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Items: 1 to 50 of 67

1.

Development and characterization of liposomal formulation of bortezomib.

Deshantri AK, Metselaar JM, Zagkou S, Storm G, Mandhane SN, Fens MHAM, Schiffelers RM.

Int J Pharm X. 2019 Mar 23;1:100011. doi: 10.1016/j.ijpx.2019.100011. eCollection 2019 Dec.

2.

ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer.

Kuninty PR, Bansal R, De Geus SWL, Mardhian DF, Schnittert J, van Baarlen J, Storm G, Bijlsma MF, van Laarhoven HW, Metselaar JM, Kuppen PJK, Vahrmeijer AL, Östman A, Sier CFM, Prakash J.

Sci Adv. 2019 Sep 4;5(9):eaax2770. doi: 10.1126/sciadv.aax2770. eCollection 2019 Sep.

PMID:
31517053
3.

Liposome-induced hypersensitivity reactions: Risk reduction by design of safe infusion protocols in pigs.

Fülöp T, Kozma GT, Vashegyi I, Mészáros T, Rosivall L, Urbanics R, Storm G, Metselaar JM, Szebeni J.

J Control Release. 2019 Jul 8;309:333-338. doi: 10.1016/j.jconrel.2019.07.005. [Epub ahead of print]

4.

Liposomal dexamethasone inhibits tumor growth in an advanced human-mouse hybrid model of multiple myeloma.

Deshantri AK, Fens MH, Ruiter RWJ, Metselaar JM, Storm G, van Bloois L, Varela-Moreira A, Mandhane SN, Mutis T, Martens ACM, Groen RWJ, Schiffelers RM.

J Control Release. 2019 Feb 28;296:232-240. doi: 10.1016/j.jconrel.2019.01.028. Epub 2019 Jan 22.

PMID:
30682443
5.

Effect of Formulation and Processing Parameters on the Size of mPEG- b-p(HPMA-Bz) Polymeric Micelles.

Bagheri M, Bresseleers J, Varela-Moreira A, Sandre O, Meeuwissen SA, Schiffelers RM, Metselaar JM, van Nostrum CF, van Hest JCM, Hennink WE.

Langmuir. 2018 Dec 18;34(50):15495-15506. doi: 10.1021/acs.langmuir.8b03576. Epub 2018 Nov 26.

6.

Comparative analysis of nanosystems' effects on human endothelial and monocytic cell functions.

Matuszak J, Dörfler P, Lyer S, Unterweger H, Juenet M, Chauvierre C, Alaarg A, Franke D, Almer G, Texier I, Metselaar JM, Prassl R, Alexiou C, Mangge H, Letourneur D, Cicha I.

Nanotoxicology. 2018 Nov;12(9):957-974. doi: 10.1080/17435390.2018.1502375. Epub 2018 Sep 28.

PMID:
30265172
7.

From design to the clinic: practical guidelines for translating cardiovascular nanomedicine.

Cicha I, Chauvierre C, Texier I, Cabella C, Metselaar JM, Szebeni J, Dézsi L, Alexiou C, Rouzet F, Storm G, Stroes E, Bruce D, MacRitchie N, Maffia P, Letourneur D.

Cardiovasc Res. 2018 Nov 1;114(13):1714-1727. doi: 10.1093/cvr/cvy219.

PMID:
30165574
8.

Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization.

Hua S, de Matos MBC, Metselaar JM, Storm G.

Front Pharmacol. 2018 Jul 17;9:790. doi: 10.3389/fphar.2018.00790. eCollection 2018. Review.

9.

Evaluation of subconjunctival liposomal steroids for the treatment of experimental uveitis.

Wong CW, Czarny B, Metselaar JM, Ho C, Ng SR, Barathi AV, Storm G, Wong TT.

Sci Rep. 2018 Apr 26;8(1):6604. doi: 10.1038/s41598-018-24545-2.

10.

Imaging fibroblast activation protein to monitor therapeutic effects of neutralizing interleukin-22 in collagen-induced arthritis.

van der Geest T, Roeleveld DM, Walgreen B, Helsen MM, Nayak TK, Klein C, Hegen M, Storm G, Metselaar JM, van den Berg WB, van der Kraan PM, Laverman P, Boerman OC, Koenders MI.

Rheumatology (Oxford). 2018 Apr 1;57(4):737-747. doi: 10.1093/rheumatology/kex456.

PMID:
29361119
11.

In Vitro Evaluation of Anti-Aggregation and Degradation Behavior of PEGylated Polymeric Nanogels under In Vivo Like Conditions.

Chen Y, Dakwar GR, Braeckmans K, Lammers T, Hennink WE, Metselaar JM.

Macromol Biosci. 2018 Jan;18(1). doi: 10.1002/mabi.201700127. Epub 2017 Nov 20.

PMID:
29152858
12.

Local delivery of liposomal prednisolone leads to an anti-inflammatory profile in renal ischaemia-reperfusion injury in the rat.

van Alem CMA, Boonstra M, Prins J, Bezhaeva T, van Essen MF, Ruben JM, Vahrmeijer AL, van der Veer EP, de Fijter JW, Reinders ME, Meijer O, Metselaar JM, van Kooten C, Rotmans JI.

Nephrol Dial Transplant. 2018 Jan 1;33(1):44-53. doi: 10.1093/ndt/gfx204.

PMID:
28992069
13.

Overcoming multidrug resistance using folate receptor-targeted and pH-responsive polymeric nanogels containing covalently entrapped doxorubicin.

Chen Y, Tezcan O, Li D, Beztsinna N, Lou B, Etrych T, Ulbrich K, Metselaar JM, Lammers T, Hennink WE.

Nanoscale. 2017 Jul 27;9(29):10404-10419. doi: 10.1039/c7nr03592f.

PMID:
28702658
14.

A systematic comparison of clinically viable nanomedicines targeting HMG-CoA reductase in inflammatory atherosclerosis.

Alaarg A, Senders ML, Varela-Moreira A, Pérez-Medina C, Zhao Y, Tang J, Fay F, Reiner T, Fayad ZA, Hennink WE, Metselaar JM, Mulder WJM, Storm G.

J Control Release. 2017 Sep 28;262:47-57. doi: 10.1016/j.jconrel.2017.07.013. Epub 2017 Jul 9.

15.

Applying nanomedicine in maladaptive inflammation and angiogenesis.

Alaarg A, Pérez-Medina C, Metselaar JM, Nahrendorf M, Fayad ZA, Storm G, Mulder WJM.

Adv Drug Deliv Rev. 2017 Sep 15;119:143-158. doi: 10.1016/j.addr.2017.05.009. Epub 2017 May 12. Review.

16.

Liposome encapsulated berberine treatment attenuates cardiac dysfunction after myocardial infarction.

Allijn IE, Czarny BMS, Wang X, Chong SY, Weiler M, da Silva AE, Metselaar JM, Lam CSP, Pastorin G, de Kleijn DPV, Storm G, Wang JW, Schiffelers RM.

J Control Release. 2017 Feb 10;247:127-133. doi: 10.1016/j.jconrel.2016.12.042. Epub 2017 Jan 5.

PMID:
28065862
17.

Docosahexaenoic acid liposomes for targeting chronic inflammatory diseases and cancer: an in vitro assessment.

Alaarg A, Jordan NY, Verhoef JJ, Metselaar JM, Storm G, Kok RJ.

Int J Nanomedicine. 2016 Oct 5;11:5027-5040. eCollection 2016.

18.

In Vivo Imaging of Antileukemic Drug Asparaginase Reveals a Rapid Macrophage-Mediated Clearance from the Bone Marrow.

van der Meer LT, Terry SY, van Ingen Schenau DS, Andree KC, Franssen GM, Roeleveld DM, Metselaar JM, Reinheckel T, Hoogerbrugge PM, Boerman OC, van Leeuwen FN.

J Nucl Med. 2017 Feb;58(2):214-220. doi: 10.2967/jnumed.116.177741. Epub 2016 Aug 4.

19.

Liposomal Treatment of Experimental Arthritis Can Be Monitored Noninvasively with a Radiolabeled Anti-Fibroblast Activation Protein Antibody.

van der Geest T, Laverman P, Gerrits D, Walgreen B, Helsen MM, Klein C, Nayak TK, Storm G, Metselaar JM, Koenders MI, Boerman OC.

J Nucl Med. 2017 Jan;58(1):151-155. doi: 10.2967/jnumed.116.177931. Epub 2016 Aug 4.

20.

Liposomal prednisolone inhibits vascular inflammation and enhances venous outward remodeling in a murine arteriovenous fistula model.

Wong C, Bezhaeva T, Rothuizen TC, Metselaar JM, de Vries MR, Verbeek FP, Vahrmeijer AL, Wezel A, van Zonneveld AJ, Rabelink TJ, Quax PH, Rotmans JI.

Sci Rep. 2016 Jul 27;6:30439. doi: 10.1038/srep30439.

21.

Radionuclide imaging of liposomal drug delivery.

van der Geest T, Laverman P, Metselaar JM, Storm G, Boerman OC.

Expert Opin Drug Deliv. 2016 Sep;13(9):1231-42. doi: 10.1080/17425247.2016.1205584. Epub 2016 Jul 7. Review.

PMID:
27351233
22.

Multiple pathway assessment to predict anti-atherogenic efficacy of drugs targeting macrophages in atherosclerotic plaques.

Alaarg A, Zheng KH, van der Valk FM, da Silva AE, Versloot M, van Ufford LC, Schulte DM, Storm G, Metselaar JM, Stroes ES, Hamers AA.

Vascul Pharmacol. 2016 Jul;82:51-9. doi: 10.1016/j.vph.2016.04.006. Epub 2016 May 14.

PMID:
27189780
23.

Polymeric Nanogels with Tailorable Degradation Behavior.

Chen Y, van Steenbergen MJ, Li D, van de Dikkenberg JB, Lammers T, van Nostrum CF, Metselaar JM, Hennink WE.

Macromol Biosci. 2016 Aug;16(8):1122-37. doi: 10.1002/mabi.201600031. Epub 2016 Apr 13.

PMID:
27072198
24.

Liposomal prednisolone promotes macrophage lipotoxicity in experimental atherosclerosis.

van der Valk FM, Schulte DM, Meiler S, Tang J, Zheng KH, Van den Bossche J, Seijkens T, Laudes M, de Winther M, Lutgens E, Alaarg A, Metselaar JM, Dallinga-Thie GM, Mulder WJ, Stroes ES, Hamers AA.

Nanomedicine. 2016 Aug;12(6):1463-70. doi: 10.1016/j.nano.2016.02.022. Epub 2016 Mar 23.

PMID:
27015770
25.

Nanoparticles for intravascular applications: physicochemical characterization and cytotoxicity testing.

Matuszak J, Baumgartner J, Zaloga J, Juenet M, da Silva AE, Franke D, Almer G, Texier I, Faivre D, Metselaar JM, Navarro FP, Chauvierre C, Prassl R, Dézsi L, Urbanics R, Alexiou C, Mangge H, Szebeni J, Letourneur D, Cicha I.

Nanomedicine (Lond). 2016 Mar;11(6):597-616. doi: 10.2217/nnm.15.216. Epub 2016 Mar 22.

26.

Comparison of three remote radiolabelling methods for long-circulating liposomes.

van der Geest T, Laverman P, Gerrits D, Franssen GM, Metselaar JM, Storm G, Boerman OC.

J Control Release. 2015 Dec 28;220(Pt A):239-244. doi: 10.1016/j.jconrel.2015.10.043. Epub 2015 Oct 26.

PMID:
26514291
27.

Glucocorticoid receptor antagonism reverts docetaxel resistance in human prostate cancer.

Kroon J, Puhr M, Buijs JT, van der Horst G, Hemmer DM, Marijt KA, Hwang MS, Masood M, Grimm S, Storm G, Metselaar JM, Meijer OC, Culig Z, van der Pluijm G.

Endocr Relat Cancer. 2016 Jan;23(1):35-45. doi: 10.1530/ERC-15-0343. Epub 2015 Oct 19.

28.

Distribution of technetium-99m PEG-liposomes during oligofructose-induced laminitis development in horses.

Underwood C, Pollitt CC, Metselaar JM, Laverman P, van Bloois L, van den Hoven JM, Storm G, van Eps AW.

Vet J. 2015 Nov;206(2):218-25. doi: 10.1016/j.tvjl.2015.07.013. Epub 2015 Jul 20.

PMID:
26403954
29.

¹¹¹In-anti-F4/80-A3-1 antibody: a novel tracer to image macrophages.

Terry SY, Boerman OC, Gerrits D, Franssen GM, Metselaar JM, Lehmann S, Oyen WJ, Gerdes CA, Abiraj K.

Eur J Nucl Med Mol Imaging. 2015 Aug;42(9):1430-8. doi: 10.1007/s00259-015-3084-8. Epub 2015 May 27.

30.

[(18)]F FDG PET/CT imaging to monitor the therapeutic effect of liposome-encapsulated prednisolone in experimental rheumatoid arthritis.

van der Geest T, Metselaar JM, Gerrits D, van Lent PL, Storm G, Laverman P, Boerman OC.

J Control Release. 2015 Jul 10;209:20-6. doi: 10.1016/j.jconrel.2015.04.019. Epub 2015 Apr 19.

PMID:
25902038
31.

Prednisolone-containing liposomes accumulate in human atherosclerotic macrophages upon intravenous administration.

van der Valk FM, van Wijk DF, Lobatto ME, Verberne HJ, Storm G, Willems MC, Legemate DA, Nederveen AJ, Calcagno C, Mani V, Ramachandran S, Paridaans MP, Otten MJ, Dallinga-Thie GM, Fayad ZA, Nieuwdorp M, Schulte DM, Metselaar JM, Mulder WJ, Stroes ES.

Nanomedicine. 2015 Jul;11(5):1039-46. doi: 10.1016/j.nano.2015.02.021. Epub 2015 Mar 17.

32.

Pharmaceutical development and preclinical evaluation of a GMP-grade anti-inflammatory nanotherapy.

Lobatto ME, Calcagno C, Otten MJ, Millon A, Ramachandran S, Paridaans MP, van der Valk FM, Storm G, Stroes ES, Fayad ZA, Mulder WJ, Metselaar JM.

Nanomedicine. 2015 Jul;11(5):1133-40. doi: 10.1016/j.nano.2015.02.020. Epub 2015 Mar 17.

33.

Liposomal delivery of dexamethasone attenuates prostate cancer bone metastatic tumor growth in vivo.

Kroon J, Buijs JT, van der Horst G, Cheung H, van der Mark M, van Bloois L, Rizzo LY, Lammers T, Pelger RC, Storm G, van der Pluijm G, Metselaar JM.

Prostate. 2015 Jun;75(8):815-24. doi: 10.1002/pros.22963. Epub 2015 Feb 8.

34.

Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging.

Lobatto ME, Calcagno C, Millon A, Senders ML, Fay F, Robson PM, Ramachandran S, Binderup T, Paridaans MP, Sensarn S, Rogalla S, Gordon RE, Cardoso L, Storm G, Metselaar JM, Contag CH, Stroes ES, Fayad ZA, Mulder WJ.

ACS Nano. 2015 Feb 24;9(2):1837-47. doi: 10.1021/nn506750r. Epub 2015 Jan 28.

35.

Features of complement activation-related pseudoallergy to liposomes with different surface charge and PEGylation: comparison of the porcine and rat responses.

Dézsi L, Fülöp T, Mészáros T, Szénási G, Urbanics R, Vázsonyi C, Őrfi E, Rosivall L, Nemes R, Kok RJ, Metselaar JM, Storm G, Szebeni J.

J Control Release. 2014 Dec 10;195:2-10. doi: 10.1016/j.jconrel.2014.08.009. Epub 2014 Aug 19.

PMID:
25148822
36.

Liposomal corticosteroids for the treatment of inflammatory disorders and cancer.

Ozbakir B, Crielaard BJ, Metselaar JM, Storm G, Lammers T.

J Control Release. 2014 Sep 28;190:624-36. doi: 10.1016/j.jconrel.2014.05.039. Epub 2014 May 27. Review.

PMID:
24878183
37.

Nanomedicines for inflammatory arthritis: head-to-head comparison of glucocorticoid-containing polymers, micelles, and liposomes.

Quan L, Zhang Y, Crielaard BJ, Dusad A, Lele SM, Rijcken CJF, Metselaar JM, Kostková H, Etrych T, Ulbrich K, Kiessling F, Mikuls TR, Hennink WE, Storm G, Lammers T, Wang D.

ACS Nano. 2014 Jan 28;8(1):458-466. doi: 10.1021/nn4048205. Epub 2013 Dec 27.

38.

Liposomal nanomedicines in the treatment of prostate cancer.

Kroon J, Metselaar JM, Storm G, van der Pluijm G.

Cancer Treat Rev. 2014 May;40(4):578-84. doi: 10.1016/j.ctrv.2013.10.005. Epub 2013 Oct 25. Review.

PMID:
24216226
39.

Complement activation by PEGylated liposomes containing prednisolone.

van den Hoven JM, Nemes R, Metselaar JM, Nuijen B, Beijnen JH, Storm G, Szebeni J.

Eur J Pharm Sci. 2013 May 13;49(2):265-71. doi: 10.1016/j.ejps.2013.03.007. Epub 2013 Mar 22.

PMID:
23528740
40.

Cyclodextrin as membrane protectant in spray-drying and freeze-drying of PEGylated liposomes.

van den Hoven JM, Metselaar JM, Storm G, Beijnen JH, Nuijen B.

Int J Pharm. 2012 Nov 15;438(1-2):209-16. doi: 10.1016/j.ijpharm.2012.08.046. Epub 2012 Aug 31.

PMID:
22960501
41.

Imaging the efficacy of anti-inflammatory liposomes in a rabbit model of atherosclerosis by non-invasive imaging.

Lobatto ME, Calcagno C, Metselaar JM, Storm G, Stroes ES, Fayad ZA, Mulder WJ.

Methods Enzymol. 2012;508:211-28. doi: 10.1016/B978-0-12-391860-4.00011-2.

42.

Motor performance of young dystrophic mdx mice treated with long-circulating prednisolone liposomes.

Weller C, Zschüntzsch J, Makosch G, Metselaar JM, Klinker F, Klinge L, Liebetanz D, Schmidt J.

J Neurosci Res. 2012 May;90(5):1067-77. doi: 10.1002/jnr.22825. Epub 2012 Jan 18.

PMID:
22253213
43.

Liposomal encapsulation of glucocorticoids alters their mode of action in the treatment of experimental autoimmune encephalomyelitis.

Schweingruber N, Haine A, Tiede K, Karabinskaya A, van den Brandt J, Wüst S, Metselaar JM, Gold R, Tuckermann JP, Reichardt HM, Lühder F.

J Immunol. 2011 Oct 15;187(8):4310-8. doi: 10.4049/jimmunol.1101604. Epub 2011 Sep 14.

44.

Liposomal drug formulations in the treatment of rheumatoid arthritis.

van den Hoven JM, Van Tomme SR, Metselaar JM, Nuijen B, Beijnen JH, Storm G.

Mol Pharm. 2011 Aug 1;8(4):1002-15. doi: 10.1021/mp2000742. Epub 2011 Jun 17. Review.

PMID:
21634436
45.

Optimizing the therapeutic index of liposomal glucocorticoids in experimental arthritis.

van den Hoven JM, Hofkens W, Wauben MH, Wagenaar-Hilbers JP, Beijnen JH, Nuijen B, Metselaar JM, Storm G.

Int J Pharm. 2011 Sep 20;416(2):471-7. doi: 10.1016/j.ijpharm.2011.03.025. Epub 2011 Apr 2.

PMID:
21440612
46.

Improving solubility and chemical stability of natural compounds for medicinal use by incorporation into liposomes.

Coimbra M, Isacchi B, van Bloois L, Torano JS, Ket A, Wu X, Broere F, Metselaar JM, Rijcken CJ, Storm G, Bilia R, Schiffelers RM.

Int J Pharm. 2011 Sep 20;416(2):433-42. doi: 10.1016/j.ijpharm.2011.01.056. Epub 2011 Feb 1.

PMID:
21291975
47.

Multimodal clinical imaging to longitudinally assess a nanomedical anti-inflammatory treatment in experimental atherosclerosis.

Lobatto ME, Fayad ZA, Silvera S, Vucic E, Calcagno C, Mani V, Dickson SD, Nicolay K, Banciu M, Schiffelers RM, Metselaar JM, van Bloois L, Wu HS, Fallon JT, Rudd JH, Fuster V, Fisher EA, Storm G, Mulder WJ.

Mol Pharm. 2010 Dec 6;7(6):2020-9. doi: 10.1021/mp100309y. Epub 2010 Nov 8.

48.

Liposomal pravastatin inhibits tumor growth by targeting cancer-related inflammation.

Coimbra M, Banciu M, Fens MH, de Smet L, Cabaj M, Metselaar JM, Storm G, Schiffelers RM.

J Control Release. 2010 Dec 20;148(3):303-10. doi: 10.1016/j.jconrel.2010.09.011. Epub 2010 Sep 30.

PMID:
20869410
49.

Liposomal glucocorticoids as tumor-targeted anti-angiogenic nanomedicine in B16 melanoma-bearing mice.

Banciu M, Metselaar JM, Schiffelers RM, Storm G.

J Steroid Biochem Mol Biol. 2008 Jul;111(1-2):101-10. doi: 10.1016/j.jsbmb.2008.05.004. Epub 2008 Jul 7.

PMID:
18602825
50.

Liposomal glucocorticosteroids in treatment of chronic autoimmune demyelination: long-term protective effects and enhanced efficacy of methylprednisolone formulations.

Linker RA, Weller C, Lühder F, Mohr A, Schmidt J, Knauth M, Metselaar JM, Gold R.

Exp Neurol. 2008 Jun;211(2):397-406. doi: 10.1016/j.expneurol.2008.02.005. Epub 2008 Feb 29.

PMID:
18394606

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