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Apoptosis and failure of checkpoint kinase 1 activation in human induced pluripotent stem cells under replication stress.

Desmarais JA, Unger C, Damjanov I, Meuth M, Andrews P.

Stem Cell Res Ther. 2016 Jan 25;7:17. doi: 10.1186/s13287-016-0279-2.


Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cells.

Zuazua-Villar P, Ganesh A, Phear G, Gagou ME, Meuth M.

Nucleic Acids Res. 2015 Nov 16;43(20):9776-87. doi: 10.1093/nar/gkv835. Epub 2015 Aug 13.


Human PIF1 helicase supports DNA replication and cell growth under oncogenic-stress.

Gagou ME, Ganesh A, Phear G, Robinson D, Petermann E, Cox A, Meuth M.

Oncotarget. 2014 Nov 30;5(22):11381-98.


Inhibitors of cell cycle checkpoints and DNA replication cause different responses in normal versus malignant urothelial cells.

Meuth M.

Mol Cell Oncol. 2014 Dec 31;1(4):e968508. doi: 10.4161/23723548.2014.968508. eCollection 2014 Oct-Dec.


Differential response of normal and malignant urothelial cells to CHK1 and ATM inhibitors.

Wang WT, Catto JW, Meuth M.

Oncogene. 2015 May 28;34(22):2887-96. doi: 10.1038/onc.2014.221. Epub 2014 Jul 21.


DNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B.

Zuazua-Villar P, Rodriguez R, Gagou ME, Eyers PA, Meuth M.

Cell Death Dis. 2014 May 22;5:e1253. doi: 10.1038/cddis.2014.231.


HDAC inhibitor confers radiosensitivity to prostate stem-like cells.

Frame FM, Pellacani D, Collins AT, Simms MS, Mann VM, Jones GD, Meuth M, Bristow RG, Maitland NJ.

Br J Cancer. 2013 Dec 10;109(12):3023-33. doi: 10.1038/bjc.2013.691. Epub 2013 Nov 12.


Deficient DNA damage response and cell cycle checkpoints lead to accumulation of point mutations in human embryonic stem cells.

Hyka-Nouspikel N, Desmarais J, Gokhale PJ, Jones M, Meuth M, Andrews PW, Nouspikel T.

Stem Cells. 2012 Sep;30(9):1901-10. doi: 10.1002/stem.1177.


Human embryonic stem cells fail to activate CHK1 and commit to apoptosis in response to DNA replication stress.

Desmarais JA, Hoffmann MJ, Bingham G, Gagou ME, Meuth M, Andrews PW.

Stem Cells. 2012 Jul;30(7):1385-93. doi: 10.1002/stem.1117.


Treatment with the Chk1 inhibitor Gö6976 enhances cisplatin cytotoxicity in SCLC cells.

Thompson R, Meuth M, Woll P, Zhu Y, Danson S.

Int J Oncol. 2012 Jan;40(1):194-202. doi: 10.3892/ijo.2011.1187. Epub 2011 Sep 5.


Suppression of apoptosis by PIF1 helicase in human tumor cells.

Gagou ME, Ganesh A, Thompson R, Phear G, Sanders C, Meuth M.

Cancer Res. 2011 Jul 15;71(14):4998-5008. doi: 10.1158/0008-5472.CAN-10-4404. Epub 2011 May 26.


Chk1 suppressed cell death.

Meuth M.

Cell Div. 2010 Sep 2;5:21. doi: 10.1186/1747-1028-5-21.


Enhanced H2AX phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1.

Gagou ME, Zuazua-Villar P, Meuth M.

Mol Biol Cell. 2010 Mar 1;21(5):739-52. doi: 10.1091/mbc.E09-07-0618. Epub 2010 Jan 6.


Distinct microRNA alterations characterize high- and low-grade bladder cancer.

Catto JW, Miah S, Owen HC, Bryant H, Myers K, Dudziec E, Larré S, Milo M, Rehman I, Rosario DJ, Di Martino E, Knowles MA, Meuth M, Harris AL, Hamdy FC.

Cancer Res. 2009 Nov 1;69(21):8472-81. doi: 10.1158/0008-5472.CAN-09-0744. Epub 2009 Oct 20.


The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links.

Al-Minawi AZ, Lee YF, Håkansson D, Johansson F, Lundin C, Saleh-Gohari N, Schultz N, Jenssen D, Bryant HE, Meuth M, Hinz JM, Helleday T.

Nucleic Acids Res. 2009 Oct;37(19):6400-13. doi: 10.1093/nar/gkp705. Epub 2009 Aug 27.


Human Pif1 helicase unwinds synthetic DNA structures resembling stalled DNA replication forks.

George T, Wen Q, Griffiths R, Ganesh A, Meuth M, Sanders CM.

Nucleic Acids Res. 2009 Oct;37(19):6491-502. doi: 10.1093/nar/gkp671. Epub 2009 Aug 21.


ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress.

Myers K, Gagou ME, Zuazua-Villar P, Rodriguez R, Meuth M.

PLoS Genet. 2009 Jan;5(1):e1000324. doi: 10.1371/journal.pgen.1000324. Epub 2009 Jan 2.


Thymidine selectively enhances growth suppressive effects of camptothecin/irinotecan in MSI+ cells and tumors containing a mutation of MRE11.

Rodriguez R, Hansen LT, Phear G, Scorah J, Spang-Thomsen M, Cox A, Helleday T, Meuth M.

Clin Cancer Res. 2008 Sep 1;14(17):5476-83. doi: 10.1158/1078-0432.CCR-08-0274.


FGFR3 mutations indicate better survival in invasive upper urinary tract and bladder tumours.

van Oers JM, Zwarthoff EC, Rehman I, Azzouzi AR, Cussenot O, Meuth M, Hamdy FC, Catto JW.

Eur Urol. 2009 Mar;55(3):650-7. doi: 10.1016/j.eururo.2008.06.013. Epub 2008 Jun 13.


A comparison of the performance of microsatellite and methylation urine analysis for predicting the recurrence of urothelial cell carcinoma, and definition of a set of markers by Bayesian network analysis.

Rouprêt M, Hupertan V, Yates DR, Comperat E, Catto JW, Meuth M, Lackmichi A, Ricci S, Lacave R, Gattegno B, Richard F, Hamdy FC, Cussenot O.

BJU Int. 2008 Jun;101(11):1448-53. doi: 10.1111/j.1464-410X.2008.07591.x. Epub 2008 Mar 4.


A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner.

Wen Q, Scorah J, Phear G, Rodgers G, Rodgers S, Meuth M.

Mol Biol Cell. 2008 Apr;19(4):1693-705. doi: 10.1091/mbc.E07-09-0975. Epub 2008 Feb 6.


Apoptosis induced by replication inhibitors in Chk1-depleted cells is dependent upon the helicase cofactor Cdc45.

Rodriguez R, Gagou ME, Meuth M.

Cell Death Differ. 2008 May;15(5):889-98. doi: 10.1038/cdd.2008.4. Epub 2008 Feb 1.


[Promoter methylation and microsatellite mutation reveals the clonal relationship of multiple urothelial carcinomas with mutator phenotype].

Stöhr R, Catto JW, Azzouzi A, Rehmann I, Feeley K, Meuth M, Hamdy F, Burger M, Hartmann A.

Verh Dtsch Ges Pathol. 2005;89:225-33. German.


Promoter hypermethylation in circulating blood cells identifies prostate cancer progression.

Rouprêt M, Hupertan V, Catto JW, Yates DR, Rehman I, Proctor LM, Phillips J, Meuth M, Cussenot O, Hamdy FC.

Int J Cancer. 2008 Feb 15;122(4):952-6.


[Mutation of the FGFR3 oncogene is an independent and favorable prognostic factor for tumor-specific survival in patients with urothelial carcinoma of the upper urinary tract].

Burger M, Catto J, van Oers J, Zwarthoff E, Hamdy FC, Meuth M, Azzouri AR, Cussenot O, Wild PJ, Stoehr R, Hartmann A.

Verh Dtsch Ges Pathol. 2006;90:244-52. German.


Promoter hypermethylation identifies progression risk in bladder cancer.

Yates DR, Rehman I, Abbod MF, Meuth M, Cross SS, Linkens DA, Hamdy FC, Catto JW.

Clin Cancer Res. 2007 Apr 1;13(7):2046-53.


Molecular detection of localized prostate cancer using quantitative methylation-specific PCR on urinary cells obtained following prostate massage.

Rouprêt M, Hupertan V, Yates DR, Catto JW, Rehman I, Meuth M, Ricci S, Lacave R, Cancel-Tassin G, de la Taille A, Rozet F, Cathelineau X, Vallancien G, Hamdy FC, Cussenot O.

Clin Cancer Res. 2007 Mar 15;13(6):1720-5.


Clinically localised prostate cancer is microsatellite stable.

Azzouzi AR, Catto JW, Rehman I, Larre S, Roupret M, Feeley KM, Cussenot O, Meuth M, Hamdy FC.

BJU Int. 2007 May;99(5):1031-5. Epub 2007 Jan 16.


Multifocal urothelial cancers with the mutator phenotype are of monoclonal origin and require panurothelial treatment for tumor clearance.

Catto JW, Hartmann A, Stoehr R, Bolderson E, Rehman I, Rosario DJ, Hamdy FC, Meuth M.

J Urol. 2006 Jun;175(6):2323-30.


Evidence for the early onset of aberrant promoter methylation in urothelial carcinoma.

Dhawan D, Hamdy FC, Rehman I, Patterson J, Cross SS, Feeley KM, Stephenson Y, Meuth M, Catto JW.

J Pathol. 2006 Jul;209(3):336-43.


Methylational urinalysis: a prospective study of bladder cancer patients and age stratified benign controls.

Yates DR, Rehman I, Meuth M, Cross SS, Hamdy FC, Catto JW.

Oncogene. 2006 Mar 23;25(13):1984-8.


Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress.

Rodriguez R, Meuth M.

Mol Biol Cell. 2006 Jan;17(1):402-12. Epub 2005 Nov 9.


Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase.

Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E, Kyle S, Meuth M, Curtin NJ, Helleday T.

Nature. 2005 Apr 14;434(7035):913-7. Erratum in: Nature. 2007 May 17;447(7142):346.


Promoter hypermethylation is associated with tumor location, stage, and subsequent progression in transitional cell carcinoma.

Catto JW, Azzouzi AR, Rehman I, Feeley KM, Cross SS, Amira N, Fromont G, Sibony M, Cussenot O, Meuth M, Hamdy FC.

J Clin Oncol. 2005 May 1;23(13):2903-10. Epub 2005 Mar 7.


Association of a common variant of the CASP8 gene with reduced risk of breast cancer.

MacPherson G, Healey CS, Teare MD, Balasubramanian SP, Reed MW, Pharoah PD, Ponder BA, Meuth M, Bhattacharyya NP, Cox A.

J Natl Cancer Inst. 2004 Dec 15;96(24):1866-9.


Proteomic analysis of voided urine after prostatic massage from patients with prostate cancer: a pilot study.

Rehman I, Azzouzi AR, Catto JW, Allen S, Cross SS, Feeley K, Meuth M, Hamdy FC.

Urology. 2004 Dec;64(6):1238-43.


ATM is required for the cellular response to thymidine induced replication fork stress.

Bolderson E, Scorah J, Helleday T, Smythe C, Meuth M.

Hum Mol Genet. 2004 Dec 1;13(23):2937-45. Epub 2004 Sep 30.


Microsatellite instability as indicator of MSH2 gene mutation in patients with upper urinary tract transitional cell carcinoma.

Roupret M, Catto J, Coulet F, Azzouzi AR, Amira N, Karmouni T, Fromont G, Sibony M, Vallancien G, Gattegno B, Meuth M, Hamdy FC, Cussenot O.

J Med Genet. 2004 Jul;41(7):e91. No abstract available.


Genetic instability and transitional cell carcinoma of the bladder.

Catto JW, Meuth M, Hamdy FC.

BJU Int. 2004 Jan;93(1):19-24. Review.


Distinct patterns of microsatellite instability are seen in tumours of the urinary tract.

Catto JW, Azzouzi AR, Amira N, Rehman I, Feeley KM, Cross SS, Fromont G, Sibony M, Hamdy FC, Cussenot O, Meuth M.

Oncogene. 2003 Nov 27;22(54):8699-706.


A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous recombination at DNA replication forks.

Mohindra A, Bolderson E, Stone J, Wells M, Helleday T, Meuth M.

Hum Mol Genet. 2004 Jan 15;13(2):203-12. Epub 2003 Nov 25.


Differential expression of hMLH1 and hMSH2 is related to bladder cancer grade, stage and prognosis but not microsatellite instability.

Catto JW, Xinarianos G, Burton JL, Meuth M, Hamdy FC.

Int J Cancer. 2003 Jul 1;105(4):484-90.


Reduced apoptotic response to camptothecin in CHO cells deficient in XRCC3.

Hinz JM, Helleday T, Meuth M.

Carcinogenesis. 2003 Feb;24(2):249-53.


Defects in homologous recombination repair in mismatch-repair-deficient tumour cell lines.

Mohindra A, Hays LE, Phillips EN, Preston BD, Helleday T, Meuth M.

Hum Mol Genet. 2002 Sep 1;11(18):2189-200.


Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells.

Lundin C, Erixon K, Arnaudeau C, Schultz N, Jenssen D, Meuth M, Helleday T.

Mol Cell Biol. 2002 Aug;22(16):5869-78.


A potential role for the XRCC2 R188H polymorphic site in DNA-damage repair and breast cancer.

Rafii S, O'Regan P, Xinarianos G, Azmy I, Stephenson T, Reed M, Meuth M, Thacker J, Cox A.

Hum Mol Genet. 2002 Jun 1;11(12):1433-8.


Suppression of the radiation-sensitive phenotype of hamster irs1 and irs2 strains selected for resistance to 3-aminobenzamide.

Ganesh A, Phillips E, Thacker J, Meuth M.

Int J Radiat Biol. 2001 May;77(5):609-16.


Microsatellite instability and the PTEN1 gene mutation in a subset of early onset gliomas carrying germline mutation or promoter methylation of the hMLH1 gene.

Kanamori M, Kon H, Nobukuni T, Nomura S, Sugano K, Mashiyama S, Kumabe T, Yoshimoto T, Meuth M, Sekiya T, Murakami Y.

Oncogene. 2000 Mar 16;19(12):1564-71.


Apoptosis induced by overexpression of hMSH2 or hMLH1.

Zhang H, Richards B, Wilson T, Lloyd M, Cranston A, Thorburn A, Fishel R, Meuth M.

Cancer Res. 1999 Jul 1;59(13):3021-7.

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