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Plasma Mitochondrial DNA Levels Are Associated With ARDS in Trauma and Sepsis Patients.

Faust HE, Reilly JP, Anderson BJ, Ittner CAG, Forker CM, Zhang P, Weaver BA, Holena DN, Lanken PN, Christie JD, Meyer NJ, Mangalmurti NS, Shashaty MGS.

Chest. 2019 Oct 14. pii: S0012-3692(19)34010-3. doi: 10.1016/j.chest.2019.09.028. [Epub ahead of print]


Plasma sRAGE Acts as Genetically Regulated Causal Intermediate in Sepsis-Associated ARDS.

Jones TK, Feng R, Kerchberger VE, Reilly JP, Anderson BJ, Shashaty MGS, Wang F, Dunn TG, Riley TR, Abbott J, Ittner CAG, Christiani DC, Mikacenic C, Wurfel MM, Ware LB, Calfee CS, Matthay MA, Christie JD, Meyer NJ.

Am J Respir Crit Care Med. 2019 Sep 5. doi: 10.1164/rccm.201810-2033OC. [Epub ahead of print]


Reply: Against Another Nonspecific Marker of Perfusion.

Bonk MP, Meyer NJ.

Ann Am Thorac Soc. 2019 Oct;16(10):1337-1338. doi: 10.1513/AnnalsATS.201906-484LE. No abstract available.


Plasma receptor interacting protein kinase-3 levels are associated with acute respiratory distress syndrome in sepsis and trauma: a cohort study.

Shashaty MGS, Reilly JP, Faust HE, Forker CM, Ittner CAG, Zhang PX, Hotz MJ, Fitzgerald D, Yang W, Anderson BJ, Holena DN, Lanken PN, Christie JD, Meyer NJ, Mangalmurti NS.

Crit Care. 2019 Jun 28;23(1):235. doi: 10.1186/s13054-019-2482-x.


Troponin I: A New Marker of Sepsis-induced Hypoperfusion?

Bonk MP, Meyer NJ.

Ann Am Thorac Soc. 2019 May;16(5):552-553. doi: 10.1513/AnnalsATS.201902-099ED. No abstract available.


Circulating heparan sulfate fragments mediate septic cognitive dysfunction.

Hippensteel JA, Anderson BJ, Orfila JE, McMurtry SA, Dietz RM, Su G, Ford JA, Oshima K, Yang Y, Zhang F, Han X, Yu Y, Liu J, Linhardt RJ, Meyer NJ, Herson PS, Schmidt EP.

J Clin Invest. 2019 Apr 1;129(4):1779-1784. doi: 10.1172/JCI124485. Epub 2019 Mar 18.


Optimal treatment allocations in space and time for on-line control of an emerging infectious disease.

Laber EB, Meyer NJ, Reich BJ, Pacifici K, Collazo JA, Drake JM.

J R Stat Soc Ser C Appl Stat. 2018 Aug;67(4):743-770. Epub 2018 Jul 18.


HDL Cholesterol: A "Pathogen Lipid Sink" for Sepsis?

Jones TK, Wong HR, Meyer NJ.

Am J Respir Crit Care Med. 2019 Apr 1;199(7):812-814. doi: 10.1164/rccm.201811-2084ED. No abstract available.


Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis.

Reilly JP, Wang F, Jones TK, Palakshappa JA, Anderson BJ, Shashaty MGS, Dunn TG, Johansson ED, Riley TR, Lim B, Abbott J, Ittner CAG, Cantu E, Lin X, Mikacenic C, Wurfel MM, Christiani DC, Calfee CS, Matthay MA, Christie JD, Feng R, Meyer NJ.

Intensive Care Med. 2018 Nov;44(11):1849-1858. doi: 10.1007/s00134-018-5328-0. Epub 2018 Oct 21.


Quantitative peripheral muscle ultrasound in sepsis: Muscle area superior to thickness.

Palakshappa JA, Reilly JP, Schweickert WD, Anderson BJ, Khoury V, Shashaty MG, Fitzgerald D, Forker C, Butler K, Ittner CA, Feng R, Files DC, Bonk MP, Christie JD, Meyer NJ.

J Crit Care. 2018 Oct;47:324-330. doi: 10.1016/j.jcrc.2018.04.003.


MUC5B Promoter Polymorphism and Development of Acute Respiratory Distress Syndrome.

Rogers AJ, Solus JF, Hunninghake GM, Baron RM, Meyer NJ, Janz DR, Schwartz DA, May AK, Lawson WE, Blackwell TS, Ware LB.

Am J Respir Crit Care Med. 2018 Nov 15;198(10):1342-1345. doi: 10.1164/rccm.201801-0140LE. No abstract available.


Genome-Wide Association Study in African Americans with Acute Respiratory Distress Syndrome Identifies the Selectin P Ligand Gene as a Risk Factor.

Bime C, Pouladi N, Sammani S, Batai K, Casanova N, Zhou T, Kempf CL, Sun X, Camp SM, Wang T, Kittles RA, Lussier YA, Jones TK, Reilly JP, Meyer NJ, Christie JD, Karnes JH, Gonzalez-Garay M, Christiani DC, Yates CR, Wurfel MM, Meduri GU, Garcia JGN.

Am J Respir Crit Care Med. 2018 Jun 1;197(11):1421-1432. doi: 10.1164/rccm.201705-0961OC.


Myeloperoxidase-derived 2-chlorofatty acids contribute to human sepsis mortality via acute respiratory distress syndrome.

Meyer NJ, Reilly JP, Feng R, Christie JD, Hazen SL, Albert CJ, Franke JD, Hartman CL, McHowat J, Ford DA.

JCI Insight. 2017 Dec 7;2(23). pii: 96432. doi: 10.1172/jci.insight.96432.


Mortality Benefit of Recombinant Human Interleukin-1 Receptor Antagonist for Sepsis Varies by Initial Interleukin-1 Receptor Antagonist Plasma Concentration.

Meyer NJ, Reilly JP, Anderson BJ, Palakshappa JA, Jones TK, Dunn TG, Shashaty MGS, Feng R, Christie JD, Opal SM.

Crit Care Med. 2018 Jan;46(1):21-28. doi: 10.1097/CCM.0000000000002749.


Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome.

Meyer NJ, Calfee CS.

Lancet Respir Med. 2017 Jun;5(6):512-523. doi: 10.1016/S2213-2600(17)30187-X. Epub 2017 May 26. Review.


What's in a Number? Platelet Count Dynamics as a Novel Mediator of Acute Respiratory Distress Syndrome Survival.

Jones TK, Meyer NJ.

Am J Respir Crit Care Med. 2017 May 15;195(10):1285-1287. doi: 10.1164/rccm.201611-2264ED. No abstract available.


Fifty Years of Research in ARDS. Genomic Contributions and Opportunities.

Reilly JP, Christie JD, Meyer NJ.

Am J Respir Crit Care Med. 2017 Nov 1;196(9):1113-1121. doi: 10.1164/rccm.201702-0405CP. Review.


SNPing Away at the Genetic Risk for Acute Kidney Injury.

Meyer NJ.

Am J Respir Crit Care Med. 2017 Feb 15;195(4):416-418. doi: 10.1164/rccm.201609-1811ED. No abstract available.


Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death.

Bhatraju PK, Mukherjee P, Robinson-Cohen C, O'Keefe GE, Frank AJ, Christie JD, Meyer NJ, Liu KD, Matthay MA, Calfee CS, Christiani DC, Himmelfarb J, Wurfel MM.

Crit Care. 2016 Nov 17;20(1):372.


Admission plasma levels of the neuronal injury marker neuron-specific enolase are associated with mortality and delirium in sepsis.

Anderson BJ, Reilly JP, Shashaty MGS, Palakshappa JA, Wysoczanski A, Dunn TG, Kazi A, Tommasini A, Mikkelsen ME, Schweickert WD, Kolson DL, Christie JD, Meyer NJ.

J Crit Care. 2016 Dec;36:18-23. doi: 10.1016/j.jcrc.2016.06.012. Epub 2016 Jun 23.


Factors affecting biomarkers of endothelial and alveolar epithelial dysfunction: response to comments by Kyo et al.

Yehya N, Thomas NJ, Meyer NJ, Margulies SS.

Intensive Care Med. 2016 Dec;42(12):2113-2114. doi: 10.1007/s00134-016-4486-1. Epub 2016 Aug 17. No abstract available.


Neutropenic sepsis is associated with distinct clinical and biological characteristics: a cohort study of severe sepsis.

Reilly JP, Anderson BJ, Hudock KM, Dunn TG, Kazi A, Tommasini A, Charles D, Shashaty MG, Mikkelsen ME, Christie JD, Meyer NJ.

Crit Care. 2016 Jul 18;20(1):222. doi: 10.1186/s13054-016-1398-y.


Circulating markers of endothelial and alveolar epithelial dysfunction are associated with mortality in pediatric acute respiratory distress syndrome.

Yehya N, Thomas NJ, Meyer NJ, Christie JD, Berg RA, Margulies SS.

Intensive Care Med. 2016 Jul;42(7):1137-45. doi: 10.1007/s00134-016-4352-1. Epub 2016 Apr 21.


Diagnostic workup for ARDS patients.

Papazian L, Calfee CS, Chiumello D, Luyt CE, Meyer NJ, Sekiguchi H, Matthay MA, Meduri GU.

Intensive Care Med. 2016 May;42(5):674-685. doi: 10.1007/s00134-016-4324-5. Epub 2016 Mar 23. Review.


Low Plasma Levels of Adiponectin Do Not Explain Acute Respiratory Distress Syndrome Risk: a Prospective Cohort Study of Patients with Severe Sepsis.

Palakshappa JA, Anderson BJ, Reilly JP, Shashaty MG, Ueno R, Wu Q, Ittner CA, Tommasini A, Dunn TG, Charles D, Kazi A, Christie JD, Meyer NJ.

Crit Care. 2016 Mar 16;20:71. doi: 10.1186/s13054-016-1244-2.


Plasma Levels of Receptor Interacting Protein Kinase-3 (RIP3), an Essential Mediator of Necroptosis, are Associated with Acute Kidney Injury in Critically Ill Trauma Patients.

Shashaty MG, Reilly JP, Sims CA, Holena DN, Qing D, Forker CM, Hotz MJ, Meyer NJ, Lanken PN, Feldman HI, Christie JD, Mangalmurti NS.

Shock. 2016 Aug;46(2):139-43. doi: 10.1097/SHK.0000000000000596.


[Induction of labour: benefits and risks].

Boulvain M, Meyer NJ.

Rev Med Suisse. 2015 Oct 28;11(492):2011-2, 2014-5. French.


Protein Quantitative Trait Loci Analysis Identifies Genetic Variation in the Innate Immune Regulator TOLLIP in Post-Lung Transplant Primary Graft Dysfunction Risk.

Cantu E, Suzuki Y, Diamond JM, Ellis J, Tiwari J, Beduhn B, Nellen JR, Shah R, Meyer NJ, Lederer DJ, Kawut SM, Palmer SM, Snyder LD, Hartwig MG, Lama VN, Bhorade S, Crespo M, Demissie E, Wille K, Orens J, Shah PD, Weinacker A, Weill D, Wilkes D, Roe D, Ware LB, Wang F, Feng R, Christie JD; Lung Transplant Outcomes Group.

Am J Transplant. 2016 Mar;16(3):833-40. doi: 10.1111/ajt.13525. Epub 2015 Dec 10.


Causal Genetic Inference Using Haplotypes as Instrumental Variables.

Wang F, Meyer NJ, Walley KR, Russell JA, Feng R.

Genet Epidemiol. 2016 Jan;40(1):35-44. doi: 10.1002/gepi.21940. Epub 2015 Dec 1.


The ABO Histo-Blood Group and AKI in Critically Ill Patients with Trauma or Sepsis.

Reilly JP, Anderson BJ, Mangalmurti NS, Nguyen TD, Holena DN, Wu Q, Nguyen ET, Reilly MP, Lanken PN, Christie JD, Meyer NJ, Shashaty MG.

Clin J Am Soc Nephrol. 2015 Nov 6;10(11):1911-20. doi: 10.2215/CJN.12201214. Epub 2015 Sep 4.


Which patients with ARDS benefit from lung biopsy?

Palakshappa JA, Meyer NJ.

Chest. 2015 Oct;148(4):1073-1082. doi: 10.1378/chest.15-0076. Review.


Comparing the prognostic performance of ASSIST to interleukin-6 and procalcitonin in patients with severe sepsis or septic shock.

Wong HR, Walley KR, Pettilä V, Meyer NJ, Russell JA, Karlsson S, Shashaty MG, Lindsell CJ.

Biomarkers. 2015 Mar;20(2):132-5. doi: 10.3109/1354750X.2014.1000971. Epub 2015 Jan 12.


Finding a needle in the haystack: leveraging bioinformatics to identify a functional genetic risk factor for sepsis death.

Meyer NJ.

Crit Care Med. 2015 Jan;43(1):242-3. doi: 10.1097/CCM.0000000000000664. No abstract available.


Induction intravenous cyclophosphamide followed by maintenance oral immunosuppression in refractory myasthenia gravis.

Buzzard KA, Meyer NJ, Hardy TA, Riminton DS, Reddel SW.

Muscle Nerve. 2015 Aug;52(2):204-10. doi: 10.1002/mus.24536. Epub 2015 Jun 18.


Beyond single-nucleotide polymorphisms: genetics, genomics, and other 'omic approaches to acute respiratory distress syndrome.

Meyer NJ.

Clin Chest Med. 2014 Dec;35(4):673-84. doi: 10.1016/j.ccm.2014.08.006. Epub 2014 Sep 23. Review.


Oxidant stress regulatory genetic variation in recipients and donors contributes to risk of primary graft dysfunction after lung transplantation.

Cantu E, Shah RJ, Lin W, Daye ZJ, Diamond JM, Suzuki Y, Ellis JH, Borders CF, Andah GA, Beduhn B, Meyer NJ, Ruschefski M, Aplenc R, Feng R, Christie JD; Lung Transplant Outcomes Group Investigators.

J Thorac Cardiovasc Surg. 2015 Feb;149(2):596-602. doi: 10.1016/j.jtcvs.2014.09.077. Epub 2014 Sep 28.


Integrative genomics identifies 7p11.2 as a novel locus for fever and clinical stress response in humans.

Ferguson JF, Meyer NJ, Qu L, Xue C, Liu Y, DerOhannessian SL, Rushefski M, Paschos GK, Tang S, Schadt EE, Li M, Christie JD, Reilly MP.

Hum Mol Genet. 2015 Mar 15;24(6):1801-12. doi: 10.1093/hmg/ddu589. Epub 2014 Nov 20.


Red blood cells induce necroptosis of lung endothelial cells and increase susceptibility to lung inflammation.

Qing DY, Conegliano D, Shashaty MG, Seo J, Reilly JP, Worthen GS, Huh D, Meyer NJ, Mangalmurti NS.

Am J Respir Crit Care Med. 2014 Dec 1;190(11):1243-54. doi: 10.1164/rccm.201406-1095OC.


PCSK9 is a critical regulator of the innate immune response and septic shock outcome.

Walley KR, Thain KR, Russell JA, Reilly MP, Meyer NJ, Ferguson JF, Christie JD, Nakada TA, Fjell CD, Thair SA, Cirstea MS, Boyd JH.

Sci Transl Med. 2014 Oct 15;6(258):258ra143. doi: 10.1126/scitranslmed.3008782.


Epidemiology and outcomes in patients with severe sepsis admitted to the hospital wards.

Whittaker SA, Fuchs BD, Gaieski DF, Christie JD, Goyal M, Meyer NJ, Kean C, Small DS, Bellamy SL, Mikkelsen ME.

J Crit Care. 2015 Feb;30(1):78-84. doi: 10.1016/j.jcrc.2014.07.012. Epub 2014 Jul 22.


A functional synonymous coding variant in the IL1RN gene is associated with survival in septic shock.

Meyer NJ, Ferguson JF, Feng R, Wang F, Patel PN, Li M, Xue C, Qu L, Liu Y, Boyd JH, Russell JA, Christie JD, Walley KR, Reilly MP.

Am J Respir Crit Care Med. 2014 Sep 15;190(6):656-64. doi: 10.1164/rccm.201403-0586OC.


Intrahepatic activation of naive CD4+ T cells by liver-resident phagocytic cells.

Tay SS, Wong YC, Roediger B, Sierro F, Lu B, McDonald DM, McGuffog CM, Meyer NJ, Alexander IE, Parish IA, Heath WR, Weninger W, Bishop GA, Gamble JR, McCaughan GW, Bertolino P, Bowen DG.

J Immunol. 2014 Sep 1;193(5):2087-95. doi: 10.4049/jimmunol.1400037. Epub 2014 Jul 28.


Pattern recognition in ARDS: a crucial first step toward personalised treatment.

Reilly JP, Meyer NJ.

Lancet Respir Med. 2014 Aug;2(8):594-5. doi: 10.1016/S2213-2600(14)70116-X. Epub 2014 May 19. No abstract available.


Heterogeneous phenotypes of acute respiratory distress syndrome after major trauma.

Reilly JP, Bellamy S, Shashaty MG, Gallop R, Meyer NJ, Lanken PN, Kaplan S, Holena DN, May AK, Ware LB, Christie JD.

Ann Am Thorac Soc. 2014 Jun;11(5):728-36. doi: 10.1513/AnnalsATS.201308-280OC.


Trapezium excision and suture suspensionplasty (TESS) for the treatment of thumb carpometacarpal arthritis.

Putnam MD, Meyer NJ, Baker D, Brehmer J, Carlson BD.

Tech Hand Up Extrem Surg. 2014 Jun;18(2):102-8. doi: 10.1097/BTH.0000000000000046.


Genetic variation in the prostaglandin E2 pathway is associated with primary graft dysfunction.

Diamond JM, Akimova T, Kazi A, Shah RJ, Cantu E, Feng R, Levine MH, Kawut SM, Meyer NJ, Lee JC, Hancock WW, Aplenc R, Ware LB, Palmer SM, Bhorade S, Lama VN, Weinacker A, Orens J, Wille K, Crespo M, Lederer DJ, Arcasoy S, Demissie E, Christie JD; Lung Transplant Outcomes Group.

Am J Respir Crit Care Med. 2014 Mar 1;189(5):567-75. doi: 10.1164/rccm.201307-1283OC.


Future clinical applications of genomics for acute respiratory distress syndrome.

Meyer NJ.

Lancet Respir Med. 2013 Dec;1(10):793-803. doi: 10.1016/S2213-2600(13)70134-6. Epub 2013 Aug 19. Review.


Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation.

Nakahira K, Kyung SY, Rogers AJ, Gazourian L, Youn S, Massaro AF, Quintana C, Osorio JC, Wang Z, Zhao Y, Lawler LA, Christie JD, Meyer NJ, Mc Causland FR, Waikar SS, Waxman AB, Chung RT, Bueno R, Rosas IO, Fredenburgh LE, Baron RM, Christiani DC, Hunninghake GM, Choi AM.

PLoS Med. 2013 Dec;10(12):e1001577; discussion e1001577. doi: 10.1371/journal.pmed.1001577. Epub 2013 Dec 31.


ABO blood type A is associated with increased risk of ARDS in whites following both major trauma and severe sepsis.

Reilly JP, Meyer NJ, Shashaty MGS, Feng R, Lanken PN, Gallop R, Kaplan S, Herlim M, Oz NL, Hiciano I, Campbell A, Holena DN, Reilly MP, Christie JD.

Chest. 2014 Apr;145(4):753-761. doi: 10.1378/chest.13-1962.


A multibiomarker-based outcome risk stratification model for adult septic shock*.

Wong HR, Lindsell CJ, Pettilä V, Meyer NJ, Thair SA, Karlsson S, Russell JA, Fjell CD, Boyd JH, Ruokonen E, Shashaty MG, Christie JD, Hart KW, Lahni P, Walley KR.

Crit Care Med. 2014 Apr;42(4):781-9. doi: 10.1097/CCM.0000000000000106.

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