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Items: 1 to 50 of 74

1.

Leveraging Human Microbiome Features to Diagnose and Stratify Children with Irritable Bowel Syndrome.

Hollister EB, Oezguen N, Chumpitazi BP, Luna RA, Weidler EM, Rubio-Gonzales M, Dahdouli M, Cope JL, Mistretta TA, Raza S, Metcalf GA, Muzny DM, Gibbs RA, Petrosino JF, Heitkemper M, Savidge TC, Shulman RJ, Versalovic J.

J Mol Diagn. 2019 May;21(3):449-461. doi: 10.1016/j.jmoldx.2019.01.006. Epub 2019 Apr 17.

2.

Temporal development of the gut microbiome in early childhood from the TEDDY study.

Stewart CJ, Ajami NJ, O'Brien JL, Hutchinson DS, Smith DP, Wong MC, Ross MC, Lloyd RE, Doddapaneni H, Metcalf GA, Muzny D, Gibbs RA, Vatanen T, Huttenhower C, Xavier RJ, Rewers M, Hagopian W, Toppari J, Ziegler AG, She JX, Akolkar B, Lernmark A, Hyoty H, Vehik K, Krischer JP, Petrosino JF.

Nature. 2018 Oct;562(7728):583-588. doi: 10.1038/s41586-018-0617-x. Epub 2018 Oct 24.

3.

Sequence-Based Analysis of Lipid-Related Metabolites in a Multiethnic Study.

Feofanova EV, Yu B, Metcalf GA, Liu X, Muzny D, Below JE, Wagenknecht LE, Gibbs RA, Morrison AC, Boerwinkle E.

Genetics. 2018 Jun;209(2):607-616. doi: 10.1534/genetics.118.300751. Epub 2018 Apr 2.

4.

Linking climate policies to advance global mitigation.

Mehling MA, Metcalf GE, Stavins RN.

Science. 2018 Mar 2;359(6379):997-998. doi: 10.1126/science.aar5988. No abstract available.

5.

Challenges of Francisella classification exemplified by an atypical clinical isolate.

Matz LM, Kamdar KY, Holder ME, Metcalf GA, Weissenberger GM, Meng Q, Vee V, Han Y, Muzny DM, Gibbs RA, Johnson CL, Revell PA, Petrosino JF.

Diagn Microbiol Infect Dis. 2018 Apr;90(4):241-247. doi: 10.1016/j.diagmicrobio.2017.11.023. Epub 2017 Dec 6.

6.

The gut mycobiome of the Human Microbiome Project healthy cohort.

Nash AK, Auchtung TA, Wong MC, Smith DP, Gesell JR, Ross MC, Stewart CJ, Metcalf GA, Muzny DM, Gibbs RA, Ajami NJ, Petrosino JF.

Microbiome. 2017 Nov 25;5(1):153. doi: 10.1186/s40168-017-0373-4.

7.

Whole-genome sequencing study of serum peptide levels: the Atherosclerosis Risk in Communities study.

de Vries PS, Yu B, Feofanova EV, Metcalf GA, Brown MR, Zeighami AL, Liu X, Muzny DM, Gibbs RA, Boerwinkle E, Morrison AC.

Hum Mol Genet. 2017 Sep 1;26(17):3442-3450. doi: 10.1093/hmg/ddx266.

8.

Whole exome sequencing in the Framingham Heart Study identifies rare variation in HYAL2 that influences platelet aggregation.

Eicher JD, Chen MH, Pitsillides AN, Lin H, Veeraraghavan N, Brody JA, Metcalf GA, Muzny DM, Gibbs RA, Becker DM, Becker LC, Faraday N, Mathias RA, Yanek LR, Boerwinkle E, Cupples LA, Johnson AD.

Thromb Haemost. 2017 Jun 2;117(6):1083-1092. doi: 10.1160/TH16-09-0677. Epub 2017 Mar 16.

PMID:
28300864
9.

Practical Approaches for Whole-Genome Sequence Analysis of Heart- and Blood-Related Traits.

Morrison AC, Huang Z, Yu B, Metcalf G, Liu X, Ballantyne C, Coresh J, Yu F, Muzny D, Feofanova E, Rustagi N, Gibbs R, Boerwinkle E.

Am J Hum Genet. 2017 Feb 2;100(2):205-215. doi: 10.1016/j.ajhg.2016.12.009. Epub 2017 Jan 12.

10.

Whole-exome sequencing reveals an inherited R566X mutation of the epithelial sodium channel β-subunit in a case of early-onset phenotype of Liddle syndrome.

Polfus LM, Boerwinkle E, Gibbs RA, Metcalf G, Muzny D, Veeraraghavan N, Grove M, Shete S, Wallace S, Milewicz D, Hanchard N, Lupski JR, Hashmi SS, Gupta-Malhotra M.

Cold Spring Harb Mol Case Stud. 2016 Nov;2(6):a001255.

11.

Whole genome sequence analysis of serum amino acid levels.

Yu B, de Vries PS, Metcalf GA, Wang Z, Feofanova EV, Liu X, Muzny DM, Wagenknecht LE, Gibbs RA, Morrison AC, Boerwinkle E.

Genome Biol. 2016 Nov 24;17(1):237.

12.

Evaluation of adipose-derived stromal vascular fraction from the lateral tailhead, inguinal region, and mesentery of horses.

Metcalf GL, McClure SR, Hostetter JM, Martinez RF, Wang C.

Can J Vet Res. 2016 Oct;80(4):294-301.

13.

Loss-of-function variants influence the human serum metabolome.

Yu B, Li AH, Metcalf GA, Muzny DM, Morrison AC, White S, Mosley TH, Gibbs RA, Boerwinkle E.

Sci Adv. 2016 Aug 31;2(8):e1600800. doi: 10.1126/sciadv.1600800. eCollection 2016 Aug.

14.

Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis.

Polfus LM, Khajuria RK, Schick UM, Pankratz N, Pazoki R, Brody JA, Chen MH, Auer PL, Floyd JS, Huang J, Lange L, van Rooij FJA, Gibbs RA, Metcalf G, Muzny D, Veeraraghavan N, Walter K, Chen L, Yanek L, Becker LC, Peloso GM, Wakabayashi A, Kals M, Metspalu A, Esko T, Fox K, Wallace R, Franceschini N, Matijevic N, Rice KM, Bartz TM, Lyytikäinen LP, Kähönen M, Lehtimäki T, Raitakari OT, Li-Gao R, Mook-Kanamori DO, Lettre G, van Duijn CM, Franco OH, Rich SS, Rivadeneira F, Hofman A, Uitterlinden AG, Wilson JG, Psaty BM, Soranzo N, Dehghan A, Boerwinkle E, Zhang X, Johnson AD, O'Donnell CJ, Johnsen JM, Reiner AP, Ganesh SK, Sankaran VG.

Am J Hum Genet. 2016 Sep 1;99(3):785. doi: 10.1016/j.ajhg.2016.08.002. Epub 2016 Sep 1. No abstract available.

15.

Amplification-Free Detection of Circulating microRNA Biomarkers from Body Fluids Based on Fluorogenic Oligonucleotide-Templated Reaction between Engineered Peptide Nucleic Acid Probes: Application to Prostate Cancer Diagnosis.

Metcalf GA, Shibakawa A, Patel H, Sita-Lumsden A, Zivi A, Rama N, Bevan CL, Ladame S.

Anal Chem. 2016 Aug 16;88(16):8091-8. doi: 10.1021/acs.analchem.6b01594. Epub 2016 Aug 7.

16.

Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis.

Polfus LM, Khajuria RK, Schick UM, Pankratz N, Pazoki R, Brody JA, Chen MH, Auer PL, Floyd JS, Huang J, Lange L, van Rooij FJ, Gibbs RA, Metcalf G, Muzny D, Veeraraghavan N, Walter K, Chen L, Yanek L, Becker LC, Peloso GM, Wakabayashi A, Kals M, Metspalu A, Esko T, Fox K, Wallace R, Franceschini N, Matijevic N, Rice KM, Bartz TM, Lyytikäinen LP, Kähönen M, Lehtimäki T, Raitakari OT, Li-Gao R, Mook-Kanamori DO, Lettre G, van Duijn CM, Franco OH, Rich SS, Rivadeneira F, Hofman A, Uitterlinden AG, Wilson JG, Psaty BM, Soranzo N, Dehghan A, Boerwinkle E, Zhang X, Johnson AD, O'Donnell CJ, Johnsen JM, Reiner AP, Ganesh SK, Sankaran VG.

Am J Hum Genet. 2016 Aug 4;99(2):481-8. doi: 10.1016/j.ajhg.2016.06.016. Erratum in: Am J Hum Genet. 2016 Sep 1;99(3):785.

17.

CLIMATE ECONOMICS. Opportunities for advances in climate change economics.

Burke M, Craxton M, Kolstad CD, Onda C, Allcott H, Baker E, Barrage L, Carson R, Gillingham K, Graff-Zivin J, Greenstone M, Hallegatte S, Hanemann WM, Heal G, Hsiang S, Jones B, Kelly DL, Kopp R, Kotchen M, Mendelsohn R, Meng K, Metcalf G, Moreno-Cruz J, Pindyck R, Rose S, Rudik I, Stock J, Tol RS.

Science. 2016 Apr 15;352(6283):292-3. doi: 10.1126/science.aad9634. Epub 2016 Apr 14. No abstract available.

PMID:
27081055
18.

Rare Exome Sequence Variants in CLCN6 Reduce Blood Pressure Levels and Hypertension Risk.

Yu B, Pulit SL, Hwang SJ, Brody JA, Amin N, Auer PL, Bis JC, Boerwinkle E, Burke GL, Chakravarti A, Correa A, Dreisbach AW, Franco OH, Ehret GB, Franceschini N, Hofman A, Lin DY, Metcalf GA, Musani SK, Muzny D, Palmas W, Raffel L, Reiner A, Rice K, Rotter JI, Veeraraghavan N, Fox E, Guo X, North KE, Gibbs RA, van Duijn CM, Psaty BM, Levy D, Newton-Cheh C, Morrison AC; CHARGE Consortium and the National Heart, Lung, and Blood Institute GO ESP*.

Circ Cardiovasc Genet. 2016 Feb;9(1):64-70. doi: 10.1161/CIRCGENETICS.115.001215. Epub 2015 Dec 11.

19.

Structure and function of the healthy pre-adolescent pediatric gut microbiome.

Hollister EB, Riehle K, Luna RA, Weidler EM, Rubio-Gonzales M, Mistretta TA, Raza S, Doddapaneni HV, Metcalf GA, Muzny DM, Gibbs RA, Petrosino JF, Shulman RJ, Versalovic J.

Microbiome. 2015 Aug 26;3:36. doi: 10.1186/s40168-015-0101-x.

20.

High-Quality Draft Genome Sequence of Francisella tularensis subsp. holarctica Strain OR96-0246.

Atkins LM, Holder ME, Ajami NJ, Metcalf GA, Weissenberger GM, Wang M, Vee V, Han Y, Muzny DM, Gibbs RA, Petrosino JF.

Genome Announc. 2015 Aug 13;3(4). pii: e00898-15. doi: 10.1128/genomeA.00898-15.

21.

Analysis of loss-of-function variants and 20 risk factor phenotypes in 8,554 individuals identifies loci influencing chronic disease.

Li AH, Morrison AC, Kovar C, Cupples LA, Brody JA, Polfus LM, Yu B, Metcalf G, Muzny D, Veeraraghavan N, Liu X, Lumley T, Mosley TH, Gibbs RA, Boerwinkle E.

Nat Genet. 2015 Jun;47(6):640-2. doi: 10.1038/ng.3270. Epub 2015 Apr 27.

22.

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.

Wessel J, Chu AY, Willems SM, Wang S, Yaghootkar H, Brody JA, Dauriz M, Hivert MF, Raghavan S, Lipovich L, Hidalgo B, Fox K, Huffman JE, An P, Lu Y, Rasmussen-Torvik LJ, Grarup N, Ehm MG, Li L, Baldridge AS, Stančáková A, Abrol R, Besse C, Boland A, Bork-Jensen J, Fornage M, Freitag DF, Garcia ME, Guo X, Hara K, Isaacs A, Jakobsdottir J, Lange LA, Layton JC, Li M, Hua Zhao J, Meidtner K, Morrison AC, Nalls MA, Peters MJ, Sabater-Lleal M, Schurmann C, Silveira A, Smith AV, Southam L, Stoiber MH, Strawbridge RJ, Taylor KD, Varga TV, Allin KH, Amin N, Aponte JL, Aung T, Barbieri C, Bihlmeyer NA, Boehnke M, Bombieri C, Bowden DW, Burns SM, Chen Y, Chen YD, Cheng CY, Correa A, Czajkowski J, Dehghan A, Ehret GB, Eiriksdottir G, Escher SA, Farmaki AE, Frånberg M, Gambaro G, Giulianini F, Goddard WA 3rd, Goel A, Gottesman O, Grove ML, Gustafsson S, Hai Y, Hallmans G, Heo J, Hoffmann P, Ikram MK, Jensen RA, Jørgensen ME, Jørgensen T, Karaleftheri M, Khor CC, Kirkpatrick A, Kraja AT, Kuusisto J, Lange EM, Lee IT, Lee WJ, Leong A, Liao J, Liu C, Liu Y, Lindgren CM, Linneberg A, Malerba G, Mamakou V, Marouli E, Maruthur NM, Matchan A, McKean-Cowdin R, McLeod O, Metcalf GA, Mohlke KL, Muzny DM, Ntalla I, Palmer ND, Pasko D, Peter A, Rayner NW, Renström F, Rice K, Sala CF, Sennblad B, Serafetinidis I, Smith JA, Soranzo N, Speliotes EK, Stahl EA, Stirrups K, Tentolouris N, Thanopoulou A, Torres M, Traglia M, Tsafantakis E, Javad S, Yanek LR, Zengini E, Becker DM, Bis JC, Brown JB, Cupples LA, Hansen T, Ingelsson E, Karter AJ, Lorenzo C, Mathias RA, Norris JM, Peloso GM, Sheu WH, Toniolo D, Vaidya D, Varma R, Wagenknecht LE, Boeing H, Bottinger EP, Dedoussis G, Deloukas P, Ferrannini E, Franco OH, Franks PW, Gibbs RA, Gudnason V, Hamsten A, Harris TB, Hattersley AT, Hayward C, Hofman A, Jansson JH, Langenberg C, Launer LJ, Levy D, Oostra BA, O'Donnell CJ, O'Rahilly S, Padmanabhan S, Pankow JS, Polasek O, Province MA, Rich SS, Ridker PM, Rudan I, Schulze MB, Smith BH, Uitterlinden AG, Walker M, Watkins H, Wong TY, Zeggini E; EPIC-InterAct Consortium, Laakso M, Borecki IB, Chasman DI, Pedersen O, Psaty BM, Tai ES, van Duijn CM, Wareham NJ, Waterworth DM, Boerwinkle E, Kao WH, Florez JC, Loos RJ, Wilson JG, Frayling TM, Siscovick DS, Dupuis J, Rotter JI, Meigs JB, Scott RA, Goodarzi MO.

Nat Commun. 2015 Jan 29;6:5897. doi: 10.1038/ncomms6897.

23.

Oligonucleotide-templated reactions based on Peptide Nucleic Acid (PNA) probes: concept and biomedical applications.

Choi Y, Metcalf G, Sleiman MH, Vair-Turnbull D, Ladame S.

Bioorg Med Chem. 2014 Aug 15;22(16):4395-8. doi: 10.1016/j.bmc.2014.05.071. Epub 2014 Jun 12.

PMID:
24957880
24.

Somatic mutations affect key pathways in lung adenocarcinoma.

Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, Cibulskis K, Sougnez C, Greulich H, Muzny DM, Morgan MB, Fulton L, Fulton RS, Zhang Q, Wendl MC, Lawrence MS, Larson DE, Chen K, Dooling DJ, Sabo A, Hawes AC, Shen H, Jhangiani SN, Lewis LR, Hall O, Zhu Y, Mathew T, Ren Y, Yao J, Scherer SE, Clerc K, Metcalf GA, Ng B, Milosavljevic A, Gonzalez-Garay ML, Osborne JR, Meyer R, Shi X, Tang Y, Koboldt DC, Lin L, Abbott R, Miner TL, Pohl C, Fewell G, Haipek C, Schmidt H, Dunford-Shore BH, Kraja A, Crosby SD, Sawyer CS, Vickery T, Sander S, Robinson J, Winckler W, Baldwin J, Chirieac LR, Dutt A, Fennell T, Hanna M, Johnson BE, Onofrio RC, Thomas RK, Tonon G, Weir BA, Zhao X, Ziaugra L, Zody MC, Giordano T, Orringer MB, Roth JA, Spitz MR, Wistuba II, Ozenberger B, Good PJ, Chang AC, Beer DG, Watson MA, Ladanyi M, Broderick S, Yoshizawa A, Travis WD, Pao W, Province MA, Weinstock GM, Varmus HE, Gabriel SB, Lander ES, Gibbs RA, Meyerson M, Wilson RK.

Nature. 2008 Oct 23;455(7216):1069-75. doi: 10.1038/nature07423.

25.

Premenstrual tension among hysterectomized women.

Braiden V, Metcalf G.

J Psychosom Obstet Gynaecol. 1995 Sep;16(3):145-51.

PMID:
8528381
26.

The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke.

Hasegawa Y, Fisher M, Baron BM, Metcalf G.

Stroke. 1994 Jun;25(6):1241-4; discussion 1245-6.

PMID:
8202987
27.

Behavioral effects of several new anxiolytics and putative anxiolytics.

Young R, Urbancic A, Emrey TA, Hall PC, Metcalf G.

Eur J Pharmacol. 1987 Nov 17;143(3):361-71.

PMID:
2891554
28.

Antihypertensive and hypotensive actions of atiprosin (AY-28,228) in rats, dogs, and monkeys.

Oshiro G, Wojdan A, Klein M, Metcalf G.

J Cardiovasc Pharmacol. 1987 Sep;10(3):341-9.

PMID:
2444784
29.

In vitro isolated tissue studies with atiprosin (AY-28,228): a new antihypertensive compound.

Grimes D, Rimele TJ, Henry DE, Heaslip RJ, Geiger G, Lee DK, Metcalf G.

J Cardiovasc Pharmacol. 1987 Sep;10(3):249-58.

PMID:
2444771
30.
31.
32.

Analeptic effects of centrally injected TRH and analogues of TRH in the pentobarbitone-anaesthetized rat.

Sharp T, Tulloch IF, Bennett GW, Marsden CA, Metcalf G, Dettmar PW.

Neuropharmacology. 1984 Mar;23(3):339-48.

PMID:
6145113
33.
34.

Brain TRH receptors are the same as pituitary TRH receptors.

Detimar PW, Lynn AG, Metcalf G, Morgan BA.

J Pharm Pharmacol. 1983 Jun;35(6):399-400. No abstract available.

PMID:
6135787
36.

The ability of RX 77368 - a stabilised analogue of TRH - to provoke the secretion of prolactin and TSH in vivo.

Dettmar PW, Lynn AG, Metcalf G, Clifford JM.

Neuropeptides. 1982 Oct;3(1):1-8.

PMID:
6818488
37.

Continuous infusion in rats as a method of assessing morphine-like physical dependence for opiates.

McCarthy PS, Metcalf G, Howe SJ.

Pharmacol Biochem Behav. 1982 May;16(5):725-9. No abstract available.

PMID:
7201141
38.

Neuropharmacological evaluation of RX 77368--a stabilised analogue of thyrotropin-releasing hormone (TRH).

Metcalf G, Dettmar PW, Fortune D, Lynn AG, Tulloch IF.

Regul Pept. 1982 Mar;3(3-4):193-206.

PMID:
6805044
39.

Thyrotropin-releasing hormone (TRH) analogues show enhanced CNS selectivity because of increased biological stability.

Metcalf G, Dettmar PW, Lynn AG, Brewster D, Havler ME.

Regul Pept. 1981 Sep;2(5):277-84.

PMID:
6795691
40.

Biologically stable analogues of TRH with increased neuropharmacological potency.

Brewster D, Dettmar PW, Metcalf G.

Neuropharmacology. 1981 May;20(5):497-503. No abstract available.

PMID:
6787451
41.

Is thyrotropin releasing hormone an endogenous ergotropic substance in the brain?

Metcalf G, Dettmar PW.

Lancet. 1981 Mar 14;1(8220 Pt 1):586-9.

PMID:
6110823
42.

The effects of opiate antagonists on food intake are stereospecific.

Sanger DJ, McCarthy PS, Metcalf G.

Neuropharmacology. 1981 Jan;20(1):45-7. No abstract available.

PMID:
6261182
43.

Biological evaluation of a TRH analogue with a modified proline residue.

Dettmar PW, Fortune D, Lynn AG, Metcalf G, Morgan BA.

Neuropharmacology. 1980 Dec;19(12):1247-8. No abstract available.

PMID:
6777711
44.

Modification of the proline residue of TRH enhances biological activity and inhibits degradation.

Brewster D, Dettmar PW, Lynn AG, Metcalf G, Morgan BA, Rance MJ.

Eur J Pharmacol. 1980 Aug 22;66(1):65-71.

PMID:
6773784
45.

Dependence, tolerance and cross-tolerance induced by morphine and ethylketocyclazocine [proceedings].

Metcalf G, Rees JM, Ward SJ.

Br J Pharmacol. 1979 Nov;67(3):427P-428P. No abstract available.

46.
47.

In vivo antagonism of analgesia and respiratory depression induced by proposed mu and kappa opiate agonists [proceedings].

Metcalf G, Rees JM, Ward SJ.

Br J Pharmacol. 1979 Jul;66(3):473P-474P. No abstract available.

48.

A study of the changes in motor behaviour caused by TRH on intracerebral injection.

Costall B, Hui SC, Metcalf G, Naylor RJ.

Eur J Pharmacol. 1979 Jan 1;53(2):143-50.

PMID:
103733
49.

Opiate analgesics: the effect of agonist-antagonist character on prolactin secretion.

Brown B, Dettmar PW, Dobson PR, Lynn AG, Metcalf G, Morgan BA.

J Pharm Pharmacol. 1978 Oct;30(10):644-5. No abstract available.

PMID:
30820
50.

Precise location within the preoptic area where noradrenaline produces hypothermia.

Metcalf G, Myers RD.

Eur J Pharmacol. 1978 Sep 1;51(1):47-53.

PMID:
699973

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