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The ProtecT trial: analysis of the patient cohort, baseline risk stratification and disease progression.

Bryant RJ, Oxley J, Young GJ, Lane JA, Metcalfe C, Davis M, Turner EL, Martin RM, Goepel JR, Varma M, Griffiths DF, Grigor K, Mayer N, Warren AY, Bhattarai S, Dormer J, Mason M, Staffurth J, Walsh E, Rosario DJ, F Catto JW, Neal DE, Donovan JL, Hamdy FC; ProtecT Study Group, Bollina P, Doble A, Doherty A, Gillatt D, Gnanapragasam V, Hughes O, Kockelbergh R, Kynaston H, Paul A, Paez E, Rowe E.

BJU Int. 2020 Jan 3. doi: 10.1111/bju.14987. [Epub ahead of print]


Results of the feasibility phase of the managed activity graded exercise in teenagers and pre-adolescents (MAGENTA) randomised controlled trial of treatments for chronic fatigue syndrome/myalgic encephalomyelitis.

Brigden A, Beasant L, Gaunt D, Hollingworth W, Mills N, Solomon-Moore E, Jago R, Metcalfe C, Garfield K, Wray C, Trist A, Vilenchik V, Grayson C, Crawley E.

Pilot Feasibility Stud. 2019 Dec 19;5:151. doi: 10.1186/s40814-019-0525-3. eCollection 2019.


Arab Threat and Social Control: An Exploration of the Relationship Between Ethnic Attitudes and Punitiveness Among Israeli Jews.

Metcalfe C, Cann D.

Int J Offender Ther Comp Criminol. 2019 Dec 24:306624X19895973. doi: 10.1177/0306624X19895973. [Epub ahead of print]


Introduction of a referral pathway guide for general dental practitioners in Cheshire & Merseyside: the effect on two-week suspected cancer referrals.

Metcalfe C, Dailey Y, Lowe D, Rogers SN.

Br Dent J. 2019 Dec;227(12):1058-1062. doi: 10.1038/s41415-019-1003-2.


A revised teaching assistant-led extracurricular physical activity programme for 8- to 10-year-olds: the Action 3:30R feasibility cluster RCT.

Jago R, Tibbitts B, Porter A, Sanderson E, Bird E, Powell JE, Metcalfe C, Sebire SJ.

Southampton (UK): NIHR Journals Library; 2019 Dec.


Guided self-help for depression in autistic adults: the ADEPT feasibility RCT.

Russell A, Gaunt D, Cooper K, Horwood J, Barton S, Ensum I, Ingham B, Parr J, Metcalfe C, Rai D, Kessler D, Wiles N.

Health Technol Assess. 2019 Dec;23(68):1-94. doi: 10.3310/hta23680.


Investigating the effectiveness and cost-effectiveness of FITNET-NHS (Fatigue In Teenagers on the interNET in the NHS) compared to activity management to treat paediatric chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME): amendment to the published protocol.

Anderson E, Gaunt D, Metcalfe C, Rai M, Hollingworth W, Mills N, Beasant L, Parslow R, Kessler D, Macleod J, Stallard P, Knoop H, Van de Putte E, Nijhof S, Bleijenberg G, Crawley E.

Trials. 2019 Dec 19;20(1):750. doi: 10.1186/s13063-019-3895-1.


Flow cytometric characterisation of the complex polyploid genome of Saccharum officinarum and modern sugarcane cultivars.

Metcalfe CJ, Li J, Giorgi D, Doležel J, Piperidis N, Aitken KS.

Sci Rep. 2019 Dec 18;9(1):19362. doi: 10.1038/s41598-019-55652-3.


Pesticides in Surface Waters in Argentina Monitored Using Polar Organic Chemical Integrative Samplers.

Corcoran S, Metcalfe CD, Sultana T, Amé MV, Menone ML.

Bull Environ Contam Toxicol. 2020 Jan;104(1):21-26. doi: 10.1007/s00128-019-02758-z. Epub 2019 Dec 6.


The feasibility of low-intensity psychological therapy for depression co-occurring with autism in adults: The Autism Depression Trial (ADEPT) - a pilot randomised controlled trial.

Russell A, Gaunt DM, Cooper K, Barton S, Horwood J, Kessler D, Metcalfe C, Ensum I, Ingham B, Parr JR, Rai D, Wiles N.

Autism. 2019 Nov 29:1362361319889272. doi: 10.1177/1362361319889272. [Epub ahead of print] Erratum in: Autism. 2019 Dec 9;:1362361319896198.


Ten-year Mortality, Disease Progression, and Treatment-related Side Effects in Men with Localised Prostate Cancer from the ProtecT Randomised Controlled Trial According to Treatment Received.

Neal DE, Metcalfe C, Donovan JL, Lane JA, Davis M, Young GJ, Dutton SJ, Walsh EI, Martin RM, Peters TJ, Turner EL, Mason M, Bryant R, Bollina P, Catto J, Doherty A, Gillatt D, Gnanapragasam V, Holding P, Hughes O, Kockelbergh R, Kynaston H, Oxley J, Paul A, Paez E, Rosario DJ, Rowe E, Staffurth J, Altman DG, Hamdy FC; ProtecT Study Group.

Eur Urol. 2019 Nov 24. pii: S0302-2838(19)30837-1. doi: 10.1016/j.eururo.2019.10.030. [Epub ahead of print]


Laparoscopically assisted versus open oesophagectomy for patients with oesophageal cancer-the Randomised Oesophagectomy: Minimally Invasive or Open (ROMIO) study: protocol for a randomised controlled trial (RCT).

Brierley RC, Gaunt D, Metcalfe C, Blazeby JM, Blencowe NS, Jepson M, Berrisford RG, Avery KNL, Hollingworth W, Rice CT, Moure-Fernandez A, Wong N, Nicklin J, Skilton A, Boddy A, Byrne JP, Underwood T, Vohra R, Catton JA, Pursnani K, Melhado R, Alkhaffaf B, Krysztopik R, Lamb P, Culliford L, Rogers C, Howes B, Chalmers K, Cousins S, Elliott J, Donovan J, Heys R, Wickens RA, Wilkerson P, Hollowood A, Streets C, Titcomb D, Humphreys ML, Wheatley T, Sanders G, Ariyarathenam A, Kelly J, Noble F, Couper G, Skipworth RJE, Deans C, Ubhi S, Williams R, Bowrey D, Exon D, Turner P, Daya Shetty V, Chaparala R, Akhtar K, Farooq N, Parsons SL, Welch NT, Houlihan RJ, Smith J, Schranz R, Rea N, Cooke J, Williams A, Hindmarsh C, Maitland S, Howie L, Barham CP.

BMJ Open. 2019 Nov 19;9(11):e030907. doi: 10.1136/bmjopen-2019-030907.


The impact of thioredoxin reduction of allosteric disulfide bonds on the therapeutic potential of monoclonal antibodies.

Gurjar SA, Wheeler JX, Wadhwa M, Thorpe R, Kimber I, Derrick JP, Dearman RJ, Metcalfe C.

J Biol Chem. 2019 Dec 20;294(51):19616-19634. doi: 10.1074/jbc.RA119.010637. Epub 2019 Nov 14.


Sub-lethal effects of a neonicotinoid, clothianidin, on wild early life stage sockeye salmon (Oncorhynchus nerka).

Marlatt VL, Leung TYG, Calbick S, Metcalfe C, Kennedy C.

Aquat Toxicol. 2019 Dec;217:105335. doi: 10.1016/j.aquatox.2019.105335. Epub 2019 Oct 19.


Evaluating the population impact of hepatitis C direct acting antiviral treatment as prevention for people who inject drugs (EPIToPe) - a natural experiment (protocol).

Hickman M, Dillon JF, Elliott L, De Angelis D, Vickerman P, Foster G, Donnan P, Eriksen A, Flowers P, Goldberg D, Hollingworth W, Ijaz S, Liddell D, Mandal S, Martin N, Beer LJZ, Drysdale K, Fraser H, Glass R, Graham L, Gunson RN, Hamilton E, Harris H, Harris M, Harris R, Heinsbroek E, Hope V, Horwood J, Inglis SK, Innes H, Lane A, Meadows J, McAuley A, Metcalfe C, Migchelsen S, Murray A, Myring G, Palmateer NE, Presanis A, Radley A, Ramsay M, Samartsidis P, Simmons R, Sinka K, Vojt G, Ward Z, Whiteley D, Yeung A, Hutchinson SJ.

BMJ Open. 2019 Sep 24;9(9):e029538. doi: 10.1136/bmjopen-2019-029538.


Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models.

Moore HM, Savage HM, O'Brien C, Zhou W, Sokol ES, Goldberg ME, Metcalfe C, Friedman LS, Lackner MR, Wilson TR.

Mol Cancer Ther. 2020 Jan;19(1):292-303. doi: 10.1158/1535-7163.MCT-19-0284. Epub 2019 Sep 18.


Acceptability of the BATHE technique amongst GPs and frequently attending patients in primary care: a nested qualitative study.

Thomas C, Cramer H, Jackson S, Kessler D, Metcalfe C, Record C, Barnes RK.

BMC Fam Pract. 2019 Sep 3;20(1):121. doi: 10.1186/s12875-019-1011-y.


Action 3:30R: process evaluation of a cluster randomised feasibility study of a revised teaching assistant-led extracurricular physical activity intervention for 8 to 10 year olds.

Tibbitts B, Porter A, Sebire SJ, Bird EL, Sanderson E, Metcalfe C, Powell JE, Jago R.

BMC Public Health. 2019 Aug 14;19(1):1111. doi: 10.1186/s12889-019-7347-3.


Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility.

Guan J, Zhou W, Hafner M, Blake RA, Chalouni C, Chen IP, De Bruyn T, Giltnane JM, Hartman SJ, Heidersbach A, Houtman R, Ingalla E, Kategaya L, Kleinheinz T, Li J, Martin SE, Modrusan Z, Nannini M, Oeh J, Ubhayakar S, Wang X, Wertz IE, Young A, Yu M, Sampath D, Hager JH, Friedman LS, Daemen A, Metcalfe C.

Cell. 2019 Aug 8;178(4):949-963.e18. doi: 10.1016/j.cell.2019.06.026. Epub 2019 Jul 25.


Child-care self-assessment to improve physical activity, oral health and nutrition for 2- to 4-year-olds: a feasibility cluster RCT.

Kipping R, Langford R, Brockman R, Wells S, Metcalfe C, Papadaki A, White J, Hollingworth W, Moore L, Ward D, Campbell R, Kadir B, Tinner L, Er V, Dias K, Busse H, Collingwood J, Nicholson A, Johnson L, Jago R.

Southampton (UK): NIHR Journals Library; 2019 Jul.


Anaesthetic-analgesic ear drops to reduce antibiotic consumption in children with acute otitis media: the CEDAR RCT.

Hay AD, Downing H, Francis NA, Young GJ, Clement C, Harris SD, Ahern A, Schofield B, Thomas TE, Horwood J, Blair PS, Hollingworth W, Wilson V, Metcalfe C, Stoddart P, Nunez D, Lyttle MD, Little P, Moore MV.

Health Technol Assess. 2019 Jul;23(34):1-48. doi: 10.3310/hta23340.


A systematic review of core outcome set development studies demonstrates difficulties in defining unique outcomes.

Young AE, Brookes ST, Avery KNL, Davies A, Metcalfe C, Blazeby JM.

J Clin Epidemiol. 2019 Nov;115:14-24. doi: 10.1016/j.jclinepi.2019.06.016. Epub 2019 Jul 2.


Risk of suicide and repeat self-harm after hospital attendance for non-fatal self-harm in Sri Lanka: a cohort study.

Knipe D, Metcalfe C, Hawton K, Pearson M, Dawson A, Jayamanne S, Konradsen F, Eddleston M, Gunnell D.

Lancet Psychiatry. 2019 Aug;6(8):659-666. doi: 10.1016/S2215-0366(19)30214-7. Epub 2019 Jul 1.


A physical activity, nutrition and oral health intervention in nursery settings: process evaluation of the NAP SACC UK feasibility cluster RCT.

Langford R, Jago R, White J, Moore L, Papadaki A, Hollingworth W, Metcalfe C, Ward D, Campbell R, Wells S, Kipping R.

BMC Public Health. 2019 Jul 3;19(1):865. doi: 10.1186/s12889-019-7102-9.


Evaluation of 'care bundles' for patients with chronic obstructive pulmonary disease (COPD): a multisite study in the UK.

Morton K, MacNeill S, Sanderson E, Dixon P, King A, Jenkins S, Metcalfe C, Shaw A, Chalder M, Benger J, Hollingworth W, Calvert J, Purdy S.

BMJ Open Respir Res. 2019 May 30;6(1):e000425. doi: 10.1136/bmjresp-2019-000425. eCollection 2019.


Cross-sectional analysis of physical activity in 2-4-year-olds in England with paediatric quality of life and family expenditure on physical activity.

Tinner L, Kipping R, White J, Jago R, Metcalfe C, Hollingworth W.

BMC Public Health. 2019 Jun 28;19(1):846. doi: 10.1186/s12889-019-7129-y.


Care bundles to reduce re-admissions for patients with chronic obstructive pulmonary disease: a mixed-methods study.

Morton K, Sanderson E, Dixon P, King A, Jenkins S, MacNeill SJ, Shaw A, Metcalfe C, Chalder M, Hollingworth W, Benger J, Calvert J, Purdy S.

Southampton (UK): NIHR Journals Library; 2019 Jun.


Factors associated with trial recruitment, preferences, and treatments received were elucidated in a comprehensive cohort study.

Donovan JL, Opmeer B, Young GJ, Mills N, Martin RM, Lane JA, Metcalfe C, Peters TJ, Davis M, Turner EL, Walsh E, Neal DE, Hamdy FC; ProtecT Study Group.

J Clin Epidemiol. 2019 Sep;113:200-213. doi: 10.1016/j.jclinepi.2019.05.036. Epub 2019 Jun 3.


A workplace-based intervention to increase levels of daily physical activity: the Travel to Work cluster RCT.

Audrey S, Fisher H, Cooper A, Gaunt D, Metcalfe C, Garfield K, Hollingworth W, Procter S, Gabe-Walters M, Rodgers S, Gillison F, Davis A, Insall P.

Southampton (UK): NIHR Journals Library; 2019 May.


A Proteomics Workflow for the Identification of Labile Disulphide Bonds at the Cell Surface.

Metcalfe C.

Methods Mol Biol. 2019;1967:21-43. doi: 10.1007/978-1-4939-9187-7_3.


A consultation-level intervention to improve care of frequently attending patients: a cluster randomised controlled feasibility trial.

Barnes RK, Cramer H, Thomas C, Sanderson E, Hollinghurst S, Metcalfe C, Jackson S, Record C, Thorley H, Kessler D.

BJGP Open. 2019 Jan 9;3(1):bjgpopen18X101623. doi: 10.3399/bjgpopen18X101623. eCollection 2019 Apr.


Implementation of Neonatal Neurocritical Care Program Improved Short-Term Outcomes in Neonates With Moderate-to-Severe Hypoxic Ischemic Encephalopathy.

Roychoudhury S, Esser MJ, Buchhalter J, Bello-Espinosa L, Zein H, Howlett A, Thomas S, Murthy P, Appendino JP, Scott JN, Metcalfe C, Lind J, Oliver N, Kozlik S, Mohammad K.

Pediatr Neurol. 2019 Dec;101:64-70. doi: 10.1016/j.pediatrneurol.2019.02.023. Epub 2019 Mar 11.


Evaluation of an intervention to promote walking during the commute to work: a cluster randomised controlled trial.

Audrey S, Fisher H, Cooper A, Gaunt D, Garfield K, Metcalfe C, Hollingworth W, Gillison F, Gabe-Walters M, Rodgers S, Davis AL, Insall P, Procter S.

BMC Public Health. 2019 Apr 24;19(1):427. doi: 10.1186/s12889-019-6791-4.


Micropollutants related to human activity in groundwater resources in Barbados, West Indies.

Edwards QA, Sultana T, Kulikov SM, Garner-O'Neale LD, Metcalfe CD.

Sci Total Environ. 2019 Jun 25;671:76-82. doi: 10.1016/j.scitotenv.2019.03.314. Epub 2019 Mar 21.


Effect of green tea and lycopene on the insulin-like growth factor system: the ProDiet randomized controlled trial.

Biernacka KM, Holly JMP, Martin RM, Frankow A, Bull CJ, Hamdy FC, Donovan JL, Neal DE, Metcalfe C, Lane A.

Eur J Cancer Prev. 2019 Nov;28(6):569-575. doi: 10.1097/CEJ.0000000000000502.


Socioeconomic position and suicidal behaviour in rural Sri Lanka: a prospective cohort study of 168,000+ people.

Knipe DW, Gunnell D, Pieris R, Priyadarshana C, Weerasinghe M, Pearson M, Jayamanne S, Hawton K, Konradsen F, Eddleston M, Metcalfe C.

Soc Psychiatry Psychiatr Epidemiol. 2019 Jul;54(7):843-855. doi: 10.1007/s00127-019-01672-3. Epub 2019 Feb 21.


Quantitation of Aloe Vera Polysaccharides by O-Acetyl and UV-Vis Spectrophotometry: First Action 2018.14.

Metcalfe C.

J AOAC Int. 2019 Jul 1;102(4):1091-1094. doi: 10.5740/jaoacint.18-0400. Epub 2019 Feb 14.


IntEgrating Smoking Cessation treatment As part of usual Psychological care for dEpression and anxiety (ESCAPE): protocol for a randomised and controlled, multicentre, acceptability, feasibility and implementation trial.

Taylor G, Aveyard P, Bartlem K, Shaw A, Player J, Metcalfe C, Kessler D, Munafò M.

Pilot Feasibility Stud. 2019 Jan 22;5:16. doi: 10.1186/s40814-018-0385-2. eCollection 2019.


The Liverpool Peritonsillar abscess Score: Development of a predictive score through a prospective multicentre observational study.

Lau AS, Selwyn DM, Yang D, Swainbank L, Ridley P, Carmichael N, Metcalfe C, Watson G, Emerson H.

Clin Otolaryngol. 2019 May;44(3):293-298. doi: 10.1111/coa.13290. Epub 2019 Feb 14.


Are left-behind families of migrant workers at increased risk of attempted suicide? - a cohort study of 178,000+ individuals in Sri Lanka.

Knipe D, Lambert H, Pearson M, Eddleston M, Jayamanne S, Wickramage K, Hawton K, Konradsen F, Metcalfe C, Gunnell D.

BMC Psychiatry. 2019 Jan 15;19(1):25. doi: 10.1186/s12888-018-2000-8.


Action 3:30R: Results of a Cluster Randomised Feasibility Study of a Revised Teaching Assistant-Led Extracurricular Physical Activity Intervention for 8 to 10 Year Olds.

Jago R, Tibbitts B, Sanderson E, Bird EL, Porter A, Metcalfe C, Powell JE, Gillett D, Sebire SJ.

Int J Environ Res Public Health. 2019 Jan 6;16(1). pii: E131. doi: 10.3390/ijerph16010131.


Correction: The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer.

Joseph JD, Darimont B, Zhou W, Arrazate A, Young A, Ingalla E, Walter K, Blake RA, Nonomiya J, Guan Z, Kategaya L, Govek SP, Lai AG, Kahraman M, Brigham D, Sensintaffar J, Lu N, Shao G, Qian J, Grillot K, Moon M, Prudente R, Bischoff E, Lee KJ, Bonnefous C, Douglas KL, Julien JD, Nagasawa JY, Aparicio A, Kaufman J, Haley B, Giltnane JM, Wertz IE, Lackner MR, Nannini MA, Sampath D, Schwarz L, Manning HC, Tantawy MN, Arteaga CL, Heyman RA, Rix PJ, Friedman L, Smith ND, Metcalfe C, Hager JH.

Elife. 2019 Jan 7;8. pii: e44851. doi: 10.7554/eLife.44851.


Correction to: The help for people with money, employment or housing problems (HOPE) intervention: pilot randomised trial with mixed methods feasibility research.

Barnes MC, Haase AM, Scott LJ, Linton MJ, Bard AM, Donovan JL, Davies R, Dursley S, Williams S, Elliott D, Potokar J, Kapur N, Hawton K, O'Connor RC, Hollingworth W, Metcalfe C, Gunnell D.

Pilot Feasibility Stud. 2018 Nov 28;4:177. doi: 10.1186/s40814-018-0374-5. eCollection 2018.


The help for people with money, employment or housing problems (HOPE) intervention: pilot randomised trial with mixed methods feasibility research.

Barnes MC, Haase AM, Scott LJ, Linton MJ, Bard AM, Donovan JL, Davies R, Dursley S, Williams S, Elliott D, Potokar J, Kapur N, Hawton K, O'Connor RC, Hollingworth W, Metcalfe C, Gunnell D.

Pilot Feasibility Stud. 2018 Nov 13;4:172. doi: 10.1186/s40814-018-0365-6. eCollection 2018. Erratum in: Pilot Feasibility Stud. 2018 Nov 28;4:177.


Association of diet in nurseries and physical activity with zBMI in 2-4-year olds in England: a cross-sectional study.

Er V, Dias KI, Papadaki A, White J, Wells S, Ward DS, Metcalfe C, Jago R, Kipping R.

BMC Public Health. 2018 Nov 14;18(1):1262. doi: 10.1186/s12889-018-6138-6.


The first World Health Organization International Standard for infliximab products: A step towards maintaining harmonized biological activity.

Metcalfe C, Dougall T, Bird C, Rigsby P, Behr-Gross ME, Wadhwa M, Study POT.

MAbs. 2019 Jan;11(1):13-25. doi: 10.1080/19420862.2018.1532766. Epub 2018 Nov 5.


Assessing the effects of environmentally relevant concentrations of antidepressant mixtures to fathead minnows exposed over a full life cycle.

Parrott JL, Metcalfe CD.

Sci Total Environ. 2019 Jan 15;648:1227-1236. doi: 10.1016/j.scitotenv.2018.08.237. Epub 2018 Aug 19.


The QuinteT Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation.

Rooshenas L, Scott LJ, Blazeby JM, Rogers CA, Tilling KM, Husbands S, Conefrey C, Mills N, Stein RC, Metcalfe C, Carr AJ, Beard DJ, Davis T, Paramasivan S, Jepson M, Avery K, Elliott D, Wilson C, Donovan JL; By-Band-Sleeve study group; CSAW study group; HAND-1 study group; Optima prelim study group; Romio feasibility study group.

J Clin Epidemiol. 2019 Feb;106:108-120. doi: 10.1016/j.jclinepi.2018.10.004. Epub 2018 Oct 16.


Investigating the effects of lycopene and green tea on the metabolome of men at risk of prostate cancer: The ProDiet randomised controlled trial.

Beynon RA, Richmond RC, Santos Ferreira DL, Ness AR, May M, Smith GD, Vincent EE, Adams C, Ala-Korpela M, Würtz P, Soidinsalo S, Metcalfe C, Donovan JL, Lane AJ, Martin RM; ProtecT Study Group; PRACTICAL consortium.

Int J Cancer. 2019 Apr 15;144(8):1918-1928. doi: 10.1002/ijc.31929. Epub 2018 Dec 7.

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