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Accumulation of uremic solutes in the cerebrospinal fluid in experimental acute renal failure.

Mair RD, Nguyen H, Huang TT, Plummer NS, Sirich TL, Meyer TW.

Am J Physiol Renal Physiol. 2019 Aug 1;317(2):F296-F302. doi: 10.1152/ajprenal.00100.2019. Epub 2019 May 29.


Contribution of 'clinically negligible' residual kidney function to clearance of uremic solutes.

Toth-Manikowski SM, Sirich TL, Meyer TW, Hostetter TH, Hwang S, Plummer NS, Hai X, Coresh J, Powe NR, Shafi T.

Nephrol Dial Transplant. 2019 Mar 15. pii: gfz042. doi: 10.1093/ndt/gfz042. [Epub ahead of print]


Characteristics of Colon-Derived Uremic Solutes.

Mair RD, Sirich TL, Plummer NS, Meyer TW.

Clin J Am Soc Nephrol. 2018 Sep 7;13(9):1398-1404. doi: 10.2215/CJN.03150318. Epub 2018 Aug 7.


Inflammation and Immunity Pathways Regulate Genetic Susceptibility to Diabetic Nephropathy.

Gurley SB, Ghosh S, Johnson SA, Azushima K, Sakban RB, George SE, Maeda M, Meyer TW, Coffman TM.

Diabetes. 2018 Oct;67(10):2096-2106. doi: 10.2337/db17-1323. Epub 2018 Jul 31.


Uremic Toxin Clearance and Cardiovascular Toxicities.

Mair RD, Sirich TL, Meyer TW.

Toxins (Basel). 2018 Jun 2;10(6). pii: E226. doi: 10.3390/toxins10060226. Review.


Residual Function Effectively Controls Plasma Concentrations of Secreted Solutes in Patients on Twice Weekly Hemodialysis.

Leong SC, Sao JN, Taussig A, Plummer NS, Meyer TW, Sirich TL.

J Am Soc Nephrol. 2018 Jul;29(7):1992-1999. doi: 10.1681/ASN.2018010081. Epub 2018 May 4.


Intensive Hemodialysis Fails to Reduce Plasma Levels of Uremic Solutes.

Sirich TL, Meyer TW.

Clin J Am Soc Nephrol. 2018 Mar 7;13(3):361-362. doi: 10.2215/CJN.00950118. Epub 2018 Feb 14. No abstract available.


Untargeted mass spectrometry discloses plasma solute levels poorly controlled by hemodialysis.

Sirich TL, Aronov PA, Fullman J, Nguyen K, Plummer NS, Meyer TW.

PLoS One. 2017 Nov 16;12(11):e0188315. doi: 10.1371/journal.pone.0188315. eCollection 2017.


Results of the HEMO Study suggest that p-cresol sulfate and indoxyl sulfate are not associated with cardiovascular outcomes.

Shafi T, Sirich TL, Meyer TW, Hostetter TH, Plummer NS, Hwang S, Melamed ML, Banerjee T, Coresh J, Powe NR.

Kidney Int. 2017 Dec;92(6):1484-1492. doi: 10.1016/j.kint.2017.05.012. Epub 2017 Jul 21.


The Effect of Uremic Solutes on the Organic Cation Transporter 2.

Cheung KWK, Hsueh CH, Zhao P, Meyer TW, Zhang L, Huang SM, Giacomini KM.

J Pharm Sci. 2017 Sep;106(9):2551-2557. doi: 10.1016/j.xphs.2017.04.076. Epub 2017 May 5.


Free and total p-cresol sulfate levels and infectious hospitalizations in hemodialysis patients in CHOICE and HEMO.

Banerjee T, Meyer TW, Shafi T, Hostetter TH, Melamed M, Zhu Y, Powe NR.

Medicine (Baltimore). 2017 Feb;96(6):e5799. doi: 10.1097/MD.0000000000005799.


Serum Asymmetric and Symmetric Dimethylarginine and Morbidity and Mortality in Hemodialysis Patients.

Shafi T, Hostetter TH, Meyer TW, Hwang S, Hai X, Melamed ML, Banerjee T, Coresh J, Powe NR.

Am J Kidney Dis. 2017 Jul;70(1):48-58. doi: 10.1053/j.ajkd.2016.10.033. Epub 2017 Jan 12.


Limited reduction in uremic solute concentrations with increased dialysis frequency and time in the Frequent Hemodialysis Network Daily Trial.

Sirich TL, Fong K, Larive B, Beck GJ, Chertow GM, Levin NW, Kliger AS, Plummer NS, Meyer TW; Frequent Hemodialysis Network (FHN) Trial Group.

Kidney Int. 2017 May;91(5):1186-1192. doi: 10.1016/j.kint.2016.11.002. Epub 2017 Jan 12.


Manipulating the microbiome.

Sirich TL, Meyer TW.

Kidney Int. 2017 Feb;91(2):274-276. doi: 10.1016/j.kint.2016.10.016.


Kt/Vurea and Nonurea Small Solute Levels in the Hemodialysis Study.

Meyer TW, Sirich TL, Fong KD, Plummer NS, Shafi T, Hwang S, Banerjee T, Zhu Y, Powe NR, Hai X, Hostetter TH.

J Am Soc Nephrol. 2016 Nov;27(11):3469-3478. Epub 2016 Mar 29.


More Dialysis Has Not Proven Much Better.

O'Brien FJ, Fong KD, Sirich TL, Meyer TW.

Semin Dial. 2016 Nov;29(6):481-490. doi: 10.1111/sdi.12533. Epub 2016 Aug 24.


Identification and Quantitative Assessment of Uremic Solutes as Inhibitors of Renal Organic Anion Transporters, OAT1 and OAT3.

Hsueh CH, Yoshida K, Zhao P, Meyer TW, Zhang L, Huang SM, Giacomini KM.

Mol Pharm. 2016 Sep 6;13(9):3130-40. doi: 10.1021/acs.molpharmaceut.6b00332. Epub 2016 Aug 9. Review.


Trimethylamine N-Oxide and Cardiovascular Events in Hemodialysis Patients.

Shafi T, Powe NR, Meyer TW, Hwang S, Hai X, Melamed ML, Banerjee T, Coresh J, Hostetter TH.

J Am Soc Nephrol. 2017 Jan;28(1):321-331. doi: 10.1681/ASN.2016030374. Epub 2016 Jul 19.


Effect of a sustained difference in hemodialytic clearance on the plasma levels of p-cresol sulfate and indoxyl sulfate.

Camacho O, Rosales MC, Shafi T, Fullman J, Plummer NS, Meyer TW, Sirich TL.

Nephrol Dial Transplant. 2016 Aug;31(8):1335-41. doi: 10.1093/ndt/gfw100. Epub 2016 May 17.


Uremic Solutes Produced by Colon Microbes.

Tanaka H, Sirich TL, Meyer TW.

Blood Purif. 2015;40(4):306-11. doi: 10.1159/000441578. Epub 2015 Nov 17.


Mechanism of Prominent Trimethylamine Oxide (TMAO) Accumulation in Hemodialysis Patients.

Hai X, Landeras V, Dobre MA, DeOreo P, Meyer TW, Hostetter TH.

PLoS One. 2015 Dec 9;10(12):e0143731. doi: 10.1371/journal.pone.0143731. eCollection 2015.


Tubular Secretion in CKD.

Suchy-Dicey AM, Laha T, Hoofnagle A, Newitt R, Sirich TL, Meyer TW, Thummel KE, Yanez ND, Himmelfarb J, Weiss NS, Kestenbaum BR.

J Am Soc Nephrol. 2016 Jul;27(7):2148-55. doi: 10.1681/ASN.2014121193. Epub 2015 Nov 27.


An Enlarged Profile of Uremic Solutes.

Tanaka H, Sirich TL, Plummer NS, Weaver DS, Meyer TW.

PLoS One. 2015 Aug 28;10(8):e0135657. doi: 10.1371/journal.pone.0135657. eCollection 2015.


Glomerular Effects of Age and APOL1.

Meyer TW, Lenihan CR.

J Am Soc Nephrol. 2015 Dec;26(12):2901-3. doi: 10.1681/ASN.2015040459. Epub 2015 Jun 2. No abstract available.


Free Levels of Selected Organic Solutes and Cardiovascular Morbidity and Mortality in Hemodialysis Patients: Results from the Retained Organic Solutes and Clinical Outcomes (ROSCO) Investigators.

Shafi T, Meyer TW, Hostetter TH, Melamed ML, Parekh RS, Hwang S, Banerjee T, Coresh J, Powe NR.

PLoS One. 2015 May 4;10(5):e0126048. doi: 10.1371/journal.pone.0126048. eCollection 2015.


Effect of increasing dietary fiber on plasma levels of colon-derived solutes in hemodialysis patients.

Sirich TL, Plummer NS, Gardner CD, Hostetter TH, Meyer TW.

Clin J Am Soc Nephrol. 2014 Sep 5;9(9):1603-10. doi: 10.2215/CJN.00490114. Epub 2014 Aug 21.


Approaches to uremia.

Meyer TW, Hostetter TH.

J Am Soc Nephrol. 2014 Oct;25(10):2151-8. doi: 10.1681/ASN.2013121264. Epub 2014 May 8. Review.


Protein-bound molecules: a large family with a bad character.

Sirich TL, Meyer TW, Gondouin B, Brunet P, Niwa T.

Semin Nephrol. 2014 Mar;34(2):106-17. doi: 10.1016/j.semnephrol.2014.02.004. Epub 2014 Feb 18.


Uremic solutes and risk of end-stage renal disease in type 2 diabetes: metabolomic study.

Niewczas MA, Sirich TL, Mathew AV, Skupien J, Mohney RP, Warram JH, Smiles A, Huang X, Walker W, Byun J, Karoly ED, Kensicki EM, Berry GT, Bonventre JV, Pennathur S, Meyer TW, Krolewski AS.

Kidney Int. 2014 May;85(5):1214-24. doi: 10.1038/ki.2013.497. Epub 2014 Jan 15.


Prominent accumulation in hemodialysis patients of solutes normally cleared by tubular secretion.

Sirich TL, Funk BA, Plummer NS, Hostetter TH, Meyer TW.

J Am Soc Nephrol. 2014 Mar;25(3):615-22. doi: 10.1681/ASN.2013060597. Epub 2013 Nov 14.


Retained organic solutes, patient characteristics and all-cause and cardiovascular mortality in hemodialysis: results from the retained organic solutes and clinical outcomes (ROSCO) investigators.

Melamed ML, Plantinga L, Shafi T, Parekh R, Meyer TW, Hostetter TH, Coresh J, Powe NR.

BMC Nephrol. 2013 Jun 27;14:134. doi: 10.1186/1471-2369-14-134.


A zebrafish model for uremic toxicity: role of the complement pathway.

Berman N, Lectura M, Thurman J, Reinecke J, Raff AC, Melamed ML, Reinecke J, Quan Z, Evans T, Meyer TW, Hostetter TH.

Blood Purif. 2013;35(4):265-269. doi: 10.1159/000348456. Epub 2013 May 8.


Numerous protein-bound solutes are cleared by the kidney with high efficiency.

Sirich TL, Aronov PA, Plummer NS, Hostetter TH, Meyer TW.

Kidney Int. 2013 Sep;84(3):585-90. doi: 10.1038/ki.2013.154. Epub 2013 May 1.


Searching for uremic toxins.

Dobre M, Meyer TW, Hostetter TH.

Clin J Am Soc Nephrol. 2013 Feb;8(2):322-7. doi: 10.2215/CJN.04260412. Epub 2012 Sep 27. Review.


The production of p-cresol sulfate and indoxyl sulfate in vegetarians versus omnivores.

Patel KP, Luo FJ, Plummer NS, Hostetter TH, Meyer TW.

Clin J Am Soc Nephrol. 2012 Jun;7(6):982-8. doi: 10.2215/CJN.12491211. Epub 2012 Apr 5.


Uremic solutes from colon microbes.

Meyer TW, Hostetter TH.

Kidney Int. 2012 May;81(10):949-954. doi: 10.1038/ki.2011.504. Epub 2012 Feb 8. Review.


Selectively increasing the clearance of protein-bound uremic solutes.

Sirich TL, Luo FJ, Plummer NS, Hostetter TH, Meyer TW.

Nephrol Dial Transplant. 2012 Apr;27(4):1574-9. doi: 10.1093/ndt/gfr691. Epub 2012 Jan 9.


The removal of protein-bound solutes by dialysis.

Meyer TW.

J Ren Nutr. 2012 Jan;22(1):203-6. doi: 10.1053/j.jrn.2011.10.011. Review.


Dialysis cannot be dosed.

Meyer TW, Sirich TL, Hostetter TH.

Semin Dial. 2011 Sep-Oct;24(5):471-9. doi: 10.1111/j.1525-139X.2011.00979.x. Epub 2011 Sep 19.


Colonic contribution to uremic solutes.

Aronov PA, Luo FJ, Plummer NS, Quan Z, Holmes S, Hostetter TH, Meyer TW.

J Am Soc Nephrol. 2011 Sep;22(9):1769-76. doi: 10.1681/ASN.2010121220. Epub 2011 Jul 22.


Indoxyl sulfate: long suspected but not yet proven guilty.

Sirich T, Meyer TW.

Clin J Am Soc Nephrol. 2011 Jan;6(1):3-4. doi: 10.2215/CJN.10141110. Epub 2010 Dec 9. No abstract available.


Contribution of residual function to removal of protein-bound solutes in hemodialysis.

Marquez IO, Tambra S, Luo FY, Li Y, Plummer NS, Hostetter TH, Meyer TW.

Clin J Am Soc Nephrol. 2011 Feb;6(2):290-6. doi: 10.2215/CJN.06100710. Epub 2010 Oct 28.


Anemia therapy in ESRD: time to move on.

Folkert VW, Meyer TW, Hostetter TH.

Clin J Am Soc Nephrol. 2010 Jul;5(7):1163-4. doi: 10.2215/CJN.03680410. Epub 2010 Jun 10. No abstract available.


Influence of genetic background on albuminuria and kidney injury in Ins2(+/C96Y) (Akita) mice.

Gurley SB, Mach CL, Stegbauer J, Yang J, Snow KP, Hu A, Meyer TW, Coffman TM.

Am J Physiol Renal Physiol. 2010 Mar;298(3):F788-95. doi: 10.1152/ajprenal.90515.2008. Epub 2009 Dec 30.


Methylamine clearance by haemodialysis is low.

Ponda MP, Quan Z, Melamed ML, Raff A, Meyer TW, Hostetter TH.

Nephrol Dial Transplant. 2010 May;25(5):1608-13. doi: 10.1093/ndt/gfp629. Epub 2009 Dec 17.


p-Cresol sulfate: further understanding of its cardiovascular disease potential in CKD.

Winchester JF, Hostetter TH, Meyer TW.

Am J Kidney Dis. 2009 Nov;54(5):792-4. doi: 10.1053/j.ajkd.2009.06.019. No abstract available.


Effect of increasing dialyzer mass transfer area coefficient and dialysate flow on clearance of protein-bound solutes: a pilot crossover trial.

Luo FJ, Patel KP, Marquez IO, Plummer NS, Hostetter TH, Meyer TW.

Am J Kidney Dis. 2009 Jun;53(6):1042-9. doi: 10.1053/j.ajkd.2009.01.265. Epub 2009 Apr 25.


Sodium octanoate to reverse indoxyl sulfate and p-cresyl sulfate albumin binding in uremic and normal serum during sample preparation followed by fluorescence liquid chromatography.

de Loor H, Meijers BK, Meyer TW, Bammens B, Verbeke K, Dehaen W, Evenepoel P.

J Chromatogr A. 2009 May 29;1216(22):4684-8. doi: 10.1016/j.chroma.2009.04.015. Epub 2009 Apr 14.


New insights into uremic toxicity.

Raff AC, Meyer TW, Hostetter TH.

Curr Opin Nephrol Hypertens. 2008 Nov;17(6):560-5. doi: 10.1097/MNH.0b013e32830f45b6. Review.


Coated carbon hemoperfusion provides limited clearance of protein-bound solutes.

Dinh DC, Recht NS, Hostetter TH, Meyer TW.

Artif Organs. 2008 Sep;32(9):717-24. doi: 10.1111/j.1525-1594.2008.00594.x. Epub 2008 Jul 30.


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