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Gait analysis with wearables predicts conversion to Parkinson's disease.

Del Din S, Elshehabi M, Galna B, Hobert M, Warmerdam E, Suenkel U, Brockmann K, Metzger F, Hansen C, Berg D, Rochester L, Maetzler W.

Ann Neurol. 2019 Jul 11. doi: 10.1002/ana.25548. [Epub ahead of print]


[Open doors in psychiatric hospitals : An overview of empirical findings].

Steinert T, Schreiber L, Metzger FG, Hirsch S.

Nervenarzt. 2019 Jul;90(7):680-689. doi: 10.1007/s00115-019-0738-y. Review. German.


Nerve sprouting capacity in a pharmacologically induced mouse model of spinal muscular atrophy.

Rimer M, Seaberg BL, Yen PF, Lam S, Hastings RL, Lee YI, Thompson WJ, Feng Z, Metzger F, Paushkin S, Ko CP.

Sci Rep. 2019 May 24;9(1):7799. doi: 10.1038/s41598-019-44222-2.


Open doors by fair means: Study protocol for a 3-year prospective controlled study with a quasi-experimental design towards (or to implement) an open Ward policy in acute care units.

Schreiber LK, Metzger FG, Duncker TA, Fallgatter AJ, Steinert T.

BMC Psychiatry. 2019 May 14;19(1):149. doi: 10.1186/s12888-019-2126-3.


"Would You Like to Skype With Your Daughter?": A Qualitative Feasibility Study of Video Telecommunication in a Psychogeriatric Hospital.

Niebler R, Eschweiler GW, Dresler T, Rieger MA, Metzger FG.

Comput Inform Nurs. 2019 Apr;37(4):181-186. doi: 10.1097/CIN.0000000000000534. No abstract available.


Comparison of speed versus complexity effects on the hemodynamic response of the trail making test in block designs.

Rosenbaum D, Blum L, Schweizer P, Fallgatter AJ, Herrmann MJ, Ehlis AC, Metzger FG.

Neurophotonics. 2018 Oct;5(4):045007. doi: 10.1117/1.NPh.5.4.045007. Epub 2018 Dec 8.


Disrupted prefrontal functional connectivity during post-stress adaption in high ruminators.

Rosenbaum D, Hilsendegen P, Thomas M, Haeussinger FB, Nuerk HC, Fallgatter AJ, Nieratschker V, Ehlis AC, Metzger FG.

Sci Rep. 2018 Oct 22;8(1):15588. doi: 10.1038/s41598-018-33777-1.


Enzymes and/or combination of organic acid and essential oils supplementation in pasture-fed free-range laying hens increased the digestibility of nutrients and non-starch polysaccharides.

Iqbal Z, Metzger F, Singh M, Morgan N, Swick RA, Perez-Maldonado RA, M'Sadeq SA, Zentek J, Ruhnke I.

Poult Sci. 2019 Mar 1;98(3):1410-1424. doi: 10.3382/ps/pey479.


Impaired myogenic development, differentiation and function in hESC-derived SMA myoblasts and myotubes.

Hellbach N, Peterson S, Haehnke D, Shankar A, LaBarge S, Pivaroff C, Saenger S, Thomas C, McCarthy K, Ebeling M, Hayhurst Bennett M, Schmidt U, Metzger F.

PLoS One. 2018 Oct 10;13(10):e0205589. doi: 10.1371/journal.pone.0205589. eCollection 2018.


Cholinergic Pathway SNPs and Postural Control in 477 Older Adults.

Arnold C, Schulte C, Moscovich M, Sünkel U, Zaunbrecher L, Metzger F, Gasser T, Eschweiler GW, Hauser AK, Berg D, Maetzler W.

Front Aging Neurosci. 2018 Sep 4;10:260. doi: 10.3389/fnagi.2018.00260. eCollection 2018.


Fungal contamination of wind instruments: Immunological and clinical consequences for musicians.

Soumagne T, Reboux G, Metzger F, Roussel S, Lefebvre A, Penven E, De Vuyst P, Thaon I, Dalphin JC.

Sci Total Environ. 2019 Jan 1;646:727-734. doi: 10.1016/j.scitotenv.2018.07.284. Epub 2018 Jul 25.


Deterioration of executive dysfunction in elderly with REM sleep behavior disorder (RBD).

Lerche S, Machetanz G, Roeben B, Wurster I, Zimmermann M, von Thaler AK, Liepelt-Scarfone I, Eschweiler GW, Fallgatter A, Metzger F, Maetzler W, Berg D, Brockmann K.

Neurobiol Aging. 2018 Oct;70:242-246. doi: 10.1016/j.neurobiolaging.2018.06.029. Epub 2018 Jun 30.


Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 ( SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA).

Ratni H, Ebeling M, Baird J, Bendels S, Bylund J, Chen KS, Denk N, Feng Z, Green L, Guerard M, Jablonski P, Jacobsen B, Khwaja O, Kletzl H, Ko CP, Kustermann S, Marquet A, Metzger F, Mueller B, Naryshkin NA, Paushkin SV, Pinard E, Poirier A, Reutlinger M, Weetall M, Zeller A, Zhao X, Mueller L.

J Med Chem. 2018 Aug 9;61(15):6501-6517. doi: 10.1021/acs.jmedchem.8b00741. Epub 2018 Jul 25.


Neurophysiological correlates of the attention training technique: A component study.

Rosenbaum D, Maier MJ, Hudak J, Metzger FG, Wells A, Fallgatter AJ, Ehlis AC.

Neuroimage Clin. 2018 Jun 18;19:1018-1024. doi: 10.1016/j.nicl.2018.06.021. eCollection 2018.


Assessment of systemic administration of PEGylated IGF-1 in a mouse model of traumatic brain injury.

Sama DM, Carlson SW, Joseph B, Saenger S, Metzger F, Saatman KE.

Restor Neurol Neurosci. 2018;36(4):559-569. doi: 10.3233/RNN-180831.


Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes.

Garcia-Lopez A, Tessaro F, Jonker HRA, Wacker A, Richter C, Comte A, Berntenis N, Schmucki R, Hatje K, Petermann O, Chiriano G, Perozzo R, Sciarra D, Konieczny P, Faustino I, Fournet G, Orozco M, Artero R, Metzger F, Ebeling M, Goekjian P, Joseph B, Schwalbe H, Scapozza L.

Nat Commun. 2018 May 23;9(1):2032. doi: 10.1038/s41467-018-04110-1.


Stress-related dysfunction of the right inferior frontal cortex in high ruminators: An fNIRS study.

Rosenbaum D, Thomas M, Hilsendegen P, Metzger FG, Haeussinger FB, Nuerk HC, Fallgatter AJ, Nieratschker V, Ehlis AC.

Neuroimage Clin. 2018 Feb 24;18:510-517. doi: 10.1016/j.nicl.2018.02.022. eCollection 2018.


Longterm persistence and nonrecurrence of depression treatment in Germany: a four-year retrospective follow-up using linked claims data.

Wagner CJ, Dintsios CM, Metzger FG, L'Hoest H, Marschall U, Stollenwerk B, Stock S.

Int J Methods Psychiatr Res. 2018 Jun;27(2):e1607. doi: 10.1002/mpr.1607. Epub 2018 Feb 15.


Effect of physical activity on cognitive flexibility, depression and RBD in healthy elderly.

Lerche S, Gutfreund A, Brockmann K, Hobert MA, Wurster I, Sünkel U, Eschweiler GW, Metzger FG, Maetzler W, Berg D.

Clin Neurol Neurosurg. 2018 Feb;165:88-93. doi: 10.1016/j.clineuro.2018.01.008. Epub 2018 Jan 9.


Cortical hemodynamic changes during the Trier Social Stress Test: An fNIRS study.

Rosenbaum D, Hilsendegen P, Thomas M, Haeussinger FB, Metzger FG, Nuerk HC, Fallgatter AJ, Nieratschker V, Ehlis AC.

Neuroimage. 2018 May 1;171:107-115. doi: 10.1016/j.neuroimage.2017.12.061. Epub 2017 Dec 20.


Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers.

Sivaramakrishnan M, McCarthy KD, Campagne S, Huber S, Meier S, Augustin A, Heckel T, Meistermann H, Hug MN, Birrer P, Moursy A, Khawaja S, Schmucki R, Berntenis N, Giroud N, Golling S, Tzouros M, Banfai B, Duran-Pacheco G, Lamerz J, Hsiu Liu Y, Luebbers T, Ratni H, Ebeling M, Cléry A, Paushkin S, Krainer AR, Allain FH, Metzger F.

Nat Commun. 2017 Nov 14;8(1):1476. doi: 10.1038/s41467-017-01559-4.


Shifted dynamic interactions between subcortical nuclei and inferior frontal gyri during response preparation in persistent developmental stuttering.

Metzger FL, Auer T, Helms G, Paulus W, Frahm J, Sommer M, Neef NE.

Brain Struct Funct. 2018 Jan;223(1):165-182. doi: 10.1007/s00429-017-1476-1. Epub 2017 Jul 24.


Gait Is Associated with Cognitive Flexibility: A Dual-Tasking Study in Healthy Older People.

Hobert MA, Meyer SI, Hasmann SE, Metzger FG, Suenkel U, Eschweiler GW, Berg D, Maetzler W.

Front Aging Neurosci. 2017 May 24;9:154. doi: 10.3389/fnagi.2017.00154. eCollection 2017.


Altered morphology of the nucleus accumbens in persistent developmental stuttering.

Neef NE, Bütfering C, Auer T, Metzger FL, Euler HA, Frahm J, Paulus W, Sommer M.

J Fluency Disord. 2018 Mar;55:84-93. doi: 10.1016/j.jfludis.2017.04.002. Epub 2017 May 24.


The Connected Steady State Model and the Interdependence of the CSF Proteome and CSF Flow Characteristics.

Metzger F, Mischek D, Stoffers F.

Front Neurosci. 2017 May 19;11:241. doi: 10.3389/fnins.2017.00241. eCollection 2017.


Aberrant functional connectivity in depression as an index of state and trait rumination.

Rosenbaum D, Haipt A, Fuhr K, Haeussinger FB, Metzger FG, Nuerk HC, Fallgatter AJ, Batra A, Ehlis AC.

Sci Rep. 2017 May 19;7(1):2174. doi: 10.1038/s41598-017-02277-z.


Application of the movement disorder society prodromal Parkinson's disease research criteria in 2 independent prospective cohorts.

Pilotto A, Heinzel S, Suenkel U, Lerche S, Brockmann K, Roeben B, Schaeffer E, Wurster I, Yilmaz R, Liepelt-Scarfone I, von Thaler AK, Metzger FG, Eschweiler GW, Postuma RB, Maetzler W, Berg D.

Mov Disord. 2017 Jul;32(7):1025-1034. doi: 10.1002/mds.27035. Epub 2017 May 16.


Discovery of a Novel Class of Survival Motor Neuron 2 Splicing Modifiers for the Treatment of Spinal Muscular Atrophy.

Pinard E, Green L, Reutlinger M, Weetall M, Naryshkin NA, Baird J, Chen KS, Paushkin SV, Metzger F, Ratni H.

J Med Chem. 2017 May 25;60(10):4444-4457. doi: 10.1021/acs.jmedchem.7b00406. Epub 2017 May 4.


PEGylated insulin-like growth factor-I affords protection and facilitates recovery of lost functions post-focal ischemia.

Parker K, Berretta A, Saenger S, Sivaramakrishnan M, Shirley SA, Metzger F, Clarkson AN.

Sci Rep. 2017 Mar 21;7(1):241. doi: 10.1038/s41598-017-00336-z.


First-in-man study with a novel PEGylated recombinant human insulin-like growth factor-I.

Kletzl H, Guenther A, Höflich A, Höflich C, Frystyk J, Staack RF, Schick E, Wandel C, Bleich N, Metzger F.

Growth Horm IGF Res. 2017 Apr;33:9-16. doi: 10.1016/j.ghir.2017.01.001. Epub 2017 Jan 10.


Brain activation in frontotemporal and Alzheimer's dementia: a functional near-infrared spectroscopy study.

Metzger FG, Schopp B, Haeussinger FB, Dehnen K, Synofzik M, Fallgatter AJ, Ehlis AC.

Alzheimers Res Ther. 2016 Dec 8;8(1):56.


Phenotype analysis of male transgenic mice overexpressing mutant IGFBP-2 lacking the Cardin-Weintraub sequence motif: Reduced expression of synaptic markers and myelin basic protein in the brain and a lower degree of anxiety-like behaviour.

Schindler N, Mayer J, Saenger S, Gimsa U, Walz C, Brenmoehl J, Ohde D, Wirthgen E, Tuchscherer A, Russo VC, Frank M, Kirschstein T, Metzger F, Hoeflich A.

Growth Horm IGF Res. 2017 Apr;33:1-8. doi: 10.1016/j.ghir.2016.11.003. Epub 2016 Nov 16.


Functional brain imaging of walking while talking - An fNIRS study.

Metzger FG, Ehlis AC, Haeussinger FB, Schneeweiss P, Hudak J, Fallgatter AJ, Schneider S.

Neuroscience. 2017 Feb 20;343:85-93. doi: 10.1016/j.neuroscience.2016.11.032. Epub 2016 Nov 30.


Cognitive Performance Patterns in Healthy Individuals with Substantia Nigra Hyperechogenicity and Early Parkinson's Disease.

Yilmaz R, Gräber S, Roeben B, Suenkel U, von Thaler AK, Heinzel S, Metzger FG, Eschweiler GW, Maetzler W, Berg D, Liepelt-Scarfone I.

Front Aging Neurosci. 2016 Nov 15;8:271. eCollection 2016.


Dual Tasking for the Differentiation between Depression and Mild Cognitive Impairment.

Metzger FG, Hobert MA, Ehlis AC, Hasmann SE, Hahn T, Eschweiler GW, Berg D, Fallgatter AJ, Maetzler W; TREND Study team.

Front Aging Neurosci. 2016 Oct 13;8:235. eCollection 2016.


Skeletal muscle-specific overexpression of IGFBP-2 promotes a slower muscle phenotype in healthy but not dystrophic mdx mice and does not affect the dystrophic pathology.

Swiderski K, Martins KJ, Chee A, Trieu J, Naim T, Gehrig SM, Baum DM, Brenmoehl J, Chau L, Koopman R, Gregorevic P, Metzger F, Hoeflich A, Lynch GS.

Growth Horm IGF Res. 2016 Oct - Dec;30-31:1-10. doi: 10.1016/j.ghir.2016.07.002. Epub 2016 Jul 29.


Cerebrospinal Fluid Progranulin, but Not Serum Progranulin, Is Reduced in GRN-Negative Frontotemporal Dementia.

Wilke C, Gillardon F, Deuschle C, Hobert MA, Jansen IE, Metzger FG, Heutink P, Gasser T, Maetzler W, Blauwendraat C, Synofzik M.

Neurodegener Dis. 2017;17(2-3):83-88. doi: 10.1159/000448896. Epub 2016 Oct 20.


Prospective longitudinal course of cognition in older subjects with mild parkinsonian signs.

Lerche S, Brockmann K, Pilotto A, Wurster I, Sünkel U, Hobert MA, von Thaler AK, Schulte C, Stoops E, Vanderstichele H, Herbst V, Brix B, Eschweiler GW, Metzger FG, Maetzler W, Berg D.

Alzheimers Res Ther. 2016 Oct 10;8(1):42.


Alpha-, Beta-, and Gamma-synuclein Quantification in Cerebrospinal Fluid by Multiple Reaction Monitoring Reveals Increased Concentrations in Alzheimer's and Creutzfeldt-Jakob Disease but No Alteration in Synucleinopathies.

Oeckl P, Metzger F, Nagl M, von Arnim CA, Halbgebauer S, Steinacker P, Ludolph AC, Otto M.

Mol Cell Proteomics. 2016 Oct;15(10):3126-3138. Epub 2016 Aug 9.


Erratum: Structural Ultrasound of the Medial Temporal Lobe in Alzheimer's Disease.

Yilmaz R, Pilotto A, Roeben B, Preische O, Suenkel U, Heinzel S, Metzger FG, Laske C, Maetzler W, Berg D.

Ultraschall Med. 2017 Jun;38(3):e16. doi: 10.1055/s-0035-1567111. Epub 2016 Jul 26. No abstract available.


Specific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy.

Ratni H, Karp GM, Weetall M, Naryshkin NA, Paushkin SV, Chen KS, McCarthy KD, Qi H, Turpoff A, Woll MG, Zhang X, Zhang N, Yang T, Dakka A, Vazirani P, Zhao X, Pinard E, Green L, David-Pierson P, Tuerck D, Poirier A, Muster W, Kirchner S, Mueller L, Gerlach I, Metzger F.

J Med Chem. 2016 Jul 14;59(13):6086-100. doi: 10.1021/acs.jmedchem.6b00459. Epub 2016 Jul 6.


Structural Ultrasound of the Medial Temporal Lobe in Alzheimer's Disease.

Yilmaz R, Pilotto A, Roeben B, Preische O, Suenkel U, Heinzel S, Metzger FG, Laske C, Maetzler W, Berg D.

Ultraschall Med. 2017 Jun;38(3):294-300. doi: 10.1055/s-0042-107150. Epub 2016 Jun 7. Erratum in: Ultraschall Med. 2017 Jun;38(3):e16.


[Implementation of auricular acupuncture by the NADA protocol in geriatric patients suffering from major depression : A mixed methods feasibility study].

Geib J, Rieger MA, Joos S, Eschweiler GW, Metzger FG.

Z Gerontol Geriatr. 2017 Jun;50(4):316-324. doi: 10.1007/s00391-016-1047-8. Epub 2016 May 4. German.


Pharmacokinetics, pharmacodynamics, and efficacy of a small-molecule SMN2 splicing modifier in mouse models of spinal muscular atrophy.

Zhao X, Feng Z, Ling KK, Mollin A, Sheedy J, Yeh S, Petruska J, Narasimhan J, Dakka A, Welch EM, Karp G, Chen KS, Metzger F, Ratni H, Lotti F, Tisdale S, Naryshkin NA, Pellizzoni L, Paushkin S, Ko CP, Weetall M.

Hum Mol Genet. 2016 May 15;25(10):1885-1899. Epub 2016 Feb 29.


State-dependent altered connectivity in late-life depression: a functional near-infrared spectroscopy study.

Rosenbaum D, Hagen K, Deppermann S, Kroczek AM, Haeussinger FB, Heinzel S, Berg D, Fallgatter AJ, Metzger FG, Ehlis AC; TREND Study Consortium.

Neurobiol Aging. 2016 Mar;39:57-68. doi: 10.1016/j.neurobiolaging.2015.11.022. Epub 2015 Dec 6.


Depression-related treatment and costs in Germany: Do they change with comorbidity? A claims data analysis.

Wagner CJ, Metzger FG, Sievers C, Marschall U, L'hoest H, Stollenwerk B, Stock S.

J Affect Disord. 2016 Mar 15;193:257-66. doi: 10.1016/j.jad.2015.12.068. Epub 2016 Jan 2.


Pharmacologically induced mouse model of adult spinal muscular atrophy to evaluate effectiveness of therapeutics after disease onset.

Feng Z, Ling KK, Zhao X, Zhou C, Karp G, Welch EM, Naryshkin N, Ratni H, Chen KS, Metzger F, Paushkin S, Weetall M, Ko CP.

Hum Mol Genet. 2016 Mar 1;25(5):964-75. doi: 10.1093/hmg/ddv629. Epub 2016 Jan 11.


Quantitative Western ligand blotting reveals common patterns and differential features of IGFBP-fingerprints in domestic ruminant breeds and species.

Wirthgen E, Höflich C, Spitschak M, Helmer C, Brand B, Langbein J, Metzger F, Hoeflich A.

Growth Horm IGF Res. 2016 Feb;26:42-9. doi: 10.1016/j.ghir.2015.11.001. Epub 2015 Nov 10.


Pilot whole-exome sequencing of a German early-onset Alzheimer's disease cohort reveals a substantial frequency of PSEN2 variants.

Blauwendraat C, Wilke C, Jansen IE, Schulte C, Simón-Sánchez J, Metzger FG, Bender B, Gasser T, Maetzler W, Rizzu P, Heutink P, Synofzik M.

Neurobiol Aging. 2016 Jan;37:208.e11-208.e17. doi: 10.1016/j.neurobiolaging.2015.09.016. Epub 2015 Sep 30.


Dissociation of somatic growth, time of sexual maturity, and life expectancy by overexpression of an RGD-deficient IGFBP-2 variant in female transgenic mice.

Hoeflich A, Reyer A, Ohde D, Schindler N, Brenmoehl J, Spitschak M, Langhammer M, Tuchscherer A, Wirthgen E, Renner-Müller I, Wanke R, Metzger F, Bielohuby M, Wolf E.

Aging Cell. 2016 Feb;15(1):111-7. doi: 10.1111/acel.12413. Epub 2015 Oct 28.

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