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Items: 29

1.

Stereoselective Analysis of Methadone and EDDP in Laboring Women and Neonates in Plasma and Dried Blood Spots and Association with Neonatal Abstinence Syndrome.

Metzger IF, Thomas AE, Evrard CA, Jones DR, Masters AR, Haas DM, Haneline LS, Quinney SK.

Am J Perinatol. 2020 Feb 12. doi: 10.1055/s-0040-1701505. [Epub ahead of print]

PMID:
32052397
2.

Influence of Uridine Diphosphate Glucuronosyltransferase Family 1 Member A1 and Solute Carrier Organic Anion Transporter Family 1 Member B1 Polymorphisms and Efavirenz on Bilirubin Disposition in Healthy Volunteers.

Collins KS, Metzger IF, Gufford BT, Lu JB, Medeiros EB, Pratt VM, Skaar TC, Desta Z.

Drug Metab Dispos. 2020 Mar;48(3):169-175. doi: 10.1124/dmd.119.089052. Epub 2019 Dec 30.

PMID:
31888882
3.

CYP2B6 Genotype-Dependent Inhibition of CYP1A2 and Induction of CYP2A6 by the Antiretroviral Drug Efavirenz in Healthy Volunteers.

Metzger IF, Dave N, Kreutz Y, Lu JBL, Galinsky RE, Desta Z.

Clin Transl Sci. 2019 Nov;12(6):657-666. doi: 10.1111/cts.12671. Epub 2019 Aug 12.

4.

Variants in the CYP2B6 3'UTR Alter In Vitro and In Vivo CYP2B6 Activity: Potential Role of MicroRNAs.

Burgess KS, Ipe J, Swart M, Metzger IF, Lu J, Gufford BT, Thong N, Desta Z, Gaedigk R, Pearce RE, Gaedigk A, Liu Y, Skaar TC.

Clin Pharmacol Ther. 2018 Jul;104(1):130-138. doi: 10.1002/cpt.892. Epub 2017 Oct 25.

5.

Population Pharmacokinetic Modeling To Estimate the Contributions of Genetic and Nongenetic Factors to Efavirenz Disposition.

Robarge JD, Metzger IF, Lu J, Thong N, Skaar TC, Desta Z, Bies RR.

Antimicrob Agents Chemother. 2016 Dec 27;61(1). pii: e01813-16. doi: 10.1128/AAC.01813-16. Print 2017 Jan.

6.

Inhibition of Cytochrome P450 2B6 Activity by Voriconazole Profiled Using Efavirenz Disposition in Healthy Volunteers.

Desta Z, Metzger IF, Thong N, Lu JB, Callaghan JT, Skaar TC, Flockhart DA, Galinsky RE.

Antimicrob Agents Chemother. 2016 Oct 21;60(11):6813-6822. doi: 10.1128/AAC.01000-16. Print 2016 Nov.

7.

Chiral Plasma Pharmacokinetics and Urinary Excretion of Bupropion and Metabolites in Healthy Volunteers.

Masters AR, Gufford BT, Lu JB, Metzger IF, Jones DR, Desta Z.

J Pharmacol Exp Ther. 2016 Aug;358(2):230-8. doi: 10.1124/jpet.116.232876. Epub 2016 Jun 2.

8.

Stereoselective Glucuronidation of Bupropion Metabolites In Vitro and In Vivo.

Gufford BT, Lu JB, Metzger IF, Jones DR, Desta Z.

Drug Metab Dispos. 2016 Apr;44(4):544-53. doi: 10.1124/dmd.115.068908. Epub 2016 Jan 22. Erratum in: Drug Metab Dispos. 2016 Nov;44(11):1852.

9.

Substantial effect of efavirenz monotherapy on bilirubin levels in healthy volunteers.

Metzger IF, Quigg TC, Epstein N, Aregbe AO, Thong N, Callaghan JT, Flockhart DA, Nguyen AT, Stevens CK, Gupta SK, Desta Z.

Curr Ther Res Clin Exp. 2014 Sep 27;76:64-9. doi: 10.1016/j.curtheres.2014.05.002. eCollection 2014 Dec.

10.

Effects of endothelial nitric oxide synthase tagSNPs haplotypes on nitrite levels in black subjects.

Metzger IF, Luizon MR, Lacchini R, Ishizawa MH, Tanus-Santos JE.

Nitric Oxide. 2013 Jan 15;28:33-8. doi: 10.1016/j.niox.2012.10.002. Epub 2012 Oct 13.

11.

Endothelial nitric oxide synthase polymorphism rs3918226 associated with hypertension does not affect plasma nitrite levels in healthy subjects.

Luizon MR, Metzger IF, Lacchini R, Tanus-Santos JE.

Hypertension. 2012 Jun;59(6):e52; author reply e53. doi: 10.1161/HYPERTENSIONAHA.112.194654. Epub 2012 Apr 30. No abstract available.

PMID:
22547447
12.

Endogenous nitric oxide formation correlates negatively with circulating matrix metalloproteinase (MMP)-2 and MMP-9 levels in black subjects.

Metzger IF, Sandrim VC, Tanus-Santos JE.

Mol Cell Biochem. 2012 Jan;360(1-2):393-9. doi: 10.1007/s11010-011-1079-8. Epub 2011 Sep 29.

PMID:
21956669
13.

Genetic variants in matrix metalloproteinase-9 gene modify metalloproteinase-9 levels in black subjects.

Metzger IF, Luizon MR, Lacchini R, Tanus-Santos JE.

DNA Cell Biol. 2012 Apr;31(4):504-10. doi: 10.1089/dna.2011.1388. Epub 2011 Sep 21.

PMID:
21936677
14.

Endothelial nitric oxide genotypes and haplotypes are not associated with end-stage renal disease.

Marson BP, Dickel S, Ishizawa MH, Metzger IF, Izidoro-Toledo T, da Costa BE, Poli-de-Figueiredo CE, Tanus-Santos JE.

DNA Cell Biol. 2011 Jan;30(1):55-9. doi: 10.1089/dna.2010.1106. Epub 2010 Sep 17.

PMID:
20849252
15.

eNOS haplotype associated with hypertension in obese children and adolescents.

Souza-Costa DC, Belo VA, Silva PS, Sertorio JT, Metzger IF, Lanna CM, Machado MA, Tanus-Santos JE.

Int J Obes (Lond). 2011 Mar;35(3):387-92. doi: 10.1038/ijo.2010.146. Epub 2010 Jul 27. Erratum in: Int J Obes (Lond). 2011 May;35(5):750. Sertorio, Jonas T [added].

PMID:
20661250
16.

Interethnic differences in the distribution of matrix metalloproteinases genetic polymorphisms are consistent with interethnic differences in disease prevalence.

Lacchini R, Metzger IF, Luizon M, Ishizawa M, Tanus-Santos JE.

DNA Cell Biol. 2010 Nov;29(11):649-55. doi: 10.1089/dna.2010.1056. Epub 2010 Jun 30.

PMID:
20590473
17.

Interethnic differences in ADMA concentrations and negative association with nitric oxide formation in preeclampsia.

Sandrim VC, Palei AC, Metzger IF, Cavalli RC, Duarte G, Tanus-Santos JE.

Clin Chim Acta. 2010 Oct 9;411(19-20):1457-60. doi: 10.1016/j.cca.2010.05.039. Epub 2010 Jun 4.

PMID:
20570587
18.

Endothelial nitric oxide synthase gene haplotypes affect nitrite levels in black subjects.

Metzger IF, Ishizawa MH, Rios-Santos F, Carvalho WA, Tanus-Santos JE.

Pharmacogenomics J. 2011 Dec;11(6):393-9. doi: 10.1038/tpj.2010.52. Epub 2010 Jun 8.

PMID:
20531373
19.

Increased circulating cell-free hemoglobin levels reduce nitric oxide bioavailability in preeclampsia.

Sandrim VC, Montenegro MF, Palei AC, Metzger IF, Sertorio JT, Cavalli RC, Tanus-Santos JE.

Free Radic Biol Med. 2010 Aug 1;49(3):493-500. doi: 10.1016/j.freeradbiomed.2010.05.012. Epub 2010 May 25.

PMID:
20510352
20.

Interethnic differences in the distribution of clinically relevant vascular endothelial growth factor genetic polymorphisms.

Muniz JJ, Izidoro-Toledo TC, Metzger IF, Sandrim VC, Tanus-Santos JE.

DNA Cell Biol. 2009 Nov;28(11):567-72. doi: 10.1089/dna.2009.0925.

PMID:
19715477
21.

Nitric oxide formation is inversely related to serum levels of antiangiogenic factors soluble fms-like tyrosine kinase-1 and soluble endogline in preeclampsia.

Sandrim VC, Palei AC, Metzger IF, Gomes VA, Cavalli RC, Tanus-Santos JE.

Hypertension. 2008 Aug;52(2):402-7. doi: 10.1161/HYPERTENSIONAHA.108.115006. Epub 2008 Jun 23.

PMID:
18574068
22.

Inverse relationship between markers of nitric oxide formation and plasma matrix metalloproteinase-9 levels in healthy volunteers.

Demacq C, Metzger IF, Gerlach RF, Tanus-Santos JE.

Clin Chim Acta. 2008 Aug;394(1-2):72-6. doi: 10.1016/j.cca.2008.04.008. Epub 2008 Apr 12.

PMID:
18455513
23.

Modulation of nitric oxide formation by endothelial nitric oxide synthase gene haplotypes.

Metzger IF, Sertório JT, Tanus-Santos JE.

Free Radic Biol Med. 2007 Sep 15;43(6):987-92. Epub 2007 Jun 15.

PMID:
17697943
24.

eNOS gene T-786C polymorphism modulates atorvastatin-induced increase in blood nitrite.

Nagassaki S, Sertório JT, Metzger IF, Bem AF, Rocha JB, Tanus-Santos JE.

Free Radic Biol Med. 2006 Oct 1;41(7):1044-9. Epub 2006 May 6.

PMID:
16962929
25.

Relationship between systemic nitric oxide metabolites and cyclic GMP in healthy male volunteers.

Metzger IF, Sertorio JT, Tanus-Santos JE.

Acta Physiol (Oxf). 2006 Oct;188(2):123-7.

PMID:
16948799
26.

Endothelial nitric oxide synthase gene haplotypes associated with circulating concentrations of nitric oxide products in healthy men.

Metzger IF, Souza-Costa DC, Marroni AS, Nagassaki S, Desta Z, Flockhart DA, Tanus-Santos JE.

Pharmacogenet Genomics. 2005 Aug;15(8):565-70.

PMID:
16007000
27.

Consistent interethnic differences in the distribution of clinically relevant endothelial nitric oxide synthase genetic polymorphisms.

Marroni AS, Metzger IF, Souza-Costa DC, Nagassaki S, Sandrim VC, Correa RX, Rios-Santos F, Tanus-Santos JE.

Nitric Oxide. 2005 May;12(3):177-82.

PMID:
15797845
28.

eNOS genotype is without effect on circulating nitrite/nitrate level in healthy male population.

Nagassaki S, Metzger IF, Souza-Costa DC, Marroni AS, Uzuelli JA, Tanus-Santos JE.

Thromb Res. 2005;115(5):375-9.

PMID:
15733970
29.

l-Arginine attenuates acute pulmonary embolism-induced oxidative stress and pulmonary hypertension.

Souza-Costa DC, Zerbini T, Metzger IF, Rocha JB, Gerlach RF, Tanus-Santos JE.

Nitric Oxide. 2005 Feb;12(1):9-14. Epub 2004 Dec 23.

PMID:
15631942

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