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Items: 1 to 50 of 294

1.

Discovery of Clinical Candidate (1R,4r)-4-((R)-2-((S)-6-Fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol (Navoximod), a Potent and Selective Inhibitor of Indoleamine 2,3-Dioxygenase 1.

Kumar S, Waldo JP, Jaipuri FA, Marcinowicz A, Van Allen C, Adams J, Kesharwani T, Zhang X, Metz R, Oh AJ, Harris SF, Mautino MR.

J Med Chem. 2019 Jul 25;62(14):6705-6733. doi: 10.1021/acs.jmedchem.9b00662. Epub 2019 Jul 2.

PMID:
31264862
2.

IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation.

Metz R, Smith C, DuHadaway JB, Chandler P, Baban B, Merlo LMF, Pigott E, Keough MP, Rust S, Mellor AL, Mandik-Nayak L, Muller AJ, Prendergast GC.

Int Immunol. 2019 Mar 5;31(3):181-182. doi: 10.1093/intimm/dxz003. No abstract available.

PMID:
31222337
3.

Vibrational Spectroscopy of Cr+(NH3) n ( n = 1-6) Reveals Coordination and Hydrogen-Bonding Motifs.

Kozubal J, Heck TR, Metz RB.

J Phys Chem A. 2019 Jun 13;123(23):4929-4936. doi: 10.1021/acs.jpca.9b03196. Epub 2019 May 31.

PMID:
31117597
4.

Probing Reactivity of Gold Atoms with Acetylene and Ethylene with VUV Photoionization Mass Spectrometry and Ab Initio Studies.

Metz RB, Altinay G, Kostko O, Ahmed M.

J Phys Chem A. 2019 Mar 21;123(11):2194-2202. doi: 10.1021/acs.jpca.8b12560. Epub 2019 Mar 7.

PMID:
30807163
5.

Bond dissociation energy and electronic spectroscopy of Cr+(NH3) and its isotopomers.

Ashraf MA, Kozubal J, Metz RB.

J Chem Phys. 2018 Nov 7;149(17):174301. doi: 10.1063/1.5053691.

PMID:
30408968
6.

Photofragment Imaging, Spectroscopy, and Theory of MnO.

Johnston MD, Gentry MR, Metz RB.

J Phys Chem A. 2018 Oct 11;122(40):8047-8053. doi: 10.1021/acs.jpca.8b07849. Epub 2018 Oct 2.

PMID:
30226771
7.

Horse Y chromosome assembly displays unique evolutionary features and putative stallion fertility genes.

Janečka JE, Davis BW, Ghosh S, Paria N, Das PJ, Orlando L, Schubert M, Nielsen MK, Stout TAE, Brashear W, Li G, Johnson CD, Metz RP, Zadjali AMA, Love CC, Varner DD, Bellott DW, Murphy WJ, Chowdhary BP, Raudsepp T.

Nat Commun. 2018 Jul 27;9(1):2945. doi: 10.1038/s41467-018-05290-6.

8.

Aortic arch thrombus caused by nitrous oxide abuse.

den Uil SH, Vermeulen EGJ, Metz R, Rijbroek A, de Vries M.

J Vasc Surg Cases Innov Tech. 2018 Apr 12;4(2):80-82. doi: 10.1016/j.jvscit.2018.01.001. eCollection 2018 Jun.

9.

Photofragment imaging and electronic spectroscopy of Al2.

Johnston MD, Lockwood SP, Metz RB.

J Chem Phys. 2018 Jun 7;148(21):214308. doi: 10.1063/1.5034353.

PMID:
29884057
10.

The relationship of gross upper and lower limb motor competence to measures of health and fitness in adolescents aged 13-14 years.

Weedon BD, Liu F, Mahmoud W, Metz R, Beunder K, Delextrat A, Morris MG, Esser P, Collett J, Meaney A, Howells K, Dawes H.

BMJ Open Sport Exerc Med. 2018 Mar 8;4(1):e000288. doi: 10.1136/bmjsem-2017-000288. eCollection 2018.

11.

PER2 regulation of mammary gland development.

McQueen CM, Schmitt EE, Sarkar TR, Elswood J, Metz RP, Earnest D, Rijnkels M, Porter WW.

Development. 2018 Mar 14;145(6). pii: dev157966. doi: 10.1242/dev.157966.

12.

A velocity map imaging mass spectrometer for photofragments of fast ion beams.

Johnston MD, Pearson WL 3rd, Wang G, Metz RB.

Rev Sci Instrum. 2018 Jan;89(1):014102. doi: 10.1063/1.5012896.

PMID:
29390723
13.

Does Posterior Fixation of Partially Unstable Open-Book Pelvic Ring Injuries Decrease Symphyseal Plate Failure? A Biomechanical Study.

Metz RM, Bledsoe JG, Moed BR.

J Orthop Trauma. 2018 Feb;32 Suppl 1:S18-S24. doi: 10.1097/BOT.0000000000001083.

PMID:
29373447
14.

Investigation of the Tissue Distribution and Physiological Roles of Indoleamine 2,3-Dioxygenase-2.

Jusof FF, Bakmiwewa SM, Weiser S, Too LK, Metz R, Prendergast GC, Fraser ST, Hunt NH, Ball HJ.

Int J Tryptophan Res. 2017 Oct 9;10:1178646917735098. doi: 10.1177/1178646917735098. eCollection 2017.

15.

Annotated Draft Genome Assemblies for the Northern Bobwhite (Colinus virginianus) and the Scaled Quail (Callipepla squamata) Reveal Disparate Estimates of Modern Genome Diversity and Historic Effective Population Size.

Oldeschulte DL, Halley YA, Wilson ML, Bhattarai EK, Brashear W, Hill J, Metz RP, Johnson CD, Rollins D, Peterson MJ, Bickhart DM, Decker JE, Sewell JF, Seabury CM.

G3 (Bethesda). 2017 Sep 7;7(9):3047-3058. doi: 10.1534/g3.117.043083.

16.

Vibrational Spectroscopy of Fe3+(CH4)n (n = 1-3) and Fe4+(CH4)4.

Copeland CW, Ashraf MA, Boyle EM, Metz RB.

J Phys Chem A. 2017 Mar 16;121(10):2132-2137. doi: 10.1021/acs.jpca.6b13074. Epub 2017 Mar 6.

PMID:
28241732
17.

Translational control of lipogenic enzymes in the cell cycle of synchronous, growing yeast cells.

Blank HM, Perez R, He C, Maitra N, Metz R, Hill J, Lin Y, Johnson CD, Bankaitis VA, Kennedy BK, Aramayo R, Polymenis M.

EMBO J. 2017 Feb 15;36(4):487-502. doi: 10.15252/embj.201695050. Epub 2017 Jan 5.

18.

Circadian Regulation of Benzo[a]Pyrene Metabolism and DNA Adduct Formation in Breast Cells and the Mouse Mammary Gland.

Schmitt EE, Barhoumi R, Metz RP, Porter WW.

Mol Pharmacol. 2017 Mar;91(3):178-188. doi: 10.1124/mol.116.106740. Epub 2016 Dec 22.

19.

Tolerance to Ethanol or Nicotine Results in Increased Ethanol Self-Administration and Long-Term Depression in the Dorsolateral Striatum.

Abburi C, Wolfman SL, Metz RA, Kamber R, McGehee DS, McDaid J.

eNeuro. 2016 Aug 4;3(4). pii: ENEURO.0112-15.2016. doi: 10.1523/ENEURO.0112-15.2016. eCollection 2016 Jul-Aug.

20.

Northern Bobwhite (Colinus virginianus) Mitochondrial Population Genomics Reveals Structure, Divergence, and Evidence for Heteroplasmy.

Halley YA, Oldeschulte DL, Bhattarai EK, Hill J, Metz RP, Johnson CD, Presley SM, Ruzicka RE, Rollins D, Peterson MJ, Murphy WJ, Seabury CM.

PLoS One. 2015 Dec 29;10(12):e0144913. doi: 10.1371/journal.pone.0144913. eCollection 2015.

21.

[Projection of prisoner numbers].

Metz R, Sohn W.

Arch Kriminol. 2015 Mar-Apr;235(3-4):80-98. German.

PMID:
26419083
22.

Vibrational Spectroscopy Reveals Varying Structural Motifs in Cu(+)(CH4)(n) and Ag(+)(CH4)(n) (n = 1-6).

Kocak A, Ashraf MA, Metz RB.

J Phys Chem A. 2015 Sep 17;119(37):9653-65. doi: 10.1021/acs.jpca.5b07079. Epub 2015 Sep 2.

PMID:
26305844
23.

Vibrational spectroscopy and theory of Fe2(+)(CH4)(n) (n = 1-3).

Ashraf MA, Copeland CW, Kocak A, McEnroe AR, Metz RB.

Phys Chem Chem Phys. 2015 Oct 21;17(39):25700-4. doi: 10.1039/c5cp01757b.

PMID:
26062433
24.

[Akinetic mutism due to fulminant multilocular cerebral venous thrombosis, including the vein of Galen].

Winkel AS, Diederich NJ, Boulanger T, Metz R.

Fortschr Neurol Psychiatr. 2015 Jan;83(1):44-8. doi: 10.1055/s-0034-1398783. Epub 2015 Jan 20. German.

PMID:
25602191
25.

Human mesenchymal stromal cells suppress T-cell proliferation independent of heme oxygenase-1.

Patel SR, Copland IB, Garcia MA, Metz R, Galipeau J.

Cytotherapy. 2015 Apr;17(4):382-91. doi: 10.1016/j.jcyt.2014.11.010. Epub 2015 Jan 14.

PMID:
25595329
26.

IDO2 in Immunomodulation and Autoimmune Disease.

Prendergast GC, Metz R, Muller AJ, Merlo LM, Mandik-Nayak L.

Front Immunol. 2014 Nov 20;5:585. doi: 10.3389/fimmu.2014.00585. eCollection 2014. Review.

27.

Modulation of RNA polymerase II phosphorylation downstream of pathogen perception orchestrates plant immunity.

Li F, Cheng C, Cui F, de Oliveira MV, Yu X, Meng X, Intorne AC, Babilonia K, Li M, Li B, Chen S, Ma X, Xiao S, Zheng Y, Fei Z, Metz RP, Johnson CD, Koiwa H, Sun W, Li Z, de Souza Filho GA, Shan L, He P.

Cell Host Microbe. 2014 Dec 10;16(6):748-58. doi: 10.1016/j.chom.2014.10.018. Epub 2014 Nov 26.

28.

Stroke awareness in luxemburg: deficit concerning symptoms and risk factors.

Droste DW, Safo J, Metz RJ, Osada N.

Clin Med Insights Cardiol. 2014 Nov 10;8(Suppl 2):9-13. doi: 10.4137/CMC.S15225. eCollection 2014.

29.

Near ultraviolet photodissociation spectroscopy of Mn(+)(H2O) and Mn(+)(D2O).

Pearson WL 3rd, Copeland C, Kocak A, Sallese Z, Metz RB.

J Chem Phys. 2014 Nov 28;141(20):204305. doi: 10.1063/1.4901982.

PMID:
25429940
30.

Regional changes in elastic fiber organization and transforming growth factor β signaling in aortas from a mouse model of marfan syndrome.

Howell DW, Popovic N, Metz RP, Wilson E.

Cell Tissue Res. 2014 Dec;358(3):807-19. doi: 10.1007/s00441-014-1993-7. Epub 2014 Sep 20.

PMID:
25238995
31.

Do workplace health promotion (wellness) programs work?

Goetzel RZ, Henke RM, Tabrizi M, Pelletier KR, Loeppke R, Ballard DW, Grossmeier J, Anderson DR, Yach D, Kelly RK, McCalister T, Serxner S, Selecky C, Shallenberger LG, Fries JF, Baase C, Isaac F, Crighton KA, Wald P, Exum E, Shurney D, Metz RD.

J Occup Environ Med. 2014 Sep;56(9):927-34. doi: 10.1097/JOM.0000000000000276. Review.

PMID:
25153303
32.

Aryl hydrocarbon receptor control of a disease tolerance defence pathway.

Bessede A, Gargaro M, Pallotta MT, Matino D, Servillo G, Brunacci C, Bicciato S, Mazza EM, Macchiarulo A, Vacca C, Iannitti R, Tissi L, Volpi C, Belladonna ML, Orabona C, Bianchi R, Lanz TV, Platten M, Della Fazia MA, Piobbico D, Zelante T, Funakoshi H, Nakamura T, Gilot D, Denison MS, Guillemin GJ, DuHadaway JB, Prendergast GC, Metz R, Geffard M, Boon L, Pirro M, Iorio A, Veyret B, Romani L, Grohmann U, Fallarino F, Puccetti P.

Nature. 2014 Jul 10;511(7508):184-90. doi: 10.1038/nature13323.

33.

Native mitochondrial RNA-binding complexes in kinetoplastid RNA editing differ in guide RNA composition.

Madina BR, Kumar V, Metz R, Mooers BH, Bundschuh R, Cruz-Reyes J.

RNA. 2014 Jul;20(7):1142-52. doi: 10.1261/rna.044495.114. Epub 2014 May 27.

34.

Vibrational spectroscopy of Co⁺(CH₄)n and Ni⁺(CH₄)n (n = 1-4).

Kocak A, Sallese Z, Johnston MD, Metz RB.

J Phys Chem A. 2014 May 8;118(18):3253-65. doi: 10.1021/jp500617n. Epub 2014 Apr 28.

PMID:
24739017
35.

Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer.

Prendergast GC, Smith C, Thomas S, Mandik-Nayak L, Laury-Kleintop L, Metz R, Muller AJ.

Cancer Immunol Immunother. 2014 Jul;63(7):721-35. doi: 10.1007/s00262-014-1549-4. Epub 2014 Apr 8. Review.

36.

IDO2 is a critical mediator of autoantibody production and inflammatory pathogenesis in a mouse model of autoimmune arthritis.

Merlo LMF, Pigott E, DuHadaway JB, Grabler S, Metz R, Prendergast GC, Mandik-Nayak L.

J Immunol. 2014 Mar 1;192(5):2082-2090. doi: 10.4049/jimmunol.1303012. Epub 2014 Jan 31.

37.

IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation.

Metz R, Smith C, DuHadaway JB, Chandler P, Baban B, Merlo LM, Pigott E, Keough MP, Rust S, Mellor AL, Mandik-Nayak L, Muller AJ, Prendergast GC.

Int Immunol. 2014 Jul;26(7):357-67. doi: 10.1093/intimm/dxt073. Epub 2014 Jan 8. Erratum in: Int Immunol. 2019 Mar 5;31(3):181-182.

38.

The SOCS3-independent expression of IDO2 supports the homeostatic generation of T regulatory cells by human dendritic cells.

Trabanelli S, Očadlíková D, Ciciarello M, Salvestrini V, Lecciso M, Jandus C, Metz R, Evangelisti C, Laury-Kleintop L, Romero P, Prendergast GC, Curti A, Lemoli RM.

J Immunol. 2014 Feb 1;192(3):1231-40. doi: 10.4049/jimmunol.1300720. Epub 2014 Jan 3.

39.

CONCURRENT WHOLE BRAIN RADIOTHERAPY AND SHORT-COURSE CHLOROQUINE IN PATIENTS WITH BRAIN METASTASES: A PILOT TRIAL.

Eldredge HB, Denittis A, Duhadaway JB, Chernick M, Metz R, Prendergast GC.

J Radiat Oncol. 2013 Sep 1;2(3). doi: 10.1007/s13566-013-0111-x.

40.

Vacuum ultraviolet photoionization studies of PtCH2 and H-Pt-CH3: a potential energy surface for the Pt+CH4 reaction.

Perera M, Metz RB, Kostko O, Ahmed M.

Angew Chem Int Ed Engl. 2013 Jan 14;52(3):888-91. doi: 10.1002/anie.201207931. Epub 2012 Nov 29. No abstract available.

PMID:
23315902
41.

IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan.

Metz R, Rust S, Duhadaway JB, Mautino MR, Munn DH, Vahanian NN, Link CJ, Prendergast GC.

Oncoimmunology. 2012 Dec 1;1(9):1460-1468.

43.

Ten modifiable health risk factors are linked to more than one-fifth of employer-employee health care spending.

Goetzel RZ, Pei X, Tabrizi MJ, Henke RM, Kowlessar N, Nelson CF, Metz RD.

Health Aff (Millwood). 2012 Nov;31(11):2474-84. doi: 10.1377/hlthaff.2011.0819.

PMID:
23129678
44.

Identification and analysis of the first 2009 pandemic H1N1 influenza virus from U.S. feral swine.

Clavijo A, Nikooienejad A, Esfahani MS, Metz RP, Schwartz S, Atashpaz-Gargari E, Deliberto TJ, Lutman MW, Pedersen K, Bazan LR, Koster LG, Jenkins-Moore M, Swenson SL, Zhang M, Beckham T, Johnson CD, Bounpheng M.

Zoonoses Public Health. 2013 Aug;60(5):327-35. doi: 10.1111/zph.12006. Epub 2012 Sep 17.

PMID:
22978260
45.

Amino acid catabolism: a pivotal regulator of innate and adaptive immunity.

McGaha TL, Huang L, Lemos H, Metz R, Mautino M, Prendergast GC, Mellor AL.

Immunol Rev. 2012 Sep;249(1):135-57. doi: 10.1111/j.1600-065X.2012.01149.x. Review.

46.

Dissociation energy and electronic and vibrational spectroscopy of Co(+)(H2O) and its isotopomers.

Kocak A, Austein-Miller G, Pearson WL 3rd, Altinay G, Metz RB.

J Phys Chem A. 2013 Feb 14;117(6):1254-64. doi: 10.1021/jp305673t. Epub 2012 Aug 10.

PMID:
22835001
47.

IDO is a nodal pathogenic driver of lung cancer and metastasis development.

Smith C, Chang MY, Parker KH, Beury DW, DuHadaway JB, Flick HE, Boulden J, Sutanto-Ward E, Soler AP, Laury-Kleintop LD, Mandik-Nayak L, Metz R, Ostrand-Rosenberg S, Prendergast GC, Muller AJ.

Cancer Discov. 2012 Aug;2(8):722-35. doi: 10.1158/2159-8290.CD-12-0014. Epub 2012 Jul 19.

48.

Treatment of post-implantation aneurysm growth by laparoscopic sac fenestration: long-term results.

Voûte MT, Bastos Gonçalves FM, Hendriks JM, Metz R, van Sambeek MR, Muhs BE, Verhagen HJ.

Eur J Vasc Endovasc Surg. 2012 Jul;44(1):40-4. doi: 10.1016/j.ejvs.2012.04.022. Epub 2012 May 22.

49.

[Actual state and prospects of acute stroke treatment in the Grand-Duchy of Luxemburg].

Droste DW, Metz R.

Bull Soc Sci Med Grand Duche Luxemb. 2011;(2):25-33. German.

PMID:
22272443
50.

Vascular smooth muscle cells: isolation, culture, and characterization.

Metz RP, Patterson JL, Wilson E.

Methods Mol Biol. 2012;843:169-76. doi: 10.1007/978-1-61779-523-7_16.

PMID:
22222531

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