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Items: 10


Crystal structure of the Schizosaccharomyces pombe U7BR E2-binding region in complex with Ubc7.

Hann ZS, Metzger MB, Weissman AM, Lima CD.

Acta Crystallogr F Struct Biol Commun. 2019 Aug 1;75(Pt 8):552-560. doi: 10.1107/S2053230X19009786. Epub 2019 Aug 2.


Substrate Insolubility Dictates Hsp104-Dependent Endoplasmic-Reticulum-Associated Degradation.

Preston GM, Guerriero CJ, Metzger MB, Michaelis S, Brodsky JL.

Mol Cell. 2018 Apr 19;70(2):242-253.e6. doi: 10.1016/j.molcel.2018.03.016.


The Ubiquitin Ligase (E3) Psh1p Is Required for Proper Segregation of both Centromeric and Two-Micron Plasmids in Saccharomyces cerevisiae.

Metzger MB, Scales JL, Dunklebarger MF, Weissman AM.

G3 (Bethesda). 2017 Nov 6;7(11):3731-3743. doi: 10.1534/g3.117.300227.


Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B.

Li S, Liang YH, Mariano J, Metzger MB, Stringer DK, Hristova VA, Li J, Randazzo PA, Tsai YC, Ji X, Weissman AM.

J Biol Chem. 2015 Dec 18;290(51):30225-39. doi: 10.1074/jbc.M115.685867. Epub 2015 Oct 16.


RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination.

Metzger MB, Pruneda JN, Klevit RE, Weissman AM.

Biochim Biophys Acta. 2014 Jan;1843(1):47-60. doi: 10.1016/j.bbamcr.2013.05.026. Epub 2013 Jun 6. Review.


A structurally unique E2-binding domain activates ubiquitination by the ERAD E2, Ubc7p, through multiple mechanisms.

Metzger MB, Liang YH, Das R, Mariano J, Li S, Li J, Kostova Z, Byrd RA, Ji X, Weissman AM.

Mol Cell. 2013 May 23;50(4):516-27. doi: 10.1016/j.molcel.2013.04.004. Epub 2013 May 9.


HECT and RING finger families of E3 ubiquitin ligases at a glance.

Metzger MB, Hristova VA, Weissman AM.

J Cell Sci. 2012 Feb 1;125(Pt 3):531-7. doi: 10.1242/jcs.091777. Review. No abstract available.


Working on a chain: E3s ganging up for ubiquitylation.

Metzger MB, Weissman AM.

Nat Cell Biol. 2010 Dec;12(12):1124-6. doi: 10.1038/ncb1210-1124.


Analysis of quality control substrates in distinct cellular compartments reveals a unique role for Rpn4p in tolerating misfolded membrane proteins.

Metzger MB, Michaelis S.

Mol Biol Cell. 2009 Feb;20(3):1006-19. doi: 10.1091/mbc.E08-02-0140. Epub 2008 Dec 10.


Degradation of a cytosolic protein requires endoplasmic reticulum-associated degradation machinery.

Metzger MB, Maurer MJ, Dancy BM, Michaelis S.

J Biol Chem. 2008 Nov 21;283(47):32302-16. doi: 10.1074/jbc.M806424200. Epub 2008 Sep 23.

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