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Items: 1 to 50 of 59

1.

Metabolism and excretion of RWJ-333369 [1,2-ethanediol, 1-(2-chlorophenyl)-, 2-carbamate, (S)-] in mice, rats, rabbits, and dogs.

Mamidi RN, Mannens G, Annaert P, Hendrickx J, Goris I, Bockx M, Janssen CG, Kao M, Kelley MF, Meuldermans W.

Drug Metab Dispos. 2007 Apr;35(4):566-75. Epub 2007 Jan 12.

2.

The absorption, metabolism, and excretion of the novel neuromodulator RWJ-333369 (1,2-ethanediol, [1-2-chlorophenyl]-, 2-carbamate, [S]-) in humans.

Mannens GS, Hendrickx J, Janssen CG, Chien S, Van Hoof B, Verhaeghe T, Kao M, Kelley MF, Goris I, Bockx M, Verreet B, Bialer M, Meuldermans W.

Drug Metab Dispos. 2007 Apr;35(4):554-65. Epub 2006 Aug 25.

3.

Cell-based models to study hepatic drug metabolism and enzyme induction in humans.

Vermeir M, Annaert P, Mamidi RN, Roymans D, Meuldermans W, Mannens G.

Expert Opin Drug Metab Toxicol. 2005 Jun;1(1):75-90. Review.

PMID:
16922654
4.

Expression and induction potential of cytochromes P450 in human cryopreserved hepatocytes.

Roymans D, Annaert P, Van Houdt J, Weygers A, Noukens J, Sensenhauser C, Silva J, Van Looveren C, Hendrickx J, Mannens G, Meuldermans W.

Drug Metab Dispos. 2005 Jul;33(7):1004-16. Epub 2005 Mar 31.

5.

Pharmacokinetics and tissue distribution of galantamine and galantamine-related radioactivity after single intravenous and oral administration in the rat.

van Beijsterveldt L, Geerts R, Verhaeghe T, Willems B, Bode W, Lavrijsen K, Meuldermans W.

Arzneimittelforschung. 2004;54(2):85-94.

PMID:
15038457
6.

Determination of cytochrome P450 1A2 and cytochrome P450 3A4 induction in cryopreserved human hepatocytes.

Roymans D, Van Looveren C, Leone A, Parker JB, McMillian M, Johnson MD, Koganti A, Gilissen R, Silber P, Mannens G, Meuldermans W.

Biochem Pharmacol. 2004 Feb 1;67(3):427-37.

PMID:
15037195
7.

Pharmacokinetics of galantamine, a cholinesterase inhibitor, in several animal species.

Monbaliu J, Verhaeghe T, Willems B, Bode W, Lavrijsen K, Meuldermans W.

Arzneimittelforschung. 2003;53(7):486-95.

PMID:
12918214
9.

Rapid permeability screening in drug discovery to predict human intestinal absorption.

Mannens GS, Bohets H, Verboven P, Steemans K, Lavrijsen K, Meuldermans W.

Ernst Schering Res Found Workshop. 2002;(37):49-67. Review. No abstract available.

PMID:
11975200
10.

The metabolism and excretion of galantamine in rats, dogs, and humans.

Mannens GS, Snel CA, Hendrickx J, Verhaeghe T, Le Jeune L, Bode W, van Beijsterveldt L, Lavrijsen K, Leempoels J, Van Osselaer N, Van Peer A, Meuldermans W.

Drug Metab Dispos. 2002 May;30(5):553-63.

11.

Strategies for absorption screening in drug discovery and development.

Bohets H, Annaert P, Mannens G, Van Beijsterveldt L, Anciaux K, Verboven P, Meuldermans W, Lavrijsen K.

Curr Top Med Chem. 2001 Nov;1(5):367-83. Review.

PMID:
11899103
12.

Identification of the cytochrome P450 enzymes involved in the metabolism of cisapride: in vitro studies of potential co-medication interactions.

Bohets H, Lavrijsen K, Hendrickx J, van Houdt J, van Genechten V, Verboven P, Meuldermans W, Heykants J.

Br J Pharmacol. 2000 Apr;129(8):1655-67.

13.

Commentary on "Hydroxypropyl cyclodextrins: potential synergism with carcinogens".

Van Cauteren H, Jacqmin P, Coussement W, Meuldermans W, Lampo A, Lammens L.

J Pharm Sci. 1997 Mar;86(3):402-4. No abstract available.

PMID:
9050815
14.
15.

The pharmacokinetic properties of topical levocabastine. A review.

Heykants J, Van Peer A, Van de Velde V, Snoeck E, Meuldermans W, Woestenborghs R.

Clin Pharmacokinet. 1995 Oct;29(4):221-30. Review.

PMID:
8549024
16.

Reduction of the prodrug loperamide oxide to its active drug loperamide in the gut of rats, dogs, and humans.

Lavrijsen K, van Dyck D, van Houdt J, Hendrickx J, Monbaliu J, Woestenborghs R, Meuldermans W, Heykants J.

Drug Metab Dispos. 1995 Mar;23(3):354-62.

PMID:
7628301
17.

Gastrointestinal distribution of the prodrug loperamide oxide and its active drug loperamide in the dog.

Van Beijsterveldt LE, Geerts RJ, Wuyts K, Woestenborghs RJ, Meuldermans WE, Heykants JJ.

Drug Metab Dispos. 1995 Feb;23(2):216-22.

PMID:
7736914
18.

Plasma protein binding of risperidone and its distribution in blood.

Mannens G, Meuldermans W, Snoeck E, Heykants J.

Psychopharmacology (Berl). 1994 May;114(4):566-72.

PMID:
7531854
19.

The pharmacokinetics of risperidone in humans: a summary.

Heykants J, Huang ML, Mannens G, Meuldermans W, Snoeck E, Van Beijsterveldt L, Van Peer A, Woestenborghs R.

J Clin Psychiatry. 1994 May;55 Suppl:13-7.

PMID:
7520903
20.

Regional brain distribution of risperidone and its active metabolite 9-hydroxy-risperidone in the rat.

van Beijsterveldt LE, Geerts RJ, Leysen JE, Megens AA, Van den Eynde HM, Meuldermans WE, Heykants JJ.

Psychopharmacology (Berl). 1994 Feb;114(1):53-62.

PMID:
7531352
21.

The metabolism and excretion of risperidone after oral administration in rats and dogs.

Meuldermans W, Hendrickx J, Mannens G, Lavrijsen K, Janssen C, Bracke J, Le Jeune L, Lauwers W, Heykants J.

Drug Metab Dispos. 1994 Jan-Feb;22(1):129-38.

PMID:
7512019
22.

Absorption, metabolism, and excretion of risperidone in humans.

Mannens G, Huang ML, Meuldermans W, Hendrickx J, Woestenborghs R, Heykants J.

Drug Metab Dispos. 1993 Nov-Dec;21(6):1134-41.

PMID:
7507814
23.

Comparative metabolism of flunarizine in rats, dogs and man: an in vitro study with subcellular liver fractions and isolated hepatocytes.

Lavrijsen K, van Houdt J, van Dyck D, Hendrickx J, Bockx M, Hurkmans R, Meuldermans W, Le Jeune L, Lauwers W, Heykants J.

Xenobiotica. 1992 Jul;22(7):815-36.

PMID:
1455902
24.

A predictive model for substrates of cytochrome P450-debrisoquine (2D6).

Koymans L, Vermeulen NP, van Acker SA, te Koppele JM, Heykants JJ, Lavrijsen K, Meuldermans W, Donné-Op den Kelder GM.

Chem Res Toxicol. 1992 Mar-Apr;5(2):211-9.

PMID:
1379482
25.

Study of the placental transfer of cisapride in sheep. Plasma levels in the pregnant ewe, the fetus, and the lamb.

Veereman-Wauters G, Monbaliu J, Meuldermans W, Woestenborghs R, Verlinden M, Heykants J, Rudolph CD.

Drug Metab Dispos. 1991 Jan-Feb;19(1):168-72.

PMID:
1673393
26.

Biotransformation of sufentanil in liver microsomes of rats, dogs, and humans.

Lavrijsen K, Van Houdt J, Van Dyck D, Hendrickx J, Lauwers W, Hurkmans R, Bockx M, Janssen C, Meuldermans W, Heykants J.

Drug Metab Dispos. 1990 Sep-Oct;18(5):704-10.

PMID:
1981724
27.

Pharmacokinetics of oral antifungals and their clinical implications.

Heykants J, Van Peer A, Lavrijsen K, Meuldermans W, Woestenborghs R, Cauwenbergh G.

Br J Clin Pract Suppl. 1990 Sep;71:50-6. Review.

PMID:
1965419
28.

Induction potential of fluconazole toward drug-metabolizing enzymes in rats.

Lavrijsen KL, Van Houdt JM, Van Dyck DM, Meuldermans WE, Heykants JJ.

Antimicrob Agents Chemother. 1990 Mar;34(3):402-8.

29.

On the terrestrial toxicity of the fungicide imazalil (enilconazole) to the earthworm species Eisenia foetida.

Van Leemput L, Swysen E, Woestenborghs R, Michielsen L, Meuldermans W, Heykants J.

Ecotoxicol Environ Saf. 1989 Dec;18(3):313-20.

PMID:
2612423
30.

The clinical pharmacokinetics of itraconazole: an overview.

Heykants J, Van Peer A, Van de Velde V, Van Rooy P, Meuldermans W, Lavrijsen K, Woestenborghs R, Van Cutsem J, Cauwenbergh G.

Mycoses. 1989;32 Suppl 1:67-87. Review.

PMID:
2561187
31.

Is the metabolism of alfentanil subject to debrisoquine polymorphism? A study using human liver microsomes.

Lavrijsen KL, Van Houdt JM, Van Dyck DM, Hendrickx JJ, Woestenborghs RJ, Lauwers W, Meuldermans WE, Heykants JJ.

Anesthesiology. 1988 Oct;69(4):535-40.

PMID:
3140691
32.

Alfentanil pharmacokinetics and metabolism in humans.

Meuldermans W, Van Peer A, Hendrickx J, Woestenborghs R, Lauwers W, Heykants J, Vanden Bussche G, Van Craeyvelt H, Van der Aa P.

Anesthesiology. 1988 Oct;69(4):527-34.

PMID:
3140690
33.

Plasma protein binding of ketanserin and its distribution in blood.

Meuldermans W, Van Houdt J, Mostmans E, Knaeps F, Verluyten W, Heykants J.

Arzneimittelforschung. 1988 Jun;38(6):794-800.

PMID:
3178920
34.

Absorption, metabolism and excretion of ketanserin in man after oral administration.

Meuldermans W, Hendrickx J, Woestenborghs R, Van Peer A, Lauwers W, De Cree J, Heykants J.

Arzneimittelforschung. 1988 Jun;38(6):789-94.

PMID:
3178919
35.

Pharmacokinetics and tissue distribution of ketanserin in rat, rabbit and dog.

Michiels M, Monbaliu J, Meuldermans W, Hendriks R, Geerts R, Woestenborghs R, Heykants J.

Arzneimittelforschung. 1988 Jun;38(6):775-84.

PMID:
3178917
36.

Excretion and biotransformation of cisapride in rats after oral administration.

Meuldermans W, Hendrickx J, Lauwers W, Hurkmans R, Mostmans E, Swysen E, Bracke J, Knaeps A, Heykants J.

Drug Metab Dispos. 1988 May-Jun;16(3):410-9.

PMID:
2900733
37.

Excretion and biotransformation of cisapride in dogs and humans after oral administration.

Meuldermans W, Van Peer A, Hendrickx J, Lauwers W, Swysen E, Bockx M, Woestenborghs R, Heykants J.

Drug Metab Dispos. 1988 May-Jun;16(3):403-9.

PMID:
2900732
38.

Identification of a biliary metabolite of cisapride.

Lauwers W, Le Jeune L, Meuldermans W.

Biomed Environ Mass Spectrom. 1988 Mar 15;15(6):323-8.

PMID:
3378119
39.

Metabolism of alfentanil by isolated hepatocytes of rat and dog.

Lavrijsen K, Van Houdt J, Meuldermans W, Knaeps F, Hendrickx J, Lauwers W, Hurkmans R, Heykants J.

Xenobiotica. 1988 Feb;18(2):183-97.

PMID:
3131971
40.

Uptake, subcellular distribution and biotransformation of 3H-labelled astemizole in cultured rat hepatocytes.

Waterkeyn C, Laduron P, Meuldermans W, Trouet A, Schneider YJ.

Biochem Pharmacol. 1987 Dec 1;36(23):4129-36.

PMID:
3120732
41.

Excretion and biotransformation of alfentanil and sufentanil in rats and dogs.

Meuldermans W, Hendrickx J, Lauwers W, Hurkmans R, Swysen E, Thijssen J, Timmerman P, Woestenborghs R, Heykants J.

Drug Metab Dispos. 1987 Nov-Dec;15(6):905-13.

PMID:
2893720
42.

The metabolism and fate of closantel (Flukiver) in sheep and cattle.

Michiels M, Meuldermans W, Heykants J.

Drug Metab Rev. 1987;18(2-3):235-51. Review.

PMID:
3330516
43.

Interaction of miconazole, ketoconazole and itraconazole with rat-liver microsomes.

Lavrijsen K, van Houdt J, Thijs D, Meuldermans W, Heykants J.

Xenobiotica. 1987 Jan;17(1):45-57.

PMID:
3030012
45.

Protein binding of the analgesics alfentanil and sufentanil in maternal and neonatal plasma.

Meuldermans W, Woestenborghs R, Noorduin H, Camu F, van Steenberge A, Heykants J.

Eur J Clin Pharmacol. 1986;30(2):217-9.

PMID:
2940093
46.

Excretion and biotransformation of ketanserin after oral and intravenous administration in rats and dogs.

Meuldermans W, Hendrickx J, Lauwers W, Swysen E, Hurkmans R, Knaeps F, Woestenborghs R, Heykants J.

Drug Metab Dispos. 1984 Nov-Dec;12(6):772-81.

PMID:
6150829
47.

Plasma levels, biotransformation and excretion of oxatomide (R 35 443) in rats, dogs and man.

Meuldermans W, Hendrickx J, Knaeps F, Lauwers W, Heykants J, Grindel JM.

Xenobiotica. 1984 Jun;14(6):445-62.

PMID:
6475104
48.

Mass spectral investigation of the metabolites of lorcainide in man.

Lauwers WF, Meuldermans WE, Bracke JO.

Eur J Drug Metab Pharmacokinet. 1983 Oct-Dec;8(4):351-62.

PMID:
6673972
49.

Excretion and metabolism of lorcainide in rats, dogs and man.

Meuldermans W, Hurkmans R, Swysen E, Hendrickx J, Thijssen J, Lauwers W, Heykants J.

Eur J Drug Metab Pharmacokinet. 1983 Oct-Dec;8(4):335-49.

PMID:
6673971
50.

Excretion and metabolism of flunarizine in rats and dogs.

Meuldermans W, Hendrickx J, Hurkmans R, Swysen E, Woestenborghs R, Lauwers W, Heykants J.

Arzneimittelforschung. 1983;33(8):1142-51.

PMID:
6685491

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