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Opioid and chemokine regulation of cortical synaptodendritic damage in HIV-associated neurocognitive disorders.

Nash B, Festa L, Lin C, Meucci O.

Brain Res. 2019 Nov 15;1723:146409. doi: 10.1016/j.brainres.2019.146409. Epub 2019 Aug 26. Review.


Morphine-Induced Modulation of Endolysosomal Iron Mediates Upregulation of Ferritin Heavy Chain in Cortical Neurons.

Nash B, Tarn K, Irollo E, Luchetta J, Festa L, Halcrow P, Datta G, Geiger JD, Meucci O.

eNeuro. 2019 Jul 31;6(4). pii: ENEURO.0237-19.2019. doi: 10.1523/ENEURO.0237-19.2019. Print 2019 Jul/Aug.


Novel Positive Allosteric Modulators of Glutamate Transport Have Neuroprotective Properties in an in Vitro Excitotoxic Model.

Falcucci RM, Wertz R, Green JL, Meucci O, Salvino J, Fontana ACK.

ACS Chem Neurosci. 2019 Aug 21;10(8):3437-3453. doi: 10.1021/acschemneuro.9b00061. Epub 2019 Jul 11.


Limiting tumor seeding as a therapeutic approach for metastatic disease.

Worrede A, Meucci O, Fatatis A.

Pharmacol Ther. 2019 Jul;199:117-128. doi: 10.1016/j.pharmthera.2019.03.007. Epub 2019 Mar 12. Review.


Impeding Circulating Tumor Cell Reseeding Decelerates Metastatic Progression and Potentiates Chemotherapy.

Qian C, Worrede-Mahdi A, Shen F, DiNatale A, Kaur R, Zhang Q, Cristofanilli M, Meucci O, Fatatis A.

Mol Cancer Res. 2018 Dec;16(12):1844-1854. doi: 10.1158/1541-7786.MCR-18-0302. Epub 2018 Aug 16.


Orai1 Plays a Crucial Role in Central Sensitization by Modulating Neuronal Excitability.

Dou Y, Xia J, Gao R, Gao X, Munoz FM, Wei D, Tian Y, Barrett JE, Ajit S, Meucci O, Putney JW Jr, Dai Y, Hu H.

J Neurosci. 2018 Jan 24;38(4):887-900. doi: 10.1523/JNEUROSCI.3007-17.2017. Epub 2017 Dec 11.


The lipid raft-dwelling protein US9 can be manipulated to target APP compartmentalization, APP processing, and neurodegenerative disease pathogenesis.

Brandimarti R, Hill GS, Geiger JD, Meucci O.

Sci Rep. 2017 Nov 8;7(1):15103. doi: 10.1038/s41598-017-15128-8.


STIMs and Orai1 regulate cytokine production in spinal astrocytes.

Gao X, Xia J, Munoz FM, Manners MT, Pan R, Meucci O, Dai Y, Hu H.

J Neuroinflammation. 2016 May 31;13(1):126. doi: 10.1186/s12974-016-0594-7.


Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells.

Shen F, Zhang Y, Jernigan DL, Feng X, Yan J, Garcia FU, Meucci O, Salvino JM, Fatatis A.

Mol Cancer Res. 2016 Jun;14(6):518-27. doi: 10.1158/1541-7786.MCR-16-0013. Epub 2016 Mar 21.


A Preclinical Model of Inflammatory Breast Cancer to Study the Involvement of CXCR4 and ACKR3 in the Metastatic Process.

Wurth R, Tarn K, Jernigan D, Fernandez SV, Cristofanilli M, Fatatis A, Meucci O.

Transl Oncol. 2015 Oct;8(5):358-367. doi: 10.1016/j.tranon.2015.07.002.


Induction of Interleukin-1β by Human Immunodeficiency Virus-1 Viral Proteins Leads to Increased Levels of Neuronal Ferritin Heavy Chain, Synaptic Injury, and Deficits in Flexible Attention.

Festa L, Gutoskey CJ, Graziano A, Waterhouse BD, Meucci O.

J Neurosci. 2015 Jul 22;35(29):10550-61. doi: 10.1523/JNEUROSCI.4403-14.2015.


Effect of μ-opioid agonist DAMGO on surface CXCR4 and HIV-1 replication in TF-1 human bone marrow progenitor cells.

Strazza M, Banerjee A, Alexaki A, Passic SR, Meucci O, Pirrone V, Wigdahl B, Nonnemacher MR.

BMC Res Notes. 2014 Oct 23;7:752. doi: 10.1186/1756-0500-7-752.


Functions of the chemokine receptor CXCR4 in the central nervous system and its regulation by μ-opioid receptors.

Nash B, Meucci O.

Int Rev Neurobiol. 2014;118:105-28. doi: 10.1016/B978-0-12-801284-0.00005-1. Review.


Molecular features contributing to virus-independent intracellular localization and dynamic behavior of the herpesvirus transport protein US9.

Pedrazzi M, Nash B, Meucci O, Brandimarti R.

PLoS One. 2014 Aug 18;9(8):e104634. doi: 10.1371/journal.pone.0104634. eCollection 2014.


Native store-operated calcium channels are functionally expressed in mouse spinal cord dorsal horn neurons and regulate resting calcium homeostasis.

Xia J, Pan R, Gao X, Meucci O, Hu H.

J Physiol. 2014 Aug 15;592(16):3443-61. doi: 10.1113/jphysiol.2014.275065. Epub 2014 May 23.


Neuronal ferritin heavy chain and drug abuse affect HIV-associated cognitive dysfunction.

Pitcher J, Abt A, Myers J, Han R, Snyder M, Graziano A, Festa L, Kutzler M, Garcia F, Gao WJ, Fischer-Smith T, Rappaport J, Meucci O.

J Clin Invest. 2014 Feb;124(2):656-69. doi: 10.1172/JCI70090. Epub 2014 Jan 9.


Multispectral imaging and automated laser capture microdissection of human cortical neurons: a quantitative study of CXCR4 expression.

Pitcher J, Wurth R, Shimizu S, Meucci O.

Methods Mol Biol. 2013;1013:31-48. doi: 10.1007/978-1-62703-426-5_3.


Bilaminar co-culture of primary rat cortical neurons and glia.

Shimizu S, Abt A, Meucci O.

J Vis Exp. 2011 Nov 12;(57). pii: 3257. doi: 10.3791/3257.


The chemokine receptor CX₃CR1 is directly involved in the arrest of breast cancer cells to the skeleton.

Jamieson-Gladney WL, Zhang Y, Fong AM, Meucci O, Fatatis A.

Breast Cancer Res. 2011 Sep 20;13(5):R91. doi: 10.1186/bcr3016.


Role of mu-opioids as cofactors in human immunodeficiency virus type 1 disease progression and neuropathogenesis.

Banerjee A, Strazza M, Wigdahl B, Pirrone V, Meucci O, Nonnemacher MR.

J Neurovirol. 2011 Aug;17(4):291-302. doi: 10.1007/s13365-011-0037-2. Epub 2011 Jul 7. Review.


CXCR7 protein expression in human adult brain and differentiated neurons.

Shimizu S, Brown M, Sengupta R, Penfold ME, Meucci O.

PLoS One. 2011;6(5):e20680. doi: 10.1371/journal.pone.0020680. Epub 2011 May 31.


Regulation of neuronal ferritin heavy chain, a new player in opiate-induced chemokine dysfunction.

Abt AC, Meucci O.

J Neuroimmune Pharmacol. 2011 Dec;6(4):466-76. doi: 10.1007/s11481-011-9278-3. Epub 2011 Apr 5. Review.


CXCL12 inhibits expression of the NMDA receptor's NR2B subunit through a histone deacetylase-dependent pathway contributing to neuronal survival.

Nicolai J, Burbassi S, Rubin J, Meucci O.

Cell Death Dis. 2010 Apr 1;1:e33. doi: 10.1038/cddis.2010.10.


Alterations of CXCR4 function in μ-opioid receptor-deficient glia.

Burbassi S, Sengupta R, Meucci O.

Eur J Neurosci. 2010 Oct;32(8):1278-88. doi: 10.1111/j.1460-9568.2010.07402.x. Epub 2010 Sep 30.


Disruption of neuronal CXCR4 function by opioids: preliminary evidence of ferritin heavy chain as a potential etiological agent in neuroAIDS.

Pitcher J, Shimizu S, Burbassi S, Meucci O.

J Neuroimmunol. 2010 Jul 27;224(1-2):66-71. doi: 10.1016/j.jneuroim.2010.05.006. Epub 2010 Jun 8. Review.


CXCL12-mediated regulation of ANP32A/Lanp, a component of the inhibitor of histone acetyl transferase (INHAT) complex, in cortical neurons.

Khan MZ, Vaidya A, Meucci O.

J Neuroimmune Pharmacol. 2011 Mar;6(1):163-70. doi: 10.1007/s11481-010-9228-5. Epub 2010 Jul 9.


Interactions between chemokines: regulation of fractalkine/CX3CL1 homeostasis by SDF/CXCL12 in cortical neurons.

Cook A, Hippensteel R, Shimizu S, Nicolai J, Fatatis A, Meucci O.

J Biol Chem. 2010 Apr 2;285(14):10563-71. doi: 10.1074/jbc.M109.035477. Epub 2010 Feb 2.


Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling.

Busillo JM, Armando S, Sengupta R, Meucci O, Bouvier M, Benovic JL.

J Biol Chem. 2010 Mar 5;285(10):7805-17. doi: 10.1074/jbc.M109.091173. Epub 2010 Jan 4.


Morphine increases brain levels of ferritin heavy chain leading to inhibition of CXCR4-mediated survival signaling in neurons.

Sengupta R, Burbassi S, Shimizu S, Cappello S, Vallee RB, Rubin JB, Meucci O.

J Neurosci. 2009 Feb 25;29(8):2534-44. doi: 10.1523/JNEUROSCI.5865-08.2009.


The chemokine CXCL12 promotes survival of postmitotic neurons by regulating Rb protein.

Khan MZ, Brandimarti R, Shimizu S, Nicolai J, Crowe E, Meucci O.

Cell Death Differ. 2008 Oct;15(10):1663-72. doi: 10.1038/cdd.2008.95. Epub 2008 Jun 27.


CX3CR1 is expressed by prostate epithelial cells and androgens regulate the levels of CX3CL1/fractalkine in the bone marrow: potential role in prostate cancer bone tropism.

Jamieson WL, Shimizu S, D'Ambrosio JA, Meucci O, Fatatis A.

Cancer Res. 2008 Mar 15;68(6):1715-22. doi: 10.1158/0008-5472.CAN-07-1315.


GTPgammaS incorporation in the rat brain: a study on mu-opioid receptors and CXCR4.

Burbassi S, Aloyo VJ, Simansky KJ, Meucci O.

J Neuroimmune Pharmacol. 2008 Mar;3(1):26-34. doi: 10.1007/s11481-007-9083-1. Epub 2007 Oct 25.


Modulation of dendritic cell maturation and function by the Tax protein of human T cell leukemia virus type 1.

Jain P, Ahuja J, Khan ZK, Shimizu S, Meucci O, Jennings SR, Wigdahl B.

J Leukoc Biol. 2007 Jul;82(1):44-56. Epub 2007 Apr 18.


Modulation of neuronal CXCR4 by the micro-opioid agonist DAMGO.

Patel JP, Sengupta R, Bardi G, Khan MZ, Mullen-Przeworski A, Meucci O.

J Neurovirol. 2006 Dec;12(6):492-500.


Role of the transcription factor E2F1 in CXCR4-mediated neurotoxicity and HIV neuropathology.

Shimizu S, Khan MZ, Hippensteel RL, Parkar A, Raghupathi R, Meucci O.

Neurobiol Dis. 2007 Jan;25(1):17-26. Epub 2006 Sep 28.


Bone-metastatic potential of human prostate cancer cells correlates with Akt/PKB activation by alpha platelet-derived growth factor receptor.

Dolloff NG, Shulby SS, Nelson AV, Stearns ME, Johannes GJ, Thomas JD, Meucci O, Fatatis A.

Oncogene. 2005 Oct 13;24(45):6848-54.


Regulation of neuronal P53 activity by CXCR 4.

Khan MZ, Shimizu S, Patel JP, Nelson A, Le MT, Mullen-Przeworski A, Brandimarti R, Fatatis A, Meucci O.

Mol Cell Neurosci. 2005 Sep;30(1):58-66.


Apoptotic and antiapoptotic effects of CXCR4: is it a matter of intrinsic efficacy? Implications for HIV neuropathogenesis.

Khan MZ, Brandimarti R, Patel JP, Huynh N, Wang J, Huang Z, Fatatis A, Meucci O.

AIDS Res Hum Retroviruses. 2004 Oct;20(10):1063-71.


Regulation of cell cycle proteins by chemokine receptors: A novel pathway in human immunodeficiency virus neuropathogenesis?

Brandimarti R, Khan MZ, Fatatis A, Meucci O.

J Neurovirol. 2004;10 Suppl 1:108-12. Review.


The chemokine receptor CXCR4 regulates cell-cycle proteins in neurons.

Khan MZ, Brandimarti R, Musser BJ, Resue DM, Fatatis A, Meucci O.

J Neurovirol. 2003 Jun;9(3):300-14.


The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling.

Roncarati R, Sestan N, Scheinfeld MH, Berechid BE, Lopez PA, Meucci O, McGlade JC, Rakic P, D'Adamio L.

Proc Natl Acad Sci U S A. 2002 May 14;99(10):7102-7.


Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival.

Meucci O, Fatatis A, Simen AA, Miller RJ.

Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8075-80. Erratum in: Proc Natl Acad Sci U S A 2001 Dec 18;98(26):15393.


AIDS and the brain: is there a chemokine connection?

Miller RJ, Meucci O.

Trends Neurosci. 1999 Oct;22(10):471-9. Review.


HIV-1 and chemokines in the brain: location, location--location?

Tran PB, Meucci O, Miller RJ.

Mol Psychiatry. 1999 May;4(3):203-5, 202. No abstract available.


Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity.

Meucci O, Fatatis A, Simen AA, Bushell TJ, Gray PW, Miller RJ.

Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14500-5.


Acetyl-L-carnitine arginine amide prevents beta 25-35-induced neurotoxicity in cerebellar granule cells.

Scorziello A, Meucci O, Calvani M, Schettini G.

Neurochem Res. 1997 Mar;22(3):257-65.


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