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The FcεRIβ homologue, MS4A4A, promotes FcεRI signal transduction and store-operated Ca2+ entry in human mast cells.

Arthur GK, Ehrhardt-Humbert LC, Snider DB, Jania C, Tilley SL, Metcalfe DD, Cruse G.

Cell Signal. 2020 Mar 30;71:109617. doi: 10.1016/j.cellsig.2020.109617. [Epub ahead of print]



Naranjo AN, Bandara G, Bai Y, Smelkinson MG, Tobío A, Komarow HD, Boyden SE, Kastner DL, Metcalfe DD, Olivera A.

J Invest Dermatol. 2020 Mar 25. pii: S0022-202X(20)31203-3. doi: 10.1016/j.jid.2020.03.936. [Epub ahead of print]


Aldh2 Attenuates Stem Cell Factor/Kit-Dependent Signaling and Activation in Mast Cells.

Kim DK, Cho YE, Song BJ, Kawamoto T, Metcalfe DD, Olivera A.

Int J Mol Sci. 2019 Dec 10;20(24). pii: E6216. doi: 10.3390/ijms20246216.


Description and Characterization of a Novel Human Mast Cell Line for Scientific Study.

Kirshenbaum AS, Yin Y, Sundstrom JB, Bandara G, Metcalfe DD.

Int J Mol Sci. 2019 Nov 6;20(22). pii: E5520. doi: 10.3390/ijms20225520.


Inhibition of Allergic Reactivity through Targeting FcεRI-Bound IgE with Humanized Low-Affinity Antibodies.

Zhang K, Elias M, Zhang H, Liu J, Kepley C, Bai Y, Metcalfe DD, Schiller Z, Wang Y, Saxon A.

J Immunol. 2019 Dec 1;203(11):2777-2790. doi: 10.4049/jimmunol.1900112. Epub 2019 Oct 21.


Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia.

Le QT, Lyons JJ, Naranjo AN, Olivera A, Lazarus RA, Metcalfe DD, Milner JD, Schwartz LB.

J Exp Med. 2019 Oct 7;216(10):2348-2361. doi: 10.1084/jem.20190701. Epub 2019 Jul 23.


Skewed Lymphocyte Subpopulations and Associated Phenotypes in Patients with Mastocytosis.

Kulinski JM, Eisch R, Young ML, Rampertaap S, Stoddard J, Monsale J, Romito K, Lyons JJ, Rosenzweig SD, Metcalfe DD, Komarow HD.

J Allergy Clin Immunol Pract. 2020 Jan;8(1):292-301.e2. doi: 10.1016/j.jaip.2019.07.004. Epub 2019 Jul 15.


Why the 20% + 2 Tryptase Formula Is a Diagnostic Gold Standard for Severe Systemic Mast Cell Activation and Mast Cell Activation Syndrome.

Valent P, Bonadonna P, Hartmann K, Broesby-Olsen S, Brockow K, Butterfield JH, Triggiani M, Lyons JJ, Oude Elberink JNG, Arock M, Metcalfe DD, Akin C.

Int Arch Allergy Immunol. 2019;180(1):44-51. doi: 10.1159/000501079. Epub 2019 Jun 28. Review.


GATA-2-deficient mast cells limit IgE-mediated immediate hypersensitivity reactions in human subjects.

Desai A, Sowerwine K, Liu Y, Lawrence MG, Chovanec J, Hsu AP, O'Connell MP, Kim J, Boris L, Jones N, Wisch L, Eisch RR, Carter MC, Komarow HD, Zerbe C, Milner JD, Maric I, Sun X, Lee CR, Tunc I, Pirooznia M, Stone KD, Holland SM, Metcalfe DD, Lyons JJ.

J Allergy Clin Immunol. 2019 Aug;144(2):613-617.e14. doi: 10.1016/j.jaci.2019.05.007. Epub 2019 May 15. No abstract available.


Maculopapular Cutaneous Mastocytosis in a Diverse Population.

Kirshenbaum AS, Abuhay H, Bolan H, Metcalfe DD, Carter MC.

J Allergy Clin Immunol Pract. 2019 Nov - Dec;7(8):2845-2847. doi: 10.1016/j.jaip.2019.04.003. Epub 2019 May 2. No abstract available.


Oncogenic D816V-KIT signaling in mast cells causes persistent IL-6 production.

Tobío A, Bandara G, Morris DA, Kim DK, O'Connell MP, Komarow HD, Carter MC, Smrz D, Metcalfe DD, Olivera A.

Haematologica. 2020 Jan;105(1):124-135. doi: 10.3324/haematol.2018.212126. Epub 2019 Apr 4.


Proposed Diagnostic Algorithm for Patients with Suspected Mast Cell Activation Syndrome.

Valent P, Akin C, Bonadonna P, Hartmann K, Brockow K, Niedoszytko M, Nedoszytko B, Siebenhaar F, Sperr WR, Oude Elberink JNG, Butterfield JH, Alvarez-Twose I, Sotlar K, Reiter A, Kluin-Nelemans HC, Hermine O, Gotlib J, Broesby-Olsen S, Orfao A, Horny HP, Triggiani M, Arock M, Schwartz LB, Metcalfe DD.

J Allergy Clin Immunol Pract. 2019 Apr;7(4):1125-1133.e1. doi: 10.1016/j.jaip.2019.01.006. Epub 2019 Feb 5. Review.


Controversies in Allergy: Is a Bone Marrow Biopsy Optional or Essential in the Evaluation of the Patient with a Suspected Mast Cell Disorder?

Greenberger PA, Metcalfe DD.

J Allergy Clin Immunol Pract. 2019 Apr;7(4):1134-1138. doi: 10.1016/j.jaip.2018.11.019. Epub 2019 Jan 8. Review. No abstract available.


Sialic acid-binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies.

Legrand F, Cao Y, Wechsler JB, Zhu X, Zimmermann N, Rampertaap S, Monsale J, Romito K, Youngblood BA, Brock EC, Makiya MA, Tomasevic N, Bebbington C, Maric I, Metcalfe DD, Bochner BS, Klion AD.

J Allergy Clin Immunol. 2019 Jun;143(6):2227-2237.e10. doi: 10.1016/j.jaci.2018.10.066. Epub 2018 Dec 10.


Adverse reactions to drugs and biologics in patients with clonal mast cell disorders: A Work Group Report of the Mast Cells Disorder Committee, American Academy of Allergy, Asthma & Immunology.

Carter MC, Metcalfe DD, Matito A, Escribano L, Butterfield JH, Schwartz LB, Bonadonna P, Zanotti R, Triggiani M, Castells M, Brockow K.

J Allergy Clin Immunol. 2019 Mar;143(3):880-893. doi: 10.1016/j.jaci.2018.10.063. Epub 2018 Dec 6. Review.


Detection of KIT D816V in peripheral blood of children with manifestations of cutaneous mastocytosis suggests systemic disease.

Carter MC, Bai Y, Ruiz-Esteves KN, Scott LM, Cantave D, Bolan H, Eisch R, Sun X, Hahn J, Maric I, Metcalfe DD.

Br J Haematol. 2018 Dec;183(5):775-782. doi: 10.1111/bjh.15624.



Olivera A, Metcalfe DD.

J Allergy Clin Immunol. 2019 Jan;143(1):451-452. doi: 10.1016/j.jaci.2018.09.015. Epub 2018 Nov 1. No abstract available.


Mastocytosis-derived extracellular vesicles exhibit a mast cell signature, transfer KIT to stellate cells, and promote their activation.

Kim DK, Cho YE, Komarow HD, Bandara G, Song BJ, Olivera A, Metcalfe DD.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10692-E10701. doi: 10.1073/pnas.1809938115. Epub 2018 Oct 23.


A personal perspective on mentoring.

Metcalfe DD.

J Allergy Clin Immunol. 2019 Feb;143(2):548-549. doi: 10.1016/j.jaci.2018.10.002. Epub 2018 Oct 9. No abstract available.


Twelve-year follow-up of omalizumab therapy for anaphylaxis in 2 patients with systemic mastocytosis.

Constantine GM, Bressler PB, Petroni D, Metcalfe DD, Carter MC.

J Allergy Clin Immunol Pract. 2019 Apr;7(4):1314-1316. doi: 10.1016/j.jaip.2018.07.041. Epub 2018 Aug 24. No abstract available.


Elevation in histamine and tryptase following exercise in patients with mastocytosis.

Kulinski JM, Metcalfe DD, Young ML, Bai Y, Yin Y, Eisch R, Scott LM, Komarow HD.

J Allergy Clin Immunol Pract. 2019 Apr;7(4):1310-1313.e2. doi: 10.1016/j.jaip.2018.07.008. Epub 2018 Jul 23. No abstract available.


Preclinical human models and emerging therapeutics for advanced systemic mastocytosis.

Arock M, Wedeh G, Hoermann G, Bibi S, Akin C, Peter B, Gleixner KV, Hartmann K, Butterfield JH, Metcalfe DD, Valent P.

Haematologica. 2018 Nov;103(11):1760-1771. doi: 10.3324/haematol.2018.195867. Epub 2018 Jul 5. Review.


Mast cell activation syndrome: Importance of consensus criteria and call for research.

Valent P, Akin C, Bonadonna P, Hartmann K, Broesby-Olsen S, Brockow K, Butterfield JH, Reiter A, Gotlib J, Castells M, Milner JD, Carter MC, Komarow H, Radia D, Pardanani A, Sotlar K, Triggiani M, Horny HP, Arock M, Schwartz LB, Metcalfe DD.

J Allergy Clin Immunol. 2018 Sep;142(3):1008-1010. doi: 10.1016/j.jaci.2018.06.004. Epub 2018 Jun 19. No abstract available.


S1P₄ Regulates Passive Systemic Anaphylaxis in Mice but Is Dispensable for Canonical IgE-Mediated Responses in Mast Cells.

Kulinski JM, Proia RL, Larson EM, Metcalfe DD, Olivera A.

Int J Mol Sci. 2018 Apr 25;19(5). pii: E1279. doi: 10.3390/ijms19051279.


Targeting Sphingosine Kinase Isoforms Effectively Reduces Growth and Survival of Neoplastic Mast Cells With D816V-KIT.

Bandara G, Muñoz-Cano R, Tobío A, Yin Y, Komarow HD, Desai A, Metcalfe DD, Olivera A.

Front Immunol. 2018 Mar 28;9:631. doi: 10.3389/fimmu.2018.00631. eCollection 2018.


Mast cells signal their importance in health and disease.

Olivera A, Beaven MA, Metcalfe DD.

J Allergy Clin Immunol. 2018 Aug;142(2):381-393. doi: 10.1016/j.jaci.2018.01.034. Epub 2018 Feb 15. Review.


Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal.

Valent P, Akin C, Arock M, Bock C, George TI, Galli SJ, Gotlib J, Haferlach T, Hoermann G, Hermine O, Jäger U, Kenner L, Kreipe H, Majeti R, Metcalfe DD, Orfao A, Reiter A, Sperr WR, Staber PB, Sotlar K, Schiffer C, Superti-Furga G, Horny HP.

EBioMedicine. 2017 Dec;26:17-24. doi: 10.1016/j.ebiom.2017.11.024. Epub 2017 Nov 26. Review.


Identification of alpha-gal sensitivity in patients with a diagnosis of idiopathic anaphylaxis.

Carter MC, Ruiz-Esteves KN, Workman L, Lieberman P, Platts-Mills TAE, Metcalfe DD.

Allergy. 2018 May;73(5):1131-1134. doi: 10.1111/all.13366. Epub 2017 Dec 27.


Chromogranin A is not a biomarker of mastocytosis.

Hanjra P, Lee CR, Maric I, Carter M, Olivera A, Metcalfe DD, Komarow HD.

J Allergy Clin Immunol Pract. 2018 Mar - Apr;6(2):687-689.e4. doi: 10.1016/j.jaip.2017.08.022. Epub 2017 Oct 13. No abstract available.


Interaction of DJ-1 with Lyn is essential for IgE-mediated stimulation of human mast cells.

Kim DK, Beaven MA, Metcalfe DD, Olivera A.

J Allergy Clin Immunol. 2018 Jul;142(1):195-206.e8. doi: 10.1016/j.jaci.2017.08.030. Epub 2017 Oct 13.


A distinct biomolecular profile identifies monoclonal mast cell disorders in patients with idiopathic anaphylaxis.

Carter MC, Desai A, Komarow HD, Bai Y, Clayton ST, Clark AS, Ruiz-Esteves KN, Long LM, Cantave D, Wilson TM, Scott LM, Simakova O, Jung MY, Hahn J, Maric I, Metcalfe DD.

J Allergy Clin Immunol. 2018 Jan;141(1):180-188.e3. doi: 10.1016/j.jaci.2017.05.036. Epub 2017 Jun 16.


An optimized protocol for the generation and functional analysis of human mast cells from CD34+ enriched cell populations.

Yin Y, Bai Y, Olivera A, Desai A, Metcalfe DD.

J Immunol Methods. 2017 Sep;448:105-111. doi: 10.1016/j.jim.2017.06.003. Epub 2017 Jun 16.


Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future.

Valent P, Akin C, Hartmann K, Nilsson G, Reiter A, Hermine O, Sotlar K, Sperr WR, Escribano L, George TI, Kluin-Nelemans HC, Ustun C, Triggiani M, Brockow K, Gotlib J, Orfao A, Schwartz LB, Broesby-Olsen S, Bindslev-Jensen C, Kovanen PT, Galli SJ, Austen KF, Arber DA, Horny HP, Arock M, Metcalfe DD.

Cancer Res. 2017 Mar 15;77(6):1261-1270. doi: 10.1158/0008-5472.CAN-16-2234. Epub 2017 Mar 2. Review.


Pathogenesis and Pathology of Mastocytosis.

Metcalfe DD, Mekori YA.

Annu Rev Pathol. 2017 Jan 24;12:487-514. doi: 10.1146/annurev-pathol-052016-100312. Review.


Proposed diagnostic criteria and classification of basophilic leukemias and related disorders.

Valent P, Sotlar K, Blatt K, Hartmann K, Reiter A, Sadovnik I, Sperr WR, Bettelheim P, Akin C, Bauer K, George TI, Hadzijusufovic E, Wolf D, Gotlib J, Mahon FX, Metcalfe DD, Horny HP, Arock M.

Leukemia. 2017 Apr;31(4):788-797. doi: 10.1038/leu.2017.15. Epub 2017 Jan 16. Review.


Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts.

Valent P, Akin C, Metcalfe DD.

Blood. 2017 Mar 16;129(11):1420-1427. doi: 10.1182/blood-2016-09-731893. Epub 2016 Dec 28. Review.


Exon skipping of FcεRIβ eliminates expression of the high-affinity IgE receptor in mast cells with therapeutic potential for allergy.

Cruse G, Yin Y, Fukuyama T, Desai A, Arthur GK, Bäumer W, Beaven MA, Metcalfe DD.

Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14115-14120. Epub 2016 Nov 21.


Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number.

Lyons JJ, Yu X, Hughes JD, Le QT, Jamil A, Bai Y, Ho N, Zhao M, Liu Y, O'Connell MP, Trivedi NN, Nelson C, DiMaggio T, Jones N, Matthews H, Lewis KL, Oler AJ, Carlson RJ, Arkwright PD, Hong C, Agama S, Wilson TM, Tucker S, Zhang Y, McElwee JJ, Pao M, Glover SC, Rothenberg ME, Hohman RJ, Stone KD, Caughey GH, Heller T, Metcalfe DD, Biesecker LG, Schwartz LB, Milner JD.

Nat Genet. 2016 Dec;48(12):1564-1569. doi: 10.1038/ng.3696. Epub 2016 Oct 17.


Advanced systemic mastocytosis: from molecular and genetic progress to clinical practice.

Ustun C, Arock M, Kluin-Nelemans HC, Reiter A, Sperr WR, George T, Horny HP, Hartmann K, Sotlar K, Damaj G, Hermine O, Verstovsek S, Metcalfe DD, Gotlib J, Akin C, Valent P.

Haematologica. 2016 Oct;101(10):1133-1143. Review.


Regulation of Reactive Oxygen Species and the Antioxidant Protein DJ-1 in Mastocytosis.

Kim DK, Beaven MA, Kulinski JM, Desai A, Bandara G, Bai Y, Prussin C, Schwartz LB, Komarow H, Metcalfe DD, Olivera A.

PLoS One. 2016 Sep 9;11(9):e0162831. doi: 10.1371/journal.pone.0162831. eCollection 2016.


Immunophenotypic and Ultrastructural Analysis of Mast Cells in Hermansky-Pudlak Syndrome Type-1: A Possible Connection to Pulmonary Fibrosis.

Kirshenbaum AS, Cruse G, Desai A, Bandara G, Leerkes M, Lee CC, Fischer ER, O'Brien KJ, Gochuico BR, Stone K, Gahl WA, Metcalfe DD.

PLoS One. 2016 Jul 26;11(7):e0159177. doi: 10.1371/journal.pone.0159177. eCollection 2016.


Vibratory Urticaria and ADGRE2.

Boyden SE, Metcalfe DD, Komarow HD.

N Engl J Med. 2016 Jul 7;375(1):95. doi: 10.1056/NEJMc1604757. No abstract available.


Consensus Opinion on Allogeneic Hematopoietic Cell Transplantation in Advanced Systemic Mastocytosis.

Ustun C, Gotlib J, Popat U, Artz A, Litzow M, Reiter A, Nakamura R, Kluin-Nelemans HC, Verstovsek S, Gajewski J, Perales MA, George T, Shore T, Sperr W, Saber W, Kota V, Yavuz AS, Pullarkat V, Rogosheske J, Hogan W, Van Besien K, Hagglund H, Damaj G, Arock M, Horny HP, Metcalfe DD, Deeg HJ, Devine S, Weisdorf D, Akin C, Valent P.

Biol Blood Marrow Transplant. 2016 Aug;22(8):1348-1356. doi: 10.1016/j.bbmt.2016.04.018. Epub 2016 Apr 27. No abstract available.


Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis.

Hox V, O'Connell MP, Lyons JJ, Sackstein P, Dimaggio T, Jones N, Nelson C, Boehm M, Holland SM, Freeman AF, Tweardy DJ, Olivera A, Metcalfe DD, Milner JD.

J Allergy Clin Immunol. 2016 Jul;138(1):187-199. doi: 10.1016/j.jaci.2015.11.024. Epub 2016 Mar 2. Erratum in: J Allergy Clin Immunol. 2017 Jul;140(1):320.


Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases.

Metcalfe DD, Pawankar R, Ackerman SJ, Akin C, Clayton F, Falcone FH, Gleich GJ, Irani AM, Johansson MW, Klion AD, Leiferman KM, Levi-Schaffer F, Nilsson G, Okayama Y, Prussin C, Schroeder JT, Schwartz LB, Simon HU, Walls AF, Triggiani M.

World Allergy Organ J. 2016 Feb 11;9:7. doi: 10.1186/s40413-016-0094-3. eCollection 2016. Review.


Subvisible Particle Content, Formulation, and Dose of an Erythropoietin Peptide Mimetic Product Are Associated With Severe Adverse Postmarketing Events.

Kotarek J, Stuart C, De Paoli SH, Simak J, Lin TL, Gao Y, Ovanesov M, Liang Y, Scott D, Brown J, Bai Y, Metcalfe DD, Marszal E, Ragheb JA.

J Pharm Sci. 2016 Mar;105(3):1023-7. doi: 10.1016/S0022-3549(15)00180-X. Epub 2016 Feb 3.


Vibratory Urticaria Associated with a Missense Variant in ADGRE2.

Boyden SE, Desai A, Cruse G, Young ML, Bolan HC, Scott LM, Eisch AR, Long RD, Lee CC, Satorius CL, Pakstis AJ, Olivera A, Mullikin JC, Chouery E, Mégarbané A, Medlej-Hashim M, Kidd KK, Kastner DL, Metcalfe DD, Komarow HD.

N Engl J Med. 2016 Feb 18;374(7):656-63. doi: 10.1056/NEJMoa1500611. Epub 2016 Feb 3.


Development and validation of the mastocytosis quality of life questionnaire: MC-QoL.

Siebenhaar F, von Tschirnhaus E, Hartmann K, Rabenhorst A, Staubach P, Peveling-Oberhag A, Wagner N, Martus P, Carter MC, Metcalfe DD, Church MK, Maurer M, Weller K.

Allergy. 2016 Jun;71(6):869-77. doi: 10.1111/all.12842. Epub 2016 Feb 15.


IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor of cytokine signaling 3.

Desai A, Jung MY, Olivera A, Gilfillan AM, Prussin C, Kirshenbaum AS, Beaven MA, Metcalfe DD.

J Allergy Clin Immunol. 2016 Jun;137(6):1863-1871.e6. doi: 10.1016/j.jaci.2015.09.059. Epub 2016 Jan 7.


Impulse oscillometry identifies peripheral airway dysfunction in children with adenosine deaminase deficiency.

Komarow HD, Sokolic R, Hershfield MS, Kohn DB, Young M, Metcalfe DD, Candotti F.

Orphanet J Rare Dis. 2015 Dec 18;10:159. doi: 10.1186/s13023-015-0365-z.

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