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Items: 50


Anti-influenza immune plasma for the treatment of patients with severe influenza A: a randomised, double-blind, phase 3 trial.

Beigel JH, Aga E, Elie-Turenne MC, Cho J, Tebas P, Clark CL, Metcalf JP, Ozment C, Raviprakash K, Beeler J, Holley HP Jr, Warner S, Chorley C, Lane HC, Hughes MD, Davey RT Jr; IRC005 Study Team.

Lancet Respir Med. 2019 Nov;7(11):941-950. doi: 10.1016/S2213-2600(19)30199-7. Epub 2019 Sep 30.


Airway Macrophage and Dendritic Cell Subsets in the Resting Human Lung.

Patel VI, Metcalf JP.

Crit Rev Immunol. 2018;38(4):303-331. doi: 10.1615/CritRevImmunol.2018026459. Review.


RIG-I Signaling via MAVS Is Dispensable for Survival in Lethal Influenza Infection In Vivo.

Wu W, Wang X, Zhang W, Tian L, Booth JL, Duggan ES, More S, Liu L, Dozmorov M, Metcalf JP.

Mediators Inflamm. 2018 Nov 8;2018:6808934. doi: 10.1155/2018/6808934. eCollection 2018.


Gene expression profiling of primary human type I alveolar epithelial cells exposed to Bacillus anthracis spores reveals induction of neutrophil and monocyte chemokines.

Booth JL, Duggan ES, Patel VI, Wu W, Burian DM, Hutchings DC, White VL, Coggeshall KM, Dozmorov MG, Metcalf JP.

Microb Pathog. 2018 Aug;121:9-21. doi: 10.1016/j.micpath.2018.04.039. Epub 2018 Apr 25.


Neither Lys- and DAP-type peptidoglycans stimulate mouse or human innate immune cells via Toll-like receptor 2.

Langer M, Girton AW, Popescu NI, Burgett T, Metcalf JP, Coggeshall KM.

PLoS One. 2018 Feb 23;13(2):e0193207. doi: 10.1371/journal.pone.0193207. eCollection 2018.


Regulation of influenza virus replication by Wnt/β-catenin signaling.

More S, Yang X, Zhu Z, Bamunuarachchi G, Guo Y, Huang C, Bailey K, Metcalf JP, Liu L.

PLoS One. 2018 Jan 11;13(1):e0191010. doi: 10.1371/journal.pone.0191010. eCollection 2018.


RIG-I overexpression decreases mortality of cigarette smoke exposed mice during influenza A virus infection.

Wang X, Wu W, Zhang W, Leland Booth J, Duggan ES, Tian L, More S, Zhao YD, Sawh RN, Liu L, Zou MH, Metcalf JP.

Respir Res. 2017 Sep 2;18(1):166. doi: 10.1186/s12931-017-0649-z.


Transcriptional Classification and Functional Characterization of Human Airway Macrophage and Dendritic Cell Subsets.

Patel VI, Booth JL, Duggan ES, Cate S, White VL, Hutchings D, Kovats S, Burian DM, Dozmorov M, Metcalf JP.

J Immunol. 2017 Feb 1;198(3):1183-1201. doi: 10.4049/jimmunol.1600777. Epub 2016 Dec 28.


Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responses.

Wu W, Zhang W, Booth JL, Hutchings DC, Wang X, White VL, Youness H, Cross CD, Zou MH, Burian D, Metcalf JP.

Respir Res. 2016 Sep 7;17(1):111. doi: 10.1186/s12931-016-0428-2.


Bacillus anthracis spore movement does not require a carrier cell and is not affected by lethal toxin in human lung models.

Booth JL, Duggan ES, Patel VI, Langer M, Wu W, Braun A, Coggeshall KM, Metcalf JP.

Microbes Infect. 2016 Oct;18(10):615-626. doi: 10.1016/j.micinf.2016.06.004. Epub 2016 Jun 16.


Identification and characterization of human dendritic cell subsets in the steady state: a review of our current knowledge.

Patel VI, Metcalf JP.

J Investig Med. 2016 Apr;64(4):833-47. doi: 10.1136/jim-2016-000072. Epub 2016 Mar 8. Review.


Homozygosity for frameshift mutations in XYLT2 result in a spondylo-ocular syndrome with bone fragility, cataracts, and hearing defects.

Munns CF, Fahiminiya S, Poudel N, Munteanu MC, Majewski J, Sillence DO, Metcalf JP, Biggin A, Glorieux F, Fassier F, Rauch F, Hinsdale ME.

Am J Hum Genet. 2015 Jun 4;96(6):971-8. doi: 10.1016/j.ajhg.2015.04.017. Epub 2015 May 28.


RIG-I and TLR3 are both required for maximum interferon induction by influenza virus in human lung alveolar epithelial cells.

Wu W, Zhang W, Duggan ES, Booth JL, Zou MH, Metcalf JP.

Virology. 2015 Aug;482:181-8. doi: 10.1016/j.virol.2015.03.048. Epub 2015 Apr 11.


Cigarette smoke attenuates the RIG-I-initiated innate antiviral response to influenza infection in two murine models.

Wu W, Zhang W, More S, Booth JL, Duggan ES, Liu L, Zhao YD, Metcalf JP.

Am J Physiol Lung Cell Mol Physiol. 2014 Dec 1;307(11):L848-58. doi: 10.1152/ajplung.00158.2014. Epub 2014 Sep 26.


Editorial: Mannose-binding lectin in fighting influenza: promise or peril?

Wu BW, Metcalf JP.

J Leukoc Biol. 2014 May;95(5):702-704. No abstract available.


N-Acetylcysteine Protection in COPD: An Alternative Mechanism of Action.

Wu W, Awab A, Metcalf JP.

Chest. 2014 Jan;145(1):193-4. doi: 10.1378/chest.13-2029. No abstract available.


The Central Society for Clinical and Translational Research: more than just a name change.

Weintraub NL, Metcalf JP.

Transl Res. 2013 Sep;162(3):201-2. doi: 10.1016/j.trsl.2013.07.001. Epub 2013 Jul 13. No abstract available.


The sepsis model: an emerging hypothesis for the lethality of inhalation anthrax.

Coggeshall KM, Lupu F, Ballard J, Metcalf JP, James JA, Farris D, Kurosawa S.

J Cell Mol Med. 2013 Jul;17(7):914-20. doi: 10.1111/jcmm.12075. Epub 2013 Jun 7.


Influenza A(H1N1)pdm09 virus suppresses RIG-I initiated innate antiviral responses in the human lung.

Wu W, Zhang W, Booth JL, Metcalf JP.

PLoS One. 2012;7(11):e49856. doi: 10.1371/journal.pone.0049856. Epub 2012 Nov 21.


Bacillus anthracis lethal toxin reduces human alveolar epithelial barrier function.

Langer M, Duggan ES, Booth JL, Patel VI, Zander RA, Silasi-Mansat R, Ramani V, Veres TZ, Prenzler F, Sewald K, Williams DM, Coggeshall KM, Awasthi S, Lupu F, Burian D, Ballard JD, Braun A, Metcalf JP.

Infect Immun. 2012 Dec;80(12):4374-87. doi: 10.1128/IAI.01011-12. Epub 2012 Oct 1.


Implications of the innate immune response to adenovirus and adenoviral vectors.

Gregory SM, Nazir SA, Metcalf JP.

Future Virol. 2011 Mar;6(3):357-374.


Cigarette smoke extract suppresses the RIG-I-initiated innate immune response to influenza virus in the human lung.

Wu W, Patel KB, Booth JL, Zhang W, Metcalf JP.

Am J Physiol Lung Cell Mol Physiol. 2011 Jun;300(6):L821-30. doi: 10.1152/ajplung.00267.2010. Epub 2011 Feb 18.


Innate immune response to influenza virus.

Wu S, Metcalf JP, Wu W.

Curr Opin Infect Dis. 2011 Jun;24(3):235-40. doi: 10.1097/QCO.0b013e328344c0e3. Review.


Protective essential oil attenuates influenza virus infection: an in vitro study in MDCK cells.

Wu S, Patel KB, Booth LJ, Metcalf JP, Lin HK, Wu W.

BMC Complement Altern Med. 2010 Nov 15;10:69. doi: 10.1186/1472-6882-10-69.


Inflammatory cytokine response to Bacillus anthracis peptidoglycan requires phagocytosis and lysosomal trafficking.

Iyer JK, Khurana T, Langer M, West CM, Ballard JD, Metcalf JP, Merkel TJ, Coggeshall KM.

Infect Immun. 2010 Jun;78(6):2418-28. doi: 10.1128/IAI.00170-10. Epub 2010 Mar 22.


Human lung innate immune cytokine response to adenovirus type 7.

Wu W, Booth JL, Duggan ES, Patel KB, Coggeshall KM, Metcalf JP.

J Gen Virol. 2010 May;91(Pt 5):1155-63. doi: 10.1099/vir.0.017905-0. Epub 2010 Jan 13.


Innate immune response to H3N2 and H1N1 influenza virus infection in a human lung organ culture model.

Wu W, Booth JL, Duggan ES, Wu S, Patel KB, Coggeshall KM, Metcalf JP.

Virology. 2010 Jan 20;396(2):178-88. doi: 10.1016/j.virol.2009.10.016. Epub 2009 Nov 12.


Resistance of human alveolar macrophages to Bacillus anthracis lethal toxin.

Wu W, Mehta H, Chakrabarty K, Booth JL, Duggan ES, Patel KB, Ballard JD, Coggeshall KM, Metcalf JP.

J Immunol. 2009 Nov 1;183(9):5799-806. doi: 10.4049/jimmunol.0803406. Epub 2009 Oct 7.


Gene expression profiling of human alveolar macrophages infected by B. anthracis spores demonstrates TNF-alpha and NF-kappab are key components of the innate immune response to the pathogen.

Dozmorov M, Wu W, Chakrabarty K, Booth JL, Hurst RE, Coggeshall KM, Metcalf JP.

BMC Infect Dis. 2009 Sep 10;9:152. doi: 10.1186/1471-2334-9-152.


Bacillus anthracis peptidoglycan stimulates an inflammatory response in monocytes through the p38 mitogen-activated protein kinase pathway.

Langer M, Malykhin A, Maeda K, Chakrabarty K, Williamson KS, Feasley CL, West CM, Metcalf JP, Coggeshall KM.

PLoS One. 2008;3(11):e3706. doi: 10.1371/journal.pone.0003706. Epub 2008 Nov 12.


Human lung innate immune response to Bacillus anthracis spore infection.

Chakrabarty K, Wu W, Booth JL, Duggan ES, Nagle NN, Coggeshall KM, Metcalf JP.

Infect Immun. 2007 Aug;75(8):3729-38. Epub 2007 May 21.


Is pseudo-Cushing's syndrome in a critically ill patient "pseudo"? Hypothesis and supportive case report.

Kem DC, Metcalf JP, Cornea A, Dunnam M, Engelbrecht A, Yu X.

Endocr Pract. 2007 Mar-Apr;13(2):153-8.


Calcium-dependent viral internalization is required for adenovirus type 7 induction of IL-8 protein.

Wu W, Booth JL, Coggeshall KM, Metcalf JP.

Virology. 2006 Nov 10;355(1):18-29. Epub 2006 Aug 4.


Innate immune response to adenovirus.

Nazir SA, Metcalf JP.

J Investig Med. 2005 Sep;53(6):292-304. doi: 10.2310/6650.2005.53605. Review.


Proteasome degradation of GRK2 during ischemia and ventricular tachyarrhythmias in a canine model of myocardial infarction.

Yu X, Huang S, Patterson E, Garrett MW, Kaufman KM, Metcalf JP, Zhu M, Dunn ST, Kem DC.

Am J Physiol Heart Circ Physiol. 2005 Nov;289(5):H1960-7. Epub 2005 Jul 1.


Adenovirus type 7 induces interleukin-8 in a lung slice model and requires activation of Erk.

Booth JL, Coggeshall KM, Gordon BE, Metcalf JP.

J Virol. 2004 Apr;78(8):4156-64.


Tumor necrosis factor-alpha activation by adenovirus E1A 13S CR3 occurs in a cell-dependent and cell-independent manner.

Sanchez TA, Booth JL, Metcalf JP.

Am J Physiol Lung Cell Mol Physiol. 2002 Sep;283(3):L619-27.


Adenovirus type 7 induces interleukin-8 production via activation of extracellular regulated kinase 1/2.

Alcorn MJ, Booth JL, Coggeshall KM, Metcalf JP.

J Virol. 2001 Jul;75(14):6450-9.


Zinc finger and carboxyl regions of adenovirus E1A 13S CR3 are important for transactivation of the cytomegalovirus major immediate early promoter by adenovirus.

Sanchez TA, Habib I, Leland Booth J, Evetts SM, Metcalf JP.

Am J Respir Cell Mol Biol. 2000 Nov;23(5):670-7.


Type-specific induction of interleukin-8 by adenovirus.

Leland Booth J, Metcalf JP.

Am J Respir Cell Mol Biol. 1999 Oct;21(4):521-7.


Adenovirus E1A 13S gene product upregulates tumor necrosis factor gene.

Metcalf JP.

Am J Physiol. 1996 Apr;270(4 Pt 1):L535-40.


Adenovirus E1A 13S gene product up-regulates the cytomegalovirus major immediate early promoter.

Metcalf JP, Monick MM, Stinski MF, Hunninghake GW.

Am J Respir Cell Mol Biol. 1994 Apr;10(4):448-52.


Gcglobulin functions as a cochemotaxin in the lower respiratory tract. A potential mechanism for lung neutrophil recruitment in cigarette smokers.

Metcalf JP, Thompson AB, Gossman GL, Nelson KJ, Koyama S, Rennard SI, Robbins RA.

Am Rev Respir Dis. 1991 Apr;143(4 Pt 1):844-9.


Chronic ethanol administration alters hepatic surface membranes as evidenced by decreased concanavalin A binding.

Metcalf JP, Casey CA, Sorrell MF, Tuma DJ.

Proc Soc Exp Biol Med. 1987 May;185(1):1-5.


Anterior pituitary gland secretion after forebrain ablation: periovulatory gonadotropin release.

Blake CA, Metcalf JP, Hendricks SE.

Endocrinology. 1982 Sep;111(3):789-93.


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