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Items: 14


Softening the Stressed Giant Titin in Diabetes Mellitus.

Methawasin M, Granzier H.

Circ Res. 2018 Jul 20;123(3):315-317. doi: 10.1161/CIRCRESAHA.118.313396. No abstract available.


The giant protein titin regulates the length of the striated muscle thick filament.

Tonino P, Kiss B, Strom J, Methawasin M, Smith JE 3rd, Kolb J, Labeit S, Granzier H.

Nat Commun. 2017 Oct 19;8(1):1041. doi: 10.1038/s41467-017-01144-9.


Increased Titin Compliance Reduced Length-Dependent Contraction and Slowed Cross-Bridge Kinetics in Skinned Myocardial Strips from Rbm (20ΔRRM) Mice.

Pulcastro HC, Awinda PO, Methawasin M, Granzier H, Dong W, Tanner BC.

Front Physiol. 2016 Jul 29;7:322. doi: 10.3389/fphys.2016.00322. eCollection 2016.


Alternative Splicing of Titin Restores Diastolic Function in an HFpEF-Like Genetic Murine Model (TtnΔIAjxn).

Bull M, Methawasin M, Strom J, Nair P, Hutchinson K, Granzier H.

Circ Res. 2016 Sep 2;119(6):764-72. doi: 10.1161/CIRCRESAHA.116.308904. Epub 2016 Jul 28.


Thin filament length in the cardiac sarcomere varies with sarcomere length but is independent of titin and nebulin.

Kolb J, Li F, Methawasin M, Adler M, Escobar YN, Nedrud J, Pappas CT, Harris SP, Granzier H.

J Mol Cell Cardiol. 2016 Aug;97:286-94. doi: 10.1016/j.yjmcc.2016.04.013. Epub 2016 Apr 30.


Deleting titin's I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function.

Granzier HL, Hutchinson KR, Tonino P, Methawasin M, Li FW, Slater RE, Bull MM, Saripalli C, Pappas CT, Gregorio CC, Smith JE 3rd.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14589-94. doi: 10.1073/pnas.1411493111. Epub 2014 Sep 22.


Experimentally increasing titin compliance in a novel mouse model attenuates the Frank-Starling mechanism but has a beneficial effect on diastole.

Methawasin M, Hutchinson KR, Lee EJ, Smith JE 3rd, Saripalli C, Hidalgo CG, Ottenheijm CA, Granzier H.

Circulation. 2014 May 13;129(19):1924-36. doi: 10.1161/CIRCULATIONAHA.113.005610. Epub 2014 Mar 5.


Shortening of the elastic tandem immunoglobulin segment of titin leads to diastolic dysfunction.

Chung CS, Hutchinson KR, Methawasin M, Saripalli C, Smith JE 3rd, Hidalgo CG, Luo X, Labeit S, Guo C, Granzier HL.

Circulation. 2013 Jul 2;128(1):19-28. doi: 10.1161/CIRCULATIONAHA.112.001268. Epub 2013 May 24.


The multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin's spring elements.

Hidalgo CG, Chung CS, Saripalli C, Methawasin M, Hutchinson KR, Tsaprailis G, Labeit S, Mattiazzi A, Granzier HL.

J Mol Cell Cardiol. 2013 Jan;54:90-7. doi: 10.1016/j.yjmcc.2012.11.012. Epub 2012 Dec 5.


Titin based viscosity in ventricular physiology: an integrative investigation of PEVK-actin interactions.

Chung CS, Methawasin M, Nelson OL, Radke MH, Hidalgo CG, Gotthardt M, Granzier HL.

J Mol Cell Cardiol. 2011 Sep;51(3):428-34. doi: 10.1016/j.yjmcc.2011.06.006. Epub 2011 Jun 16.


Mouse intact cardiac myocyte mechanics: cross-bridge and titin-based stress in unactivated cells.

King NM, Methawasin M, Nedrud J, Harrell N, Chung CS, Helmes M, Granzier H.

J Gen Physiol. 2011 Jan;137(1):81-91. doi: 10.1085/jgp.201010499.


Prolactin decreases expression of Runx2, osteoprotegerin, and RANKL in primary osteoblasts derived from tibiae of adult female rats.

Charoenphandhu N, Teerapornpuntakit J, Methawasin M, Wongdee K, Thongchote K, Krishnamra N.

Can J Physiol Pharmacol. 2008 May;86(5):240-8. doi: 10.1139/y08-037.


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