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Items: 1 to 50 of 247

1.

4th ESPT summer school: precision medicine and personalised health.

Mlakar V, Marc J, Manolopoulos VG, Cascorbi I, Stanković S, Llerena A, Simmaco M, Visvikis-Siest S, Amstutz U, Sipeky C, Meyer UA, Meier-Abt P, van Schaik RH, Ansari M.

Pharmacogenomics. 2019 May;20(7):471-474. doi: 10.2217/pgs-2019-0008.

2.

Introduction to the Theme "New Therapeutic Targets".

Insel PA, Amara SG, Blaschke TF, Meyer UA.

Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:15-20. doi: 10.1146/annurev-pharmtox-101018-112717.

PMID:
30625286
3.

The 9th Santorini Conference: Systems Medicine, Personalised Health and Therapy. "The Odyssey from Hope to Practice", Santorini, Greece, 30 September⁻3 October 2018.

Visvikis-Siest S, Gorenjak V, Stathopoulou MG, Petrelis AM, Weryha G, Masson C, Hiegel B, Kumar S, Barouki R, Boerwinkle E, Dagher G, Deloukas P, Innocenti F, Lamont J, Marschler M, Meyer H, Meyer UA, Nofziger C, Paulmichl M, Vacher C, Webster L.

J Pers Med. 2018 Dec 12;8(4). pii: E43. doi: 10.3390/jpm8040043.

4.

Creation of the Swiss group of Pharmacogenomics and personalised Therapy (SPT).

Amstutz U, Mlakar V, Curtis PH, Samer C, Baumann P, Bühlmann RP, Meier-Abt P, Meyer UA, van Schaik RHN, Ansari M; Swiss group of Pharmacogenomics and Personalised Therapy.

Drug Metab Pers Ther. 2017 Dec 20;32(4):173-174. doi: 10.1515/dmpt-2017-0033. No abstract available.

5.

Introduction to the Theme "New Approaches for Studying Drug and Toxicant Action: Applications to Drug Discovery and Development".

Insel PA, Amara SG, Blaschke TF, Meyer UA.

Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:33-36. doi: 10.1146/annurev-pharmtox-092617-121952. Epub 2017 Oct 20.

PMID:
29058990
6.

Pharmacogénomique et thérapie personnalisée.

Baumann P, Amstutz U, Bühlmann RP, Meier-Abt P, Meyer UA, Samer C, Ansari M.

Rev Med Suisse. 2017 Sep 6;13(573):1544-1545. French. No abstract available.

PMID:
28876714
7.

8th Santorini Conference: Systems medicine and personalized health and therapy, Santorini, Greece, 3-5 October 2016.

Visvikis-Siest S, Aldasoro Arguinano AA, Stathopoulou M, Xie T, Petrelis A, Weryha G, Froguel P, Meier-Abt P, Meyer UA, Mlakar V, Ansari M, Papassotiropoulos A, Dedoussis G, Pan B, Bühlmann RP, Noyer-Weidner M, Dietrich PY, Van Schaik R, Innocenti F, März W, Bekris LM, Deloukas P.

Drug Metab Pers Ther. 2017 May 24;32(2):119-127. doi: 10.1515/dmpt-2017-0011. No abstract available.

PMID:
28475488
8.

Introduction to the Theme "New Methods and Novel Therapeutic Approaches in Pharmacology and Toxicology".

Insel PA, Amara SG, Blaschke TF, Meyer UA.

Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:13-17. doi: 10.1146/annurev-pharmtox-091616-023708. Epub 2016 Oct 12.

PMID:
27732830
9.

Introduction to the Theme "Cancer Pharmacology".

Insel PA, Amara SG, Blaschke TF, Meyer UA.

Annu Rev Pharmacol Toxicol. 2016;56:19-22. doi: 10.1146/annurev-pharmtox-102015-123106. Epub 2015 Nov 9. No abstract available.

PMID:
26551200
10.

Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting.

Kalman LV, Agúndez J, Appell ML, Black JL, Bell GC, Boukouvala S, Bruckner C, Bruford E, Caudle K, Coulthard SA, Daly AK, Del Tredici A, den Dunnen JT, Drozda K, Everts RE, Flockhart D, Freimuth RR, Gaedigk A, Hachad H, Hartshorne T, Ingelman-Sundberg M, Klein TE, Lauschke VM, Maglott DR, McLeod HL, McMillin GA, Meyer UA, Müller DJ, Nickerson DA, Oetting WS, Pacanowski M, Pratt VM, Relling MV, Roberts A, Rubinstein WS, Sangkuhl K, Schwab M, Scott SA, Sim SC, Thirumaran RK, Toji LH, Tyndale RF, van Schaik R, Whirl-Carrillo M, Yeo K, Zanger UM.

Clin Pharmacol Ther. 2016 Feb;99(2):172-85. doi: 10.1002/cpt.280. Epub 2015 Nov 20. Review.

11.

Human cytochrome P450 epoxygenases: variability in expression and role in inflammation-related disorders.

Shahabi P, Siest G, Meyer UA, Visvikis-Siest S.

Pharmacol Ther. 2014 Nov;144(2):134-61. doi: 10.1016/j.pharmthera.2014.05.011. Epub 2014 Jun 2. Review.

PMID:
24882266
12.

Omics and drug response.

Meyer UA, Zanger UM, Schwab M.

Annu Rev Pharmacol Toxicol. 2013;53:475-502. doi: 10.1146/annurev-pharmtox-010510-100502. Epub 2012 Nov 5. Review.

PMID:
23140244
13.

Cytochrome P450 enzymes.

Meyer UA.

Drug Metabol Drug Interact. 2012;27(1):1-2. doi: 10.1515/dmdi-2012-0002. No abstract available.

PMID:
22718619
14.

Personalized medicine: a personal view.

Meyer UA.

Clin Pharmacol Ther. 2012 Mar;91(3):373-5. doi: 10.1038/clpt.2011.238.

PMID:
22343810
15.
16.

Transcriptional activation of PPARalpha by phenobarbital in the absence of CAR and PXR.

Tamasi V, Juvan P, Beer M, Rozman D, Meyer UA.

Mol Pharm. 2009 Sep-Oct;6(5):1573-81. doi: 10.1021/mp9001552.

PMID:
19708687
17.

Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers.

Rezen T, Tamasi V, Lövgren-Sandblom A, Björkhem I, Meyer UA, Rozman D.

BMC Genomics. 2009 Aug 19;10:384. doi: 10.1186/1471-2164-10-384.

18.

A regulatory science perspective on warfarin therapy: a pharmacogenetic opportunity.

Kim MJ, Huang SM, Meyer UA, Rahman A, Lesko LJ.

J Clin Pharmacol. 2009 Feb;49(2):138-46. doi: 10.1177/0091270008328098. Review.

PMID:
19179293
19.

Sterol regulatory element binding protein 1 interacts with pregnane X receptor and constitutive androstane receptor and represses their target genes.

Roth A, Looser R, Kaufmann M, Meyer UA.

Pharmacogenet Genomics. 2008 Apr;18(4):325-37. doi: 10.1097/FPC.0b013e3282f706e0.

PMID:
18334917
20.

The Sterolgene v0 cDNA microarray: a systemic approach to studies of cholesterol homeostasis and drug metabolism.

Rezen T, Juvan P, Fon Tacer K, Kuzman D, Roth A, Pompon D, Aggerbeck LP, Meyer UA, Rozman D.

BMC Genomics. 2008 Feb 11;9:76. doi: 10.1186/1471-2164-9-76.

21.

Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression.

Roth A, Looser R, Kaufmann M, Blättler SM, Rencurel F, Huang W, Moore DD, Meyer UA.

Mol Pharmacol. 2008 Apr;73(4):1282-9. doi: 10.1124/mol.107.041012. Epub 2008 Jan 10.

PMID:
18187584
22.

Effects of rifampicin on global gene expression in human small intestine.

Oscarson M, Burk O, Winter S, Schwab M, Wolbold R, Dippon J, Eichelbaum M, Meyer UA.

Pharmacogenet Genomics. 2007 Nov;17(11):907-18.

PMID:
18075461
23.

Regulation of human liver delta-aminolevulinic acid synthase by bile acids.

Peyer AK, Jung D, Beer M, Gnerre C, Keogh A, Stroka D, Zavolan M, Meyer UA.

Hepatology. 2007 Dec;46(6):1960-70.

PMID:
17975826
24.

Endo-xenobiotic crosstalk and the regulation of cytochromes P450.

Meyer UA.

Drug Metab Rev. 2007;39(2-3):639-46. Review.

PMID:
17786644
25.

Hypolipidemic effects of silymarin are not mediated by the peroxisome proliferator-activated receptor alpha.

Orolin J, Vecera R, Jung D, Meyer UA, Skottová N, Anzenbacher P.

Xenobiotica. 2007 Jul;37(7):725-35.

PMID:
17620219
26.

Dehydroepiandrosterone induces human CYP2B6 through the constitutive androstane receptor.

Kohalmy K, Tamási V, Kóbori L, Sárváry E, Pascussi JM, Porrogi P, Rozman D, Prough RA, Meyer UA, Monostory K.

Drug Metab Dispos. 2007 Sep;35(9):1495-501. Epub 2007 Jun 25.

27.

In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase.

Blättler SM, Rencurel F, Kaufmann MR, Meyer UA.

Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):1045-50. Epub 2007 Jan 9.

28.

Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine.

Oscarson M, Zanger UM, Rifki OF, Klein K, Eichelbaum M, Meyer UA.

Clin Pharmacol Ther. 2006 Nov;80(5):440-456.

PMID:
17112801
29.

Sulfonylureas and glinides exhibit peroxisome proliferator-activated receptor gamma activity: a combined virtual screening and biological assay approach.

Scarsi M, Podvinec M, Roth A, Hug H, Kersten S, Albrecht H, Schwede T, Meyer UA, Rücker C.

Mol Pharmacol. 2007 Feb;71(2):398-406. Epub 2006 Nov 2.

PMID:
17082235
30.

Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver.

Rencurel F, Foretz M, Kaufmann MR, Stroka D, Looser R, Leclerc I, da Silva Xavier G, Rutter GA, Viollet B, Meyer UA.

Mol Pharmacol. 2006 Dec;70(6):1925-34. Epub 2006 Sep 20.

PMID:
16988011
31.
32.

Pregnane X receptor is a target of farnesoid X receptor.

Jung D, Mangelsdorf DJ, Meyer UA.

J Biol Chem. 2006 Jul 14;281(28):19081-91. Epub 2006 May 8.

33.

Cytosolic persistence of mouse brain CYP1A1 in chronic heme deficiency.

Meyer RP, Lindberg RL, Hoffmann F, Meyer UA.

Biol Chem. 2005 Nov;386(11):1157-64.

PMID:
16307481
34.

Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha.

Handschin C, Lin J, Rhee J, Peyer AK, Chin S, Wu PH, Meyer UA, Spiegelman BM.

Cell. 2005 Aug 26;122(4):505-15.

35.

Three haplotypes associated with CYP2A6 phenotypes in Caucasians.

Haberl M, Anwald B, Klein K, Weil R, Fuss C, Gepdiremen A, Zanger UM, Meyer UA, Wojnowski L.

Pharmacogenet Genomics. 2005 Sep;15(9):609-24.

PMID:
16041240
36.

LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver.

Gnerre C, Schuster GU, Roth A, Handschin C, Johansson L, Looser R, Parini P, Podvinec M, Robertsson K, Gustafsson JA, Meyer UA.

J Lipid Res. 2005 Aug;46(8):1633-42. Epub 2005 Jun 1.

37.

Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids.

Handschin C, Gnerre C, Fraser DJ, Martinez-Jimenez C, Jover R, Meyer UA.

Arch Biochem Biophys. 2005 Feb 1;434(1):75-85.

PMID:
15629111
38.

Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.

Handschin C, Meyer UA.

Arch Biochem Biophys. 2005 Jan 15;433(2):387-96. Review.

PMID:
15581595
39.

The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals.

Handschin C, Blättler S, Roth A, Looser R, Oscarson M, Kaufmann MR, Podvinec M, Gnerre C, Meyer UA.

Nucl Recept. 2004 Oct 12;2(1):7.

40.

Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene.

Gnerre C, Blättler S, Kaufmann MR, Looser R, Meyer UA.

Pharmacogenetics. 2004 Oct;14(10):635-45.

PMID:
15454728
41.

Pharmacogenetics - five decades of therapeutic lessons from genetic diversity.

Meyer UA.

Nat Rev Genet. 2004 Sep;5(9):669-76. Review.

PMID:
15372089
42.

Identification of the xenosensors regulating human 5-aminolevulinate synthase.

Podvinec M, Handschin C, Looser R, Meyer UA.

Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9127-32. Epub 2004 Jun 3.

43.

In silico approaches, and in vitro and in vivo experiments to predict induction of drug metabolism.

Handschin C, Podvinec M, Meyer UA.

Drug News Perspect. 2003 Sep;16(7):423-34. Review.

PMID:
14668938
44.

Induction of drug metabolism: the role of nuclear receptors.

Handschin C, Meyer UA.

Pharmacol Rev. 2003 Dec;55(4):649-73. Review.

PMID:
14657421
45.
46.

Molecular cloning and characterization of chicken orphan nuclear receptor cTR2.

Sanyal S, Handschin C, Podvinec M, Song KH, Kim HJ, Kim JY, Seo YW, Kim SA, Kwon HB, Lee K, Kim WS, Meyer UA, Choi HS.

Gen Comp Endocrinol. 2003 Jul;132(3):474-84.

PMID:
12849971
47.

Genomics and the prediction of xenobiotic toxicity.

Meyer UA, Gut J.

Toxicology. 2002 Dec 27;181-182:463-6. Review.

PMID:
12505353
48.

Cytochrome P450 CYP1A1 accumulates in the cytosol of kidney and brain and is activated by heme.

Meyer RP, Podvinec M, Meyer UA.

Mol Pharmacol. 2002 Nov;62(5):1061-7.

PMID:
12391268
49.

Bosentan, a dual endothelin receptor antagonist, activates the pregnane X nuclear receptor.

van Giersbergen PL, Gnerre C, Treiber A, Dingemanse J, Meyer UA.

Eur J Pharmacol. 2002 Aug 23;450(2):115-21.

PMID:
12206849
50.

Stereoselective metabolism of bufuralol racemate and enantiomers in human liver microsomes.

Narimatsu S, Takemi C, Tsuzuki D, Kataoka H, Yamamoto S, Shimada N, Suzuki S, Satoh T, Meyer UA, Gonzalez FJ.

J Pharmacol Exp Ther. 2002 Oct;303(1):172-8.

PMID:
12235248

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