Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 101


p110δ PI3-Kinase Inhibition Perturbs APP and TNFα Trafficking, Reduces Plaque Burden, Dampens Neuroinflammation, and Prevents Cognitive Decline in an Alzheimer's Disease Mouse Model.

Martínez-Mármol R, Mohannak N, Qian L, Wang T, Gormal RS, Ruitenberg MJ, Vanhaesebroeck B, Coulson EJ, Meunier FA.

J Neurosci. 2019 Oct 2;39(40):7976-7991. doi: 10.1523/JNEUROSCI.0674-19.2019. Epub 2019 Jul 30.


Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines.

Padmanabhan P, Martínez-Mármol R, Xia D, Götz J, Meunier FA.

Elife. 2019 Jun 25;8. pii: e45040. doi: 10.7554/eLife.45040.


STXBP1 encephalopathy: Connecting neurodevelopmental disorders with α-synucleinopathies?

Lanoue V, Chai YJ, Brouillet JZ, Weckhuysen S, Palmer EE, Collins BM, Meunier FA.

Neurology. 2019 Jul 16;93(3):114-123. doi: 10.1212/WNL.0000000000007786. Epub 2019 Jun 20. Review.


Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2.

Brennan FH, Jogia T, Gillespie ER, Blomster LV, Li XX, Nowlan B, Williams GM, Jacobson E, Osborne GW, Meunier FA, Taylor SM, Campbell KE, MacDonald KP, Levesque JP, Woodruff TM, Ruitenberg MJ.

JCI Insight. 2019 May 2;4(9). pii: 98254. doi: 10.1172/jci.insight.98254. eCollection 2019 May 2.


Need for speed: Super-resolving the dynamic nanoclustering of syntaxin-1 at exocytic fusion sites.

Padmanabhan P, Bademosi AT, Kasula R, Lauwers E, Verstreken P, Meunier FA.

Neuropharmacology. 2019 Feb 28. pii: S0028-3908(19)30075-9. doi: 10.1016/j.neuropharm.2019.02.036. [Epub ahead of print] Review.


Actin Remodeling in Regulated Exocytosis: Toward a Mesoscopic View.

Li P, Bademosi AT, Luo J, Meunier FA.

Trends Cell Biol. 2018 Sep;28(9):685-697. doi: 10.1016/j.tcb.2018.04.004. Epub 2018 May 11. Review.


Publisher Correction: In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters.

Bademosi AT, Lauwers E, Padmanabhan P, Odierna L, Chai YJ, Papadopulos A, Goodhill GJ, Verstreken P, van Swinderen B, Meunier FA.

Nat Commun. 2018 Apr 10;9:16191. doi: 10.1038/ncomms16191.


In Vivo Single-Molecule Tracking at the Drosophila Presynaptic Motor Nerve Terminal.

Bademosi AT, Lauwers E, Amor R, Verstreken P, van Swinderen B, Meunier FA.

J Vis Exp. 2018 Jan 14;(131). doi: 10.3791/56952.


Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic.

Bademosi AT, Steeves J, Karunanithi S, Zalucki OH, Gormal RS, Liu S, Lauwers E, Verstreken P, Anggono V, Meunier FA, van Swinderen B.

Cell Rep. 2018 Jan 9;22(2):427-440. doi: 10.1016/j.celrep.2017.12.054.


Amyloid-β and tau complexity - towards improved biomarkers and targeted therapies.

Polanco JC, Li C, Bodea LG, Martinez-Marmol R, Meunier FA, Götz J.

Nat Rev Neurol. 2018 Jan;14(1):22-39. doi: 10.1038/nrneurol.2017.162. Epub 2017 Dec 15. Review.


Visualizing endocytic recycling and trafficking in live neurons by subdiffractional tracking of internalized molecules.

Joensuu M, Martínez-Mármol R, Padmanabhan P, Glass NR, Durisic N, Pelekanos M, Mollazade M, Balistreri G, Amor R, Cooper-White JJ, Goodhill GJ, Meunier FA.

Nat Protoc. 2017 Dec;12(12):2590-2622. doi: 10.1038/nprot.2017.116. Epub 2017 Nov 30.


A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation.

Chhabra Y, Wong HY, Nikolajsen LF, Steinocher H, Papadopulos A, Tunny KA, Meunier FA, Smith AG, Kragelund BB, Brooks AJ, Waters MJ.

Oncogene. 2018 Jan 25;37(4):489-501. doi: 10.1038/onc.2017.352. Epub 2017 Oct 2.


G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channel Activation by the p75 Neurotrophin Receptor Is Required for Amyloid β Toxicity.

May LM, Anggono V, Gooch HM, Jang SE, Matusica D, Kerbler GM, Meunier FA, Sah P, Coulson EJ.

Front Neurosci. 2017 Aug 8;11:455. doi: 10.3389/fnins.2017.00455. eCollection 2017.


ENA/VASP proteins regulate exocytosis by mediating myosin VI-dependent recruitment of secretory granules to the cortical actin network.

Tomatis VM, Josh P, Papadopulos A, Gormal RS, Lanoue V, Martin S, Meunier FA.

Mol Cell Neurosci. 2017 Oct;84:100-111. doi: 10.1016/j.mcn.2017.07.005. Epub 2017 Aug 7.


The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals.

Vanhauwaert R, Kuenen S, Masius R, Bademosi A, Manetsberger J, Schoovaerts N, Bounti L, Gontcharenko S, Swerts J, Vilain S, Picillo M, Barone P, Munshi ST, de Vrij FM, Kushner SA, Gounko NV, Mandemakers W, Bonifati V, Meunier FA, Soukup SF, Verstreken P.

EMBO J. 2017 May 15;36(10):1392-1411. doi: 10.15252/embj.201695773. Epub 2017 Mar 22.


Comparative analyses of glycerotoxin expression unveil a novel structural organization of the bloodworm venom system.

Richter S, Helm C, Meunier FA, Hering L, Campbell LI, Drukewitz SH, Undheim EA, Jenner RA, Schiavo G, Bleidorn C.

BMC Evol Biol. 2017 Mar 4;17(1):64. doi: 10.1186/s12862-017-0904-4.


Erratum: In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters.

Bademosi AT, Lauwers E, Padmanabhan P, Odierna L, Chai YJ, Papadopulos A, Goodhill GJ, Verstreken P, van Swinderen B, Meunier FA.

Nat Commun. 2017 Feb 9;8:14492. doi: 10.1038/ncomms14492. No abstract available.


In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters.

Bademosi AT, Lauwers E, Padmanabhan P, Odierna L, Chai YJ, Papadopulos A, Goodhill GJ, Verstreken P, van Swinderen B, Meunier FA.

Nat Commun. 2017 Jan 3;8:13660. doi: 10.1038/ncomms13660. Erratum in: Nat Commun. 2018 Apr 10;9:16191.


Corrigendum: Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB.

Wang T, Martin S, Nguyen TH, Harper CB, Gormal RS, Martínez-Mármol R, Karunanithi S, Coulson EJ, Glass NR, Cooper-White JJ, van Swinderen B, Meunier FA.

Nat Commun. 2016 Nov 23;7:13768. doi: 10.1038/ncomms13768. No abstract available.


Subdiffractional tracking of internalized molecules reveals heterogeneous motion states of synaptic vesicles.

Joensuu M, Padmanabhan P, Durisic N, Bademosi AT, Cooper-Williams E, Morrow IC, Harper CB, Jung W, Parton RG, Goodhill GJ, Papadopulos A, Meunier FA.

J Cell Biol. 2016 Oct 24;215(2):277-292. Epub 2016 Oct 24.


Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB.

Wang T, Martin S, Nguyen TH, Harper CB, Gormal RS, Martínez-Mármol R, Karunanithi S, Coulson EJ, Glass NR, Cooper-White JJ, van Swinderen B, Meunier FA.

Nat Commun. 2016 Sep 30;7:12976. doi: 10.1038/ncomms12976. Erratum in: Nat Commun. 2016 Nov 23;7:13768.


The Munc18-1 domain 3a hinge-loop controls syntaxin-1A nanodomain assembly and engagement with the SNARE complex during secretory vesicle priming.

Kasula R, Chai YJ, Bademosi AT, Harper CB, Gormal RS, Morrow IC, Hosy E, Collins BM, Choquet D, Papadopulos A, Meunier FA.

J Cell Biol. 2016 Sep 26;214(7):847-58. doi: 10.1083/jcb.201508118. Epub 2016 Sep 19.


Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation.

Chai YJ, Sierecki E, Tomatis VM, Gormal RS, Giles N, Morrow IC, Xia D, Götz J, Parton RG, Collins BM, Gambin Y, Meunier FA.

J Cell Biol. 2016 Sep 12;214(6):705-18. doi: 10.1083/jcb.201512016. Epub 2016 Sep 5.


Captivating New Roles of F-Actin Cortex in Exocytosis and Bulk Endocytosis in Neurosecretory Cells.

Meunier FA, Gutiérrez LM.

Trends Neurosci. 2016 Sep;39(9):605-613. doi: 10.1016/j.tins.2016.07.003. Epub 2016 Jul 27. Review.


The 18th International Symposia on Chromaffin Cell Biology.

Meunier FA, Keating DJ.

J Neurochem. 2016 Jun;137(6):847-8. doi: 10.1111/jnc.13631. No abstract available.


Botulinum neurotoxin type-A enters a non-recycling pool of synaptic vesicles.

Harper CB, Papadopulos A, Martin S, Matthews DR, Morgan GP, Nguyen TH, Wang T, Nair D, Choquet D, Meunier FA.

Sci Rep. 2016 Jan 25;6:19654. doi: 10.1038/srep19654.


Profiling of Free Fatty Acids Using Stable Isotope Tagging Uncovers a Role for Saturated Fatty Acids in Neuroexocytosis.

Narayana VK, Tomatis VM, Wang T, Kvaskoff D, Meunier FA.

Chem Biol. 2015 Nov 19;22(11):1552-1561. doi: 10.1016/j.chembiol.2015.09.010. Epub 2015 Oct 22.


Small molecules demonstrate the role of dynamin as a bi-directional regulator of the exocytosis fusion pore and vesicle release.

Jackson J, Papadopulos A, Meunier FA, McCluskey A, Robinson PJ, Keating DJ.

Mol Psychiatry. 2015 Jul;20(7):810-9. doi: 10.1038/mp.2015.56. Epub 2015 May 5.


Control of autophagosome axonal retrograde flux by presynaptic activity unveiled using botulinum neurotoxin type a.

Wang T, Martin S, Papadopulos A, Harper CB, Mavlyutov TA, Niranjan D, Glass NR, Cooper-White JJ, Sibarita JB, Choquet D, Davletov B, Meunier FA.

J Neurosci. 2015 Apr 15;35(15):6179-94. doi: 10.1523/JNEUROSCI.3757-14.2015.


Activity-driven relaxation of the cortical actomyosin II network synchronizes Munc18-1-dependent neurosecretory vesicle docking.

Papadopulos A, Gomez GA, Martin S, Jackson J, Gormal RS, Keating DJ, Yap AS, Meunier FA.

Nat Commun. 2015 Feb 24;6:6297. doi: 10.1038/ncomms7297.


An acto-myosin II constricting ring initiates the fission of activity-dependent bulk endosomes in neurosecretory cells.

Gormal RS, Nguyen TH, Martin S, Papadopulos A, Meunier FA.

J Neurosci. 2015 Jan 28;35(4):1380-9. doi: 10.1523/JNEUROSCI.3228-14.2015.


A HIV-1 Tat mutant protein disrupts HIV-1 Rev function by targeting the DEAD-box RNA helicase DDX1.

Lin MH, Sivakumaran H, Jones A, Li D, Harper C, Wei T, Jin H, Rustanti L, Meunier FA, Spann K, Harrich D.

Retrovirology. 2014 Dec 14;11:121. doi: 10.1186/s12977-014-0121-9.


Increased polyubiquitination and proteasomal degradation of a Munc18-1 disease-linked mutant causes temperature-sensitive defect in exocytosis.

Martin S, Papadopulos A, Tomatis VM, Sierecki E, Malintan NT, Gormal RS, Giles N, Johnston WA, Alexandrov K, Gambin Y, Collins BM, Meunier FA.

Cell Rep. 2014 Oct 9;9(1):206-218. doi: 10.1016/j.celrep.2014.08.059. Epub 2014 Oct 2.


A role for SNAREs in neuronal survival?

Harper CB, Bademosi AT, Coulson EJ, Meunier FA.

J Neurochem. 2014 Jun;129(5):753-5. doi: 10.1111/jnc.12699. Epub 2014 Apr 2. No abstract available.


Bulk endocytosis at neuronal synapses.

Nguyen TH, Qiu X, Sun J, Meunier FA.

Sci China Life Sci. 2014 Apr;57(4):378-83. doi: 10.1007/s11427-014-4636-z. Epub 2014 Mar 18. Review.


PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model.

Low PC, Manzanero S, Mohannak N, Narayana VK, Nguyen TH, Kvaskoff D, Brennan FH, Ruitenberg MJ, Gelderblom M, Magnus T, Kim HA, Broughton BR, Sobey CG, Vanhaesebroeck B, Stow JL, Arumugam TV, Meunier FA.

Nat Commun. 2014 Mar 14;5:3450. doi: 10.1038/ncomms4450.


Mapping organelle motion reveals a vesicular conveyor belt spatially replenishing secretory vesicles in stimulated chromaffin cells.

Maucort G, Kasula R, Papadopulos A, Nieminen TA, Rubinsztein-Dunlop H, Meunier FA.

PLoS One. 2014 Jan 29;9(1):e87242. doi: 10.1371/journal.pone.0087242. eCollection 2014.


Secretagogue stimulation of neurosecretory cells elicits filopodial extensions uncovering new functional release sites.

Papadopulos A, Martin S, Tomatis VM, Gormal RS, Meunier FA.

J Neurosci. 2013 Dec 4;33(49):19143-53. doi: 10.1523/JNEUROSCI.2634-13.2013.


The cortical acto-Myosin network: from diffusion barrier to functional gateway in the transport of neurosecretory vesicles to the plasma membrane.

Papadopulos A, Tomatis VM, Kasula R, Meunier FA.

Front Endocrinol (Lausanne). 2013 Oct 21;4:153. doi: 10.3389/fendo.2013.00153. Review.


Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis.

McCluskey A, Daniel JA, Hadzic G, Chau N, Clayton EL, Mariana A, Whiting A, Gorgani NN, Lloyd J, Quan A, Moshkanbaryans L, Krishnan S, Perera S, Chircop M, von Kleist L, McGeachie AB, Howes MT, Parton RG, Campbell M, Sakoff JA, Wang X, Sun JY, Robertson MJ, Deane FM, Nguyen TH, Meunier FA, Cousin MA, Robinson PJ.

Traffic. 2013 Dec;14(12):1272-89. doi: 10.1111/tra.12119. Epub 2013 Oct 9.


Synthetic self-assembling clostridial chimera for modulation of sensory functions.

Ferrari E, Gu C, Niranjan D, Restani L, Rasetti-Escargueil C, Obara I, Geranton SM, Arsenault J, Goetze TA, Harper CB, Nguyen TH, Maywood E, O'Brien J, Schiavo G, Wheeler DW, Meunier FA, Hastings M, Edwardson JM, Sesardic D, Caleo M, Hunt SP, Davletov B.

Bioconjug Chem. 2013 Oct 16;24(10):1750-9. doi: 10.1021/bc4003103. Epub 2013 Sep 20.


The Munc18-1 domain 3a loop is essential for neuroexocytosis but not for syntaxin-1A transport to the plasma membrane.

Martin S, Tomatis VM, Papadopulos A, Christie MP, Malintan NT, Gormal RS, Sugita S, Martin JL, Collins BM, Meunier FA.

J Cell Sci. 2013 Jun 1;126(Pt 11):2353-60. doi: 10.1242/jcs.126813.


Inhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell death.

Martin S, Harper CB, May LM, Coulson EJ, Meunier FA, Osborne SL.

PLoS One. 2013;8(3):e60152. doi: 10.1371/journal.pone.0060152. Epub 2013 Mar 27.


Myosin VI small insert isoform maintains exocytosis by tethering secretory granules to the cortical actin.

Tomatis VM, Papadopulos A, Malintan NT, Martin S, Wallis T, Gormal RS, Kendrick-Jones J, Buss F, Meunier FA.

J Cell Biol. 2013 Feb 4;200(3):301-20. doi: 10.1083/jcb.201204092.


Targeting membrane trafficking in infection prophylaxis: dynamin inhibitors.

Harper CB, Popoff MR, McCluskey A, Robinson PJ, Meunier FA.

Trends Cell Biol. 2013 Feb;23(2):90-101. doi: 10.1016/j.tcb.2012.10.007. Epub 2012 Nov 17. Review.


Phosphoinositides in neuroexocytosis and neuronal diseases.

Wen PJ, Osborne SL, Meunier FA.

Curr Top Microbiol Immunol. 2012;362:87-98. doi: 10.1007/978-94-007-5025-8_4. Review.


Actin- and dynamin-dependent maturation of bulk endocytosis restores neurotransmission following synaptic depletion.

Nguyen TH, Maucort G, Sullivan RK, Schenning M, Lavidis NA, McCluskey A, Robinson PJ, Meunier FA.

PLoS One. 2012;7(5):e36913. doi: 10.1371/journal.pone.0036913. Epub 2012 May 22.


Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells.

Wen PJ, Osborne SL, Zanin M, Low PC, Wang HT, Schoenwaelder SM, Jackson SP, Wedlich-Söldner R, Vanhaesebroeck B, Keating DJ, Meunier FA.

Nat Commun. 2011 Oct 4;2:491. doi: 10.1038/ncomms1500.


Munc18-1 domain-1 controls vesicle docking and secretion by interacting with syntaxin-1 and chaperoning it to the plasma membrane.

Han GA, Malintan NT, Saw NM, Li L, Han L, Meunier FA, Collins BM, Sugita S.

Mol Biol Cell. 2011 Nov;22(21):4134-49. doi: 10.1091/mbc.E11-02-0135. Epub 2011 Sep 7.


Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulism.

Harper CB, Martin S, Nguyen TH, Daniels SJ, Lavidis NA, Popoff MR, Hadzic G, Mariana A, Chau N, McCluskey A, Robinson PJ, Meunier FA.

J Biol Chem. 2011 Oct 14;286(41):35966-76. doi: 10.1074/jbc.M111.283879. Epub 2011 Aug 5.

Supplemental Content

Loading ...
Support Center