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Items: 1 to 50 of 68

1.

Pharmacokinetics, pharmacodynamics, and safety of a prostaglandin D2 receptor antagonist.

Lai E, Wenning LA, Crumley TM, De Lepeleire I, Liu F, de Hoon JN, Van Hecken A, Depré M, Hilliard D, Greenberg H, O'Neill G, Metters K, Gottesdiener KG, Wagner JA.

Clin Pharmacol Ther. 2008 Jun;83(6):840-7. Epub 2007 Sep 19.

PMID:
17882161
2.

Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524).

Sturino CF, O'Neill G, Lachance N, Boyd M, Berthelette C, Labelle M, Li L, Roy B, Scheigetz J, Tsou N, Aubin Y, Bateman KP, Chauret N, Day SH, Lévesque JF, Seto C, Silva JH, Trimble LA, Carriere MC, Denis D, Greig G, Kargman S, Lamontagne S, Mathieu MC, Sawyer N, Slipetz D, Abraham WM, Jones T, McAuliffe M, Piechuta H, Nicoll-Griffith DA, Wang Z, Zamboni R, Young RN, Metters KM.

J Med Chem. 2007 Feb 22;50(4):794-806.

PMID:
17300164
3.

Comparison between two classes of selective EP(3) antagonists and their biological activities.

Belley M, Chan CC, Gareau Y, Gallant M, Juteau H, Houde K, Lachance N, Labelle M, Sawyer N, Tremblay N, Lamontagne S, Carrière MC, Denis D, Greig GM, Slipetz D, Gordon R, Chauret N, Li C, Zamboni RJ, Metters KM.

Bioorg Med Chem Lett. 2006 Nov 1;16(21):5639-42. Epub 2006 Aug 22.

PMID:
16931013
4.

Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans.

Cheng K, Wu TJ, Wu KK, Sturino C, Metters K, Gottesdiener K, Wright SD, Wang Z, O'Neill G, Lai E, Waters MG.

Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6682-7. Epub 2006 Apr 14.

5.

Identification of an indole series of prostaglandin D2 receptor antagonists.

Sturino CF, Lachance N, Boyd M, Berthelette C, Labelle M, Li L, Roy B, Scheigetz J, Tsou N, Brideau C, Cauchon E, Carriere MC, Denis D, Greig G, Kargman S, Lamontagne S, Mathieu MC, Sawyer N, Slipetz D, O'Neill G, Wang Z, Zamboni R, Metters KM, Young RN.

Bioorg Med Chem Lett. 2006 Jun 1;16(11):3043-8. Epub 2006 Mar 10.

PMID:
16529930
6.

2,3-Diarylthiophenes as selective EP1 receptor antagonists.

Ducharme Y, Blouin M, Carrière MC, Chateauneuf A, Côté B, Denis D, Frenette R, Greig G, Kargman S, Lamontagne S, Martins E, Nantel F, O'Neill G, Sawyer N, Metters KM, Friesen RW.

Bioorg Med Chem Lett. 2005 Feb 15;15(4):1155-60.

PMID:
15686932
7.

Structure-activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP(3) antagonists.

Belley M, Gallant M, Roy B, Houde K, Lachance N, Labelle M, Trimble LA, Chauret N, Li C, Sawyer N, Tremblay N, Lamontagne S, Carrière MC, Denis D, Greig GM, Slipetz D, Metters KM, Gordon R, Chan CC, Zamboni RJ.

Bioorg Med Chem Lett. 2005 Feb 1;15(3):527-30.

PMID:
15664806
8.

Expression of prostaglandin D synthase and the prostaglandin D2 receptors DP and CRTH2 in human nasal mucosa.

Nantel F, Fong C, Lamontagne S, Wright DH, Giaid A, Desrosiers M, Metters KM, O'Neill GP, Gervais FG.

Prostaglandins Other Lipid Mediat. 2004 Jan;73(1-2):87-101.

PMID:
15165034
9.

Structure-activity relationship of triaryl propionic acid analogues on the human EP3 prostanoid receptor.

Gallant M, Belley M, Carrière MC, Chateauneuf A, Denis D, Lachance N, Lamontagne S, Metters KM, Sawyer N, Slipetz D, Truchon JF, Labelle M.

Bioorg Med Chem Lett. 2003 Nov 3;13(21):3813-6.

PMID:
14552786
10.

Discovery of a potent and selective agonist of the prostaglandin EP4 receptor.

Billot X, Chateauneuf A, Chauret N, Denis D, Greig G, Mathieu MC, Metters KM, Slipetz DM, Young RN.

Bioorg Med Chem Lett. 2003 Mar 24;13(6):1129-32.

PMID:
12643927
11.

Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2.

Sawyer N, Cauchon E, Chateauneuf A, Cruz RP, Nicholson DW, Metters KM, O'Neill GP, Gervais FG.

Br J Pharmacol. 2002 Dec;137(8):1163-72.

12.

Structure-activity relationship of biaryl acylsulfonamide analogues on the human EP(3) prostanoid receptor.

Gallant M, Carrière MC, Chateauneuf A, Denis D, Gareau Y, Godbout C, Greig G, Juteau H, Lachance N, Lacombe P, Lamontagne S, Metters KM, Rochette C, Ruel R, Slipetz D, Sawyer N, Tremblay N, Labelle M.

Bioorg Med Chem Lett. 2002 Sep 16;12(18):2583-6.

PMID:
12182865
13.

Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP.

Gervais FG, Cruz RP, Chateauneuf A, Gale S, Sawyer N, Nantel F, Metters KM, O'neill GP.

J Allergy Clin Immunol. 2001 Dec;108(6):982-8.

PMID:
11742277
14.

Localization of phosphodiesterase-4 isoforms in the medulla and nodose ganglion of the squirrel monkey.

Lamontagne S, Meadows E, Luk P, Normandin D, Muise E, Boulet L, Pon DJ, Robichaud A, Robertson GS, Metters KM, Nantel F.

Brain Res. 2001 Nov 30;920(1-2):84-96.

PMID:
11716814
15.

Sequestration and phosphorylation of the prostaglandin E2 EP4 receptor: dependence on the C-terminal tail.

Slipetz D, Buchanan S, Mackereth C, Brewer N, Pellow V, Hao C, Adam M, Abramovitz M, Metters KM.

Biochem Pharmacol. 2001 Oct 15;62(8):997-1012.

PMID:
11597569
16.

Structure-activity relationship of cinnamic acylsulfonamide analogues on the human EP3 prostanoid receptor.

Juteau H, Gareau Y, Labelle M, Sturino CF, Sawyer N, Tremblay N, Lamontagne S, Carrière MC, Denis D, Metters KM.

Bioorg Med Chem. 2001 Aug;9(8):1977-84.

PMID:
11504634
17.

Prostaglandin receptor EP(4) mediates the bone anabolic effects of PGE(2).

Machwate M, Harada S, Leu CT, Seedor G, Labelle M, Gallant M, Hutchins S, Lachance N, Sawyer N, Slipetz D, Metters KM, Rodan SB, Young R, Rodan GA.

Mol Pharmacol. 2001 Jul;60(1):36-41. Erratum in: Mol Pharmacol. 2003 Jul;64(1):192.

PMID:
11408598
18.

The anticonvulsant, antihyperalgesic agent gabapentin is an agonist at brain gamma-aminobutyric acid type B receptors negatively coupled to voltage-dependent calcium channels.

Bertrand S, Ng GY, Purisai MG, Wolfe SE, Severidt MW, Nouel D, Robitaille R, Low MJ, O'Neill GP, Metters K, Lacaille JC, Chronwall BM, Morris SJ.

J Pharmacol Exp Ther. 2001 Jul;298(1):15-24.

PMID:
11408520
19.

Key structural features of prostaglandin E(2) and prostanoid analogs involved in binding and activation of the human EP(1) prostanoid receptor.

Ungrin MD, Carrière MC, Denis D, Lamontagne S, Sawyer N, Stocco R, Tremblay N, Metters KM, Abramovitz M.

Mol Pharmacol. 2001 Jun;59(6):1446-56.

PMID:
11353805
20.

Structure-activity relationship on the human EP3 prostanoid receptor by use of solid-support chemistry.

Juteau H, Gareau Y, Labelle M, Lamontagne S, Tremblay N, Carrière MC, Sawyer N, Denis D, Metters KM.

Bioorg Med Chem Lett. 2001 Mar 12;11(5):747-9.

PMID:
11266183
21.

The human prostanoid DP receptor stimulates mucin secretion in LS174T cells.

Wright DH, Ford-Hutchinson AW, Chadee K, Metters KM.

Br J Pharmacol. 2000 Dec;131(8):1537-45.

22.

Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action.

Ng GY, Bertrand S, Sullivan R, Ethier N, Wang J, Yergey J, Belley M, Trimble L, Bateman K, Alder L, Smith A, McKernan R, Metters K, O'Neill GP, Lacaille JC, Hébert TE.

Mol Pharmacol. 2001 Jan;59(1):144-52.

PMID:
11125035
23.

Cellular distribution of prostanoid EP receptors mRNA in the rat gastrointestinal tract.

Northey A, Denis D, Cirino M, Metters KM, Nantel F.

Prostaglandins Other Lipid Mediat. 2000 Jul;62(2):145-56.

PMID:
10938408
24.

Characterization of the human cysteinyl leukotriene 2 receptor.

Heise CE, O'Dowd BF, Figueroa DJ, Sawyer N, Nguyen T, Im DS, Stocco R, Bellefeuille JN, Abramovitz M, Cheng R, Williams DL Jr, Zeng Z, Liu Q, Ma L, Clements MK, Coulombe N, Liu Y, Austin CP, George SR, O'Neill GP, Metters KM, Lynch KR, Evans JF.

J Biol Chem. 2000 Sep 29;275(39):30531-6.

25.

Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor.

Sullivan R, Chateauneuf A, Coulombe N, Kolakowski LF Jr, Johnson MP, Hebert TE, Ethier N, Belley M, Metters K, Abramovitz M, O'Neill GP, Ng GY.

J Pharmacol Exp Ther. 2000 May;293(2):460-7.

PMID:
10773016
26.

The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs.

Abramovitz M, Adam M, Boie Y, Carrière M, Denis D, Godbout C, Lamontagne S, Rochette C, Sawyer N, Tremblay NM, Belley M, Gallant M, Dufresne C, Gareau Y, Ruel R, Juteau H, Labelle M, Ouimet N, Metters KM.

Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93.

PMID:
10634944
27.

Distribution and regulation of cyclooxygenase-2 in carrageenan-induced inflammation.

Nantel F, Denis D, Gordon R, Northey A, Cirino M, Metters KM, Chan CC.

Br J Pharmacol. 1999 Oct;128(4):853-9.

28.

Characterization of the cloned guinea pig leukotriene B4 receptor: comparison to its human orthologue.

Boie Y, Stocco R, Sawyer N, Greig GM, Kargman S, Slipetz DM, O'Neill GP, Shimizu T, Yokomizo T, Metters KM, Abramovitz M.

Eur J Pharmacol. 1999 Sep 10;380(2-3):203-13.

PMID:
10513580
29.

New class of biphenylene dibenzazocinones as potent ligands for the human EP1 prostanoid receptor.

Ruel R, Lacombe P, Abramovitz M, Godbout C, Lamontagne S, Rochette C, Sawyer N, Stocco R, Tremblay NM, Metters KM, Labelle M.

Bioorg Med Chem Lett. 1999 Sep 20;9(18):2699-704.

PMID:
10509919
30.

Immunolocalization of cyclooxygenase-2 in the macula densa of human elderly.

Nantel F, Meadows E, Denis D, Connolly B, Metters KM, Giaid A.

FEBS Lett. 1999 Sep 3;457(3):475-7.

31.

A novel biological role for prostaglandin D2 is suggested by distribution studies of the rat DP prostanoid receptor.

Wright DH, Nantel F, Metters KM, Ford-Hutchinson AW.

Eur J Pharmacol. 1999 Jul 14;377(1):101-15.

PMID:
10448933
32.

Characterization of the human cysteinyl leukotriene CysLT1 receptor.

Lynch KR, O'Neill GP, Liu Q, Im DS, Sawyer N, Metters KM, Coulombe N, Abramovitz M, Figueroa DJ, Zeng Z, Connolly BM, Bai C, Austin CP, Chateauneuf A, Stocco R, Greig GM, Kargman S, Hooks SB, Hosfield E, Williams DL Jr, Ford-Hutchinson AW, Caskey CT, Evans JF.

Nature. 1999 Jun 24;399(6738):789-93.

PMID:
10391245
33.

A series of non-quinoline cysLT1 receptor antagonists: SAR study on pyridyl analogs of Singulair.

Guay D, Gauthier JY, Dufresne C, Jones TR, McAuliffe M, McFarlane C, Metters KM, Prasit P, Rochette C, Roy P, Sawyer N, Zamboni R.

Bioorg Med Chem Lett. 1998 Mar 3;8(5):453-8.

PMID:
9871597
34.

Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist.

Wright DH, Metters KM, Abramovitz M, Ford-Hutchinson AW.

Br J Pharmacol. 1998 Apr;123(7):1317-24.

35.

Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes.

Boie Y, Stocco R, Sawyer N, Slipetz DM, Ungrin MD, Neuschäfer-Rube F, Püschel GP, Metters KM, Abramovitz M.

Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41.

PMID:
9537820
36.

A novel photoaffinity probe for the LTD4 receptor.

Gallant M, Sawyer N, Metters KM, Zamboni RJ.

Bioorg Med Chem. 1998 Jan;6(1):63-72.

PMID:
9502106
37.

Leukotriene receptors.

Metters KM.

J Lipid Mediat Cell Signal. 1995 Oct;12(2-3):413-27. Review.

PMID:
8777583
38.

Molecular cloning and characterization of the human prostanoid DP receptor.

Boie Y, Sawyer N, Slipetz DM, Metters KM, Abramovitz M.

J Biol Chem. 1995 Aug 11;270(32):18910-6.

39.

Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase.

Slipetz DM, O'Neill GP, Favreau L, Dufresne C, Gallant M, Gareau Y, Guay D, Labelle M, Metters KM.

Mol Pharmacol. 1995 Aug;48(2):352-61.

PMID:
7651369
40.

Characterization of specific binding sites for cysteinyl leukotrienes in sheep lung.

Metters KM, Gareau Y, Lord A, Rochette C, Sawyer N.

J Pharmacol Exp Ther. 1994 Jul;270(1):399-406.

PMID:
8035338
41.

Leukotriene D4-induced increases in cytosolic calcium in THP-1 cells: dependence on extracellular calcium and inhibition with selective leukotriene D4 receptor antagonists.

Chan CC, Ecclestone P, Nicholson DW, Metters KM, Pon DJ, Rodger IW.

J Pharmacol Exp Ther. 1994 Jun;269(3):891-6.

PMID:
8014876
42.

Microsomal glutathione S-transferase is the predominant leukotriene C4 binding site in cellular membranes.

Metters KM, Sawyer N, Nicholson DW.

J Biol Chem. 1994 Apr 29;269(17):12816-23.

43.

Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype.

Bastien L, Sawyer N, Grygorczyk R, Metters KM, Adam M.

J Biol Chem. 1994 Apr 22;269(16):11873-7.

44.

Cloning and expression of a cDNA for the human prostanoid IP receptor.

Boie Y, Rushmore TH, Darmon-Goodwin A, Grygorczyk R, Slipetz DM, Metters KM, Abramovitz M.

J Biol Chem. 1994 Apr 22;269(16):12173-8.

45.

Cloning and expression of three isoforms of the human EP3 prostanoid receptor.

Adam M, Boie Y, Rushmore TH, Müller G, Bastien L, McKee KT, Metters KM, Abramovitz M.

FEBS Lett. 1994 Jan 31;338(2):170-4.

46.

Cloning and expression of a cDNA for the human prostanoid FP receptor.

Abramovitz M, Boie Y, Nguyen T, Rushmore TH, Bayne MA, Metters KM, Slipetz DM, Grygorczyk R.

J Biol Chem. 1994 Jan 28;269(4):2632-6.

47.

Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype.

Funk CD, Furci L, FitzGerald GA, Grygorczyk R, Rochette C, Bayne MA, Abramovitz M, Adam M, Metters KM.

J Biol Chem. 1993 Dec 15;268(35):26767-72.

48.

Identification of both NK1 and NK2 receptors in guinea-pig airways.

McKee KT, Millar L, Rodger IW, Metters KM.

Br J Pharmacol. 1993 Oct;110(2):693-700.

49.

Identification and target-size analysis of the leukotriene D4 receptor in the human THP-1 cell line.

Rochette C, Nicholson DW, Metters KM.

Biochim Biophys Acta. 1993 Jun 30;1177(3):283-90.

PMID:
8391851
50.

Photoaffinity labeling of the leukotriene D4 receptor in guinea pig lung.

Metters KM, Zamboni RJ.

J Biol Chem. 1993 Mar 25;268(9):6487-95.

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