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Items: 46

1.

Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity.

Fettel J, Kühn B, Guillen NA, Sürün D, Peters M, Bauer R, Angioni C, Geisslinger G, Schnütgen F, Meyer Zu Heringdorf D, Werz O, Meybohm P, Zacharowski K, Steinhilber D, Roos J, Maier TJ.

FASEB J. 2019 Feb;33(2):1711-1726. doi: 10.1096/fj.201800221R. Epub 2018 Sep 6.

PMID:
30188757
2.

Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells.

Blanchard O, Stepanovska B, Starck M, Erhardt M, Römer I, Meyer Zu Heringdorf D, Pfeilschifter J, Zangemeister-Wittke U, Huwiler A.

Int J Mol Sci. 2018 May 17;19(5). pii: E1498. doi: 10.3390/ijms19051498.

3.

Bradykinin mediates myogenic differentiation in murine myoblasts through the involvement of SK1/Spns2/S1P2 axis.

Bruno G, Cencetti F, Bernacchioni C, Donati C, Blankenbach KV, Thomas D, Meyer Zu Heringdorf D, Bruni P.

Cell Signal. 2018 May;45:110-121. doi: 10.1016/j.cellsig.2018.02.001. Epub 2018 Feb 3.

PMID:
29408301
4.

Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage.

Vienken H, Mabrouki N, Grabau K, Claas RF, Rudowski A, Schömel N, Pfeilschifter J, Lütjohann D, van Echten-Deckert G, Meyer Zu Heringdorf D.

Sci Rep. 2017 Mar 6;7:43575. doi: 10.1038/srep43575.

5.

Sphingosine-1-Phosphate Receptor-2 Antagonists: Therapeutic Potential and Potential Risks.

Blankenbach KV, Schwalm S, Pfeilschifter J, Meyer Zu Heringdorf D.

Front Pharmacol. 2016 Jun 21;7:167. doi: 10.3389/fphar.2016.00167. eCollection 2016. Review.

6.

Transforming growth factor β2 (TGF-β2)-induced connective tissue growth factor (CTGF) expression requires sphingosine 1-phosphate receptor 5 (S1P5) in human mesangial cells.

Wünsche C, Koch A, Goldschmeding R, Schwalm S, Meyer Zu Heringdorf D, Huwiler A, Pfeilschifter J.

Biochim Biophys Acta. 2015 May;1851(5):519-26. doi: 10.1016/j.bbalip.2015.01.003. Epub 2015 Jan 17.

PMID:
25601519
7.

Upregulation of ABC transporters contributes to chemoresistance of sphingosine 1-phosphate lyase-deficient fibroblasts.

Ihlefeld K, Vienken H, Claas RF, Blankenbach K, Rudowski A, ter Braak M, Koch A, Van Veldhoven PP, Pfeilschifter J, Meyer zu Heringdorf D.

J Lipid Res. 2015 Jan;56(1):60-9. doi: 10.1194/jlr.M052761. Epub 2014 Nov 10.

8.

Novel oxazolo-oxazole derivatives of FTY720 reduce endothelial cell permeability, immune cell chemotaxis and symptoms of experimental autoimmune encephalomyelitis in mice.

Imeri F, Fallegger D, Zivkovic A, Schwalm S, Enzmann G, Blankenbach K, Meyer zu Heringdorf D, Homann T, Kleuser B, Pfeilschifter J, Engelhardt B, Stark H, Huwiler A.

Neuropharmacology. 2014 Oct;85:314-27. doi: 10.1016/j.neuropharm.2014.05.012. Epub 2014 May 23.

PMID:
24863045
9.

Sphingosine 1-phosphate (S1P) induces COX-2 expression and PGE2 formation via S1P receptor 2 in renal mesangial cells.

Völzke A, Koch A, Meyer Zu Heringdorf D, Huwiler A, Pfeilschifter J.

Biochim Biophys Acta. 2014 Jan;1841(1):11-21. doi: 10.1016/j.bbalip.2013.09.009. Epub 2013 Sep 21.

PMID:
24064301
10.

PPARγ agonists upregulate sphingosine 1-phosphate (S1P) receptor 1 expression, which in turn reduces S1P-induced [Ca(2+)]i increases in renal mesangial cells.

Koch A, Völzke A, Puff B, Blankenbach K, Meyer Zu Heringdorf D, Huwiler A, Pfeilschifter J.

Biochim Biophys Acta. 2013 Nov;1831(11):1634-43. doi: 10.1016/j.bbalip.2013.07.011. Epub 2013 Jul 30.

PMID:
23906789
11.

Evidence for a link between histone deacetylation and Ca²+ homoeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts.

Ihlefeld K, Claas RF, Koch A, Pfeilschifter JM, Meyer Zu Heringdorf D.

Biochem J. 2012 Nov 1;447(3):457-64. doi: 10.1042/BJ20120811.

PMID:
22908849
12.

Thiazolidinedione-dependent activation of sphingosine kinase 1 causes an anti-fibrotic effect in renal mesangial cells.

Koch A, Völzke A, Wünsche C, Meyer zu Heringdorf D, Huwiler A, Pfeilschifter J.

Br J Pharmacol. 2012 Jun;166(3):1018-32. doi: 10.1111/j.1476-5381.2012.01824.x.

13.

IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation.

Oberoi TK, Dogan T, Hocking JC, Scholz RP, Mooz J, Anderson CL, Karreman C, Meyer zu Heringdorf D, Schmidt G, Ruonala M, Namikawa K, Harms GS, Carpy A, Macek B, Köster RW, Rajalingam K.

EMBO J. 2012 Jan 4;31(1):14-28. doi: 10.1038/emboj.2011.423. Epub 2011 Nov 25.

14.

Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulator.

Ter Braak M, Claas RF, Hegen B, Labocha S, Ferreirós N, Pfeilschifter J, Huwiler A, van Echten-Deckert G, Meyer Zu Heringdorf D.

Biochem Pharmacol. 2011 Mar 1;81(5):617-25. doi: 10.1016/j.bcp.2010.12.002. Epub 2010 Dec 14.

PMID:
21163254
15.

Galpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors.

ter Braak M, Danneberg K, Lichte K, Liphardt K, Ktistakis NT, Pitson SM, Hla T, Jakobs KH, Meyer zu Heringdorf D.

Biochim Biophys Acta. 2009 May;1791(5):357-70.

PMID:
19830907
16.

Activation of sphingosine kinase by muscarinic receptors enhances NO-mediated and attenuates EDHF-mediated vasorelaxation.

Mulders AC, Mathy MJ, Meyer zu Heringdorf D, ter Braak M, Hajji N, Olthof DC, Michel MC, Alewijnse AE, Peters SL.

Basic Res Cardiol. 2009 Jan;104(1):50-9. doi: 10.1007/s00395-008-0744-x. Epub 2008 Sep 5.

PMID:
18777003
17.

Lysophospholipid receptor-mediated calcium signaling in human keratinocytes.

Lichte K, Rossi R, Danneberg K, ter Braak M, Kürschner U, Jakobs KH, Kleuser B, Meyer zu Heringdorf D.

J Invest Dermatol. 2008 Jun;128(6):1487-98. doi: 10.1038/sj.jid.5701207. Epub 2008 Jan 3.

18.

Regulation and functional roles of sphingosine kinases.

Alemany R, van Koppen CJ, Danneberg K, Ter Braak M, Meyer Zu Heringdorf D.

Naunyn Schmiedebergs Arch Pharmacol. 2007 Feb;374(5-6):413-28. Epub 2007 Jan 23. Review.

PMID:
17242884
19.

Renal mesangial cells: moving on sphingosine kinase-1.

Meyer zu Heringdorf D, Jakobs KH.

Br J Pharmacol. 2007 Feb;150(3):255-7. Epub 2007 Jan 2.

20.

Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism.

Meyer zu Heringdorf D, Jakobs KH.

Biochim Biophys Acta. 2007 Apr;1768(4):923-40. Epub 2006 Oct 4. Review.

21.

Lysophospholipid receptor-dependent and -independent calcium signaling.

Meyer Zu Heringdorf D.

J Cell Biochem. 2004 Aug 1;92(5):937-48. Review.

PMID:
15258917
22.

Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors.

Meyer zu Heringdorf D, Liliom K, Schaefer M, Danneberg K, Jaggar JH, Tigyi G, Jakobs KH.

FEBS Lett. 2003 Nov 20;554(3):443-9.

23.

Sphingosylphosphorylcholine, a naturally occurring lipid mediator, inhibits human platelet function.

Altmann C, Meyer Zu Heringdorf D, Böyükbas D, Haude M, Jakobs KH, Michel MC.

Br J Pharmacol. 2003 Feb;138(3):435-44.

24.

Sphingosylphosphorylcholine-biological functions and mechanisms of action.

Meyer zu Heringdorf D, Himmel HM, Jakobs KH.

Biochim Biophys Acta. 2002 May 23;1582(1-3):178-89. Review.

PMID:
12069827
25.

Transient relaxation of rat mesenteric microvessels by ceramides.

Czyborra P, Saxe M, Fetscher C, Meyer Zu Heringdorf D, Herzig S, Jakobs KH, Michel MC, Bischoff A.

Br J Pharmacol. 2002 Jan;135(2):417-26.

26.

Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate.

Alemany R, Kleuser B, Ruwisch L, Danneberg K, Lass H, Hashemi R, Spiegel S, Jakobs KH, Meyer zu Heringdorf D.

FEBS Lett. 2001 Dec 7;509(2):239-44.

27.

Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors.

van Koppen CJ, Meyer zu Heringdorf D, Alemany R, Jakobs KH.

Life Sci. 2001 Apr 27;68(22-23):2535-40.

PMID:
11392623
28.

Lysosphingolipid receptor-mediated diuresis and natriuresis in anaesthetized rats.

Bischoff A, Meyer Zu Heringdorf D, Jakobs KH, Michel MC.

Br J Pharmacol. 2001 Apr;132(8):1925-33.

29.

Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors.

Meyer zu Heringdorf D, Lass H, Kuchar I, Lipinski M, Alemany R, Rümenapp U, Jakobs KH.

Eur J Pharmacol. 2001 Mar 2;414(2-3):145-54.

PMID:
11239914
30.

Sphingosine-1-phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin-sensitive manner.

Bischoff A, Czyborra P, Meyer Zu Heringdorf D, Jakobs KH, Michel MC.

Br J Pharmacol. 2000 Aug;130(8):1878-83.

31.

Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro.

Bischoff A, Czyborra P, Fetscher C, Meyer Zu Heringdorf D, Jakobs KH, Michel MC.

Br J Pharmacol. 2000 Aug;130(8):1871-7.

32.

Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes.

Himmel HM, Meyer Zu Heringdorf D, Graf E, Dobrev D, Kortner A, Schüler S, Jakobs KH, Ravens U.

Mol Pharmacol. 2000 Aug;58(2):449-54.

PMID:
10908314
33.

Sphingolipid receptor signaling and function in human bladder carcinoma cells: inhibition of LPA- but enhancement of thrombin-stimulated cell motility.

Rümenapp U, Lümmen G, Virchow S, Hanske J, Meyer zu Heringdorf D, Jakobs KH.

Naunyn Schmiedebergs Arch Pharmacol. 2000 Jan;361(1):1-11.

PMID:
10651140
34.

Role of sphingosine kinase in Ca(2+) signalling by epidermal growth factor receptor.

Meyer zu Heringdorf D, Lass H, Kuchar I, Alemany R, Guo Y, Schmidt M, Jakobs KH.

FEBS Lett. 1999 Nov 19;461(3):217-22.

35.

Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase.

Alemany R, Meyer zu Heringdorf D, van Koppen CJ, Jakobs KH.

J Biol Chem. 1999 Feb 12;274(7):3994-9.

36.

Discrimination between plasma membrane and intracellular target sites of sphingosylphosphorylcholine.

Meyer zu Heringdorf D, Niederdräing N, Neumann E, Fröde R, Lass H, Van Koppen CJ, Jakobs KH.

Eur J Pharmacol. 1998 Jul 31;354(1):113-22.

PMID:
9726638
37.

Guanine nucleotide-sensitive inhibition of L-type Ca2+ current by lysosphingolipids in RINm5F insulinoma cells.

Himmel HM, Meyer zu Heringdorf D, Windorfer B, van Koppen CJ, Ravens U, Jakobs KH.

Mol Pharmacol. 1998 May;53(5):862-9.

PMID:
9584212
38.

Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors.

Meyer zu Heringdorf D, Lass H, Alemany R, Laser KT, Neumann E, Zhang C, Schmidt M, Rauen U, Jakobs KH, van Koppen CJ.

EMBO J. 1998 May 15;17(10):2830-7.

39.

Molecular diversity of sphingolipid signalling.

Meyer zu Heringdorf D, van Koppen CJ, Jakobs KH.

FEBS Lett. 1997 Jun 23;410(1):34-8. Review.

40.
41.

A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils.

Van Koppen CJ, Meyer Zu Heringdorf D, Zhang C, Laser KT, Jakobs KH.

Mol Pharmacol. 1996 Jun;49(6):956-61.

PMID:
8649355
42.

Translocation of microfilament-associated inhibitory guanine-nucleotide-binding proteins to the plasma membrane in myeloid differentiated human leukemia (HL-60) cells.

Meyer zu Heringdorf D, Liedel K, Kaldenberg-Stasch S, Michel MC, Jakobs KH, Wieland T.

Eur J Biochem. 1996 Feb 1;235(3):670-6.

43.

Closing in on the toxic domain through analysis of a variant Clostridium difficile cytotoxin B.

von Eichel-Streiber C, Meyer zu Heringdorf D, Habermann E, Sartingen S.

Mol Microbiol. 1995 Jul;17(2):313-21.

PMID:
7494480
44.

Analysis of receptor-G protein interactions in permeabilized cells.

Wieland T, Liedel K, Kaldenberg-Stasch S, Meyer zu Heringdorf D, Schmidt M, Jakobs KH.

Naunyn Schmiedebergs Arch Pharmacol. 1995 Apr;351(4):329-36.

PMID:
7630424
45.

Palytoxin induces K+ efflux from yeast cells expressing the mammalian sodium pump.

Scheiner-Bobis G, Meyer zu Heringdorf D, Christ M, Habermann E.

Mol Pharmacol. 1994 Jun;45(6):1132-6.

PMID:
7912814
46.

Chains and fragments of tetanus toxin. Separation, reassociation and pharmacological properties.

Weller U, Dauzenroth ME, Meyer zu Heringdorf D, Habermann E.

Eur J Biochem. 1989 Jul 1;182(3):649-56.

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