0064675. Print 2013.

46.

Expression, regulation and putative nutrient-sensing function of taste GPCRs in the heart.

Foster SR, Porrello ER, Purdue B, Chan HW, Voigt A, Frenzel S, Hannan RD, Moritz KM, Simmons DG, Molenaar P, Roura E, Boehm U, Meyerhof W, Thomas WG.

PLoS One. 2013 May 15;8(5):e64579. doi: 10.1371/journal.pone.0064579. Print 2013.

47.

Genetic, functional, and phenotypic diversity in TAS2R38-mediated bitter taste perception.

Behrens M, Gunn HC, Ramos PC, Meyerhof W, Wooding SP.

Chem Senses. 2013 Jul;38(6):475-84. doi: 10.1093/chemse/bjt016. Epub 2013 Apr 30.

PMID:
23632915
48.

Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol.

Thalmann S, Behrens M, Meyerhof W.

Biochem Biophys Res Commun. 2013 May 31;435(2):267-73. doi: 10.1016/j.bbrc.2013.04.066. Epub 2013 Apr 28.

PMID:
23632330
49.

Taste responses in mice lacking taste receptor subunit T1R1.

Kusuhara Y, Yoshida R, Ohkuri T, Yasumatsu K, Voigt A, Hübner S, Maeda K, Boehm U, Meyerhof W, Ninomiya Y.

J Physiol. 2013 Apr 1;591(7):1967-85. doi: 10.1113/jphysiol.2012.236604. Epub 2013 Jan 21.

50.

Different phenolic compounds activate distinct human bitter taste receptors.

Soares S, Kohl S, Thalmann S, Mateus N, Meyerhof W, De Freitas V.

J Agric Food Chem. 2013 Feb 20;61(7):1525-33. doi: 10.1021/jf304198k. Epub 2013 Feb 6.

PMID:
23311874

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