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Items: 1 to 50 of 140

1.

Increased WISP1 expression in human osteoarthritic articular cartilage is epigenetically regulated and decreases cartilage matrix production.

van den Bosch MHJ, Ramos YFM, den Hollander W, Bomer N, Nelissen RGHH, Bovée JVMG, van den Berg WB, van Lent PLEM, Blom AB, van der Kraan PM, Meulenbelt I.

Rheumatology (Oxford). 2019 Jun 1;58(6):1065-1074. doi: 10.1093/rheumatology/key426.

PMID:
30649473
2.

RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage.

Coutinho de Almeida R, Ramos YFM, Mahfouz A, den Hollander W, Lakenberg N, Houtman E, van Hoolwerff M, Suchiman HED, Rodríguez Ruiz A, Slagboom PE, Mei H, Kiełbasa SM, Nelissen RGHH, Reinders M, Meulenbelt I.

Ann Rheum Dis. 2019 Feb;78(2):270-277. doi: 10.1136/annrheumdis-2018-213882. Epub 2018 Dec 1.

3.

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.

Ligthart S, Vaez A, Võsa U, Stathopoulou MG, de Vries PS, Prins BP, Van der Most PJ, Tanaka T, Naderi E, Rose LM, Wu Y, Karlsson R, Barbalic M, Lin H, Pool R, Zhu G, Macé A, Sidore C, Trompet S, Mangino M, Sabater-Lleal M, Kemp JP, Abbasi A, Kacprowski T, Verweij N, Smith AV, Huang T, Marzi C, Feitosa MF, Lohman KK, Kleber ME, Milaneschi Y, Mueller C, Huq M, Vlachopoulou E, Lyytikäinen LP, Oldmeadow C, Deelen J, Perola M, Zhao JH, Feenstra B; LifeLines Cohort Study, Amini M; CHARGE Inflammation Working Group, Lahti J, Schraut KE, Fornage M, Suktitipat B, Chen WM, Li X, Nutile T, Malerba G, Luan J, Bak T, Schork N, Del Greco M F, Thiering E, Mahajan A, Marioni RE, Mihailov E, Eriksson J, Ozel AB, Zhang W, Nethander M, Cheng YC, Aslibekyan S, Ang W, Gandin I, Yengo L, Portas L, Kooperberg C, Hofer E, Rajan KB, Schurmann C, den Hollander W, Ahluwalia TS, Zhao J, Draisma HHM, Ford I, Timpson N, Teumer A, Huang H, Wahl S, Liu Y, Huang J, Uh HW, Geller F, Joshi PK, Yanek LR, Trabetti E, Lehne B, Vozzi D, Verbanck M, Biino G, Saba Y, Meulenbelt I, O'Connell JR, Laakso M, Giulianini F, Magnusson PKE, Ballantyne CM, Hottenga JJ, Montgomery GW, Rivadineira F, Rueedi R, Steri M, Herzig KH, Stott DJ, Menni C, Frånberg M, St Pourcain B, Felix SB, Pers TH, Bakker SJL, Kraft P, Peters A, Vaidya D, Delgado G, Smit JH, Großmann V, Sinisalo J, Seppälä I, Williams SR, Holliday EG, Moed M, Langenberg C, Räikkönen K, Ding J, Campbell H, Sale MM, Chen YI, James AL, Ruggiero D, Soranzo N, Hartman CA, Smith EN, Berenson GS, Fuchsberger C, Hernandez D, Tiesler CMT, Giedraitis V, Liewald D, Fischer K, Mellström D, Larsson A, Wang Y, Scott WR, Lorentzon M, Beilby J, Ryan KA, Pennell CE, Vuckovic D, Balkau B, Concas MP, Schmidt R, Mendes de Leon CF, Bottinger EP, Kloppenburg M, Paternoster L, Boehnke M, Musk AW, Willemsen G, Evans DM, Madden PAF, Kähönen M, Kutalik Z, Zoledziewska M, Karhunen V, Kritchevsky SB, Sattar N, Lachance G, Clarke R, Harris TB, Raitakari OT, Attia JR, van Heemst D, Kajantie E, Sorice R, Gambaro G, Scott RA, Hicks AA, Ferrucci L, Standl M, Lindgren CM, Starr JM, Karlsson M, Lind L, Li JZ, Chambers JC, Mori TA, de Geus EJCN, Heath AC, Martin NG, Auvinen J, Buckley BM, de Craen AJM, Waldenberger M, Strauch K, Meitinger T, Scott RJ, McEvoy M, Beekman M, Bombieri C, Ridker PM, Mohlke KL, Pedersen NL, Morrison AC, Boomsma DI, Whitfield JB, Strachan DP, Hofman A, Vollenweider P, Cucca F, Jarvelin MR, Jukema JW, Spector TD, Hamsten A, Zeller T, Uitterlinden AG, Nauck M, Gudnason V, Qi L, Grallert H, Borecki IB, Rotter JI, März W, Wild PS, Lokki ML, Boyle M, Salomaa V, Melbye M, Eriksson JG, Wilson JF, Penninx BWJH, Becker DM, Worrall BB, Gibson G, Krauss RM, Ciullo M, Zaza G, Wareham NJ, Oldehinkel AJ, Palmer LJ, Murray SS, Pramstaller PP, Bandinelli S, Heinrich J, Ingelsson E, Deary IJ, Mägi R, Vandenput L, van der Harst P, Desch KC, Kooner JS, Ohlsson C, Hayward C, Lehtimäki T, Shuldiner AR, Arnett DK, Beilin LJ, Robino A, Froguel P, Pirastu M, Jess T, Koenig W, Loos RJF, Evans DA, Schmidt H, Smith GD, Slagboom PE, Eiriksdottir G, Morris AP, Psaty BM, Tracy RP, Nolte IM, Boerwinkle E, Visvikis-Siest S, Reiner AP, Gross M, Bis JC, Franke L, Franco OH, Benjamin EJ, Chasman DI, Dupuis J, Snieder H, Dehghan A, Alizadeh BZ.

Am J Hum Genet. 2018 Nov 1;103(5):691-706. doi: 10.1016/j.ajhg.2018.09.009.

4.

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.

Teumer A, Chaker L, Groeneweg S, Li Y, Di Munno C, Barbieri C, Schultheiss UT, Traglia M, Ahluwalia TS, Akiyama M, Appel EVR, Arking DE, Arnold A, Astrup A, Beekman M, Beilby JP, Bekaert S, Boerwinkle E, Brown SJ, De Buyzere M, Campbell PJ, Ceresini G, Cerqueira C, Cucca F, Deary IJ, Deelen J, Eckardt KU, Ekici AB, Eriksson JG, Ferrrucci L, Fiers T, Fiorillo E, Ford I, Fox CS, Fuchsberger C, Galesloot TE, Gieger C, Gögele M, De Grandi A, Grarup N, Greiser KH, Haljas K, Hansen T, Harris SE, van Heemst D, den Heijer M, Hicks AA, den Hollander W, Homuth G, Hui J, Ikram MA, Ittermann T, Jensen RA, Jing J, Jukema JW, Kajantie E, Kamatani Y, Kasbohm E, Kaufman JM, Kiemeney LA, Kloppenburg M, Kronenberg F, Kubo M, Lahti J, Lapauw B, Li S, Liewald DCM; Lifelines Cohort Study, Lim EM, Linneberg A, Marina M, Mascalzoni D, Matsuda K, Medenwald D, Meisinger C, Meulenbelt I, De Meyer T, Meyer Zu Schwabedissen HE, Mikolajczyk R, Moed M, Netea-Maier RT, Nolte IM, Okada Y, Pala M, Pattaro C, Pedersen O, Petersmann A, Porcu E, Postmus I, Pramstaller PP, Psaty BM, Ramos YFM, Rawal R, Redmond P, Richards JB, Rietzschel ER, Rivadeneira F, Roef G, Rotter JI, Sala CF, Schlessinger D, Selvin E, Slagboom PE, Soranzo N, Sørensen TIA, Spector TD, Starr JM, Stott DJ, Taes Y, Taliun D, Tanaka T, Thuesen B, Tiller D, Toniolo D, Uitterlinden AG, Visser WE, Walsh JP, Wilson SG, Wolffenbuttel BHR, Yang Q, Zheng HF, Cappola A, Peeters RP, Naitza S, Völzke H, Sanna S, Köttgen A, Visser TJ, Medici M.

Nat Commun. 2018 Oct 26;9(1):4455. doi: 10.1038/s41467-018-06356-1.

5.

Annotating Transcriptional Effects of Genetic Variants in Disease-Relevant Tissue: Transcriptome-Wide Allelic Imbalance in Osteoarthritic Cartilage.

den Hollander W, Pulyakhina I, Boer C, Bomer N, van der Breggen R, Arindrarto W, Couthino de Almeida R, Lakenberg N, Sentner T, Laros JFJ, 't Hoen PAC, Slagboom EPE, Nelissen RGHH, van Meurs J, Ramos YFM, Meulenbelt I.

Arthritis Rheumatol. 2019 Apr;71(4):561-570. doi: 10.1002/art.40748. Epub 2019 Feb 23.

PMID:
30298554
6.

ANP32A regulates ATM expression and prevents oxidative stress in cartilage, brain, and bone.

Cornelis FMF, Monteagudo S, Guns LKA, den Hollander W, Nelissen RGHH, Storms L, Peeters T, Jonkers I, Meulenbelt I, Lories RJ.

Sci Transl Med. 2018 Sep 12;10(458). pii: eaar8426. doi: 10.1126/scitranslmed.aar8426.

PMID:
30209244
7.

Osteoarthritis as a disease of the cartilage pericellular matrix.

Guilak F, Nims RJ, Dicks A, Wu CL, Meulenbelt I.

Matrix Biol. 2018 Oct;71-72:40-50. doi: 10.1016/j.matbio.2018.05.008. Epub 2018 May 22. Review.

PMID:
29800616
8.

Validity, reliability, responsiveness and feasibility of four hand mobility measures in hand osteoarthritis.

Kroon FPB, Damman W, Liu R, Bijsterbosch J, Meulenbelt I, van der Heijde D, Kloppenburg M.

Rheumatology (Oxford). 2018 Mar 1;57(3):525-532. doi: 10.1093/rheumatology/kex438.

PMID:
29253246
9.

Involvement of epigenetics in osteoarthritis.

Coutinho de Almeida R, Ramos YFM, Meulenbelt I.

Best Pract Res Clin Rheumatol. 2017 Oct;31(5):634-648. doi: 10.1016/j.berh.2018.03.002. Review.

PMID:
30509410
10.

Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand.

den Hollander W, Boer CG, Hart DJ, Yau MS, Ramos YFM, Metrustry S, Broer L, Deelen J, Cupples LA, Rivadeneira F, Kloppenburg M, Peters M, Spector TD, Hofman A, Slagboom PE, Nelissen RGHH, Uitterlinden AG, Felson DT, Valdes AM, Meulenbelt I, van Meurs JJB.

Ann Rheum Dis. 2017 Dec;76(12):2046-2053. doi: 10.1136/annrheumdis-2017-211214. Epub 2017 Aug 30.

11.

Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis.

Steinberg J, Ritchie GRS, Roumeliotis TI, Jayasuriya RL, Clark MJ, Brooks RA, Binch ALA, Shah KM, Coyle R, Pardo M, Le Maitre CL, Ramos YFM, Nelissen RGHH, Meulenbelt I, McCaskie AW, Choudhary JS, Wilkinson JM, Zeggini E.

Sci Rep. 2017 Aug 21;7(1):8935. doi: 10.1038/s41598-017-09335-6.

12.

Radiographic endophenotyping in hip osteoarthritis improves the precision of genetic association analysis.

Panoutsopoulou K, Thiagarajah S, Zengini E, Day-Williams AG, Ramos YF, Meessen JM, Huetink K, Nelissen RG, Southam L, Rayner NW; arcOGEN Consortium, Doherty M, Meulenbelt I, Zeggini E, Wilkinson JM.

Ann Rheum Dis. 2017 Jul;76(7):1199-1206. doi: 10.1136/annrheumdis-2016-210373. Epub 2016 Dec 14.

13.

The role of epigenetics in osteoarthritis: current perspective.

Ramos YF, Meulenbelt I.

Curr Opin Rheumatol. 2017 Jan;29(1):119-129. Review.

PMID:
27749371
14.

Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis.

Castaño-Betancourt MC, Evans DS, Ramos YF, Boer CG, Metrustry S, Liu Y, den Hollander W, van Rooij J, Kraus VB, Yau MS, Mitchell BD, Muir K, Hofman A, Doherty M, Doherty S, Zhang W, Kraaij R, Rivadeneira F, Barrett-Connor E, Maciewicz RA, Arden N, Nelissen RG, Kloppenburg M, Jordan JM, Nevitt MC, Slagboom EP, Hart DJ, Lafeber F, Styrkarsdottir U, Zeggini E, Evangelou E, Spector TD, Uitterlinden AG, Lane NE, Meulenbelt I, Valdes AM, van Meurs JB.

PLoS Genet. 2016 Oct 4;12(10):e1006260. doi: 10.1371/journal.pgen.1006260. eCollection 2016 Oct.

15.

Translation of clinical problems in osteoarthritis into pathophysiological research goals.

van der Kraan PM, Berenbaum F, Blanco FJ, Cosimo de B, Lafeber F, Hauge E, Higginbottom A, Ioan-Facsinay A, Loughlin J, Meulenbelt I, Moilanen E, Pitsillidou I, Tsezou A, van Meurs J, Vincent T, Wittoek R, Lories R; EULAR Study group in OA (http://www.eular.org/investigative_rheumatology_study_groups.cfm).

RMD Open. 2016 May 26;2(1):e000224. doi: 10.1136/rmdopen-2015-000224. eCollection 2016. Erratum in: RMD Open. 2016 Oct 7;2(2):e000224corr1.

16.

Aberrant Calreticulin Expression in Articular Cartilage of Dio2 Deficient Mice.

Bomer N, Cornelis FM, Ramos YF, den Hollander W, Lakenberg N, van der Breggen R, Storms L, Slagboom PE, Lories RJ, Meulenbelt I.

PLoS One. 2016 May 10;11(5):e0154999. doi: 10.1371/journal.pone.0154999. eCollection 2016.

17.

Genetic Contribution to the Development of Radiographic Knee Osteoarthritis in a Population Presenting with Nonacute Knee Symptoms a Decade Earlier.

Huétink K, van der Voort P, Bloem JL, Nelissen RG, Meulenbelt I.

Clin Med Insights Arthritis Musculoskelet Disord. 2016 Apr 28;9:57-63. doi: 10.4137/CMAMD.S30657. eCollection 2016.

18.

Associations between joint effusion in the knee and gene expression levels in the circulation: a meta-analysis.

Peters MJ, Ramos YF, den Hollander W, Schiphof D, Hofman A, Uitterlinden AG, Oei EH, Slagboom PE, Kloppenburg M, Bloem JL, Bierma-Zeinstra SM, Meulenbelt I, van Meurs JB.

F1000Res. 2016 Jan 27;5:109. doi: 10.12688/f1000research.7763.1. eCollection 2016.

19.

Translating genomics into mechanisms of disease: Osteoarthritis.

Bomer N, den Hollander W, Ramos YF, Meulenbelt I.

Best Pract Res Clin Rheumatol. 2015 Dec;29(6):683-91. doi: 10.1016/j.berh.2016.01.001. Epub 2016 Mar 4. Review.

PMID:
27107506
20.

The first international workshop on the epigenetics of osteoarthritis.

Meulenbelt IM, Bhutani N, den Hollander W, Gay S, Oppermann U, Reynard LN, Skelton AJ, Young DA, Beier F, Loughlin J.

Connect Tissue Res. 2017 Jan;58(1):37-48. doi: 10.3109/03008207.2016.1168409. Epub 2016 Mar 30.

PMID:
27028588
21.

DNA Methylation in Osteoarthritis.

den Hollander W, Meulenbelt I.

Curr Genomics. 2015 Dec;16(6):419-26. doi: 10.2174/1389202916666150817212711.

22.

Neo-cartilage engineered from primary chondrocytes is epigenetically similar to autologous cartilage, in contrast to using mesenchymal stem cells.

Bomer N, den Hollander W, Suchiman H, Houtman E, Slieker RC, Heijmans BT, Slagboom PE, Nelissen RG, Ramos YF, Meulenbelt I.

Osteoarthritis Cartilage. 2016 Aug;24(8):1423-30. doi: 10.1016/j.joca.2016.03.009. Epub 2016 Mar 17.

23.

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.

Kilpeläinen TO, Carli JF, Skowronski AA, Sun Q, Kriebel J, Feitosa MF, Hedman ÅK, Drong AW, Hayes JE, Zhao J, Pers TH, Schick U, Grarup N, Kutalik Z, Trompet S, Mangino M, Kristiansson K, Beekman M, Lyytikäinen LP, Eriksson J, Henneman P, Lahti J, Tanaka T, Luan J, Del Greco M F, Pasko D, Renström F, Willems SM, Mahajan A, Rose LM, Guo X, Liu Y, Kleber ME, Pérusse L, Gaunt T, Ahluwalia TS, Ju Sung Y, Ramos YF, Amin N, Amuzu A, Barroso I, Bellis C, Blangero J, Buckley BM, Böhringer S, I Chen YD, de Craen AJ, Crosslin DR, Dale CE, Dastani Z, Day FR, Deelen J, Delgado GE, Demirkan A, Finucane FM, Ford I, Garcia ME, Gieger C, Gustafsson S, Hallmans G, Hankinson SE, Havulinna AS, Herder C, Hernandez D, Hicks AA, Hunter DJ, Illig T, Ingelsson E, Ioan-Facsinay A, Jansson JO, Jenny NS, Jørgensen ME, Jørgensen T, Karlsson M, Koenig W, Kraft P, Kwekkeboom J, Laatikainen T, Ladwig KH, LeDuc CA, Lowe G, Lu Y, Marques-Vidal P, Meisinger C, Menni C, Morris AP, Myers RH, Männistö S, Nalls MA, Paternoster L, Peters A, Pradhan AD, Rankinen T, Rasmussen-Torvik LJ, Rathmann W, Rice TK, Brent Richards J, Ridker PM, Sattar N, Savage DB, Söderberg S, Timpson NJ, Vandenput L, van Heemst D, Uh HW, Vohl MC, Walker M, Wichmann HE, Widén E, Wood AR, Yao J, Zeller T, Zhang Y, Meulenbelt I, Kloppenburg M, Astrup A, Sørensen TI, Sarzynski MA, Rao DC, Jousilahti P, Vartiainen E, Hofman A, Rivadeneira F, Uitterlinden AG, Kajantie E, Osmond C, Palotie A, Eriksson JG, Heliövaara M, Knekt PB, Koskinen S, Jula A, Perola M, Huupponen RK, Viikari JS, Kähönen M, Lehtimäki T, Raitakari OT, Mellström D, Lorentzon M, Casas JP, Bandinelli S, März W, Isaacs A, van Dijk KW, van Duijn CM, Harris TB, Bouchard C, Allison MA, Chasman DI, Ohlsson C, Lind L, Scott RA, Langenberg C, Wareham NJ, Ferrucci L, Frayling TM, Pramstaller PP, Borecki IB, Waterworth DM, Bergmann S, Waeber G, Vollenweider P, Vestergaard H, Hansen T, Pedersen O, Hu FB, Eline Slagboom P, Grallert H, Spector TD, Jukema JW, Klein RJ, Schadt EE, Franks PW, Lindgren CM, Leibel RL, Loos RJ.

Nat Commun. 2016 Feb 1;7:10494. doi: 10.1038/ncomms10494.

24.

The transcriptional landscape of age in human peripheral blood.

Peters MJ, Joehanes R, Pilling LC, Schurmann C, Conneely KN, Powell J, Reinmaa E, Sutphin GL, Zhernakova A, Schramm K, Wilson YA, Kobes S, Tukiainen T; NABEC/UKBEC Consortium, Ramos YF, Göring HH, Fornage M, Liu Y, Gharib SA, Stranger BE, De Jager PL, Aviv A, Levy D, Murabito JM, Munson PJ, Huan T, Hofman A, Uitterlinden AG, Rivadeneira F, van Rooij J, Stolk L, Broer L, Verbiest MM, Jhamai M, Arp P, Metspalu A, Tserel L, Milani L, Samani NJ, Peterson P, Kasela S, Codd V, Peters A, Ward-Caviness CK, Herder C, Waldenberger M, Roden M, Singmann P, Zeilinger S, Illig T, Homuth G, Grabe HJ, Völzke H, Steil L, Kocher T, Murray A, Melzer D, Yaghootkar H, Bandinelli S, Moses EK, Kent JW, Curran JE, Johnson MP, Williams-Blangero S, Westra HJ, McRae AF, Smith JA, Kardia SL, Hovatta I, Perola M, Ripatti S, Salomaa V, Henders AK, Martin NG, Smith AK, Mehta D, Binder EB, Nylocks KM, Kennedy EM, Klengel T, Ding J, Suchy-Dicey AM, Enquobahrie DA, Brody J, Rotter JI, Chen YD, Houwing-Duistermaat J, Kloppenburg M, Slagboom PE, Helmer Q, den Hollander W, Bean S, Raj T, Bakhshi N, Wang QP, Oyston LJ, Psaty BM, Tracy RP, Montgomery GW, Turner ST, Blangero J, Meulenbelt I, Ressler KJ, Yang J, Franke L, Kettunen J, Visscher PM, Neely GG, Korstanje R, Hanson RL, Prokisch H, Ferrucci L, Esko T, Teumer A, van Meurs JB, Johnson AD.

Nat Commun. 2015 Oct 22;6:8570. doi: 10.1038/ncomms9570.

25.

Genotype-Based Score Test for Association Testing in Families.

Uh HW, Beekman M, Meulenbelt I, Houwing-Duistermaat JJ.

Stat Biosci. 2015;7(2):394-416. Epub 2015 Mar 17.

26.

Radiographic progression of knee osteoarthritis is associated with MRI abnormalities in both the patellofemoral and tibiofemoral joint.

de Lange-Brokaar BJ, Bijsterbosch J, Kornaat PR, Yusuf E, Ioan-Facsinay A, Zuurmond AM, Kroon HM, Meulenbelt I, Bloem JL, Kloppenburg M.

Osteoarthritis Cartilage. 2016 Mar;24(3):473-9. doi: 10.1016/j.joca.2015.09.021. Epub 2015 Oct 22.

27.

Time-efficient interleaved human (23)Na and (1)H data acquisition at 7 T.

de Bruin PW, Koken P, Versluis MJ, Aussenhofer SA, Meulenbelt I, Börnert P, Webb AG.

NMR Biomed. 2015 Oct;28(10):1228-35. doi: 10.1002/nbm.3368. Epub 2015 Aug 13.

PMID:
26269329
28.

Innate immune response and implant loosening: Interferon gamma is inversely associated with early migration of total knee prostheses.

Schoeman MA, Pijls BG, Oostlander AE, Keurentjes JC, Valstar ER, Nelissen RG, Meulenbelt I.

J Orthop Res. 2016 Jan;34(1):121-6. doi: 10.1002/jor.22988. Epub 2015 Aug 6.

29.

Implementation of Functional Genomics for Bench-to-Bedside Transition in Osteoarthritis.

Ramos YF, Meulenbelt I.

Curr Rheumatol Rep. 2015 Aug;17(8):53. doi: 10.1007/s11926-015-0528-x. Review.

PMID:
26113014
30.

Transcriptional associations of osteoarthritis-mediated loss of epigenetic control in articular cartilage.

den Hollander W, Ramos YF, Bomer N, Elzinga S, van der Breggen R, Lakenberg N, de Dijcker WJ, Suchiman HE, Duijnisveld BJ, Houwing-Duistermaat JJ, Slagboom PE, Bos SD, Nelissen RG, Meulenbelt I.

Arthritis Rheumatol. 2015 May;67(8):2108-16. doi: 10.1002/art.39162.

31.

The effect of forced exercise on knee joints in Dio2(-/-) mice: type II iodothyronine deiodinase-deficient mice are less prone to develop OA-like cartilage damage upon excessive mechanical stress.

Bomer N, Cornelis FM, Ramos YF, den Hollander W, Storms L, van der Breggen R, Lakenberg N, Slagboom PE, Meulenbelt I, Lories RJ.

Ann Rheum Dis. 2016 Mar;75(3):571-7. doi: 10.1136/annrheumdis-2014-206608. Epub 2014 Dec 30.

PMID:
25550340
32.

Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches.

den Hollander W, Ramos YF, Bos SD, Bomer N, van der Breggen R, Lakenberg N, de Dijcker WJ, Duijnisveld BJ, Slagboom PE, Nelissen RG, Meulenbelt I.

Ann Rheum Dis. 2014 Dec;73(12):2208-12. doi: 10.1136/annrheumdis-2014-205980. Epub 2014 Sep 26.

PMID:
25261579
33.

A common mineralocorticoid receptor polymorphism (I180V) interacts with life events in relation to perfectionism in eating disorders: a pilot study.

Slof-Op't Landt MC, DeRijk RH, van Son GE, Suchiman HE, Meulenbelt I, Slagboom PE, Van Furth EF.

Eur Eat Disord Rev. 2014 Nov;22(6):423-9. doi: 10.1002/erv.2319. Epub 2014 Sep 14.

PMID:
25220664
34.

Mortality in osteoarthritis patients.

Liu R, Kwok WY, Vliet Vlieland TP, Kroon HM, Meulenbelt I, Houwing-Duistermaat JJ, Rosendaal FR, Huizinga TW, Kloppenburg M.

Scand J Rheumatol. 2015;44(1):70-3. doi: 10.3109/03009742.2014.922213. Epub 2014 Sep 2.

PMID:
25179456
35.

Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance.

Ramos YF, Metrustry S, Arden N, Bay-Jensen AC, Beekman M, de Craen AJ, Cupples LA, Esko T, Evangelou E, Felson DT, Hart DJ, Ioannidis JP, Karsdal M, Kloppenburg M, Lafeber F, Metspalu A, Panoutsopoulou K, Slagboom PE, Spector TD, van Spil EW, Uitterlinden AG, Zhu Y; arcOGEN Consortium; TreatOA Collaborators, Valdes AM, van Meurs JB, Meulenbelt I.

J Med Genet. 2014 Sep;51(9):596-604. doi: 10.1136/jmedgenet-2014-102478. Epub 2014 Jul 23.

PMID:
25057126
36.

Genes involved in the osteoarthritis process identified through genome wide expression analysis in articular cartilage; the RAAK study.

Ramos YF, den Hollander W, Bovée JV, Bomer N, van der Breggen R, Lakenberg N, Keurentjes JC, Goeman JJ, Slagboom PE, Nelissen RG, Bos SD, Meulenbelt I.

PLoS One. 2014 Jul 23;9(7):e103056. doi: 10.1371/journal.pone.0103056. eCollection 2014.

37.

Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies.

Rodriguez-Fontenla C, Calaza M, Evangelou E, Valdes AM, Arden N, Blanco FJ, Carr A, Chapman K, Deloukas P, Doherty M, Esko T, Garcés Aletá CM, Gomez-Reino Carnota JJ, Helgadottir H, Hofman A, Jonsdottir I, Kerkhof HJ, Kloppenburg M, McCaskie A, Ntzani EE, Ollier WE, Oreiro N, Panoutsopoulou K, Ralston SH, Ramos YF, Riancho JA, Rivadeneira F, Slagboom PE, Styrkarsdottir U, Thorsteinsdottir U, Thorleifsson G, Tsezou A, Uitterlinden AG, Wallis GA, Wilkinson JM, Zhai G, Zhu Y; arcOGEN Consortium, Felson DT, Ioannidis JP, Loughlin J, Metspalu A, Meulenbelt I, Stefansson K, van Meurs JB, Zeggini E, Spector TD, Gonzalez A.

Arthritis Rheumatol. 2014 Apr;66(4):940-9. doi: 10.1002/art.38300.

38.

A gain of function mutation in TNFRSF11B encoding osteoprotegerin causes osteoarthritis with chondrocalcinosis.

Ramos YF, Bos SD, van der Breggen R, Kloppenburg M, Ye K, Lameijer EW, Nelissen RG, Slagboom PE, Meulenbelt I.

Ann Rheum Dis. 2015 Sep;74(9):1756-62. doi: 10.1136/annrheumdis-2013-205149. Epub 2014 Apr 17.

PMID:
24743232
39.

Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31.

Styrkarsdottir U, Thorleifsson G, Helgadottir HT, Bomer N, Metrustry S, Bierma-Zeinstra S, Strijbosch AM, Evangelou E, Hart D, Beekman M, Jonasdottir A, Sigurdsson A, Eiriksson FF, Thorsteinsdottir M, Frigge ML, Kong A, Gudjonsson SA, Magnusson OT, Masson G; TREAT-OA Consortium; arcOGEN Consortium, Hofman A, Arden NK, Ingvarsson T, Lohmander S, Kloppenburg M, Rivadeneira F, Nelissen RG, Spector T, Uitterlinden A, Slagboom PE, Thorsteinsdottir U, Jonsdottir I, Valdes AM, Meulenbelt I, van Meurs J, Jonsson H, Stefansson K.

Nat Genet. 2014 May;46(5):498-502. doi: 10.1038/ng.2957. Epub 2014 Apr 13.

PMID:
24728293
40.

Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis.

Bomer N, den Hollander W, Ramos YF, Bos SD, van der Breggen R, Lakenberg N, Pepers BA, van Eeden AE, Darvishan A, Tobi EW, Duijnisveld BJ, van den Akker EB, Heijmans BT, van Roon-Mom WM, Verbeek FJ, van Osch GJ, Nelissen RG, Slagboom PE, Meulenbelt I.

Ann Rheum Dis. 2015 Aug;74(8):1571-9. doi: 10.1136/annrheumdis-2013-204739. Epub 2014 Apr 2.

41.

Are baseline high molecular weight adiponectin levels associated with radiographic progression in rheumatoid arthritis and osteoarthritis?

Klein-Wieringa IR, Andersen SN, Herb-van Toorn L, Kwekkeboom JC, van der Helm-van Mil AH, Meulenbelt I, Huizinga TW, Kloppenburg M, Toes RE, Ioan-Facsinay A.

J Rheumatol. 2014 May;41(5):853-7. doi: 10.3899/jrheum.130888. Epub 2014 Apr 1.

PMID:
24692529
42.

Large scale meta-analysis of urinary C-terminal telopeptide, serum cartilage oligomeric protein and matrix metalloprotease degraded type II collagen and their role in prevalence, incidence and progression of osteoarthritis.

Valdes AM, Meulenbelt I, Chassaing E, Arden NK, Bierma-Zeinstra S, Hart D, Hofman A, Karsdal M, Kloppenburg M, Kroon HM, Slagboom EP, Spector TD, Uitterlinden AG, van Meurs JB, Bay-Jensen AC.

Osteoarthritis Cartilage. 2014 May;22(5):683-9. doi: 10.1016/j.joca.2014.02.007. Epub 2014 Feb 25.

43.

Republished: Value of biomarkers in osteoarthritis: current status and perspectives.

Lotz M, Martel-Pelletier J, Christiansen C, Brandi ML, Bruyère O, Chapurlat R, Collette J, Cooper C, Giacovelli G, Kanis JA, Karsdal MA, Kraus V, Lems WF, Meulenbelt I, Pelletier JP, Raynauld JP, Reiter-Niesert S, Rizzoli R, Sandell LJ, Van Spil WE, Reginster JY.

Postgrad Med J. 2014 Mar;90(1061):171-8. doi: 10.1136/postgradmedj-2013-203726rep.

44.

A genome-wide association study of anorexia nervosa.

Boraska V, Franklin CS, Floyd JA, Thornton LM, Huckins LM, Southam L, Rayner NW, Tachmazidou I, Klump KL, Treasure J, Lewis CM, Schmidt U, Tozzi F, Kiezebrink K, Hebebrand J, Gorwood P, Adan RA, Kas MJ, Favaro A, Santonastaso P, Fernández-Aranda F, Gratacos M, Rybakowski F, Dmitrzak-Weglarz M, Kaprio J, Keski-Rahkonen A, Raevuori A, Van Furth EF, Slof-Op 't Landt MC, Hudson JI, Reichborn-Kjennerud T, Knudsen GP, Monteleone P, Kaplan AS, Karwautz A, Hakonarson H, Berrettini WH, Guo Y, Li D, Schork NJ, Komaki G, Ando T, Inoko H, Esko T, Fischer K, Männik K, Metspalu A, Baker JH, Cone RD, Dackor J, DeSocio JE, Hilliard CE, O'Toole JK, Pantel J, Szatkiewicz JP, Taico C, Zerwas S, Trace SE, Davis OS, Helder S, Bühren K, Burghardt R, de Zwaan M, Egberts K, Ehrlich S, Herpertz-Dahlmann B, Herzog W, Imgart H, Scherag A, Scherag S, Zipfel S, Boni C, Ramoz N, Versini A, Brandys MK, Danner UN, de Kovel C, Hendriks J, Koeleman BP, Ophoff RA, Strengman E, van Elburg AA, Bruson A, Clementi M, Degortes D, Forzan M, Tenconi E, Docampo E, Escaramís G, Jiménez-Murcia S, Lissowska J, Rajewski A, Szeszenia-Dabrowska N, Slopien A, Hauser J, Karhunen L, Meulenbelt I, Slagboom PE, Tortorella A, Maj M, Dedoussis G, Dikeos D, Gonidakis F, Tziouvas K, Tsitsika A, Papezova H, Slachtova L, Martaskova D, Kennedy JL, Levitan RD, Yilmaz Z, Huemer J, Koubek D, Merl E, Wagner G, Lichtenstein P, Breen G, Cohen-Woods S, Farmer A, McGuffin P, Cichon S, Giegling I, Herms S, Rujescu D, Schreiber S, Wichmann HE, Dina C, Sladek R, Gambaro G, Soranzo N, Julia A, Marsal S, Rabionet R, Gaborieau V, Dick DM, Palotie A, Ripatti S, Widén E, Andreassen OA, Espeseth T, Lundervold A, Reinvang I, Steen VM, Le Hellard S, Mattingsdal M, Ntalla I, Bencko V, Foretova L, Janout V, Navratilova M, Gallinger S, Pinto D, Scherer SW, Aschauer H, Carlberg L, Schosser A, Alfredsson L, Ding B, Klareskog L, Padyukov L, Courtet P, Guillaume S, Jaussent I, Finan C, Kalsi G, Roberts M, Logan DW, Peltonen L, Ritchie GR, Barrett JC; Wellcome Trust Case Control Consortium 3, Estivill X, Hinney A, Sullivan PF, Collier DA, Zeggini E, Bulik CM.

Mol Psychiatry. 2014 Oct;19(10):1085-94. doi: 10.1038/mp.2013.187. Epub 2014 Feb 11.

45.

GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis-associated factors.

Leijten JC, Bos SD, Landman EB, Georgi N, Jahr H, Meulenbelt I, Post JN, van Blitterswijk CA, Karperien M.

Arthritis Res Ther. 2013 Sep 19;15(5):R126. doi: 10.1186/ar4306.

46.

Association study of the estrogen receptor I gene (ESR1) in anorexia nervosa and eating disorders: no replication found.

Slof-Op 't Landt MC, van Furth EF, Meulenbelt I, Bartels M, Hottenga JJ, Slagboom PE, Boomsma DI.

Int J Eat Disord. 2014 Mar;47(2):211-4. doi: 10.1002/eat.22228. Epub 2013 Nov 26.

PMID:
24282178
47.

A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.

Evangelou E, Kerkhof HJ, Styrkarsdottir U, Ntzani EE, Bos SD, Esko T, Evans DS, Metrustry S, Panoutsopoulou K, Ramos YF, Thorleifsson G, Tsilidis KK; arcOGEN Consortium, Arden N, Aslam N, Bellamy N, Birrell F, Blanco FJ, Carr A, Chapman K, Day-Williams AG, Deloukas P, Doherty M, Engström G, Helgadottir HT, Hofman A, Ingvarsson T, Jonsson H, Keis A, Keurentjes JC, Kloppenburg M, Lind PA, McCaskie A, Martin NG, Milani L, Montgomery GW, Nelissen RG, Nevitt MC, Nilsson PM, Ollier WE, Parimi N, Rai A, Ralston SH, Reed MR, Riancho JA, Rivadeneira F, Rodriguez-Fontenla C, Southam L, Thorsteinsdottir U, Tsezou A, Wallis GA, Wilkinson JM, Gonzalez A, Lane NE, Lohmander LS, Loughlin J, Metspalu A, Uitterlinden AG, Jonsdottir I, Stefansson K, Slagboom PE, Zeggini E, Meulenbelt I, Ioannidis JP, Spector TD, van Meurs JB, Valdes AM.

Ann Rheum Dis. 2014 Dec;73(12):2130-6. doi: 10.1136/annrheumdis-2012-203114. Epub 2013 Aug 29. Review.

48.

Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array.

Slieker RC, Bos SD, Goeman JJ, Bovée JV, Talens RP, van der Breggen R, Suchiman HE, Lameijer EW, Putter H, van den Akker EB, Zhang Y, Jukema JW, Slagboom PE, Meulenbelt I, Heijmans BT.

Epigenetics Chromatin. 2013 Aug 6;6(1):26. doi: 10.1186/1756-8935-6-26.

49.

Value of biomarkers in osteoarthritis: current status and perspectives.

Lotz M, Martel-Pelletier J, Christiansen C, Brandi ML, Bruyère O, Chapurlat R, Collette J, Cooper C, Giacovelli G, Kanis JA, Karsdal MA, Kraus V, Lems WF, Meulenbelt I, Pelletier JP, Raynauld JP, Reiter-Niesert S, Rizzoli R, Sandell LJ, Van Spil WE, Reginster JY.

Ann Rheum Dis. 2013 Nov;72(11):1756-63. doi: 10.1136/annrheumdis-2013-203726. Epub 2013 Jul 29. Review. Erratum in: Ann Rheum Dis. 2017 May 25;:.

50.

Genes expressed in blood link osteoarthritis with apoptotic pathways.

Ramos YF, Bos SD, Lakenberg N, Böhringer S, den Hollander WJ, Kloppenburg M, Slagboom PE, Meulenbelt I.

Ann Rheum Dis. 2014 Oct;73(10):1844-53. doi: 10.1136/annrheumdis-2013-203405. Epub 2013 Jul 17.

PMID:
23864235

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