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Items: 1 to 50 of 89

1.

Dietary cholesterol is essential to mast cell activation and associated obesity and diabetes in mice.

Zhang X, Huang Q, Wang X, Deng Z, Li J, Yan X, Jauhiainen M, Metso J, Libby P, Liu J, Shi GP.

Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1690-1700. doi: 10.1016/j.bbadis.2019.04.006. Epub 2019 Apr 9.

PMID:
30978390
2.

Human ApoA-I Overexpression Enhances Macrophage-Specific Reverse Cholesterol Transport but Fails to Prevent Inherited Diabesity in Mice.

Méndez-Lara KA, Farré N, Santos D, Rivas-Urbina A, Metso J, Sánchez-Quesada JL, Llorente-Cortes V, Errico TL, Lerma E, Jauhiainen M, Martín-Campos JM, Alonso N, Escolà-Gil JC, Blanco-Vaca F, Julve J.

Int J Mol Sci. 2019 Feb 2;20(3). pii: E655. doi: 10.3390/ijms20030655.

3.

USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages.

Ruuth M, Soronen J, Kaiharju E, Merikanto K, Perttilä J, Metso J, Lee-Rueckert M, Taskinen MR, Kovanen PT, Öörni K, Olkkonen VM, Jauhiainen MS, Laurila PP.

Lipids Health Dis. 2018 Dec 13;17(1):285. doi: 10.1186/s12944-018-0930-2.

4.

Complement Factor H and Apolipoprotein E Participate in Regulation of Inflammation in THP-1 Macrophages.

Nissilä E, Hakala P, Leskinen K, Roig A, Syed S, Van Kessel KPM, Metso J, De Haas CJC, Saavalainen P, Meri S, Chroni A, Van Strijp JAG, Öörni K, Jauhiainen M, Jokiranta TS, Haapasalo K.

Front Immunol. 2018 Nov 21;9:2701. doi: 10.3389/fimmu.2018.02701. eCollection 2018.

5.

Impaired HDL (High-Density Lipoprotein)-Mediated Macrophage Cholesterol Efflux in Patients With Abdominal Aortic Aneurysm-Brief Report.

Martínez-López D, Cedó L, Metso J, Burillo E, García-León A, Canyelles M, Lindholt JS, Torres-Fonseca M, Blanco-Colio LM, Vázquez J, Blanco-Vaca F, Jauhiainen M, Martín-Ventura JL, Escolà-Gil JC.

Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2750-2754. doi: 10.1161/ATVBAHA.118.311704.

PMID:
30354236
6.

Salivary biomarkers in association with periodontal parameters and the periodontitis risk haplotype.

Liukkonen J, Gürsoy UK, Könönen E, Gürsoy M, Metso J, Salminen A, Kopra E, Jauhiainen M, Mäntylä P, Buhlin K, Paju S, Sorsa T, Nieminen MS, Lokki ML, Sinisalo J, Pussinen PJ.

Innate Immun. 2018 Oct;24(7):439-447. doi: 10.1177/1753425918796207. Epub 2018 Sep 3.

PMID:
30176756
7.

Altered HDL Remodeling and Functionality in Familial Hypercholesterolemia.

Cedó L, Plana N, Metso J, Lee-Rueckert M, Sanchez-Quesada JL, Kovanen PT, Jauhiainen M, Masana L, Escolà-Gil JC, Blanco-Vaca F.

J Am Coll Cardiol. 2018 Jan 30;71(4):466-468. doi: 10.1016/j.jacc.2017.11.035. No abstract available.

8.

PCSK9 inhibition alters the lipidome of plasma and lipoprotein fractions.

Hilvo M, Simolin H, Metso J, Ruuth M, Öörni K, Jauhiainen M, Laaksonen R, Baruch A.

Atherosclerosis. 2018 Feb;269:159-165. doi: 10.1016/j.atherosclerosis.2018.01.004. Epub 2018 Jan 12.

PMID:
29366988
9.

ANGPTL3 serum concentration and rare genetic variants in Finnish population.

Tikka A, Metso J, Jauhiainen M.

Scand J Clin Lab Invest. 2017 Dec;77(8):601-609. doi: 10.1080/00365513.2017.1379608. Epub 2017 Oct 3.

PMID:
28972399
10.

LXR-dependent regulation of macrophage-specific reverse cholesterol transport is impaired in a model of genetic diabesity.

Errico TL, Méndez-Lara KA, Santos D, Cabrerizo N, Baila-Rueda L, Metso J, Cenarro A, Pardina E, Lecube A, Jauhiainen M, Peinado-Onsurbe J, Escolà-Gil JC, Blanco-Vaca F, Julve J.

Transl Res. 2017 Aug;186:19-35.e5. doi: 10.1016/j.trsl.2017.05.004. Epub 2017 May 18.

PMID:
28583767
11.

Effects of atorvastatin and diet interventions on atherosclerotic plaque inflammation and [18F]FDG uptake in Ldlr-/-Apob100/100 mice.

Hellberg S, Sippola S, Liljenbäck H, Virta J, Silvola JMU, Ståhle M, Savisto N, Metso J, Jauhiainen M, Saukko P, Ylä-Herttuala S, Nuutila P, Knuuti J, Roivainen A, Saraste A.

Atherosclerosis. 2017 Aug;263:369-376. doi: 10.1016/j.atherosclerosis.2017.04.004. Epub 2017 Apr 11.

PMID:
28457625
12.

Impaired HDL2-mediated cholesterol efflux is associated with metabolic syndrome in families with early onset coronary heart disease and low HDL-cholesterol level.

Paavola T, Kuusisto S, Jauhiainen M, Kakko S, Kangas-Kontio T, Metso J, Soininen P, Ala-Korpela M, Bloigu R, Hannuksela ML, Savolainen MJ, Salonurmi T.

PLoS One. 2017 Feb 16;12(2):e0171993. doi: 10.1371/journal.pone.0171993. eCollection 2017.

13.

ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer.

Cedó L, García-León A, Baila-Rueda L, Santos D, Grijalva V, Martínez-Cignoni MR, Carbó JM, Metso J, López-Vilaró L, Zorzano A, Valledor AF, Cenarro A, Jauhiainen M, Lerma E, Fogelman AM, Reddy ST, Escolà-Gil JC, Blanco-Vaca F.

Sci Rep. 2016 Nov 3;6:36387. doi: 10.1038/srep36387.

14.

A loss-of-function variant in OSBPL1A predisposes to low plasma HDL cholesterol levels and impaired cholesterol efflux capacity.

Motazacker MM, Pirhonen J, van Capelleveen JC, Weber-Boyvat M, Kuivenhoven JA, Shah S, Hovingh GK, Metso J, Li S, Ikonen E, Jauhiainen M, Dallinga-Thie GM, Olkkonen VM.

Atherosclerosis. 2016 Jun;249:140-7. doi: 10.1016/j.atherosclerosis.2016.04.005. Epub 2016 Apr 11.

PMID:
27105157
15.

Effects of angiopoietin-like protein 3 deficiency on postprandial lipid and lipoprotein metabolism.

Minicocci I, Tikka A, Poggiogalle E, Metso J, Montali A, Ceci F, Labbadia G, Fontana M, Di Costanzo A, Maranghi M, Rosano A, Ehnholm C, Donini LM, Jauhiainen M, Arca M.

J Lipid Res. 2016 Jun;57(6):1097-107. doi: 10.1194/jlr.P066183. Epub 2016 Apr 3.

16.

Type 2 diabetes enhances arterial uptake of choline in atherosclerotic mice: an imaging study with positron emission tomography tracer ¹⁸F-fluoromethylcholine.

Hellberg S, Silvola JM, Kiugel M, Liljenbäck H, Metsälä O, Viljanen T, Metso J, Jauhiainen M, Saukko P, Nuutila P, Ylä-Herttuala S, Knuuti J, Roivainen A, Saraste A.

Cardiovasc Diabetol. 2016 Feb 6;15:26. doi: 10.1186/s12933-016-0340-6.

17.

USF1 deficiency activates brown adipose tissue and improves cardiometabolic health.

Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, Kaiharju E, Coomans CP, Van Den Berg SA, Autio A, Sarin AP, Kettunen J, Tikkanen E, Manninen T, Metso J, Silvennoinen R, Merikanto K, Ruuth M, Perttilä J, Mäkelä A, Isomi A, Tuomainen AM, Tikka A, Ramadan UA, Seppälä I, Lehtimäki T, Eriksson J, Havulinna A, Jula A, Karhunen PJ, Salomaa V, Perola M, Ehnholm C, Lee-Rueckert M, Van Eck M, Roivainen A, Taskinen MR, Peltonen L, Mervaala E, Jalanko A, Hohtola E, Olkkonen VM, Ripatti S, Kovanen PT, Rensen PC, Suomalainen A, Jauhiainen M.

Sci Transl Med. 2016 Jan 27;8(323):323ra13. doi: 10.1126/scitranslmed.aad0015.

PMID:
26819196
18.

Carboxyl-Terminal Cleavage of Apolipoprotein A-I by Human Mast Cell Chymase Impairs Its Anti-Inflammatory Properties.

Nguyen SD, Maaninka K, Lappalainen J, Nurmi K, Metso J, Öörni K, Navab M, Fogelman AM, Jauhiainen M, Lee-Rueckert M, Kovanen PT.

Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):274-84. doi: 10.1161/ATVBAHA.115.306827. Epub 2015 Dec 17.

19.

Identification and analysis of anti-HDL scFv-antibodies obtained from phage display based synthetic antibody library.

Negi P, Lövgren J, Malmi P, Sirkka N, Metso J, Huovinen T, Brockmann EC, Pettersson K, Jauhiainen M, Lamminmäki U.

Clin Biochem. 2016 Apr;49(6):472-479. doi: 10.1016/j.clinbiochem.2015.11.020. Epub 2015 Dec 2.

PMID:
26656638
20.

Complement Factor H Binds to Human Serum Apolipoprotein E and Mediates Complement Regulation on High Density Lipoprotein Particles.

Haapasalo K, van Kessel K, Nissilä E, Metso J, Johansson T, Miettinen S, Varjosalo M, Kirveskari J, Kuusela P, Chroni A, Jauhiainen M, van Strijp J, Jokiranta TS.

J Biol Chem. 2015 Nov 27;290(48):28977-87. doi: 10.1074/jbc.M115.669226. Epub 2015 Oct 14.

21.

Influence of Isoforms and Carboxyl-Terminal Truncations on the Capacity of Apolipoprotein E To Associate with and Activate Phospholipid Transfer Protein.

Dafnis I, Metso J, Zannis VI, Jauhiainen M, Chroni A.

Biochemistry. 2015 Sep 29;54(38):5856-66. doi: 10.1021/acs.biochem.5b00681. Epub 2015 Sep 17.

PMID:
26337529
22.

Regulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin.

Nidhina Haridas PA, Soronen J, Sädevirta S, Mysore R, Quagliarini F, Pasternack A, Metso J, Perttilä J, Leivonen M, Smas CM, Fischer-Posovszky P, Wabitsch M, Ehnholm C, Ritvos O, Jauhiainen M, Olkkonen VM, Yki-Järvinen H.

J Clin Endocrinol Metab. 2015 Oct;100(10):E1299-307. doi: 10.1210/jc.2015-1254. Epub 2015 Jul 23.

PMID:
26204133
23.

Consumption of polyunsaturated fat improves the saturated fatty acid-mediated impairment of HDL antioxidant potential.

Cedó L, Metso J, Santos D, Sánchez-Quesada JL, Julve J, García-León A, Mora-Brugués J, Jauhiainen M, Blanco-Vaca F, Escolà-Gil JC.

Mol Nutr Food Res. 2015 Oct;59(10):1987-96. doi: 10.1002/mnfr.201500336. Epub 2015 Aug 12.

PMID:
26118785
24.

Partial filling affinity capillary electrophoresis including adsorption energy distribution calculations--towards reliable and feasible biomolecular interaction studies.

Witos J, Samuelsson J, Cilpa-Karhu G, Metso J, Jauhiainen M, Riekkola ML.

Analyst. 2015 May 7;140(9):3175-82. doi: 10.1039/c5an00210a. Epub 2015 Mar 9.

PMID:
25751597
25.

PPAR-β/δ activation promotes phospholipid transfer protein expression.

Chehaibi K, Cedó L, Metso J, Palomer X, Santos D, Quesada H, Naceur Slimane M, Wahli W, Julve J, Vázquez-Carrera M, Jauhiainen M, Blanco-Vaca F, Escolà-Gil JC.

Biochem Pharmacol. 2015 Mar 15;94(2):101-8. doi: 10.1016/j.bcp.2015.01.016. Epub 2015 Feb 7.

PMID:
25662586
26.

Matrix metalloproteinase 8 degrades apolipoprotein A-I and reduces its cholesterol efflux capacity.

Salminen A, Åström P, Metso J, Soliymani R, Salo T, Jauhiainen M, Pussinen PJ, Sorsa T.

FASEB J. 2015 Apr;29(4):1435-45. doi: 10.1096/fj.14-262956. Epub 2014 Dec 30.

PMID:
25550459
27.
28.

The orientation and dynamics of estradiol and estradiol oleate in lipid membranes and HDL disc models.

Vogel A, Scheidt HA, Feller SE, Metso J, Badeau RM, Tikkanen MJ, Wähälä K, Jauhiainen M, Huster D.

Biophys J. 2014 Jul 1;107(1):114-25. doi: 10.1016/j.bpj.2014.04.060.

29.

Partial-filling affinity capillary electrophoresis and quartz crystal microbalance with adsorption energy distribution calculations in the study of biomolecular interactions with apolipoprotein E as interaction partner.

Lipponen K, Tähkä S, Samuelsson J, Jauhiainen M, Metso J, Cilpa-Karhu G, Fornstedt T, Kostiainen M, Riekkola ML.

Anal Bioanal Chem. 2014 Jul;406(17):4137-46. doi: 10.1007/s00216-014-7821-9. Epub 2014 May 2.

PMID:
24788890
30.

Phospholipid transfer protein is expressed in cerebrovascular endothelial cells and involved in high density lipoprotein biogenesis and remodeling at the blood-brain barrier.

Chirackal Manavalan AP, Kober A, Metso J, Lang I, Becker T, Hasslitzer K, Zandl M, Fanaee-Danesh E, Pippal JB, Sachdev V, Kratky D, Stefulj J, Jauhiainen M, Panzenboeck U.

J Biol Chem. 2014 Feb 21;289(8):4683-98. doi: 10.1074/jbc.M113.499129. Epub 2013 Dec 25.

31.

Angptl3 deficiency is associated with increased insulin sensitivity, lipoprotein lipase activity, and decreased serum free fatty acids.

Robciuc MR, Maranghi M, Lahikainen A, Rader D, Bensadoun A, Öörni K, Metso J, Minicocci I, Ciociola E, Ceci F, Montali A, Arca M, Ehnholm C, Jauhiainen M.

Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1706-13. doi: 10.1161/ATVBAHA.113.301397. Epub 2013 May 9. Erratum in: Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):e124. Oörni, Katariina [corrected to Öörni, Katariina].

PMID:
23661675
32.

Osbpl8 deficiency in mouse causes an elevation of high-density lipoproteins and gender-specific alterations of lipid metabolism.

Béaslas O, Metso J, Nissilä E, Laurila PP, Kaiharju E, Batchu KC, Kaipiainen L, Mäyränpää MI, Yan D, Gylling H, Jauhiainen M, Olkkonen VM.

PLoS One. 2013;8(3):e58856. doi: 10.1371/journal.pone.0058856. Epub 2013 Mar 15.

33.

The impact of gender and serum estradiol levels on HDL-mediated reverse cholesterol transport.

Badeau RM, Metso J, Kovanen PT, Lee-Rueckert M, Tikkanen MJ, Jauhiainen M.

Eur J Clin Invest. 2013 Apr;43(4):317-23. doi: 10.1111/eci.12044. Epub 2013 Feb 9.

PMID:
23397902
34.

Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-feces RCT and HDL antioxidant properties.

Escolà-Gil JC, Chen X, Julve J, Quesada H, Santos D, Metso J, Tous M, Jauhiainen M, Blanco-Vaca F.

Biochim Biophys Acta. 2013 Apr;1831(4):691-7. doi: 10.1016/j.bbalip.2013.01.003. Epub 2013 Jan 15.

PMID:
23328279
35.

Acute psychological stress accelerates reverse cholesterol transport via corticosterone-dependent inhibition of intestinal cholesterol absorption.

Silvennoinen R, Escola-Gil JC, Julve J, Rotllan N, Llaverias G, Metso J, Valledor AF, He J, Yu L, Jauhiainen M, Blanco-Vaca F, Kovanen PT, Lee-Rueckert M.

Circ Res. 2012 Nov 9;111(11):1459-69. doi: 10.1161/CIRCRESAHA.112.277962. Epub 2012 Aug 28.

PMID:
22931956
36.

Spontaneous remodeling of HDL particles at acidic pH enhances their capacity to induce cholesterol efflux from human macrophage foam cells.

Nguyen SD, Öörni K, Lee-Rueckert M, Pihlajamaa T, Metso J, Jauhiainen M, Kovanen PT.

J Lipid Res. 2012 Oct;53(10):2115-25. doi: 10.1194/jlr.M028118. Epub 2012 Aug 1.

37.

Phospholipid transfer protein is differentially expressed in human arterial and venous placental endothelial cells and enhances cholesterol efflux to fetal HDL.

Scholler M, Wadsack C, Metso J, Chirackal Manavalan AP, Sreckovic I, Schweinzer C, Hiden U, Jauhiainen M, Desoye G, Panzenboeck U.

J Clin Endocrinol Metab. 2012 Jul;97(7):2466-74. doi: 10.1210/jc.2011-2969. Epub 2012 Apr 6.

PMID:
22492872
38.

Apolipoprotein A-I exerts bactericidal activity against Yersinia enterocolitica serotype O:3.

Biedzka-Sarek M, Metso J, Kateifides A, Meri T, Jokiranta TS, Muszyński A, Radziejewska-Lebrecht J, Zannis V, Skurnik M, Jauhiainen M.

J Biol Chem. 2011 Nov 4;286(44):38211-9. doi: 10.1074/jbc.M111.249482. Epub 2011 Sep 6.

39.

Dry eye symptoms are increased in mice deficient in phospholipid transfer protein (PLTP).

Setälä NL, Metso J, Jauhiainen M, Sajantila A, Holopainen JM.

Am J Pathol. 2011 May;178(5):2058-65. doi: 10.1016/j.ajpath.2011.01.027.

40.

Mast cell activation in vivo impairs the macrophage reverse cholesterol transport pathway in the mouse.

Lee-Rueckert M, Silvennoinen R, Rotllan N, Judström I, Blanco-Vaca F, Metso J, Jauhiainen M, Kovanen PT, Escola-Gil JC.

Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):520-7. doi: 10.1161/ATVBAHA.110.221069. Epub 2011 Jan 6.

PMID:
21212401
41.

Interaction of phospholipid transfer protein with human tear fluid mucins.

Setälä NL, Holopainen JM, Metso J, Yohannes G, Hiidenhovi J, Andersson LC, Eriksson O, Robciuc A, Jauhiainen M.

J Lipid Res. 2010 Nov;51(11):3126-34. doi: 10.1194/jlr.M006239. Epub 2010 Aug 19.

42.

Human apoA-I increases macrophage foam cell derived PLTP activity without affecting the PLTP mass.

Robciuc MR, Metso J, Sima A, Ehnholm C, Jauhiainen M.

Lipids Health Dis. 2010 Jun 9;9:59. doi: 10.1186/1476-511X-9-59.

43.

Mast cells promote atherosclerosis by inducing both an atherogenic lipid profile and vascular inflammation.

Heikkilä HM, Trosien J, Metso J, Jauhiainen M, Pentikäinen MO, Kovanen PT, Lindstedt KA.

J Cell Biochem. 2010 Feb 15;109(3):615-23. doi: 10.1002/jcb.22443.

PMID:
20024959
44.

Mast cell-dependent proteolytic modification of HDL particles during anaphylactic shock in the mouse reduces their ability to induce cholesterol efflux from macrophage foam cells ex vivo.

Judström I, Jukkola H, Metso J, Jauhiainen M, Kovanen PT, Lee-Rueckert M.

Atherosclerosis. 2010 Jan;208(1):148-54. doi: 10.1016/j.atherosclerosis.2009.07.027. Epub 2009 Jul 23.

PMID:
19679305
45.

Human macrophage cholesterol efflux potential is enhanced by HDL-associated 17beta-estradiol fatty acyl esters.

Badeau RM, Metso J, Wähälä K, Tikkanen MJ, Jauhiainen M.

J Steroid Biochem Mol Biol. 2009 Aug;116(1-2):44-9. doi: 10.1016/j.jsbmb.2009.04.008. Epub 2009 May 3.

PMID:
19406243
46.

Avian phospholipid transfer protein causes HDL conversion without affecting cholesterol efflux from macrophages.

Saarela J, Metso J, Schneider WJ, Jauhiainen M.

Biochim Biophys Acta. 2009 Aug;1791(8):781-9. doi: 10.1016/j.bbalip.2009.04.005. Epub 2009 Apr 22.

PMID:
19393763
47.

Serum, but not monocyte macrophage foam cells derived from low HDL-C subjects, displays reduced cholesterol efflux capacity.

Nakanishi S, Vikstedt R, Söderlund S, Lee-Rueckert M, Hiukka A, Ehnholm C, Muilu M, Metso J, Naukkarinen J, Palotie L, Kovanen PT, Jauhiainen M, Taskinen MR.

J Lipid Res. 2009 Feb;50(2):183-92. doi: 10.1194/jlr.M800196-JLR200. Epub 2008 Sep 11.

48.

Plasma phospholipid transfer activity is essential for increased atherogenesis in PLTP transgenic mice: a mutation-inactivation study.

Samyn H, Moerland M, van Gent T, van Haperen R, Metso J, Grosveld F, Jauhiainen M, van Tol A, de Crom R.

J Lipid Res. 2008 Dec;49(12):2504-12. doi: 10.1194/jlr.M800080-JLR200. Epub 2008 Aug 18.

49.

HDL2 of heavy alcohol drinkers enhances cholesterol efflux from raw macrophages via phospholipid-rich HDL 2b particles.

Mäkelä SM, Jauhiainen M, Ala-Korpela M, Metso J, Lehto TM, Savolainen MJ, Hannuksela ML.

Alcohol Clin Exp Res. 2008 Jun;32(6):991-1000. doi: 10.1111/j.1530-0277.2008.00660.x.

PMID:
18498551
50.

Association of cholesteryl ester transfer protein with HDL particles reduces its proteolytic inactivation by mast cell chymase.

Lee-Rueckert M, Vikstedt R, Metso J, Jauhiainen M, Kovanen PT.

J Lipid Res. 2008 Feb;49(2):358-68. Epub 2007 Nov 8.

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