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Items: 1 to 50 of 81

1.

Dimethyl fumarate alters intracellular Ca2+ handling in immune cells by redox-mediated pleiotropic effects.

Herrmann AK, Wüllner V, Moos S, Graf J, Chen J, Kieseier B, Kurschus FC, Albrecht P, Vangheluwe P, Methner A.

Free Radic Biol Med. 2019 Sep;141:338-347. doi: 10.1016/j.freeradbiomed.2019.07.005. Epub 2019 Jul 4.

PMID:
31279969
2.

Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease.

Arnoux I, Willam M, Griesche N, Krummeich J, Watari H, Offermann N, Weber S, Narayan Dey P, Chen C, Monteiro O, Buettner S, Meyer K, Bano D, Radyushkin K, Langston R, Lambert JJ, Wanker E, Methner A, Krauss S, Schweiger S, Stroh A.

Elife. 2018 Sep 4;7. pii: e38744. doi: 10.7554/eLife.38744.

3.

Crucial role for Nox2 and sleep deprivation in aircraft noise-induced vascular and cerebral oxidative stress, inflammation, and gene regulation.

Kröller-Schön S, Daiber A, Steven S, Oelze M, Frenis K, Kalinovic S, Heimann A, Schmidt FP, Pinto A, Kvandova M, Vujacic-Mirski K, Filippou K, Dudek M, Bosmann M, Klein M, Bopp T, Hahad O, Wild PS, Frauenknecht K, Methner A, Schmidt ER, Rapp S, Mollnau H, Münzel T.

Eur Heart J. 2018 Oct 7;39(38):3528-3539. doi: 10.1093/eurheartj/ehy333.

4.

Oxytosis/Ferroptosis-(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System.

Lewerenz J, Ates G, Methner A, Conrad M, Maher P.

Front Neurosci. 2018 Apr 20;12:214. doi: 10.3389/fnins.2018.00214. eCollection 2018. Review.

5.

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.

Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolaños JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Düssmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, Jekabsons MB, Jonas EA, Jordán J, Lipton SA, Manfredi G, Mattson MP, McLaughlin B, Methner A, Murphy AN, Murphy MP, Nicholls DG, Polster BM, Pozzan T, Rizzuto R, Satrústegui J, Slack RS, Swanson RA, Swerdlow RH, Will Y, Ying Z, Joselin A, Gioran A, Moreira Pinho C, Watters O, Salvucci M, Llorente-Folch I, Park DS, Bano D, Ankarcrona M, Pizzo P, Prehn JHM.

Cell Death Differ. 2018 Mar;25(3):542-572. doi: 10.1038/s41418-017-0020-4. Epub 2017 Dec 11. Review.

6.

Dimethyl fumarate treatment after traumatic brain injury prevents depletion of antioxidative brain glutathione and confers neuroprotection.

Krämer T, Grob T, Menzel L, Hirnet T, Griemert E, Radyushkin K, Thal SC, Methner A, Schaefer MKE.

J Neurochem. 2017 Dec;143(5):523-533. doi: 10.1111/jnc.14220. Epub 2017 Oct 26.

7.

Adaptation of Surface-Associated Bacteria to the Open Ocean: A Genomically Distinct Subpopulation of Phaeobacter gallaeciensis Colonizes Pacific Mesozooplankton.

Freese HM, Methner A, Overmann J.

Front Microbiol. 2017 Aug 31;8:1659. doi: 10.3389/fmicb.2017.01659. eCollection 2017.

8.

Bcl-xL knockout attenuates mitochondrial respiration and causes oxidative stress that is compensated by pentose phosphate pathway activity.

Pfeiffer A, Schneider J, Bueno D, Dolga A, Voss TD, Lewerenz J, Wüllner V, Methner A.

Free Radic Biol Med. 2017 Nov;112:350-359. doi: 10.1016/j.freeradbiomed.2017.08.007. Epub 2017 Aug 12.

PMID:
28807815
9.

Presenilin-1 Delta E9 Mutant Induces STIM1-Driven Store-Operated Calcium Channel Hyperactivation in Hippocampal Neurons.

Ryazantseva M, Goncharova A, Skobeleva K, Erokhin M, Methner A, Georgiev P, Kaznacheyeva E.

Mol Neurobiol. 2018 Jun;55(6):4667-4680. doi: 10.1007/s12035-017-0674-4. Epub 2017 Jul 13.

PMID:
28707074
10.

Optical coherence tomography for the diagnosis and monitoring of idiopathic intracranial hypertension.

Albrecht P, Blasberg C, Ringelstein M, Müller AK, Finis D, Guthoff R, Kadas EM, Lagreze W, Aktas O, Hartung HP, Paul F, Brandt AU, Methner A.

J Neurol. 2017 Jul;264(7):1370-1380. doi: 10.1007/s00415-017-8532-x. Epub 2017 Jun 5.

PMID:
28584914
11.

The role of Ca2+ in cell death caused by oxidative glutamate toxicity and ferroptosis.

Maher P, van Leyen K, Dey PN, Honrath B, Dolga A, Methner A.

Cell Calcium. 2018 Mar;70:47-55. doi: 10.1016/j.ceca.2017.05.007. Epub 2017 May 12. Review.

12.

The thiol switch C684 in Mitofusin-2 mediates redox-induced alterations of mitochondrial shape and respiration.

Thaher O, Wolf C, Dey PN, Pouya A, Wüllner V, Tenzer S, Methner A.

Neurochem Int. 2018 Jul;117:167-173. doi: 10.1016/j.neuint.2017.05.009. Epub 2017 May 17.

PMID:
28527631
13.

Dimethyl Fumarate Induces Glutathione Recycling by Upregulation of Glutathione Reductase.

Hoffmann C, Dietrich M, Herrmann AK, Schacht T, Albrecht P, Methner A.

Oxid Med Cell Longev. 2017;2017:6093903. doi: 10.1155/2017/6093903. Epub 2017 Jan 1.

14.

Absence of system xc- on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis.

Merckx E, Albertini G, Paterka M, Jensen C, Albrecht P, Dietrich M, Van Liefferinge J, Bentea E, Verbruggen L, Demuyser T, Deneyer L, Lewerenz J, van Loo G, De Keyser J, Sato H, Maher P, Methner A, Massie A.

J Neuroinflammation. 2017 Jan 13;14(1):9. doi: 10.1186/s12974-016-0787-0.

15.

The more the merrier? Scoring, statistics and animal welfare in experimental autoimmune encephalomyelitis.

Palle P, Ferreira FM, Methner A, Buch T.

Lab Anim. 2016 Dec;50(6):427-432.

PMID:
27909192
16.

Tetrahydrocarbazoles decrease elevated SOCE in medium spiny neurons from transgenic YAC128 mice, a model of Huntington's disease.

Czeredys M, Maciag F, Methner A, Kuznicki J.

Biochem Biophys Res Commun. 2017 Feb 19;483(4):1194-1205. doi: 10.1016/j.bbrc.2016.08.106. Epub 2016 Aug 20.

17.

TOX3 regulates neural progenitor identity.

Sahu SK, Fritz A, Tiwari N, Kovacs Z, Pouya A, Wüllner V, Bora P, Schacht T, Baumgart J, Peron S, Berninger B, Tiwari VK, Methner A.

Biochim Biophys Acta. 2016 Jul;1859(7):833-40. doi: 10.1016/j.bbagrm.2016.04.005. Epub 2016 Apr 11.

PMID:
27080130
18.

Androgen-inducible gene 1 increases the ER Ca(2+) content and cell death susceptibility against oxidative stress.

Nickel N, Cleven A, Enders V, Lisak D, Schneider L, Methner A.

Gene. 2016 Jul 15;586(1):62-8. doi: 10.1016/j.gene.2016.03.055. Epub 2016 Mar 31.

PMID:
27040980
19.

BAX inhibitor-1 is a Ca(2+) channel critically important for immune cell function and survival.

Lisak D, Schacht T, Gawlitza A, Albrecht P, Aktas O, Koop B, Gliem M, Hofstetter HH, Zanger K, Bultynck G, Parys JB, De Smedt H, Kindler T, Adams-Quack P, Hahn M, Waisman A, Reed JC, Hövelmeyer N, Methner A.

Cell Death Differ. 2016 Feb;23(2):358-68. doi: 10.1038/cdd.2015.115. Epub 2015 Oct 16.

20.

Curcumin therapy in a Plp1 transgenic mouse model of Pelizaeus-Merzbacher disease.

Epplen DB, Prukop T, Nientiedt T, Albrecht P, Arlt FA, Stassart RM, Kassmann CM, Methner A, Nave KA, Werner HB, Sereda MW.

Ann Clin Transl Neurol. 2015 Aug;2(8):787-96. doi: 10.1002/acn3.219. Epub 2015 Jun 24.

21.

A novel automated segmentation method for retinal layers in OCT images proves retinal degeneration after optic neuritis.

Droby A, Panagoulias M, Albrecht P, Reuter E, Duning T, Hildebrandt A, Wiendl H, Zipp F, Methner A.

Br J Ophthalmol. 2016 Apr;100(4):484-90. doi: 10.1136/bjophthalmol-2014-306015. Epub 2015 Aug 25.

PMID:
26307452
22.

Retinal pathology in idiopathic moyamoya angiopathy detected by optical coherence tomography.

Albrecht P, Blasberg C, Lukas S, Ringelstein M, Müller AK, Harmel J, Kadas EM, Finis D, Guthoff R, Aktas O, Hartung HP, Paul F, Brandt AU, Berlit P, Methner A, Kraemer M.

Neurology. 2015 Aug 11;85(6):521-7. doi: 10.1212/WNL.0000000000001832. Epub 2015 Jul 15.

PMID:
26180140
23.

The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA²⁺-filling state.

Lisak DA, Schacht T, Enders V, Habicht J, Kiviluoto S, Schneider J, Henke N, Bultynck G, Methner A.

Biochim Biophys Acta. 2015 Sep;1853(9):2104-14. doi: 10.1016/j.bbamcr.2015.03.002. Epub 2015 Mar 9.

24.

Subtle retinal pathology in amyotrophic lateral sclerosis.

Ringelstein M, Albrecht P, Südmeyer M, Harmel J, Müller AK, Keser N, Finis D, Ferrea S, Guthoff R, Schnitzler A, Hartung HP, Methner A, Aktas O.

Ann Clin Transl Neurol. 2014 Apr;1(4):290-7. doi: 10.1002/acn3.46. Epub 2014 Mar 11.

25.

Bax inhibitor-1 is likely a pH-sensitive calcium leak channel, not a H+/Ca2+ exchanger.

Bultynck G, Kiviluoto S, Methner A.

Sci Signal. 2014 Sep 16;7(343):pe22. doi: 10.1126/scisignal.2005764.

PMID:
25227609
26.

Protein kinase inhibitor β enhances the constitutive activity of G-protein-coupled zinc receptor GPR39.

Kovacs Z, Schacht T, Herrmann AK, Albrecht P, Lefkimmiatis K, Methner A.

Biochem J. 2014 Aug 15;462(1):125-32. doi: 10.1042/BJ20131198.

PMID:
24869658
27.

Regulators of mitochondrial Ca(2+) homeostasis in cerebral ischemia.

Schäfer MK, Pfeiffer A, Jaeckel M, Pouya A, Dolga AM, Methner A.

Cell Tissue Res. 2014 Aug;357(2):395-405. doi: 10.1007/s00441-014-1807-y. Epub 2014 Apr 9. Review.

PMID:
24715113
28.

Expression of genes encoding the calcium signalosome in cellular and transgenic models of Huntington's disease.

Czeredys M, Gruszczynska-Biegala J, Schacht T, Methner A, Kuznicki J.

Front Mol Neurosci. 2013 Nov 25;6:42. doi: 10.3389/fnmol.2013.00042. eCollection 2013.

29.

Mitochondrial function and energy metabolism in neuronal HT22 cells resistant to oxidative stress.

Pfeiffer A, Jaeckel M, Lewerenz J, Noack R, Pouya A, Schacht T, Hoffmann C, Winter J, Schweiger S, Schäfer MK, Methner A.

Br J Pharmacol. 2014 Apr;171(8):2147-58. doi: 10.1111/bph.12549.

30.

Interaction of Bcl-2 with the autophagy-related GABAA receptor-associated protein (GABARAP): biophysical characterization and functional implications.

Ma P, Schwarten M, Schneider L, Boeske A, Henke N, Lisak D, Weber S, Mohrlüder J, Stoldt M, Strodel B, Methner A, Hoffmann S, Weiergräber OH, Willbold D.

J Biol Chem. 2013 Dec 27;288(52):37204-15. doi: 10.1074/jbc.M113.528067. Epub 2013 Nov 15.

31.

Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsy.

Lewerenz J, Baxter P, Kassubek R, Albrecht P, Van Liefferinge J, Westhoff MA, Halatsch ME, Karpel-Massler G, Meakin PJ, Hayes JD, Aronica E, Smolders I, Ludolph AC, Methner A, Conrad M, Massie A, Hardingham GE, Maher P.

Antioxid Redox Signal. 2014 Jun 20;20(18):2907-22. doi: 10.1089/ars.2013.5455. Epub 2014 Feb 6.

32.

Genetic shift of env V3 loop viral sequences in patients with HIV-associated neurocognitive disorder during antiretroviral therapy.

Eggers C, Müller O, Thordsen I, Schreiber M, Methner A.

J Neurovirol. 2013 Dec;19(6):523-30. doi: 10.1007/s13365-013-0207-5. Epub 2013 Oct 8.

PMID:
24101298
33.

Bax Inhibitor-1-mediated Ca2+ leak is decreased by cytosolic acidosis.

Kiviluoto S, Luyten T, Schneider L, Lisak D, Rojas-Rivera D, Welkenhuyzen K, Missaen L, De Smedt H, Parys JB, Hetz C, Methner A, Bultynck G.

Cell Calcium. 2013 Sep;54(3):186-92. doi: 10.1016/j.ceca.2013.06.002. Epub 2013 Jul 16.

PMID:
23867001
34.

Promoting myelination in an in vitro mouse model of the peripheral nervous system: the effect of wine ingredients [corrected].

Stettner M, Wolffram K, Mausberg AK, Albrecht P, Derksen A, Methner A, Dehmel T, Hartung HP, Dietrich H, Kieseier BC.

PLoS One. 2013 Jun 7;8(6):e66079. doi: 10.1371/journal.pone.0066079. Print 2013. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/a9d91925-7bb9-48a6-b261-40429a319bae.

35.

Extracellular cyclic GMP and its derivatives GMP and guanosine protect from oxidative glutamate toxicity.

Albrecht P, Henke N, Tien ML, Issberner A, Bouchachia I, Maher P, Lewerenz J, Methner A.

Neurochem Int. 2013 Apr;62(5):610-9. doi: 10.1016/j.neuint.2013.01.019. Epub 2013 Jan 26.

PMID:
23357478
36.

The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress.

Henke N, Albrecht P, Bouchachia I, Ryazantseva M, Knoll K, Lewerenz J, Kaznacheyeva E, Maher P, Methner A.

Cell Death Dis. 2013 Jan 24;4:e470. doi: 10.1038/cddis.2012.216.

37.

Multiple sclerosis in 2012: Novel therapeutic options and drug targets in MS.

Methner A, Zipp F.

Nat Rev Neurol. 2013 Feb;9(2):72-3. doi: 10.1038/nrneurol.2012.277. Epub 2013 Jan 22. Review. Erratum in: Nat Rev Neurol. 2013 May;9(5):240.

PMID:
23338282
38.

Retinal neurodegeneration in Wilson's disease revealed by spectral domain optical coherence tomography.

Albrecht P, Müller AK, Ringelstein M, Finis D, Geerling G, Cohn E, Aktas O, Hartung HP, Hefter H, Methner A.

PLoS One. 2012;7(11):e49825. doi: 10.1371/journal.pone.0049825. Epub 2012 Nov 16.

39.

An emboligenic pulmonary abscess leading to ischemic stroke and secondary brain abscess.

Albrecht P, Stettner M, Husseini L, Macht S, Jander S, Mackenzie C, Oesterlee U, Slotty P, Methner A, Hartung HP, Aktas O.

BMC Neurol. 2012 Nov 5;12:133. doi: 10.1186/1471-2377-12-133.

40.

Stromal interaction molecule 1 (STIM1) is involved in the regulation of mitochondrial shape and bioenergetics and plays a role in oxidative stress.

Henke N, Albrecht P, Pfeiffer A, Toutzaris D, Zanger K, Methner A.

J Biol Chem. 2012 Dec 7;287(50):42042-52. doi: 10.1074/jbc.M112.417212. Epub 2012 Oct 17.

41.

Bax inhibitor-1 is a novel IP₃ receptor-interacting and -sensitizing protein.

Kiviluoto S, Schneider L, Luyten T, Vervliet T, Missiaen L, De Smedt H, Parys JB, Methner A, Bultynck G.

Cell Death Dis. 2012 Aug 9;3:e367. doi: 10.1038/cddis.2012.103. No abstract available.

42.

Effects of dimethyl fumarate on neuroprotection and immunomodulation.

Albrecht P, Bouchachia I, Goebels N, Henke N, Hofstetter HH, Issberner A, Kovacs Z, Lewerenz J, Lisak D, Maher P, Mausberg AK, Quasthoff K, Zimmermann C, Hartung HP, Methner A.

J Neuroinflammation. 2012 Jul 7;9:163. doi: 10.1186/1742-2094-9-163.

43.

Neuromyelitis optica following human papillomavirus vaccination.

Menge T, Cree B, Saleh A, Waterboer T, Berthele A, Kalluri SR, Hemmer B, Aktas O, Hartung HP, Methner A, Kieseier BC.

Neurology. 2012 Jul 17;79(3):285-7. doi: 10.1212/WNL.0b013e31825fdead. Epub 2012 Jun 20. No abstract available.

PMID:
22722628
44.

The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities.

Lewerenz J, Hewett SJ, Huang Y, Lambros M, Gout PW, Kalivas PW, Massie A, Smolders I, Methner A, Pergande M, Smith SB, Ganapathy V, Maher P.

Antioxid Redox Signal. 2013 Feb 10;18(5):522-55. doi: 10.1089/ars.2011.4391. Epub 2012 Aug 3. Review.

45.

A case of relapsing-remitting neuroborreliosis? Challenges in the differential diagnosis of recurrent myelitis.

Albrecht P, Henke N, Lehmann HC, Macht S, Hefter H, Goebels N, Mackenzie C, Rupprecht TA, Fingerle V, Hartung HP, Methner A.

Case Rep Neurol. 2012 Jan;4(1):47-53. doi: 10.1159/000337223. Epub 2012 Mar 14.

46.

Optical coherence tomography in parkinsonian syndromes.

Albrecht P, Müller AK, Südmeyer M, Ferrea S, Ringelstein M, Cohn E, Aktas O, Dietlein T, Lappas A, Foerster A, Hartung HP, Schnitzler A, Methner A.

PLoS One. 2012;7(4):e34891. doi: 10.1371/journal.pone.0034891. Epub 2012 Apr 13.

47.

Degeneration of retinal layers in multiple sclerosis subtypes quantified by optical coherence tomography.

Albrecht P, Ringelstein M, Müller AK, Keser N, Dietlein T, Lappas A, Foerster A, Hartung HP, Aktas O, Methner A.

Mult Scler. 2012 Oct;18(10):1422-9. Epub 2012 Mar 2.

PMID:
22389411
48.

The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.

Bultynck G, Kiviluoto S, Henke N, Ivanova H, Schneider L, Rybalchenko V, Luyten T, Nuyts K, De Borggraeve W, Bezprozvanny I, Parys JB, De Smedt H, Missiaen L, Methner A.

J Biol Chem. 2012 Jan 20;287(4):2544-57. doi: 10.1074/jbc.M111.275354. Epub 2011 Nov 28.

49.

Mutation of ATF4 mediates resistance of neuronal cell lines against oxidative stress by inducing xCT expression.

Lewerenz J, Sato H, Albrecht P, Henke N, Noack R, Methner A, Maher P.

Cell Death Differ. 2012 May;19(5):847-58. doi: 10.1038/cdd.2011.165. Epub 2011 Nov 18.

50.

Charcot-Marie-Tooth disease CMT4A: GDAP1 increases cellular glutathione and the mitochondrial membrane potential.

Noack R, Frede S, Albrecht P, Henke N, Pfeiffer A, Knoll K, Dehmel T, Meyer Zu Hörste G, Stettner M, Kieseier BC, Summer H, Golz S, Kochanski A, Wiedau-Pazos M, Arnold S, Lewerenz J, Methner A.

Hum Mol Genet. 2012 Jan 1;21(1):150-62. doi: 10.1093/hmg/ddr450. Epub 2011 Sep 28.

PMID:
21965300

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