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Characterization of the local wound environment following treatment of chronic leg ulcers with SIS wound matrix.

Hodde JP, Hiles MC, Metzger DW.

J Tissue Viability. 2019 Dec 13. pii: S0965-206X(19)30091-9. doi: 10.1016/j.jtv.2019.12.003. [Epub ahead of print]


The bacterial second messenger cyclic di-AMP modulates the competence state in Streptococcus pneumoniae.

Zarrella TM, Yang J, Metzger DW, Bai G.

J Bacteriol. 2019 Nov 25. pii: JB.00691-19. doi: 10.1128/JB.00691-19. [Epub ahead of print]


Evaluation of Pneumococcal Surface Protein A as a Vaccine Antigen against Secondary Streptococcus pneumoniae Challenge during Influenza A Infection.

Roberts S, Williams CM, Salmon SL, Bonin JL, Metzger DW, Furuya Y.

Vaccines (Basel). 2019 Oct 11;7(4). pii: E146. doi: 10.3390/vaccines7040146.


Compartmentalized effects of aging on group 2 innate lymphoid cell development and function.

D'Souza SS, Shen X, Fung ITH, Ye L, Kuentzel M, Chittur SV, Furuya Y, Siebel CW, Maillard IP, Metzger DW, Yang Q.

Aging Cell. 2019 Dec;18(6):e13019. doi: 10.1111/acel.13019. Epub 2019 Aug 20.


Allergic Airway Disease Prevents Lethal Synergy of Influenza A Virus-Streptococcus pneumoniae Coinfection.

Roberts S, Salmon SL, Steiner DJ, Williams CM, Metzger DW, Furuya Y.

mBio. 2019 Jul 2;10(4). pii: e01335-19. doi: 10.1128/mBio.01335-19.


Topical application of nebulized human IgG, IgA and IgAM in the lungs of rats and non-human primates.

Vonarburg C, Loetscher M, Spycher MO, Kropf A, Illi M, Salmon S, Roberts S, Steinfuehrer K, Campbell I, Koernig S, Bain J, Edler M, Baumann U, Miescher S, Metzger DW, Schaub A, Käsermann F, Zuercher AW.

Respir Res. 2019 May 22;20(1):99. doi: 10.1186/s12931-019-1057-3.


Influenza and Staphylococcus aureus Coinfection: TLR9 at Play.

Sun K, Metzger DW.

Trends Microbiol. 2019 May;27(5):383-384. doi: 10.1016/j.tim.2019.02.006. Epub 2019 Mar 11.


Effects of Influenza on Alveolar Macrophage Viability Are Dependent on Mouse Genetic Strain.

Califano D, Furuya Y, Metzger DW.

J Immunol. 2018 Jul 1;201(1):134-144. doi: 10.4049/jimmunol.1701406. Epub 2018 May 14.


Influenza Vaccination Protects Against Pandemic H1N1 Infection in Sickle Cell Disease Mice.

Roberts S, Metzger DW, Szczepanek SM.

Viral Immunol. 2018 Jul/Aug;31(6):470-471. doi: 10.1089/vim.2018.0024. Epub 2018 Apr 24.


Stress Suppressor Screening Leads to Detection of Regulation of Cyclic di-AMP Homeostasis by a Trk Family Effector Protein in Streptococcus pneumoniae.

Zarrella TM, Metzger DW, Bai G.

J Bacteriol. 2018 May 24;200(12). pii: e00045-18. doi: 10.1128/JB.00045-18. Print 2018 Jun 15.


Detrimental Influence of Alveolar Macrophages on Protective Humoral Immunity during Francisella tularensis SchuS4 Pulmonary Infection.

Steiner DJ, Furuya Y, Metzger DW.

Infect Immun. 2018 Mar 22;86(4). pii: e00787-17. doi: 10.1128/IAI.00787-17. Print 2018 Apr.


Defective anti-polysaccharide IgG vaccine responses in IgA deficient mice.

Furuya Y, Kirimanjeswara GS, Roberts S, Racine R, Wilson-Welder J, Sanfilippo AM, Salmon SL, Metzger DW.

Vaccine. 2017 Sep 5;35(37):4997-5005. doi: 10.1016/j.vaccine.2017.07.071. Epub 2017 Jul 31.


IFN-γ increases susceptibility to influenza A infection through suppression of group II innate lymphoid cells.

Califano D, Furuya Y, Roberts S, Avram D, McKenzie ANJ, Metzger DW.

Mucosal Immunol. 2018 Jan;11(1):209-219. doi: 10.1038/mi.2017.41. Epub 2017 May 17.


Protective Role for Macrophages in Respiratory Francisella tularensis Infection.

Steiner DJ, Furuya Y, Jordan MB, Metzger DW.

Infect Immun. 2017 May 23;85(6). pii: e00064-17. doi: 10.1128/IAI.00064-17. Print 2017 Jun.


Nox2-derived oxidative stress results in inefficacy of antibiotics against post-influenza S. aureus pneumonia.

Sun K, Yajjala VK, Bauer C, Talmon GA, Fischer KJ, Kielian T, Metzger DW.

J Exp Med. 2016 Aug 22;213(9):1851-64. doi: 10.1084/jem.20150514. Epub 2016 Aug 15.


Intestinal Interleukin-17 Receptor Signaling Mediates Reciprocal Control of the Gut Microbiota and Autoimmune Inflammation.

Kumar P, Monin L, Castillo P, Elsegeiny W, Horne W, Eddens T, Vikram A, Good M, Schoenborn AA, Bibby K, Montelaro RC, Metzger DW, Gulati AS, Kolls JK.

Immunity. 2016 Mar 15;44(3):659-671. doi: 10.1016/j.immuni.2016.02.007.


Poor Long-Term Efficacy of Prevnar-13 in Sickle Cell Disease Mice Is Associated with an Inability to Sustain Pneumococcal-Specific Antibody Titers.

Szczepanek SM, Roberts S, Rogers K, Cotte C, Adami AJ, Bracken SJ, Salmon S, Secor ER Jr, Thrall RS, Andemariam B, Metzger DW.

PLoS One. 2016 Feb 24;11(2):e0149261. doi: 10.1371/journal.pone.0149261. eCollection 2016.


Role of Maternal Dietary Peanut Exposure in Development of Food Allergy and Oral Tolerance.

Järvinen KM, Westfall J, De Jesus M, Mantis NJ, Carroll JA, Metzger DW, Sampson HA, Berin MC.

PLoS One. 2015 Dec 10;10(12):e0143855. doi: 10.1371/journal.pone.0143855. eCollection 2015.


Prevention of Influenza Virus-Induced Immunopathology by TGF-β Produced during Allergic Asthma.

Furuya Y, Furuya AK, Roberts S, Sanfilippo AM, Salmon SL, Metzger DW.

PLoS Pathog. 2015 Sep 25;11(9):e1005180. doi: 10.1371/journal.ppat.1005180. eCollection 2015 Sep.


Role of Interleukin-12 in Protection against Pulmonary Infection with Methicillin-Resistant Staphylococcus aureus.

Nguyen QT, Furuya Y, Roberts S, Metzger DW.

Antimicrob Agents Chemother. 2015 Oct;59(10):6308-16. doi: 10.1128/AAC.00968-15. Epub 2015 Jul 27.


Border Patrol Gone Awry: Lung NKT Cell Activation by Francisella tularensis Exacerbates Tularemia-Like Disease.

Hill TM, Gilchuk P, Cicek BB, Osina MA, Boyd KL, Durrant DM, Metzger DW, Khanna KM, Joyce S.

PLoS Pathog. 2015 Jun 11;11(6):e1004975. doi: 10.1371/journal.ppat.1004975. eCollection 2015 Jun.


Alarmin function of galectin-9 in murine respiratory tularemia.

Steichen AL, Simonson TJ, Salmon SL, Metzger DW, Mishra BB, Sharma J.

PLoS One. 2015 Apr 21;10(4):e0123573. doi: 10.1371/journal.pone.0123573. eCollection 2015.


Limited Efficacy of Antibacterial Vaccination Against Secondary Serotype 3 Pneumococcal Pneumonia Following Influenza Infection.

Metzger DW, Furuya Y, Salmon SL, Roberts S, Sun K.

J Infect Dis. 2015 Aug 1;212(3):445-52. doi: 10.1093/infdis/jiv066. Epub 2015 Feb 3.


Expression of suppressor of cytokine signaling 1 (SOCS1) impairs viral clearance and exacerbates lung injury during influenza infection.

Sun K, Salmon S, Yajjala VK, Bauer C, Metzger DW.

PLoS Pathog. 2014 Dec 11;10(12):e1004560. doi: 10.1371/journal.ppat.1004560. eCollection 2014 Dec.


Host-pathogen interactions and immune evasion strategies in Francisella tularensis pathogenicity.

Steiner DJ, Furuya Y, Metzger DW.

Infect Drug Resist. 2014 Sep 18;7:239-51. doi: 10.2147/IDR.S53700. eCollection 2014. Review.


Detection of cyclic di-AMP using a competitive ELISA with a unique pneumococcal cyclic di-AMP binding protein.

Underwood AJ, Zhang Y, Metzger DW, Bai G.

J Microbiol Methods. 2014 Dec;107:58-62. doi: 10.1016/j.mimet.2014.08.026. Epub 2014 Sep 16.


Does Type I Interferon Limit Protective Neutrophil Responses during Pulmonary Francisella Tularensis Infection?

Furuya Y, Steiner D, Metzger DW.

Front Immunol. 2014 Jul 23;5:355. doi: 10.3389/fimmu.2014.00355. eCollection 2014. Review. No abstract available.


Asthma increases susceptibility to heterologous but not homologous secondary influenza.

Furuya Y, Roberts S, Hurteau GJ, Sanfilippo AM, Racine R, Metzger DW.

J Virol. 2014 Aug;88(16):9166-81. doi: 10.1128/JVI.00265-14. Epub 2014 Jun 4.


Use and misuse of statistical significance in survival analyses.

Furuya Y, Wijesundara DK, Neeman T, Metzger DW.

mBio. 2014 Mar 4;5(2):e00904-14. doi: 10.1128/mBio.00904-14. No abstract available.


Cyclic di-AMP impairs potassium uptake mediated by a cyclic di-AMP binding protein in Streptococcus pneumoniae.

Bai Y, Yang J, Zarrella TM, Zhang Y, Metzger DW, Bai G.

J Bacteriol. 2014 Feb;196(3):614-23. doi: 10.1128/JB.01041-13. Epub 2013 Nov 22.


Two DHH subfamily 1 proteins in Streptococcus pneumoniae possess cyclic di-AMP phosphodiesterase activity and affect bacterial growth and virulence.

Bai Y, Yang J, Eisele LE, Underwood AJ, Koestler BJ, Waters CM, Metzger DW, Bai G.

J Bacteriol. 2013 Nov;195(22):5123-32. doi: 10.1128/JB.00769-13. Epub 2013 Sep 6.


Immune dysfunction and bacterial coinfections following influenza.

Metzger DW, Sun K.

J Immunol. 2013 Sep 1;191(5):2047-52. doi: 10.4049/jimmunol.1301152. Review.


Deletion of arcD in Streptococcus pneumoniae D39 impairs its capsule and attenuates virulence.

Gupta R, Yang J, Dong Y, Swiatlo E, Zhang JR, Metzger DW, Bai G.

Infect Immun. 2013 Oct;81(10):3903-11. doi: 10.1128/IAI.00778-13. Epub 2013 Aug 5.


Increased susceptibility of IgA-deficient mice to pulmonary Francisella tularensis live vaccine strain infection.

Furuya Y, Kirimanjeswara GS, Roberts S, Metzger DW.

Infect Immun. 2013 Sep;81(9):3434-41. doi: 10.1128/IAI.00408-13. Epub 2013 Jul 8.


Identification of a live attenuated vaccine candidate for tularemia prophylaxis.

Mahawar M, Rabadi SM, Banik S, Catlett SV, Metzger DW, Malik M, Bakshi CS.

PLoS One. 2013 Apr 17;8(4):e61539. doi: 10.1371/journal.pone.0061539. Print 2013.


Differing effects of interleukin-10 on cutaneous and pulmonary Francisella tularensis live vaccine strain infection.

Metzger DW, Salmon SL, Kirimanjeswara G.

Infect Immun. 2013 Jun;81(6):2022-7. doi: 10.1128/IAI.00024-13. Epub 2013 Mar 25.


Galectin-3 functions as an alarmin: pathogenic role for sepsis development in murine respiratory tularemia.

Mishra BB, Li Q, Steichen AL, Binstock BJ, Metzger DW, Teale JM, Sharma J.

PLoS One. 2013;8(3):e59616. doi: 10.1371/journal.pone.0059616. Epub 2013 Mar 20.


The vitamin B₆ biosynthesis pathway in Streptococcus pneumoniae is controlled by pyridoxal 5'-phosphate and the transcription factor PdxR and has an impact on ear infection.

El Qaidi S, Yang J, Zhang JR, Metzger DW, Bai G.

J Bacteriol. 2013 May;195(10):2187-96. doi: 10.1128/JB.00041-13. Epub 2013 Mar 8.


IgA is important for clearance and critical for protection from rotavirus infection.

Blutt SE, Miller AD, Salmon SL, Metzger DW, Conner ME.

Mucosal Immunol. 2012 Nov;5(6):712-9. doi: 10.1038/mi.2012.51. Epub 2012 Jun 27.


Identification of a novel Francisella tularensis factor required for intramacrophage survival and subversion of innate immune response.

Mahawar M, Atianand MK, Dotson RJ, Mora V, Rabadi SM, Metzger DW, Huntley JF, Harton JA, Malik M, Bakshi CS.

J Biol Chem. 2012 Jul 20;287(30):25216-29. doi: 10.1074/jbc.M112.367672. Epub 2012 May 31.


Rational design of pathogen-mimicking amphiphilic materials as nanoadjuvants.

Ulery BD, Petersen LK, Phanse Y, Kong CS, Broderick SR, Kumar D, Ramer-Tait AE, Carrillo-Conde B, Rajan K, Wannemuehler MJ, Bellaire BH, Metzger DW, Narasimhan B.

Sci Rep. 2011;1:198. doi: 10.1038/srep00198. Epub 2011 Dec 16.


Intranasal administration of an inactivated Yersinia pestis vaccine with interleukin-12 generates protective immunity against pneumonic plague.

Kumar D, Kirimanjeswara G, Metzger DW.

Clin Vaccine Immunol. 2011 Nov;18(11):1925-35. doi: 10.1128/CVI.05117-11. Epub 2011 Aug 31.


Identification of Francisella tularensis outer membrane protein A (FopA) as a protective antigen for tularemia.

Hickey AJ, Hazlett KR, Kirimanjeswara GS, Metzger DW.

Vaccine. 2011 Sep 16;29(40):6941-7. doi: 10.1016/j.vaccine.2011.07.075. Epub 2011 Jul 29.


Design of a protective single-dose intranasal nanoparticle-based vaccine platform for respiratory infectious diseases.

Ulery BD, Kumar D, Ramer-Tait AE, Metzger DW, Wannemuehler MJ, Narasimhan B.

PLoS One. 2011 Mar 3;6(3):e17642. doi: 10.1371/journal.pone.0017642.


Seasonal FluMist vaccination induces cross-reactive T cell immunity against H1N1 (2009) influenza and secondary bacterial infections.

Sun K, Ye J, Perez DR, Metzger DW.

J Immunol. 2011 Jan 15;186(2):987-93. doi: 10.4049/jimmunol.1002664. Epub 2010 Dec 15.


Interleukin-12 as an adjuvant for induction of protective antibody responses.

Metzger DW.

Cytokine. 2010 Oct-Nov;52(1-2):102-7. doi: 10.1016/j.cyto.2010.06.011. Epub 2010 Jul 22. Review.

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